cimetidine has been researched along with Muscle Relaxation in 42 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cimetidine effect was dramatically potentiated in denuded tracheal strips (+40." | 1.32 | Functional identification of epithelial and smooth muscle histamine-dependent relaxing mechanisms in the bovine trachea, but not in bronchi. ( Desmecht, D; Jolly, S, 2003) |
| "Treatment with cimetidine attenuated the sustained relaxation, whereas chlorpheniramine or indomethacin depressed the phasic relaxation." | 1.29 | Histamine actions in dog retinal central arteries as compared to those in middle cerebral and temporal arteries. ( Kani, K; Kitamura, Y; Okamura, T; Toda, N, 1995) |
| "Treatment with indomethacin inhibited the phasic component in the strips with endothelium, but did not influence the relaxation after endothelium denudation." | 1.28 | [Mechanisms of histamine-induced relaxation in isolated dog mesenteric arteries and veins]. ( Toda, N; Yamazaki, M, 1992) |
| "Histamine was infused at 1." | 1.28 | Developmental changes in effects of histamine on segmental pulmonary vascular resistances. ( Chu, K; Clément de Cléty, S; Gordon, JB, 1991) |
| "(+)-Pindolol was less potent as antagonist of the relaxant effects of (-)-noradrenaline on trachea than against those of (-)-adrenaline, (-)-isoprenaline and (+/-)-salbutamol." | 1.27 | Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of beta-adrenoceptor subtypes in the dissociation between blockade and stimulation. ( Kaumann, AJ; Lemoine, H; Walter, M, 1984) |
| " In aortic ring segments, precontracted by norepinephrine, three types of dose-response curves were found: relaxation (rat), contraction (guinea-pig, cat, mouse) and relaxation followed by contraction at higher doses (rabbit)." | 1.27 | Effect of histamine on aorta preparations of different species. ( Leusen, I; Van de Voorde, J, 1984) |
| " However, when the preparations were precontracted with histamine (10(-5)M), dose-response curves for relaxation were shifted to the right, and low-concentrations of all three histamine H2-antagonists augmented histamine-induced tone." | 1.27 | Direct effects of H2-receptor antagonists on airway smooth muscle and on responses mediated by H1- and H2-receptors. ( Hashimoto, Y; Iwatsuki, N; Koga, Y, 1987) |
| "When dimaprit was compared with 4-methylhistamine, it acted only as a relaxing agent, not as a constricting agent." | 1.27 | Participation of vascular H1-receptors in histaminergic relaxation of rabbit middle cerebral artery in vitro. ( Kim, LE; Oudart, N; Sercombe, R; Teste, JF, 1986) |
| " Cimetidine shifted the dose-response curve for histamine to the right, but chlorpheniramine did not alter the response." | 1.27 | Mechanisms of histamine-induced relaxation in isolated monkey and dog coronary arteries. ( Toda, N, 1986) |
| " Pretreatment of parenchymal strips with cimetidine or YM-11170, H2-receptor antagonists, resulted in a parallel shift of the dimaprit dose-response curve to the right." | 1.26 | Effects of histamine H2-receptor agonists and antagonists on isolated guinea-pig airway muscles. ( Tomioka, K; Yamada, T, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (57.14) | 18.7374 |
