Page last updated: 2024-10-25

cimetidine and Muscle Relaxation

cimetidine has been researched along with Muscle Relaxation in 42 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.

Research Excerpts

ExcerptRelevanceReference
"Cimetidine effect was dramatically potentiated in denuded tracheal strips (+40."1.32Functional identification of epithelial and smooth muscle histamine-dependent relaxing mechanisms in the bovine trachea, but not in bronchi. ( Desmecht, D; Jolly, S, 2003)
"Treatment with cimetidine attenuated the sustained relaxation, whereas chlorpheniramine or indomethacin depressed the phasic relaxation."1.29Histamine actions in dog retinal central arteries as compared to those in middle cerebral and temporal arteries. ( Kani, K; Kitamura, Y; Okamura, T; Toda, N, 1995)
"Treatment with indomethacin inhibited the phasic component in the strips with endothelium, but did not influence the relaxation after endothelium denudation."1.28[Mechanisms of histamine-induced relaxation in isolated dog mesenteric arteries and veins]. ( Toda, N; Yamazaki, M, 1992)
"Histamine was infused at 1."1.28Developmental changes in effects of histamine on segmental pulmonary vascular resistances. ( Chu, K; Clément de Cléty, S; Gordon, JB, 1991)
"(+)-Pindolol was less potent as antagonist of the relaxant effects of (-)-noradrenaline on trachea than against those of (-)-adrenaline, (-)-isoprenaline and (+/-)-salbutamol."1.27Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of beta-adrenoceptor subtypes in the dissociation between blockade and stimulation. ( Kaumann, AJ; Lemoine, H; Walter, M, 1984)
" In aortic ring segments, precontracted by norepinephrine, three types of dose-response curves were found: relaxation (rat), contraction (guinea-pig, cat, mouse) and relaxation followed by contraction at higher doses (rabbit)."1.27Effect of histamine on aorta preparations of different species. ( Leusen, I; Van de Voorde, J, 1984)
" However, when the preparations were precontracted with histamine (10(-5)M), dose-response curves for relaxation were shifted to the right, and low-concentrations of all three histamine H2-antagonists augmented histamine-induced tone."1.27Direct effects of H2-receptor antagonists on airway smooth muscle and on responses mediated by H1- and H2-receptors. ( Hashimoto, Y; Iwatsuki, N; Koga, Y, 1987)
"When dimaprit was compared with 4-methylhistamine, it acted only as a relaxing agent, not as a constricting agent."1.27Participation of vascular H1-receptors in histaminergic relaxation of rabbit middle cerebral artery in vitro. ( Kim, LE; Oudart, N; Sercombe, R; Teste, JF, 1986)
" Cimetidine shifted the dose-response curve for histamine to the right, but chlorpheniramine did not alter the response."1.27Mechanisms of histamine-induced relaxation in isolated monkey and dog coronary arteries. ( Toda, N, 1986)
" Pretreatment of parenchymal strips with cimetidine or YM-11170, H2-receptor antagonists, resulted in a parallel shift of the dimaprit dose-response curve to the right."1.26Effects of histamine H2-receptor agonists and antagonists on isolated guinea-pig airway muscles. ( Tomioka, K; Yamada, T, 1982)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199024 (57.14)18.7374
1990's13 (30.95)18.2507
2000's4 (9.52)29.6817
2010's1 (2.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kurtz, KH1
Moor, AN1
Souza-Smith, FM1
Breslin, JW1
Ziberna, L1
Zorman, T1
Drevensek, G1
Bozarov, A1
Wang, YZ1
Yu, JG1
Wunderlich, J1
Hassanain, HH1
Alhaj, M1
Cooke, HJ1
Grants, I1
Ren, T1
Christofi, FL1
Jolly, S1
Desmecht, D1
Pangalis, A1
Giala, M1
Mironidou, M1
Papadakis, E1
Crassaris, L1
Paradelis, AG1
Viaro, F1
Celotto, AC1
Capellini, VK1
Baldo, CF1
Rodrigues, AJ1
Vicente, WV1
Evora, PR1
Walter, M1
Lemoine, H1
Kaumann, AJ1
Kenakin, TP1
Beek, D1
Tomioka, K1
Yamada, T1
Vincenc, K1
Black, J1
Shaw, J1
Duncan, PG1
Brink, C2
Adolphson, RL1
Douglas, JS1
Senaratne, M1
Kappagoda, T1
Godfraind, T1
Miller, RC1
Van de Voorde, J3
Leusen, I2
Carrier, GO1
White, RE1
Kirby, ML1
Tsuru, H1
Iwata, M1
Shigei, T1
Ebeigbe, AB2
Gantzos, RD1
Webb, RC1
Kitamura, Y1
Okamura, T2
Kani, K1
Toda, N4
Jansen-Olesen, I1
Ottosson, A1
Cantera, L1
Strunk, S1
Lassen, LH1
Olesen, J1
Mortensen, A1
Engel, U1
Edvinsson, L1
O'Dowd, A1
Miller, DJ1
Delaey, C1
Depypere, H1
Vanheel, B1
Ayajiki, K1
Bennett, BM1
McDonald, BJ1
St James, MJ1
Ortiz, JL1
Labat, C1
Norel, X1
Gorenne, I1
Verley, J1
Yamazaki, M1
Gordon, JB1
Clément de Cléty, S1
Chu, K1
Benedito, S2
Prieto, D2
Nyborg, NC2
Nielsen, PJ1
Keitoku, M1
Maruyama, Y1
Takishima, T1
Liu, SF1
Yacoub, M1
Barnes, PJ1
Trevethick, MA1
Feniuk, W1
Humphrey, PP1
Tanaka, DT1
Grunstein, MM1
Tarutani, M1
Sakuma, H1
Shiratsuchi, K1
Mieda, M1
Ponce-Monter, H1
Estrada, AV1
Pedrón, N1
Valencia, A1
Gallegos, AJ1
Koga, Y1
Iwatsuki, N1
Hashimoto, Y1
Advenier, C1
Gnassounou, JP1
Scarpignato, C1
Kim, LE1
Teste, JF1
Sercombe, R1
Oudart, N2
Abacioğlu, N1
Ercan, ZS1
Kanzik, L1
Zengil, H1
Demiryürek, T1
Türker, RK1
Ea-Kim, L1

