Page last updated: 2024-10-25

cimetidine and Neoplasms

cimetidine has been researched along with Neoplasms in 45 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"Paclitaxel 135 mg/m2 was infused as a single dose over 1 hour or was divided into three doses infused over 1 hour on 3 consecutive days."2.68One-hour paclitaxel infusion schedules: a phase I/II comparative trial. ( Greco, FA; Hainsworth, JD, 1995)
"Paclitaxel dosage was escalated in 10 mg/m2/wk increments in subsequent patients, to a maximum dosage of 90 mg/m2/wk."2.68Schedule- and dose-intensified paclitaxel as weekly 1-hour infusion in pretreated solid tumors: results of a phase I/II trial. ( Freund, W; Hausamen, TU; Lipke, J; Löffler, TM, 1996)
"Coumarin is a relatively nontoxic, oral, outpatient therapy that warrants further investigations for the treatment of human malignancies."2.67Phase I evaluation of coumarin (1,2-benzopyrone) and cimetidine in patients with advanced malignancies. ( Butler, K; Fried, A; Marshall, ME, 1991)
"Histamine was perfectly tolerated up to 4 mg/day."2.66Clinical improvement in advanced cancer disease after treatment combining histamine and H2-antihistaminics (ranitidine or cimetidine). ( Bernard, P; Burtin, C; Galoppin, L; Noirot, C; Sabolovic, D; Scheinmann, P, 1988)
"Its anticancer effect is also compared to that of the other H(2) receptor antagonists as well as outcomes of cimetidine in clinical studies in cancer patients."2.47Cimetidine: an anticancer drug? ( Bobek, V; Kacprzak, G; Kolostova, K; Kubecova, M; Pinterova, D, 2011)
"The "cimetidine + ibuprofen"-treated mice displayed greater T-bet expression than the un-treated mice (P<0."1.72Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer. ( Hassan, ZM; Jafarzadeh, A; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2022)
"Of 180 eligible cancer patients, 100 patients received paclitaxel weekly and 80 patients, every 3 weeks."1.35Oral premedication for the prevention of hypersensitivity reactions to paclitaxel. ( Abzah, A; Farraj, Z; Friedman, E; Hussein, O; Tamam, S; Zidan, J, 2008)
"An excess risk for gastric cancer was observed, with a relative risk of about 10 in the first year after beginning use of the drug, which decreased thereafter."1.28Cancer occurrence in a cohort of patients treated with cimetidine. ( Klefter, R; Lindvig, K; Mosbech, J; Møller Jensen, O; Møller, H, 1989)
"In the case of cancer patients, mononuclear cell cultures from peripheral blood fail to respond to cimetidine even though basal transformation rates are not significantly different from those of healthy controls; this suggests some intrinsic impairment of monocyte function, possibly mediated by blocking factors produced by the tumor."1.27Effects of cimetidine on in vitro transformation of peripheral monocytes to macrophages in healthy volunteers and cancer patients. ( Cilano, L; Giulivi, A; Massari, A; Perrone, G; Petrella, A; Roncoroni, L; Rossi, F; Spina, MP; Ventura, M; Visca, U, 1986)
" The scheme successfully detected and quantified some already known adverse effects of cimetidine and did not detect any new effects."1.27Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report. ( Colin Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1985)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-199022 (48.89)18.7374
1990's10 (22.22)18.2507
2000's6 (13.33)29.6817
2010's5 (11.11)24.3611
2020's2 (4.44)2.80

