cimetidine has been researched along with Neoplasms in 45 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Excerpt | Relevance | Reference |
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"Paclitaxel 135 mg/m2 was infused as a single dose over 1 hour or was divided into three doses infused over 1 hour on 3 consecutive days." | 2.68 | One-hour paclitaxel infusion schedules: a phase I/II comparative trial. ( Greco, FA; Hainsworth, JD, 1995) |
"Paclitaxel dosage was escalated in 10 mg/m2/wk increments in subsequent patients, to a maximum dosage of 90 mg/m2/wk." | 2.68 | Schedule- and dose-intensified paclitaxel as weekly 1-hour infusion in pretreated solid tumors: results of a phase I/II trial. ( Freund, W; Hausamen, TU; Lipke, J; Löffler, TM, 1996) |
"Coumarin is a relatively nontoxic, oral, outpatient therapy that warrants further investigations for the treatment of human malignancies." | 2.67 | Phase I evaluation of coumarin (1,2-benzopyrone) and cimetidine in patients with advanced malignancies. ( Butler, K; Fried, A; Marshall, ME, 1991) |
"Histamine was perfectly tolerated up to 4 mg/day." | 2.66 | Clinical improvement in advanced cancer disease after treatment combining histamine and H2-antihistaminics (ranitidine or cimetidine). ( Bernard, P; Burtin, C; Galoppin, L; Noirot, C; Sabolovic, D; Scheinmann, P, 1988) |
"Its anticancer effect is also compared to that of the other H(2) receptor antagonists as well as outcomes of cimetidine in clinical studies in cancer patients." | 2.47 | Cimetidine: an anticancer drug? ( Bobek, V; Kacprzak, G; Kolostova, K; Kubecova, M; Pinterova, D, 2011) |
"The "cimetidine + ibuprofen"-treated mice displayed greater T-bet expression than the un-treated mice (P<0." | 1.72 | Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer. ( Hassan, ZM; Jafarzadeh, A; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2022) |
"Of 180 eligible cancer patients, 100 patients received paclitaxel weekly and 80 patients, every 3 weeks." | 1.35 | Oral premedication for the prevention of hypersensitivity reactions to paclitaxel. ( Abzah, A; Farraj, Z; Friedman, E; Hussein, O; Tamam, S; Zidan, J, 2008) |
"An excess risk for gastric cancer was observed, with a relative risk of about 10 in the first year after beginning use of the drug, which decreased thereafter." | 1.28 | Cancer occurrence in a cohort of patients treated with cimetidine. ( Klefter, R; Lindvig, K; Mosbech, J; Møller Jensen, O; Møller, H, 1989) |
"In the case of cancer patients, mononuclear cell cultures from peripheral blood fail to respond to cimetidine even though basal transformation rates are not significantly different from those of healthy controls; this suggests some intrinsic impairment of monocyte function, possibly mediated by blocking factors produced by the tumor." | 1.27 | Effects of cimetidine on in vitro transformation of peripheral monocytes to macrophages in healthy volunteers and cancer patients. ( Cilano, L; Giulivi, A; Massari, A; Perrone, G; Petrella, A; Roncoroni, L; Rossi, F; Spina, MP; Ventura, M; Visca, U, 1986) |
" The scheme successfully detected and quantified some already known adverse effects of cimetidine and did not detect any new effects." | 1.27 | Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report. ( Colin Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1985) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 22 (48.89) | 18.7374 |
1990's | 10 (22.22) | 18.2507 |
2000's | 6 (13.33) | 29.6817 |
2010's | 5 (11.11) | 24.3611 |
2020's | 2 (4.44) | 2.80 |
Authors | Studies |
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Diamandis, P | 1 |