Other Studies

42 other studies available for cimetidine and Muscle Relaxation

ArticleYear
Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
    Microcirculation (New York, N.Y. : 1994), 2014, Volume: 21, Issue:7

    Topics: Animals; Cimetidine; Endothelium, Lymphatic; Guanylate Cyclase; Histamine H1 Antagonists; Histamine

2014
Characterization of histamine-induced relaxation in pre-contracted rat aorta.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2009, Volume: 58 Suppl 1

    Topics: Animals; Aorta; Cimetidine; Ethylenediamines; Histamine; Histamine H1 Antagonists; Histamine H2 Anta

2009
Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:6

    Topics: Adenosine; Animals; Chlorides; Cimetidine; Colon; Dihydropyridines; Dimaprit; Dose-Response Relation

2009
Functional identification of epithelial and smooth muscle histamine-dependent relaxing mechanisms in the bovine trachea, but not in bronchi.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2003, Volume: 134, Issue:1

    Topics: Animals; Bronchi; Cattle; Cimetidine; Dose-Response Relationship, Drug; Histamine; Histamine H2 Anta

2003
Interaction of aminoglycoside antibiotics with H2-blockers and calcium channel blockers in isolated smooth muscles of rat aorta.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl

    Topics: Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Calcium Channel Blockers; Cimetidine; His

1989
Compound 48/80 induces endothelium-dependent and histamine release-independent relaxation in rabbit aorta.
    Nitric oxide : biology and chemistry, 2008, Volume: 18, Issue:2

    Topics: Animals; Aorta; Cimetidine; Endothelium, Vascular; Estrenes; Histamine H1 Antagonists; Histamine Rel

2008
Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of beta-adrenoceptor subtypes in the dissociation between blockade and stimulation.
    Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 327, Issue:2

    Topics: Animals; Bupranolol; Cimetidine; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoproterenol

1984
A quantitative analysis of histamine H2-receptor-mediated relaxation of rabbit trachea.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:2

    Topics: Animals; Cimetidine; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Male; Muscle Contract

1982
Effects of histamine H2-receptor agonists and antagonists on isolated guinea-pig airway muscles.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 255, Issue:1

    Topics: Airway Resistance; Animals; Cimetidine; Dimaprit; Drug Interactions; Guinea Pigs; Histamine H2 Antag

1982
Relaxation and contraction responses to histamine in the human lung parenchymal strip.
    European journal of pharmacology, 1984, Feb-17, Volume: 98, Issue:2

    Topics: Cimetidine; Dose-Response Relationship, Drug; Histamine; Histamine H1 Antagonists; Histamine H2 Anta