Authors

AuthorsStudies
Diamandis, P1
Wildenhain, J1
Clarke, ID1
Sacher, AG1
Graham, J1
Bellows, DS1
Ling, EK1
Ward, RJ1
Jamieson, LG1
Tyers, M1
Dirks, PB1
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L1
Hitosugi, T1
Zhang, L1
Zhang, S1
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Li, Y1
Mao, H1
Chen, PR1
Wang, D1
Chen, GZ1
Hurwitz, SJ1
Lonial, S1
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J1
Gharibkandi, NA1
Molavipordanjani, S1
Mardanshahi, A1
Hosseinimehr, SJ1
Oladpour, O1
Taghipour, F1
Hassan, ZM2
Rezayati, MT1
Nemati, M2
Taghipour, Z1
Jafarzadeh, A2
Khorramdelazad, H1
Kihara, K1
Kamimura, H1
Isayama, H1
Fujii, Y1
Iino, Y1
Kubecova, M1
Kolostova, K1
Pinterova, D1
Kacprzak, G1
Bobek, V1
Zhang, J1
Zhou, W1
Zhukovsky, DS1
Thomas, RR1
Quinn, MG1
Schuler, B1
Grem, JL1
Kaledin, VI1
Nikolin, VP1
Baimak, TY1
Galyamova, MR1
Popova, NA1
Andreeva, EM1
Dillman, RO1
Soori, G1
DePriest, C1
Nayak, SK1
Beutel, LD1
Schiltz, PM1
de Leon, C1
O'Connor, AA1
Zidan, J1
Hussein, O1
Abzah, A1
Tamam, S1
Farraj, Z1
Friedman, E1
Baker, JP1
Carella, G1
Mathews, KP1
Hadden, JW1
Talpaz, M1
Medina, JE1
Patt, YZ1
Goepfert, H1
Guillamondegui, OM1
Wong, W1
Mavligit, GM1
Aram, H2
Klimenko, VS1
Osipov, SG1
Masenko, VP1
Titov, VN1
Humphries, TJ1
Myerson, RM1
Gifford, LM1
Aeugle, ME1
Josie, ME1
Wood, SL1
Tannenbaum, PJ1
Hubbard, WN1
Nielsen, HJ1
Greco, FA2
Hainsworth, JD2
Löffler, TM1
Freund, W1
Lipke, J1
Hausamen, TU1
Bookman, MA1
Kloth, DD1
Kover, PE1
Smolinski, S1
Ozols, RF1
Hellstrand, K1
Hermodsson, S1
Naredi, P1
Mellqvist, UH1
Brune, M1
Armitage, JO1
Sidner, RD1
Marshall, ME2
Butler, K1
Fried, A1
al-Ghamdi, MS1
Ibrahim, EM1
al-Idrissi, HY1
al-Khatti, AA1
al-Faraj, A1
Smith, T1
Kumar, A1
Møller, H2
Lindvig, K1
Klefter, R1
Mosbech, J1
Møller Jensen, O1
Jensen, OM1
Wiernik, PH2
Schwartz, EL2
Strauman, JJ2
Dutcher, JP2
Lipton, RB2
Paietta, E1
Einzig, A1
Riley, LK1
Rhoades, J1
Eichhorn, T1
Jennings, CD1
Cibull, M1
Thompson, J1
McCarty, MF1
Burtin, C1
Noirot, C1
Scheinmann, P1
Galoppin, L1
Sabolovic, D1
Bernard, P1
Giulivi, A1
Cilano, L1
Roncoroni, L1
Petrella, A1
Perrone, G1
Visca, U1
Spina, MP1
Ventura, M1
Rossi, F1
Massari, A1
Colin Jones, DG1
Langman, MJ1
Lawson, DH1
Vessey, MP1
Maguire, LC1
Roszman, TL1
Lackey, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534]29 participants (Actual)Observational2015-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

13 reviews available for cimetidine and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015
Immunomodulatory properties of cimetidine: Its therapeutic potentials for treatment of immune-related diseases.
    International immunopharmacology, 2019, Volume: 70

    Topics: Animals; Bone Resorption; Burns; Cimetidine; Dendritic Cells; Histamine; Humans; Hypersensitivity; I

2019
Cimetidine: an anticancer drug?
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Apr-18, Volume: 42, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Proliferation; Cimetidine; Clinical T

