cimetidine has been researched along with Myocardial Ischemia in 2 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Surprisingly, the incidences of ischaemia- and reperfusion-induced arrhythmias were not reduced by ranitidine over an equivalent concentration range (0." | 3.69 | Protection by cimetidine, but not ranitidine, implies that H2 receptors do not mediate arrhythmogenesis in a rat model of regional ischaemia and reperfusion in vitro. ( Banning, MM; Curtis, MJ, 1995) |
| "Chloramphenicol is an inhibitor of mitochondrial protein synthesis and is also an inhibitor of a subset of cytochrome P450 monooxygenases (CYPs)." | 1.32 | Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. ( Gottlieb, RA; Granville, DJ; Gustafsson, AB; Huang, C; Sayen, MR; Takeuchi, C; Tashakkor, B; Wentworth, P; Yeager, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Granville, DJ | 1 |
| Tashakkor, B | 1 |
| Takeuchi, C | 1 |
| Gustafsson, AB | 1 |
| Huang, C | 1 |
| Sayen, MR | 1 |
| Wentworth, P | 1 |
| Yeager, M | 1 |
| Gottlieb, RA | 1 |
| Banning, MM | 1 |
| Curtis, MJ | 1 |
2 other studies available for cimetidine and Myocardial Ischemia
| Article | Year |
|---|---|
Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors.
Topics: Animals; Chloramphenicol; Cimetidine; Creatine Kinase; Cytochrome P-450 Enzyme Inhibitors; Cytochrom | 2004 |
Protection by cimetidine, but not ranitidine, implies that H2 receptors do not mediate arrhythmogenesis in a rat model of regional ischaemia and reperfusion in vitro.
Topics: Animals; Arrhythmias, Cardiac; Cimetidine; Dose-Response Relationship, Drug; Electrocardiography; Hi | 1995 |