| 1990's | 13 (30.95) | 18.2507 |
| 2000's | 4 (9.52) | 29.6817 |
| 2010's | 1 (2.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kurtz, KH | 1 |
| Moor, AN | 1 |
| Souza-Smith, FM | 1 |
| Breslin, JW | 1 |
| Ziberna, L | 1 |
| Zorman, T | 1 |
| Drevensek, G | 1 |
| Bozarov, A | 1 |
| Wang, YZ | 1 |
| Yu, JG | 1 |
| Wunderlich, J | 1 |
| Hassanain, HH | 1 |
| Alhaj, M | 1 |
| Cooke, HJ | 1 |
| Grants, I | 1 |
| Ren, T | 1 |
| Christofi, FL | 1 |
| Jolly, S | 1 |
| Desmecht, D | 1 |
| Pangalis, A | 1 |
| Giala, M | 1 |
| Mironidou, M | 1 |
| Papadakis, E | 1 |
| Crassaris, L | 1 |
| Paradelis, AG | 1 |
| Viaro, F | 1 |
| Celotto, AC | 1 |
| Capellini, VK | 1 |
| Baldo, CF | 1 |
| Rodrigues, AJ | 1 |
| Vicente, WV | 1 |
| Evora, PR | 1 |
| Walter, M | 1 |
| Lemoine, H | 1 |
| Kaumann, AJ | 1 |
| Kenakin, TP | 1 |
| Beek, D | 1 |
| Tomioka, K | 1 |
| Yamada, T | 1 |
| Vincenc, K | 1 |
| Black, J | 1 |
| Shaw, J | 1 |
| Duncan, PG | 1 |
| Brink, C | 2 |
| Adolphson, RL | 1 |
| Douglas, JS | 1 |
| Senaratne, M | 1 |
| Kappagoda, T | 1 |
| Godfraind, T | 1 |
| Miller, RC | 1 |
| Van de Voorde, J | 3 |
| Leusen, I | 2 |
| Carrier, GO | 1 |
| White, RE | 1 |
| Kirby, ML | 1 |
| Tsuru, H | 1 |
| Iwata, M | 1 |
| Shigei, T | 1 |
| Ebeigbe, AB | 2 |
| Gantzos, RD | 1 |
| Webb, RC | 1 |
| Kitamura, Y | 1 |
| Okamura, T | 2 |
| Kani, K | 1 |
| Toda, N | 4 |
| Jansen-Olesen, I | 1 |
| Ottosson, A | 1 |
| Cantera, L | 1 |
| Strunk, S | 1 |
| Lassen, LH | 1 |
| Olesen, J | 1 |
| Mortensen, A | 1 |
| Engel, U | 1 |
| Edvinsson, L | 1 |
| O'Dowd, A | 1 |
| Miller, DJ | 1 |
| Delaey, C | 1 |
| Depypere, H | 1 |
| Vanheel, B | 1 |
| Ayajiki, K | 1 |
| Bennett, BM | 1 |
| McDonald, BJ | 1 |
| St James, MJ | 1 |
| Ortiz, JL | 1 |
| Labat, C | 1 |
| Norel, X | 1 |
| Gorenne, I | 1 |
| Verley, J | 1 |
| Yamazaki, M | 1 |
| Gordon, JB | 1 |
| Clément de Cléty, S | 1 |
| Chu, K | 1 |
| Benedito, S | 2 |
| Prieto, D | 2 |
| Nyborg, NC | 2 |
| Nielsen, PJ | 1 |
| Keitoku, M | 1 |
| Maruyama, Y | 1 |
| Takishima, T | 1 |
| Liu, SF | 1 |
| Yacoub, M | 1 |
| Barnes, PJ | 1 |
| Trevethick, MA | 1 |
| Feniuk, W | 1 |
| Humphrey, PP | 1 |
| Tanaka, DT | 1 |
| Grunstein, MM | 1 |
| Tarutani, M | 1 |
| Sakuma, H | 1 |
| Shiratsuchi, K | 1 |
| Mieda, M | 1 |
| Ponce-Monter, H | 1 |
| Estrada, AV | 1 |
| Pedrón, N | 1 |
| Valencia, A | 1 |
| Gallegos, AJ | 1 |
| Koga, Y | 1 |
| Iwatsuki, N | 1 |
| Hashimoto, Y | 1 |
| Advenier, C | 1 |
| Gnassounou, JP | 1 |
| Scarpignato, C | 1 |
| Kim, LE | 1 |
| Teste, JF | 1 |
| Sercombe, R | 1 |
| Oudart, N | 2 |
| Abacioğlu, N | 1 |
| Ercan, ZS | 1 |
| Kanzik, L | 1 |
| Zengil, H | 1 |
| Demiryürek, T | 1 |
| Türker, RK | 1 |
| Ea-Kim, L | 1 |
42 other studies available for cimetidine and Muscle Relaxation
| Article | Year |
|---|---|
Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
Topics: Animals; Cimetidine; Endothelium, Lymphatic; Guanylate Cyclase; Histamine H1 Antagonists; Histamine | 2014 |
Characterization of histamine-induced relaxation in pre-contracted rat aorta.
Topics: Animals; Aorta; Cimetidine; Ethylenediamines; Histamine; Histamine H1 Antagonists; Histamine H2 Anta | 2009 |
Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.