Wildenhain, J | 1 |
Clarke, ID | 1 |
Sacher, AG | 1 |
Graham, J | 1 |
Bellows, DS | 1 |
Ling, EK | 1 |
Ward, RJ | 1 |
Jamieson, LG | 1 |
Tyers, M | 1 |
Dirks, PB | 1 |
Lin, R | 1 |
Elf, S | 1 |
Shan, C | 1 |
Kang, HB | 1 |
Ji, Q | 1 |
Zhou, L | 1 |
Hitosugi, T | 1 |
Zhang, L | 1 |
Zhang, S | 1 |
Seo, JH | 1 |
Xie, J | 1 |
Tucker, M | 1 |
Gu, TL | 1 |
Sudderth, J | 1 |
Jiang, L | 1 |
Mitsche, M | 1 |
DeBerardinis, RJ | 1 |
Wu, S | 1 |
Li, Y | 1 |
Mao, H | 1 |
Chen, PR | 1 |
Wang, D | 1 |
Chen, GZ | 1 |
Hurwitz, SJ | 1 |
Lonial, S | 1 |
Arellano, ML | 1 |
Khoury, HJ | 1 |
Khuri, FR | 1 |
Lee, BH | 1 |
Lei, Q | 1 |
Brat, DJ | 1 |
Ye, K | 1 |
Boggon, TJ | 1 |
He, C | 1 |
Kang, S | 1 |
Fan, J | 1 |
Chen, J | 1 |
Gharibkandi, NA | 1 |
Molavipordanjani, S | 1 |
Mardanshahi, A | 1 |
Hosseinimehr, SJ | 1 |
Oladpour, O | 1 |
Taghipour, F | 1 |
Hassan, ZM | 2 |
Rezayati, MT | 1 |
Nemati, M | 2 |
Taghipour, Z | 1 |
Jafarzadeh, A | 2 |
Khorramdelazad, H | 1 |
Kihara, K | 1 |
Kamimura, H | 1 |
Isayama, H | 1 |
Fujii, Y | 1 |
Iino, Y | 1 |
Kubecova, M | 1 |
Kolostova, K | 1 |
Pinterova, D | 1 |
Kacprzak, G | 1 |
Bobek, V | 1 |
Zhang, J | 1 |
Zhou, W | 1 |
Zhukovsky, DS | 1 |
Thomas, RR | 1 |
Quinn, MG | 1 |
Schuler, B | 1 |
Grem, JL | 1 |
Kaledin, VI | 1 |
Nikolin, VP | 1 |
Baimak, TY | 1 |
Galyamova, MR | 1 |
Popova, NA | 1 |
Andreeva, EM | 1 |
Dillman, RO | 1 |
Soori, G | 1 |
DePriest, C | 1 |
Nayak, SK | 1 |
Beutel, LD | 1 |
Schiltz, PM | 1 |
de Leon, C | 1 |
O'Connor, AA | 1 |
Zidan, J | 1 |
Hussein, O | 1 |
Abzah, A | 1 |
Tamam, S | 1 |
Farraj, Z | 1 |
Friedman, E | 1 |
Baker, JP | 1 |
Carella, G | 1 |
Mathews, KP | 1 |
Hadden, JW | 1 |
Talpaz, M | 1 |
Medina, JE | 1 |
Patt, YZ | 1 |
Goepfert, H | 1 |
Guillamondegui, OM | 1 |
Wong, W | 1 |
Mavligit, GM | 1 |
Aram, H | 2 |
Klimenko, VS | 1 |
Osipov, SG | 1 |
Masenko, VP | 1 |
Titov, VN | 1 |
Humphries, TJ | 1 |
Myerson, RM | 1 |
Gifford, LM | 1 |
Aeugle, ME | 1 |
Josie, ME | 1 |
Wood, SL | 1 |
Tannenbaum, PJ | 1 |
Hubbard, WN | 1 |
Nielsen, HJ | 1 |
Greco, FA | 2 |
Hainsworth, JD | 2 |
Löffler, TM | 1 |
Freund, W | 1 |
Lipke, J | 1 |
Hausamen, TU | 1 |
Bookman, MA | 1 |
Kloth, DD | 1 |
Kover, PE | 1 |
Smolinski, S | 1 |
Ozols, RF | 1 |
Hellstrand, K | 1 |
Hermodsson, S | 1 |
Naredi, P | 1 |
Mellqvist, UH | 1 |
Brune, M | 1 |
Armitage, JO | 1 |
Sidner, RD | 1 |
Marshall, ME | 2 |
Butler, K | 1 |
Fried, A | 1 |
al-Ghamdi, MS | 1 |
Ibrahim, EM | 1 |
al-Idrissi, HY | 1 |
al-Khatti, AA | 1 |
al-Faraj, A | 1 |
Smith, T | 1 |
Kumar, A | 1 |
Møller, H | 2 |
Lindvig, K | 1 |
Klefter, R | 1 |
Mosbech, J | 1 |
Møller Jensen, O | 1 |
Jensen, OM | 1 |
Wiernik, PH | 2 |
Schwartz, EL | 2 |
Strauman, JJ | 2 |
Dutcher, JP | 2 |
Lipton, RB | 2 |
Paietta, E | 1 |
Einzig, A | 1 |
Riley, LK | 1 |
Rhoades, J | 1 |
Eichhorn, T | 1 |
Jennings, CD | 1 |
Cibull, M | 1 |
Thompson, J | 1 |
McCarty, MF | 1 |
Burtin, C | 1 |
Noirot, C | 1 |
Scheinmann, P | 1 |
Galoppin, L | 1 |
Sabolovic, D | 1 |
Bernard, P | 1 |
Giulivi, A | 1 |
Cilano, L | 1 |
Roncoroni, L | 1 |
Petrella, A | 1 |
Perrone, G | 1 |
Visca, U | 1 |
Spina, MP | 1 |
Ventura, M | 1 |
Rossi, F | 1 |
Massari, A | 1 |
Colin Jones, DG | 1 |
Langman, MJ | 1 |
Lawson, DH | 1 |
Vessey, MP | 1 |
Maguire, LC | 1 |
Roszman, TL | 1 |
Lackey, S | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
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Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
13 reviews available for cimetidine and Neoplasms
Article | Year |
---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Immunomodulatory properties of cimetidine: Its therapeutic potentials for treatment of immune-related diseases.