2011
Fever and sweats in the patient with advanced cancer.
    Hematology/oncology clinics of North America, 2002, Volume: 16, Issue:3

    Topics: Analgesics, Non-Narcotic; Baths; Body Temperature; Causality; Cimetidine; Cryotherapy; Diagnosis, Di

2002
Hypersensitivity and idiosyncratic reactions to oxaliplatin.
    Cancer, 2003, May-01, Volume: 97, Issue:9

    Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents; Antiemetics; Antineoplastic Agents; Cim

2003
[Antagonists of histamine H1 and H2 receptors: pharmacologic aspects and clinical significance].
    La Clinica terapeutica, 1984, Aug-31, Volume: 110, Issue:4

    Topics: Burimamide; Cardiovascular System; Chlorpheniramine; Cimetidine; Duodenal Ulcer; Gastric Acid; Hista

1984
Urticaria and angioedema.
    The Journal of allergy and clinical immunology, 1983, Volume: 72, Issue:1

    Topics: Adrenal Cortex Hormones; Angioedema; Child; Cimetidine; Cold Temperature; Complement System Proteins

1983
Acquired ichthyosis and related conditions.
    International journal of dermatology, 1984, Volume: 23, Issue:7

    Topics: Aged; Cimetidine; Clofazimine; Female; Hodgkin Disease; Humans; Ichthyosis; Lymphoma; Male; Neoplasm

1984
[Diagnostic value of a study of beta 2-microglobulin in the blood serum and urine].
    Terapevticheskii arkhiv, 1984, Volume: 56, Issue:5

    Topics: Aminoglycosides; Anti-Bacterial Agents; beta 2-Microglobulin; Cimetidine; Creatinine; Diabetic Nephr

1984
Histamine and cytokine therapy.
    Acta oncologica (Stockholm, Sweden), 1998, Volume: 37, Issue:4

    Topics: Animals; Antineoplastic Agents; Cimetidine; Combined Modality Therapy; Histamine; Humans; Immunother

1998
Histamine type 2-receptor antagonists and cancer immunotherapy.
    Comprehensive therapy, 1990, Volume: 16, Issue:1

    Topics: Cimetidine; Clinical Trials as Topic; Famotidine; Histamine H2 Antagonists; Humans; Immunotherapy; N

1990
Cimetidine: an immunomodulator.
    DICP : the annals of pharmacotherapy, 1990, Volume: 24, Issue:3

    Topics: Adjuvants, Immunologic; Cimetidine; Humans; Immunotherapy; Neoplasms; T-Lymphocytes, Regulatory

1990
Cimetidine in dermatology.
    International journal of dermatology, 1987, Volume: 26, Issue:3

    Topics: Androgen Antagonists; Animals; Cimetidine; Humans; Immunity, Cellular; Neoplasms; Pruritus; Skin Dis

1987

Trials

9 trials available for cimetidine and Neoplasms

ArticleYear
Treatment of human solid malignancies with autologous activated lymphocytes and cimetidine: a phase II trial of the cancer biotherapy research group.
    Cancer biotherapy & radiopharmaceuticals, 2003, Volume: 18, Issue:5

    Topics: Adoptive Transfer; Adult; Aged; Cell- and Tissue-Based Therapy; Cimetidine; Combined Modality Therap

2003
One-hour paclitaxel infusion schedules: a phase I/II comparative trial.
    Seminars in oncology, 1995, Volume: 22, Issue:3 Suppl 6

    Topics: Blood Cell Count; Breast Neoplasms; Cimetidine; Dexamethasone; Diphenhydramine; Drug Administration

1995
Paclitaxel administered by 1-hour infusion. Preliminary results of a phase I/II trial comparing two schedules.
    Cancer, 1994, Aug-15, Volume: 74, Issue:4

    Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cimetidine; Dexamethasone; Diphenhydr