1984
Cyclic nucleotides and contraction/relaxation in airway muscle: H1 and H2 agonists and antagonists.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 215, Issue:2

    Topics: Animals; Cimetidine; Cyclic AMP; Cyclic GMP; Ethylamines; Female; Guinea Pigs; Histamine; Histamine

1980
Tetrodotoxin-resistant relaxation to transmural nerve stimulation in isolated saphenous vein.
    The American journal of physiology, 1984, Volume: 247, Issue:6 Pt 2

    Topics: Aminophylline; Animals; Biomechanical Phenomena; Cimetidine; Cyproheptadine; Dogs; Drug Resistance;

1984
Effects of histamine and the histamine antagonists mepyramine and cimetidine on human coronary arteries in vitro.
    British journal of pharmacology, 1983, Volume: 79, Issue:4

    Topics: Adolescent; Adult; Aged; Aminopyridines; Child; Cimetidine; Coronary Vessels; Histamine; Humans; In

1983
Effect of histamine on aorta preparations of different species.
    Archives internationales de pharmacodynamie et de therapie, 1984, Volume: 268, Issue:1

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Cats; Cimetidine; Guinea Pigs; Histamine; In Vitro Techniqu

1984
Histamine-induced relaxation of rat aorta. Importance of H1 receptor and vascular endothelium.
    Blood vessels, 1984, Volume: 21, Issue:4

    Topics: Animals; Aorta, Thoracic; Binding, Competitive; Cimetidine; Diphenhydramine; Endothelium; Histamine;

1984
Relaxation of isolated rabbit veins mediated by latent histamine H2-receptors.
    Experientia, 1983, Jun-15, Volume: 39, Issue:6

    Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Histamine; Male; Muscle Contraction; Muscle R

1983
Relaxation of rat tail artery to electrical stimulation.
    Life sciences, 1983, Jul-25, Volume: 33, Issue:4

    Topics: Animals; Arteries; Calcium; Cimetidine; Dose-Response Relationship, Drug; Electric Stimulation; Hist

1983
Vascular endothelium and the relaxation effect of histamine on aorta of the rat.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 256, Issue:2

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Atropine; Cimetidine; Endothelium; Histamine; In Vitro Tech

1982
Histamine actions in dog retinal central arteries as compared to those in middle cerebral and temporal arteries.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1995,Summer, Volume: 11, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Arteries; Chlorpheniramine; Cimetidine; D

1995
Role of endothelium and nitric oxide in histamine-induced responses in human cranial arteries and detection of mRNA encoding H1- and H2-receptors by RT-PCR.
    British journal of pharmacology, 1997, Volume: 121, Issue:1

    Topics: Cerebral Arteries; Cimetidine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel

1997
Analysis of an H1 receptor-mediated, zinc-potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein.
    British journal of pharmacology, 1998, Volume: 125, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carnosine; Cimetidine; Drug Interactions; Histamin

1998
Role of the endothelium in the vasorelaxing influence of histamine on isolated human subcutaneous resistance arteries.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1999, Volume: 48 Suppl 1

    Topics: Adipose Tissue; Arteries; Cimetidine; Endothelium, Vascular; Histamine; Histamine Agonists; Histamin

1999
Involvement of nitric oxide in endothelium-dependent, phasic relaxation caused by histamine in monkey cerebral arteries.
    Japanese journal of pharmacology, 1992, Volume: 60, Issue:4

    Topics: Animals; Arginine; Basilar Artery; Cerebral Arteries; Chlorpheniramine; Cimetidine; Dinoprost; Endot

1992
Hepatic cytochrome P-450-mediated activation of rat aortic guanylyl cyclase by glyceryl trinitrate.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:2

    Topics: Animals; Aorta; Cimetidine; Cytochrome P-450 Enzyme System; Enzyme Activation; Guanylate Cyclase; Ma

1992
Histamine receptors on human isolated pulmonary arterial muscle preparations: effects of endothelial cell removal and nitric oxide inhibitors.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2

    Topics: Arginine; Burimamide; Chlorpheniramine; Cimetidine; Dimaprit; Endothelium, Vascular; Histamine; Huma

1992
[Mechanisms of histamine-induced relaxation in isolated dog mesenteric arteries and veins].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1992, Volume: 99, Issue:1

    Topics: Animals; Chlorpheniramine; Cimetidine; Dogs; Dose-Response Relationship, Drug; Epoprostenol; Female;

1992
Developmental changes in effects of histamine on segmental pulmonary vascular resistances.
    Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 71, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Chlorpheniramine; Cimetidine; Histamine; Histamine H1 Antagonists;