Topics: Animals; Bone Resorption; Burns; Cimetidine; Dendritic Cells; Histamine; Humans; Hypersensitivity; I | 2019 |
Cimetidine: an anticancer drug?
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Proliferation; Cimetidine; Clinical T | 2011 |
Fever and sweats in the patient with advanced cancer.
Topics: Analgesics, Non-Narcotic; Baths; Body Temperature; Causality; Cimetidine; Cryotherapy; Diagnosis, Di | 2002 |
Hypersensitivity and idiosyncratic reactions to oxaliplatin.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents; Antiemetics; Antineoplastic Agents; Cim | 2003 |
[Antagonists of histamine H1 and H2 receptors: pharmacologic aspects and clinical significance].
Topics: Burimamide; Cardiovascular System; Chlorpheniramine; Cimetidine; Duodenal Ulcer; Gastric Acid; Hista | 1984 |
Urticaria and angioedema.
Topics: Adrenal Cortex Hormones; Angioedema; Child; Cimetidine; Cold Temperature; Complement System Proteins | 1983 |
Acquired ichthyosis and related conditions.
Topics: Aged; Cimetidine; Clofazimine; Female; Hodgkin Disease; Humans; Ichthyosis; Lymphoma; Male; Neoplasm | 1984 |
[Diagnostic value of a study of beta 2-microglobulin in the blood serum and urine].
Topics: Aminoglycosides; Anti-Bacterial Agents; beta 2-Microglobulin; Cimetidine; Creatinine; Diabetic Nephr | 1984 |
Histamine and cytokine therapy.
Topics: Animals; Antineoplastic Agents; Cimetidine; Combined Modality Therapy; Histamine; Humans; Immunother | 1998 |
Histamine type 2-receptor antagonists and cancer immunotherapy.
Topics: Cimetidine; Clinical Trials as Topic; Famotidine; Histamine H2 Antagonists; Humans; Immunotherapy; N | 1990 |
Cimetidine: an immunomodulator.
Topics: Adjuvants, Immunologic; Cimetidine; Humans; Immunotherapy; Neoplasms; T-Lymphocytes, Regulatory | 1990 |
Cimetidine in dermatology.
Topics: Androgen Antagonists; Animals; Cimetidine; Humans; Immunity, Cellular; Neoplasms; Pruritus; Skin Dis | 1987 |
9 trials available for cimetidine and Neoplasms
Article | Year |
---|---|
Treatment of human solid malignancies with autologous activated lymphocytes and cimetidine: a phase II trial of the cancer biotherapy research group.
Topics: Adoptive Transfer; Adult; Aged; Cell- and Tissue-Based Therapy; Cimetidine; Combined Modality Therap | 2003 |
One-hour paclitaxel infusion schedules: a phase I/II comparative trial.
Topics: Blood Cell Count; Breast Neoplasms; Cimetidine; Dexamethasone; Diphenhydramine; Drug Administration | 1995 |
Paclitaxel administered by 1-hour infusion. Preliminary results of a phase I/II trial comparing two schedules.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cimetidine; Dexamethasone; Diphenhydr | 1994 |
Schedule- and dose-intensified paclitaxel as weekly 1-hour infusion in pretreated solid tumors: results of a phase I/II trial.
Topics: Adult; Aged; Anti-Allergic Agents; Antiemetics; Antineoplastic Agents, Phytogenic; Cimetidine; Clema | 1996 |
Short-course intravenous prophylaxis for paclitaxel-related hypersensitivity reactions.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphen | 1997 |
Phase I evaluation of coumarin (1,2-benzopyrone) and cimetidine in patients with advanced malignancies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarins; Dose-Response Re | 1991 |
Antiemetic efficacy of cimetidine randomized, double-blind, crossover study with dexamethasone in cancer patients receiving emetogenic chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Dexamethasone; Double-Blind Method; Fema | 1991 |
Histamine type 2-receptor antagonists and cancer immunotherapy.
Topics: Cimetidine; Clinical Trials as Topic; Famotidine; Histamine H2 Antagonists; Humans; Immunotherapy; N | 1990 |
Clinical improvement in advanced cancer disease after treatment combining histamine and H2-antihistaminics (ranitidine or cimetidine).