1994
Schedule- and dose-intensified paclitaxel as weekly 1-hour infusion in pretreated solid tumors: results of a phase I/II trial.
    Seminars in oncology, 1996, Volume: 23, Issue:6 Suppl 16

    Topics: Adult; Aged; Anti-Allergic Agents; Antiemetics; Antineoplastic Agents, Phytogenic; Cimetidine; Clema

1996
Short-course intravenous prophylaxis for paclitaxel-related hypersensitivity reactions.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphen

1997
Phase I evaluation of coumarin (1,2-benzopyrone) and cimetidine in patients with advanced malignancies.
    Molecular biotherapy, 1991, Volume: 3, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarins; Dose-Response Re

1991
Antiemetic efficacy of cimetidine randomized, double-blind, crossover study with dexamethasone in cancer patients receiving emetogenic chemotherapy.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1991, Volume: 2, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Dexamethasone; Double-Blind Method; Fema

1991
Histamine type 2-receptor antagonists and cancer immunotherapy.
    Comprehensive therapy, 1990, Volume: 16, Issue:1

    Topics: Cimetidine; Clinical Trials as Topic; Famotidine; Histamine H2 Antagonists; Humans; Immunotherapy; N

1990
Clinical improvement in advanced cancer disease after treatment combining histamine and H2-antihistaminics (ranitidine or cimetidine).
    European journal of cancer & clinical oncology, 1988, Volume: 24, Issue:2

    Topics: Adult; Aged; Cimetidine; Drug Therapy, Combination; Female; Histamine; Humans; Male; Middle Aged; Ne

1988

Other Studies

24 other studies available for cimetidine and Neoplasms

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic

2007
The Influence of Kidneys Ion Transport Inhibitors on the Pharmacokinetic and Tumor Uptake Behaviors of a HER2-targeted Small Size Radiolabeled Peptide.
    Current drug metabolism, 2022, Volume: 23, Issue:1

    Topics: Animals; Cations; Cimetidine; Furosemide; Humans; Ion Transport; Kidney; Mice; Mice, Nude; Neoplasms

2022
Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer.
    Asian Pacific journal of cancer prevention : APJCP, 2022, Jun-01, Volume: 23, Issue:6

    Topics: Animals; Cimetidine; Disease Models, Animal; Forkhead Transcription Factors; Ibuprofen; Mice; Mice,

2022
[Suppression of renin-angiotensin system and cancer therapy (discussion)].
    Nihon rinsho. Japanese journal of clinical medicine, 2010, Volume: 68, Issue:6

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; B

2010
Ameliorative effects of SLC22A2 gene polymorphism 808 G/T and cimetidine on cisplatin-induced nephrotoxicity in Chinese cancer patients.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:7

    Topics: Adult; Antineoplastic Agents; Base Sequence; Blood Urea Nitrogen; China; Cimetidine; Cisplatin; Crea

2012
Phenobarbital modifies antitumor effect of cyclophosphamide depending on the type of tumor cell death caused by it.
    Bulletin of experimental biology and medicine, 2003, Volume: 135, Issue:3

    Topics: Animals; Anticonvulsants; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cimetidine

2003
Oral premedication for the prevention of hypersensitivity reactions to paclitaxel.
    Medical oncology (Northwood, London, England), 2008, Volume: 25, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Allergic Agents; Antineoplastic Agents, P

2008
A new series of oral medications for chronic (cancer) pain relief.
    Comprehensive therapy, 1984, Volume: 10, Issue:5

    Topics: Administration, Oral; Aluminum Hydroxide; Analgesics, Opioid; Antacids; Antiemetics; Cimetidine; Coc

1984
Combination of cimetidine with other drugs for treatment of cancer.
    The New England journal of medicine, 1983, Mar-10, Volume: 308, Issue:10

    Topics: Aged; Animals; Cimetidine; Coumarins; Female; Guanidines; Histamine; Humans; Interferons; Male; Mela

