cimetidine has been researched along with Neoplasms in 45 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paclitaxel 135 mg/m2 was infused as a single dose over 1 hour or was divided into three doses infused over 1 hour on 3 consecutive days." | 2.68 | One-hour paclitaxel infusion schedules: a phase I/II comparative trial. ( Greco, FA; Hainsworth, JD, 1995) |
| "Paclitaxel dosage was escalated in 10 mg/m2/wk increments in subsequent patients, to a maximum dosage of 90 mg/m2/wk." | 2.68 | Schedule- and dose-intensified paclitaxel as weekly 1-hour infusion in pretreated solid tumors: results of a phase I/II trial. ( Freund, W; Hausamen, TU; Lipke, J; Löffler, TM, 1996) |
| "Coumarin is a relatively nontoxic, oral, outpatient therapy that warrants further investigations for the treatment of human malignancies." | 2.67 | Phase I evaluation of coumarin (1,2-benzopyrone) and cimetidine in patients with advanced malignancies. ( Butler, K; Fried, A; Marshall, ME, 1991) |
| "Histamine was perfectly tolerated up to 4 mg/day." | 2.66 | Clinical improvement in advanced cancer disease after treatment combining histamine and H2-antihistaminics (ranitidine or cimetidine). ( Bernard, P; Burtin, C; Galoppin, L; Noirot, C; Sabolovic, D; Scheinmann, P, 1988) |
| "Its anticancer effect is also compared to that of the other H(2) receptor antagonists as well as outcomes of cimetidine in clinical studies in cancer patients." | 2.47 | Cimetidine: an anticancer drug? ( Bobek, V; Kacprzak, G; Kolostova, K; Kubecova, M; Pinterova, D, 2011) |
| "The "cimetidine + ibuprofen"-treated mice displayed greater T-bet expression than the un-treated mice (P<0." | 1.72 | Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer. ( Hassan, ZM; Jafarzadeh, A; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2022) |
| "Of 180 eligible cancer patients, 100 patients received paclitaxel weekly and 80 patients, every 3 weeks." | 1.35 | Oral premedication for the prevention of hypersensitivity reactions to paclitaxel. ( Abzah, A; Farraj, Z; Friedman, E; Hussein, O; Tamam, S; Zidan, J, 2008) |
| "An excess risk for gastric cancer was observed, with a relative risk of about 10 in the first year after beginning use of the drug, which decreased thereafter." | 1.28 | Cancer occurrence in a cohort of patients treated with cimetidine. ( Klefter, R; Lindvig, K; Mosbech, J; Møller Jensen, O; Møller, H, 1989) |
| "In the case of cancer patients, mononuclear cell cultures from peripheral blood fail to respond to cimetidine even though basal transformation rates are not significantly different from those of healthy controls; this suggests some intrinsic impairment of monocyte function, possibly mediated by blocking factors produced by the tumor." | 1.27 | Effects of cimetidine on in vitro transformation of peripheral monocytes to macrophages in healthy volunteers and cancer patients. ( Cilano, L; Giulivi, A; Massari, A; Perrone, G; Petrella, A; Roncoroni, L; Rossi, F; Spina, MP; Ventura, M; Visca, U, 1986) |
| " The scheme successfully detected and quantified some already known adverse effects of cimetidine and did not detect any new effects." | 1.27 | Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report. ( Colin Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (48.89) | 18.7374 |
