cimetidine has been researched along with Nervous System Disorders in 9 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Weekly paclitaxel at a dose of 67 mg/m2/week was found to have a better safety profile and seemed to be as effective as the equivalently dosed schedule every 3 weeks." | 2.70 | Randomized trial of single agent paclitaxel given weekly versus every three weeks and with peroral versus intravenous steroid premedication to patients with ovarian cancer previously treated with platinum. ( Andersson, H; Boman, K; Parö, G; Puistola, U; Ridderheim, M; Rosenberg, P; Sorbe, B, 2002) |
| " Most of the early excess in mortality was attributable to cimetidine being given in the late stages of many diseases, often to counter adverse gastric effects of other drugs." | 1.28 | Postmarketing surveillance of the safety of cimetidine: 10 year mortality report. ( Colin-Jones, DG; Langman, MJ; Lawson, DH; Logan, RF; Paterson, KR; Vessey, MP, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rosenberg, P | 1 |
| Andersson, H | 1 |
| Boman, K | 1 |
| Ridderheim, M | 1 |
| Sorbe, B | 1 |
| Puistola, U | 1 |
| Parö, G | 1 |
| Mariani, L | 1 |
| Minora, T | 1 |
| Smitz, S | 1 |
| Legros, JJ | 1 |
| Rousseau, JJ | 1 |
| Devreux, F | 1 |
| Hans, P | 1 |
| Born, JD | 1 |
| Hails, KC | 1 |
| Ng, JY | 1 |
| Jones, TE | 1 |
| Disney, AP | 1 |
| Mathew, TH | 1 |
| Alván, G | 1 |
| Gustafsson, LL | 1 |
| Ohman, B | 1 |
| Colin-Jones, DG | 1 |
| Langman, MJ | 1 |
| Lawson, DH | 1 |
| Logan, RF | 1 |
| Paterson, KR | 1 |
| Vessey, MP | 1 |
| Andersen, M | 1 |
| Schou, JS | 1 |
| Wiernik, PH | 1 |
| Schwartz, EL | 1 |
| Einzig, A | 1 |
| Strauman, JJ | 1 |
| Lipton, RB | 1 |
| Dutcher, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for cimetidine and Nervous System Disorders
| Article | Year |
|---|---|
Randomized trial of single agent paclitaxel given weekly versus every three weeks and with peroral versus intravenous steroid premedication to patients with ovarian cancer previously treated with platinum.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemot | 2002 |
8 other studies available for cimetidine and Nervous System Disorders
| Article | Year |
|---|---|
[Drug surveillance. Monitoring the collateral effects of drugs in the post-marketing phase: cimetidine. I].
Topics: Chemical and Drug Induced Liver Injury; Cimetidine; Endocrine System Diseases; Evaluation Studies as | 1984 |
[Cimetidine and neuropsychological disorders].
Topics: Age Factors; Aged; Cimetidine; Drug Interactions; Guanidines; Humans; Nervous System Diseases; Psych | 1983 |
Neuropsychiatric side effects of cimetidine.
Topics: Adult; Aged; Cimetidine; Delirium; Depression; Duodenal Ulcer; Gastric Acid; Gastritis; Gastrointest | 1982 |
Prolonged confusion after cimetidine.
Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Female; Guanidines; Humans; Male; Nervous System D | 1981 |
[Adverse effects of cimetidine--the current situation].
Topics: Cardiovascular Diseases; Cimetidine; Endocrine System Diseases; Guanidines; Hematologic Diseases; Hu | 1979 |
Postmarketing surveillance of the safety of cimetidine: 10 year mortality report.
Topics: Cimetidine; Duodenal Neoplasms; Esophageal Neoplasms; Female; Histamine H2 Antagonists; Humans; Live | 1992 |
Adverse reactions to H2-receptor antagonists in Denmark before and after transfer of cimetidine and ranitidine to over-the-counter status.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Anti-Ulcer Agents; Cimetidine; Denmark; Drug Interact | 1991 |
Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphenhydramine; Drug Admin | 1987 |