Topics: Adenosine; Animals; Chlorides; Cimetidine; Colon; Dihydropyridines; Dimaprit; Dose-Response Relation | 2009 |
Functional identification of epithelial and smooth muscle histamine-dependent relaxing mechanisms in the bovine trachea, but not in bronchi.
Topics: Animals; Bronchi; Cattle; Cimetidine; Dose-Response Relationship, Drug; Histamine; Histamine H2 Anta | 2003 |
Interaction of aminoglycoside antibiotics with H2-blockers and calcium channel blockers in isolated smooth muscles of rat aorta.
Topics: Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Calcium Channel Blockers; Cimetidine; His | 1989 |
Compound 48/80 induces endothelium-dependent and histamine release-independent relaxation in rabbit aorta.
Topics: Animals; Aorta; Cimetidine; Endothelium, Vascular; Estrenes; Histamine H1 Antagonists; Histamine Rel | 2008 |
Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of beta-adrenoceptor subtypes in the dissociation between blockade and stimulation.
Topics: Animals; Bupranolol; Cimetidine; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoproterenol | 1984 |
A quantitative analysis of histamine H2-receptor-mediated relaxation of rabbit trachea.
Topics: Animals; Cimetidine; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Male; Muscle Contract | 1982 |
Effects of histamine H2-receptor agonists and antagonists on isolated guinea-pig airway muscles.
Topics: Airway Resistance; Animals; Cimetidine; Dimaprit; Drug Interactions; Guinea Pigs; Histamine H2 Antag | 1982 |
Relaxation and contraction responses to histamine in the human lung parenchymal strip.
Topics: Cimetidine; Dose-Response Relationship, Drug; Histamine; Histamine H1 Antagonists; Histamine H2 Anta | 1984 |
Cyclic nucleotides and contraction/relaxation in airway muscle: H1 and H2 agonists and antagonists.
Topics: Animals; Cimetidine; Cyclic AMP; Cyclic GMP; Ethylamines; Female; Guinea Pigs; Histamine; Histamine | 1980 |
Tetrodotoxin-resistant relaxation to transmural nerve stimulation in isolated saphenous vein.
Topics: Aminophylline; Animals; Biomechanical Phenomena; Cimetidine; Cyproheptadine; Dogs; Drug Resistance; | 1984 |
Effects of histamine and the histamine antagonists mepyramine and cimetidine on human coronary arteries in vitro.
Topics: Adolescent; Adult; Aged; Aminopyridines; Child; Cimetidine; Coronary Vessels; Histamine; Humans; In | 1983 |
Effect of histamine on aorta preparations of different species.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cats; Cimetidine; Guinea Pigs; Histamine; In Vitro Techniqu | 1984 |
Histamine-induced relaxation of rat aorta. Importance of H1 receptor and vascular endothelium.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Cimetidine; Diphenhydramine; Endothelium; Histamine; | 1984 |
Relaxation of isolated rabbit veins mediated by latent histamine H2-receptors.
Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Histamine; Male; Muscle Contraction; Muscle R | 1983 |
Relaxation of rat tail artery to electrical stimulation.
Topics: Animals; Arteries; Calcium; Cimetidine; Dose-Response Relationship, Drug; Electric Stimulation; Hist | 1983 |
Vascular endothelium and the relaxation effect of histamine on aorta of the rat.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Atropine; Cimetidine; Endothelium; Histamine; In Vitro Tech | 1982 |
Histamine actions in dog retinal central arteries as compared to those in middle cerebral and temporal arteries.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Arteries; Chlorpheniramine; Cimetidine; D | 1995 |
Role of endothelium and nitric oxide in histamine-induced responses in human cranial arteries and detection of mRNA encoding H1- and H2-receptors by RT-PCR.
Topics: Cerebral Arteries; Cimetidine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel | 1997 |
Analysis of an H1 receptor-mediated, zinc-potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carnosine; Cimetidine; Drug Interactions; Histamin | 1998 |
Role of the endothelium in the vasorelaxing influence of histamine on isolated human subcutaneous resistance arteries.
Topics: Adipose Tissue; Arteries; Cimetidine; Endothelium, Vascular; Histamine; Histamine Agonists; Histamin | 1999 |
Involvement of nitric oxide in endothelium-dependent, phasic relaxation caused by histamine in monkey cerebral arteries.
Topics: Animals; Arginine; Basilar Artery; Cerebral Arteries; Chlorpheniramine; Cimetidine; Dinoprost; Endot | 1992 |
Hepatic cytochrome P-450-mediated activation of rat aortic guanylyl cyclase by glyceryl trinitrate.