| 1990's | 10 (22.22) | 18.2507 |
| 2000's | 6 (13.33) | 29.6817 |
| 2010's | 5 (11.11) | 24.3611 |
| 2020's | 2 (4.44) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Gharibkandi, NA | 1 |
| Molavipordanjani, S | 1 |
| Mardanshahi, A | 1 |
| Hosseinimehr, SJ | 1 |
| Oladpour, O | 1 |
| Taghipour, F | 1 |
| Hassan, ZM | 2 |
| Rezayati, MT | 1 |
| Nemati, M | 2 |
| Taghipour, Z | 1 |
| Jafarzadeh, A | 2 |
| Khorramdelazad, H | 1 |
| Kihara, K | 1 |
| Kamimura, H | 1 |
| Isayama, H | 1 |
| Fujii, Y | 1 |
| Iino, Y | 1 |
| Kubecova, M | 1 |
| Kolostova, K | 1 |
| Pinterova, D | 1 |
| Kacprzak, G | 1 |
| Bobek, V | 1 |
| Zhang, J | 1 |
| Zhou, W | 1 |
| Zhukovsky, DS | 1 |
| Thomas, RR | 1 |
| Quinn, MG | 1 |
| Schuler, B | 1 |
| Grem, JL | 1 |
| Kaledin, VI | 1 |
| Nikolin, VP | 1 |
| Baimak, TY | 1 |
| Galyamova, MR | 1 |
| Popova, NA | 1 |
| Andreeva, EM | 1 |
| Dillman, RO | 1 |
| Soori, G | 1 |
| DePriest, C | 1 |
| Nayak, SK | 1 |
| Beutel, LD | 1 |
| Schiltz, PM | 1 |
| de Leon, C | 1 |
| O'Connor, AA | 1 |
| Zidan, J | 1 |
| Hussein, O | 1 |
| Abzah, A | 1 |
| Tamam, S | 1 |
| Farraj, Z | 1 |
| Friedman, E | 1 |
| Baker, JP | 1 |
| Carella, G | 1 |
| Mathews, KP | 1 |
| Hadden, JW | 1 |
| Talpaz, M | 1 |
| Medina, JE | 1 |
| Patt, YZ | 1 |
| Goepfert, H | 1 |
| Guillamondegui, OM | 1 |
| Wong, W | 1 |
| Mavligit, GM | 1 |
| Aram, H | 2 |
| Klimenko, VS | 1 |
| Osipov, SG | 1 |
| Masenko, VP | 1 |
| Titov, VN | 1 |
| Humphries, TJ | 1 |
| Myerson, RM | 1 |
| Gifford, LM | 1 |
| Aeugle, ME | 1 |
| Josie, ME | 1 |
| Wood, SL | 1 |
| Tannenbaum, PJ | 1 |
| Hubbard, WN | 1 |
| Nielsen, HJ | 1 |
| Greco, FA | 2 |
| Hainsworth, JD | 2 |
| Löffler, TM | 1 |
| Freund, W | 1 |
| Lipke, J | 1 |
| Hausamen, TU | 1 |
| Bookman, MA | 1 |
| Kloth, DD | 1 |
| Kover, PE | 1 |
| Smolinski, S | 1 |
| Ozols, RF | 1 |
| Hellstrand, K | 1 |
| Hermodsson, S | 1 |
| Naredi, P | 1 |
| Mellqvist, UH | 1 |
| Brune, M | 1 |
| Armitage, JO | 1 |
| Sidner, RD | 1 |
| Marshall, ME | 2 |
| Butler, K | 1 |
| Fried, A | 1 |
| al-Ghamdi, MS | 1 |
| Ibrahim, EM | 1 |
| al-Idrissi, HY | 1 |
| al-Khatti, AA | 1 |
| al-Faraj, A | 1 |
| Smith, T | 1 |
| Kumar, A | 1 |
| Møller, H | 2 |
| Lindvig, K | 1 |
| Klefter, R | 1 |
| Mosbech, J | 1 |
| Møller Jensen, O | 1 |
| Jensen, OM | 1 |
| Wiernik, PH | 2 |
| Schwartz, EL | 2 |
| Strauman, JJ | 2 |
| Dutcher, JP | 2 |
| Lipton, RB | 2 |
| Paietta, E | 1 |
| Einzig, A | 1 |
| Riley, LK | 1 |
| Rhoades, J | 1 |
| Eichhorn, T | 1 |
| Jennings, CD | 1 |
| Cibull, M | 1 |
| Thompson, J | 1 |
| McCarty, MF | 1 |
| Burtin, C | 1 |
| Noirot, C | 1 |
| Scheinmann, P | 1 |
| Galoppin, L | 1 |
| Sabolovic, D | 1 |
| Bernard, P | 1 |
| Giulivi, A | 1 |
| Cilano, L | 1 |
| Roncoroni, L | 1 |
| Petrella, A | 1 |
| Perrone, G | 1 |
| Visca, U | 1 |
| Spina, MP | 1 |
| Ventura, M | 1 |
| Rossi, F | 1 |
| Massari, A | 1 |
| Colin Jones, DG | 1 |
| Langman, MJ | 1 |
| Lawson, DH | 1 |
| Vessey, MP | 1 |
| Maguire, LC | 1 |
| Roszman, TL | 1 |
| Lackey, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for cimetidine and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Immunomodulatory properties of cimetidine: Its therapeutic potentials for treatment of immune-related diseases.