1991
Influence of the endothelium on histamine-induced relaxation of rat middle cerebral arteries in vitro.
    Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:1

    Topics: Animals; Cerebral Arteries; Cimetidine; Dimaprit; Dose-Response Relationship, Drug; Endothelium, Vas

1991
Histamine induces endothelium-dependent relaxation of bovine retinal arteries.
    Investigative ophthalmology & visual science, 1991, Volume: 32, Issue:1

    Topics: Acetylcholine; Animals; Cattle; Cimetidine; Dimaprit; Endothelium, Vascular; Histamine; Muscle Relax

1991
Different histamine actions in proximal and distal human coronary arteries in vitro.
    Cardiovascular research, 1990, Volume: 24, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Cimetidine; Coronary Vessels; Culture Tech

1990
Effect of histamine on human bronchial arteries in vitro.
    Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 342, Issue:1

    Topics: Adult; Bronchial Arteries; Cimetidine; Dinoprost; Histamine; Humans; In Vitro Techniques; Middle Age

1990
5-Carboxamidotryptamine: a potent agonist mediating relaxation and elevation of cyclic AMP in the isolated neonatal porcine vena cava.
    Life sciences, 1986, Apr-21, Volume: 38, Issue:16

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atropine; Cimetidine; Cocaine; Cyclic AMP; D

1986
Vasoactive effects of substance P on isolated rabbit pulmonary artery.
    Journal of applied physiology (Bethesda, Md. : 1985), 1985, Volume: 58, Issue:4

    Topics: Animals; Atropine; Biomechanical Phenomena; Chlorpheniramine; Cimetidine; Dose-Response Relationship

1985
Histamine H2-receptor antagonistic action of N-(3-[3-(1-piperidinylmethyl)phenoxy]propyl)acetoxyacetamide hydrochloride (TZU-0460).
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:4

    Topics: Animals; Cimetidine; Dimaprit; Dogs; Female; Gastric Acid; Guinea Pigs; Heart Atria; Heart Rate; His

1985
The zoapatle. X. The in vitro effect of zoapatle aqueous crude extract (ZACE) and histamine upon rat and guinea pig uterine strips.
    Contraception, 1985, Volume: 31, Issue:5

    Topics: Animals; Cimetidine; Diphenhydramine; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; Hist

1985
Species variations in the relaxation of tail arteries to electrical stimulation.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1986, Volume: 85, Issue:1

    Topics: Animals; Arteries; Cats; Cimetidine; Electric Stimulation; In Vitro Techniques; Muscle Relaxation; M

1986
Direct effects of H2-receptor antagonists on airway smooth muscle and on responses mediated by H1- and H2-receptors.
    Anesthesiology, 1987, Volume: 66, Issue:2

    Topics: Animals; Cimetidine; Famotidine; Guinea Pigs; Histamine H2 Antagonists; In Vitro Techniques; Male; M

1987
Relaxant effect of the H2-receptor antagonist oxmetidine on guinea-pig and human airways.
    British journal of pharmacology, 1987, Volume: 90, Issue:3

    Topics: Acetylcholine; Animals; Bronchi; Calcium; Cimetidine; Guinea Pigs; Histamine; Histamine H2 Antagonis

1987
Participation of vascular H1-receptors in histaminergic relaxation of rabbit middle cerebral artery in vitro.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 283, Issue:2

    Topics: Animals; Cerebral Arteries; Cimetidine; Dimaprit; Drug Interactions; Histamine; In Vitro Techniques;

1986
Endothelium-dependent relaxing effect of histamine on the isolated guinea-pig main pulmonary artery strips.
    Agents and actions, 1987, Volume: 22, Issue:1-2

    Topics: Animals; Cimetidine; Endothelium, Vascular; Female; Guinea Pigs; Histamine; Imidazoles; Impromidine;

1987
A highly potent and selective H3 agonist relaxes rabbit middle cerebral artery, in vitro.
    European journal of pharmacology, 1988, Jun-10, Volume: 150, Issue:3

    Topics: Animals; Cerebral Arteries; Cimetidine; Histamine; Imidazoles; Impromidine; In Vitro Techniques; Mal

1988
Mechanisms of histamine-induced relaxation in isolated monkey and dog coronary arteries.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:2

    Topics: Animals; Benzoquinones; Chlorpheniramine; Cimetidine; Coronary Vessels; Dogs; Female; Histamine; Ind

1986