1983
Chemically defined immunotherapeutic agents.
    Progress in clinical and biological research, 1983, Volume: 132E

    Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Aziridines; Benzimidazoles; Cime

1983
The immune restorative effect of cimetidine administration in vivo on the local graft-versus-host reaction of cancer patients.
    Clinical immunology and immunopathology, 1982, Volume: 24, Issue:2

    Topics: Animals; Cimetidine; Graft vs Host Reaction; Guanidines; Humans; Neoplasms; Rats; T-Lymphocytes, Reg

1982
A unique postmarket outpatient surveillance program of cimetidine: report on phase II and final summary.
    The American journal of gastroenterology, 1984, Volume: 79, Issue:8

    Topics: Adolescent; Adult; Age Factors; Aged; Child; Cimetidine; Confusion; Drug Interactions; Female; Gastr

1984
Development of medicinals and the dilemma of patient care.
    Perspectives in biology and medicine, 1982,Summer, Volume: 25, Issue:4

    Topics: Anti-Inflammatory Agents; Bacterial Infections; Cardiovascular Diseases; Cimetidine; Drug Therapy; H

1982
Possible effect of histamine-2 receptor blockade on the antitumour response to interleukin-2.
    European journal of cancer (Oxford, England : 1990), 1995, Volume: 31A, Issue:9

    Topics: Cimetidine; Drug Synergism; Histamine H2 Antagonists; Humans; Interleukin-2; Neoplasms; Ranitidine

1995
Antitumour effect of cimetidine.
    Lancet (London, England), 1979, Apr-21, Volume: 1, Issue:8121

    Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Cimetidine; Female

1979
Cancer occurrence in a cohort of patients treated with cimetidine.
    Gut, 1989, Volume: 30, Issue:11

    Topics: Cimetidine; Cohort Studies; Denmark; Female; Humans; Male; Neoplasms; Peptic Ulcer; Risk Factors; St

1989
[Occurrence of cancer among users of antiulcer agents].
    Ugeskrift for laeger, 1989, May-29, Volume: 151, Issue:22

    Topics: Cimetidine; Humans; Neoplasms; Peptic Ulcer

1989
Phase I clinical and pharmacokinetic study of taxol.
    Cancer research, 1987, May-01, Volume: 47, Issue:9

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alkaloids; Alopecia; Cimetidine; Dexamethasone; Diph

1987
Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:8

    Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphenhydramine; Drug Admin

1987
Effects of coumarin (1,2-benzopyrone) and cimetidine on peripheral blood lymphocytes, natural killer cells, and monocytes in patients with advanced malignancies.
    Journal of biological response modifiers, 1989, Volume: 8, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Cimetidine; Coumarins; Female; Humans; Killer Cells, Natural; Lympho

1989
Cimetidine as an adjuvant for allogeneic lymphocyte immunotherapy of cancer.
    Medical hypotheses, 1985, Volume: 17, Issue:2

    Topics: Blood Transfusion; Cimetidine; Humans; Immunotherapy; Lymphocyte Transfusion; Neoplasms; T-Lymphocyt

1985
Effects of cimetidine on in vitro transformation of peripheral monocytes to macrophages in healthy volunteers and cancer patients.
    International journal of immunopharmacology, 1986, Volume: 8, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Cell Differentiation; Cimetidine; Female; Humans; In Vitro Technique

1986
Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report.
    The Quarterly journal of medicine, 1985, Volume: 54, Issue:215

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cimetidine; Drug Interactions; Erectile Dysfunctio

1985
Failure of cimetidine as an immunomodulator in cancer patients and normal subjects.
    Southern medical journal, 1985, Volume: 78, Issue:9

    Topics: Adenocarcinoma; Adjuvants, Immunologic; Cimetidine; Humans; Immunoglobulins; Leukocyte Count; Lympho

1985