Topics: Animals; Bone Resorption; Burns; Cimetidine; Dendritic Cells; Histamine; Humans; Hypersensitivity; I | 2019 |
Cimetidine: an anticancer drug?
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Proliferation; Cimetidine; Clinical T | 2011 |
Fever and sweats in the patient with advanced cancer.
Topics: Analgesics, Non-Narcotic; Baths; Body Temperature; Causality; Cimetidine; Cryotherapy; Diagnosis, Di | 2002 |
Hypersensitivity and idiosyncratic reactions to oxaliplatin.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents; Antiemetics; Antineoplastic Agents; Cim | 2003 |
[Antagonists of histamine H1 and H2 receptors: pharmacologic aspects and clinical significance].
Topics: Burimamide; Cardiovascular System; Chlorpheniramine; Cimetidine; Duodenal Ulcer; Gastric Acid; Hista | 1984 |
Urticaria and angioedema.
Topics: Adrenal Cortex Hormones; Angioedema; Child; Cimetidine; Cold Temperature; Complement System Proteins | 1983 |
Acquired ichthyosis and related conditions.
Topics: Aged; Cimetidine; Clofazimine; Female; Hodgkin Disease; Humans; Ichthyosis; Lymphoma; Male; Neoplasm | 1984 |
[Diagnostic value of a study of beta 2-microglobulin in the blood serum and urine].
Topics: Aminoglycosides; Anti-Bacterial Agents; beta 2-Microglobulin; Cimetidine; Creatinine; Diabetic Nephr | 1984 |
Histamine and cytokine therapy.
Topics: Animals; Antineoplastic Agents; Cimetidine; Combined Modality Therapy; Histamine; Humans; Immunother | 1998 |
Histamine type 2-receptor antagonists and cancer immunotherapy.
Topics: Cimetidine; Clinical Trials as Topic; Famotidine; Histamine H2 Antagonists; Humans; Immunotherapy; N | 1990 |
Cimetidine: an immunomodulator.
Topics: Adjuvants, Immunologic; Cimetidine; Humans; Immunotherapy; Neoplasms; T-Lymphocytes, Regulatory | 1990 |
Cimetidine in dermatology.
Topics: Androgen Antagonists; Animals; Cimetidine; Humans; Immunity, Cellular; Neoplasms; Pruritus; Skin Dis | 1987 |
9 trials available for cimetidine and Neoplasms
| Article | Year |
|---|---|
Treatment of human solid malignancies with autologous activated lymphocytes and cimetidine: a phase II trial of the cancer biotherapy research group.
Topics: Adoptive Transfer; Adult; Aged; Cell- and Tissue-Based Therapy; Cimetidine; Combined Modality Therap | 2003 |
One-hour paclitaxel infusion schedules: a phase I/II comparative trial.
Topics: Blood Cell Count; Breast Neoplasms; Cimetidine; Dexamethasone; Diphenhydramine; Drug Administration | 1995 |
Paclitaxel administered by 1-hour infusion. Preliminary results of a phase I/II trial comparing two schedules.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cimetidine; Dexamethasone; Diphenhydr | 1994 |
Schedule- and dose-intensified paclitaxel as weekly 1-hour infusion in pretreated solid tumors: results of a phase I/II trial.
Topics: Adult; Aged; Anti-Allergic Agents; Antiemetics; Antineoplastic Agents, Phytogenic; Cimetidine; Clema | 1996 |
Short-course intravenous prophylaxis for paclitaxel-related hypersensitivity reactions.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphen | 1997 |
Phase I evaluation of coumarin (1,2-benzopyrone) and cimetidine in patients with advanced malignancies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarins; Dose-Response Re | 1991 |
Antiemetic efficacy of cimetidine randomized, double-blind, crossover study with dexamethasone in cancer patients receiving emetogenic chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Dexamethasone; Double-Blind Method; Fema | 1991 |
Histamine type 2-receptor antagonists and cancer immunotherapy.
Topics: Cimetidine; Clinical Trials as Topic; Famotidine; Histamine H2 Antagonists; Humans; Immunotherapy; N | 1990 |
Clinical improvement in advanced cancer disease after treatment combining histamine and H2-antihistaminics (ranitidine or cimetidine).
Topics: Adult; Aged; Cimetidine; Drug Therapy, Combination; Female; Histamine; Humans; Male; Middle Aged; Ne | 1988 |
24 other studies available for cimetidine and Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
The Influence of Kidneys Ion Transport Inhibitors on the Pharmacokinetic and Tumor Uptake Behaviors of a HER2-targeted Small Size Radiolabeled Peptide.