Topics: Adult; Aged; Cimetidine; Drug Therapy, Combination; Female; Histamine; Humans; Male; Middle Aged; Ne | 1988 |
24 other studies available for cimetidine and Neoplasms
Article | Year |
---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
The Influence of Kidneys Ion Transport Inhibitors on the Pharmacokinetic and Tumor Uptake Behaviors of a HER2-targeted Small Size Radiolabeled Peptide.
Topics: Animals; Cations; Cimetidine; Furosemide; Humans; Ion Transport; Kidney; Mice; Mice, Nude; Neoplasms | 2022 |
Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer.
Topics: Animals; Cimetidine; Disease Models, Animal; Forkhead Transcription Factors; Ibuprofen; Mice; Mice, | 2022 |
[Suppression of renin-angiotensin system and cancer therapy (discussion)].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; B | 2010 |
Ameliorative effects of SLC22A2 gene polymorphism 808 G/T and cimetidine on cisplatin-induced nephrotoxicity in Chinese cancer patients.
Topics: Adult; Antineoplastic Agents; Base Sequence; Blood Urea Nitrogen; China; Cimetidine; Cisplatin; Crea | 2012 |
Phenobarbital modifies antitumor effect of cyclophosphamide depending on the type of tumor cell death caused by it.
Topics: Animals; Anticonvulsants; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cimetidine | 2003 |
Oral premedication for the prevention of hypersensitivity reactions to paclitaxel.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Allergic Agents; Antineoplastic Agents, P | 2008 |
A new series of oral medications for chronic (cancer) pain relief.
Topics: Administration, Oral; Aluminum Hydroxide; Analgesics, Opioid; Antacids; Antiemetics; Cimetidine; Coc | 1984 |
Combination of cimetidine with other drugs for treatment of cancer.
Topics: Aged; Animals; Cimetidine; Coumarins; Female; Guanidines; Histamine; Humans; Interferons; Male; Mela | 1983 |
Chemically defined immunotherapeutic agents.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Aziridines; Benzimidazoles; Cime | 1983 |
The immune restorative effect of cimetidine administration in vivo on the local graft-versus-host reaction of cancer patients.
Topics: Animals; Cimetidine; Graft vs Host Reaction; Guanidines; Humans; Neoplasms; Rats; T-Lymphocytes, Reg | 1982 |
A unique postmarket outpatient surveillance program of cimetidine: report on phase II and final summary.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Cimetidine; Confusion; Drug Interactions; Female; Gastr | 1984 |
Development of medicinals and the dilemma of patient care.
Topics: Anti-Inflammatory Agents; Bacterial Infections; Cardiovascular Diseases; Cimetidine; Drug Therapy; H | 1982 |
Possible effect of histamine-2 receptor blockade on the antitumour response to interleukin-2.
Topics: Cimetidine; Drug Synergism; Histamine H2 Antagonists; Humans; Interleukin-2; Neoplasms; Ranitidine | 1995 |
Antitumour effect of cimetidine.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Cimetidine; Female | 1979 |
Cancer occurrence in a cohort of patients treated with cimetidine.
Topics: Cimetidine; Cohort Studies; Denmark; Female; Humans; Male; Neoplasms; Peptic Ulcer; Risk Factors; St | 1989 |
[Occurrence of cancer among users of antiulcer agents].
Topics: Cimetidine; Humans; Neoplasms; Peptic Ulcer | 1989 |
Phase I clinical and pharmacokinetic study of taxol.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alkaloids; Alopecia; Cimetidine; Dexamethasone; Diph | 1987 |
Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphenhydramine; Drug Admin | 1987 |
Effects of coumarin (1,2-benzopyrone) and cimetidine on peripheral blood lymphocytes, natural killer cells, and monocytes in patients with advanced malignancies.
Topics: Adult; Aged; Aged, 80 and over; Cimetidine; Coumarins; Female; Humans; Killer Cells, Natural; Lympho | 1989 |
Cimetidine as an adjuvant for allogeneic lymphocyte immunotherapy of cancer.
Topics: Blood Transfusion; Cimetidine; Humans; Immunotherapy; Lymphocyte Transfusion; Neoplasms; T-Lymphocyt | 1985 |
Effects of cimetidine on in vitro transformation of peripheral monocytes to macrophages in healthy volunteers and cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Cell Differentiation; Cimetidine; Female; Humans; In Vitro Technique | 1986 |
Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cimetidine; Drug Interactions; Erectile Dysfunctio | 1985 |
Failure of cimetidine as an immunomodulator in cancer patients and normal subjects.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Cimetidine; Humans; Immunoglobulins; Leukocyte Count; Lympho | 1985 |