Topics: Animals; Cations; Cimetidine; Furosemide; Humans; Ion Transport; Kidney; Mice; Mice, Nude; Neoplasms | 2022 |
Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer.
Topics: Animals; Cimetidine; Disease Models, Animal; Forkhead Transcription Factors; Ibuprofen; Mice; Mice, | 2022 |
[Suppression of renin-angiotensin system and cancer therapy (discussion)].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; B | 2010 |
Ameliorative effects of SLC22A2 gene polymorphism 808 G/T and cimetidine on cisplatin-induced nephrotoxicity in Chinese cancer patients.
Topics: Adult; Antineoplastic Agents; Base Sequence; Blood Urea Nitrogen; China; Cimetidine; Cisplatin; Crea | 2012 |
Phenobarbital modifies antitumor effect of cyclophosphamide depending on the type of tumor cell death caused by it.
Topics: Animals; Anticonvulsants; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cimetidine | 2003 |
Oral premedication for the prevention of hypersensitivity reactions to paclitaxel.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Allergic Agents; Antineoplastic Agents, P | 2008 |
A new series of oral medications for chronic (cancer) pain relief.
Topics: Administration, Oral; Aluminum Hydroxide; Analgesics, Opioid; Antacids; Antiemetics; Cimetidine; Coc | 1984 |
Combination of cimetidine with other drugs for treatment of cancer.
Topics: Aged; Animals; Cimetidine; Coumarins; Female; Guanidines; Histamine; Humans; Interferons; Male; Mela | 1983 |
Chemically defined immunotherapeutic agents.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Aziridines; Benzimidazoles; Cime | 1983 |
The immune restorative effect of cimetidine administration in vivo on the local graft-versus-host reaction of cancer patients.
Topics: Animals; Cimetidine; Graft vs Host Reaction; Guanidines; Humans; Neoplasms; Rats; T-Lymphocytes, Reg | 1982 |
A unique postmarket outpatient surveillance program of cimetidine: report on phase II and final summary.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Cimetidine; Confusion; Drug Interactions; Female; Gastr | 1984 |
Development of medicinals and the dilemma of patient care.
Topics: Anti-Inflammatory Agents; Bacterial Infections; Cardiovascular Diseases; Cimetidine; Drug Therapy; H | 1982 |
Possible effect of histamine-2 receptor blockade on the antitumour response to interleukin-2.
Topics: Cimetidine; Drug Synergism; Histamine H2 Antagonists; Humans; Interleukin-2; Neoplasms; Ranitidine | 1995 |
Antitumour effect of cimetidine.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Cimetidine; Female | 1979 |
Cancer occurrence in a cohort of patients treated with cimetidine.
Topics: Cimetidine; Cohort Studies; Denmark; Female; Humans; Male; Neoplasms; Peptic Ulcer; Risk Factors; St | 1989 |
[Occurrence of cancer among users of antiulcer agents].
Topics: Cimetidine; Humans; Neoplasms; Peptic Ulcer | 1989 |
Phase I clinical and pharmacokinetic study of taxol.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alkaloids; Alopecia; Cimetidine; Dexamethasone; Diph | 1987 |
Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphenhydramine; Drug Admin | 1987 |
Effects of coumarin (1,2-benzopyrone) and cimetidine on peripheral blood lymphocytes, natural killer cells, and monocytes in patients with advanced malignancies.
Topics: Adult; Aged; Aged, 80 and over; Cimetidine; Coumarins; Female; Humans; Killer Cells, Natural; Lympho | 1989 |
Cimetidine as an adjuvant for allogeneic lymphocyte immunotherapy of cancer.
Topics: Blood Transfusion; Cimetidine; Humans; Immunotherapy; Lymphocyte Transfusion; Neoplasms; T-Lymphocyt | 1985 |
Effects of cimetidine on in vitro transformation of peripheral monocytes to macrophages in healthy volunteers and cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Cell Differentiation; Cimetidine; Female; Humans; In Vitro Technique | 1986 |
Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cimetidine; Drug Interactions; Erectile Dysfunctio | 1985 |
Failure of cimetidine as an immunomodulator in cancer patients and normal subjects.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Cimetidine; Humans; Immunoglobulins; Leukocyte Count; Lympho | 1985 |