Topics: Animals; Aorta; Cimetidine; Cytochrome P-450 Enzyme System; Enzyme Activation; Guanylate Cyclase; Ma | 1992 |
Histamine receptors on human isolated pulmonary arterial muscle preparations: effects of endothelial cell removal and nitric oxide inhibitors.
Topics: Arginine; Burimamide; Chlorpheniramine; Cimetidine; Dimaprit; Endothelium, Vascular; Histamine; Huma | 1992 |
[Mechanisms of histamine-induced relaxation in isolated dog mesenteric arteries and veins].
Topics: Animals; Chlorpheniramine; Cimetidine; Dogs; Dose-Response Relationship, Drug; Epoprostenol; Female; | 1992 |
Developmental changes in effects of histamine on segmental pulmonary vascular resistances.
Topics: Aging; Animals; Animals, Newborn; Chlorpheniramine; Cimetidine; Histamine; Histamine H1 Antagonists; | 1991 |
Influence of the endothelium on histamine-induced relaxation of rat middle cerebral arteries in vitro.
Topics: Animals; Cerebral Arteries; Cimetidine; Dimaprit; Dose-Response Relationship, Drug; Endothelium, Vas | 1991 |
Histamine induces endothelium-dependent relaxation of bovine retinal arteries.
Topics: Acetylcholine; Animals; Cattle; Cimetidine; Dimaprit; Endothelium, Vascular; Histamine; Muscle Relax | 1991 |
Different histamine actions in proximal and distal human coronary arteries in vitro.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Cimetidine; Coronary Vessels; Culture Tech | 1990 |
Effect of histamine on human bronchial arteries in vitro.
Topics: Adult; Bronchial Arteries; Cimetidine; Dinoprost; Histamine; Humans; In Vitro Techniques; Middle Age | 1990 |
5-Carboxamidotryptamine: a potent agonist mediating relaxation and elevation of cyclic AMP in the isolated neonatal porcine vena cava.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atropine; Cimetidine; Cocaine; Cyclic AMP; D | 1986 |
Vasoactive effects of substance P on isolated rabbit pulmonary artery.
Topics: Animals; Atropine; Biomechanical Phenomena; Chlorpheniramine; Cimetidine; Dose-Response Relationship | 1985 |
Histamine H2-receptor antagonistic action of N-(3-[3-(1-piperidinylmethyl)phenoxy]propyl)acetoxyacetamide hydrochloride (TZU-0460).
Topics: Animals; Cimetidine; Dimaprit; Dogs; Female; Gastric Acid; Guinea Pigs; Heart Atria; Heart Rate; His | 1985 |
The zoapatle. X. The in vitro effect of zoapatle aqueous crude extract (ZACE) and histamine upon rat and guinea pig uterine strips.
Topics: Animals; Cimetidine; Diphenhydramine; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; Hist | 1985 |
Species variations in the relaxation of tail arteries to electrical stimulation.
Topics: Animals; Arteries; Cats; Cimetidine; Electric Stimulation; In Vitro Techniques; Muscle Relaxation; M | 1986 |
Direct effects of H2-receptor antagonists on airway smooth muscle and on responses mediated by H1- and H2-receptors.
Topics: Animals; Cimetidine; Famotidine; Guinea Pigs; Histamine H2 Antagonists; In Vitro Techniques; Male; M | 1987 |
Relaxant effect of the H2-receptor antagonist oxmetidine on guinea-pig and human airways.
Topics: Acetylcholine; Animals; Bronchi; Calcium; Cimetidine; Guinea Pigs; Histamine; Histamine H2 Antagonis | 1987 |
Participation of vascular H1-receptors in histaminergic relaxation of rabbit middle cerebral artery in vitro.
Topics: Animals; Cerebral Arteries; Cimetidine; Dimaprit; Drug Interactions; Histamine; In Vitro Techniques; | 1986 |
Endothelium-dependent relaxing effect of histamine on the isolated guinea-pig main pulmonary artery strips.
Topics: Animals; Cimetidine; Endothelium, Vascular; Female; Guinea Pigs; Histamine; Imidazoles; Impromidine; | 1987 |
A highly potent and selective H3 agonist relaxes rabbit middle cerebral artery, in vitro.
Topics: Animals; Cerebral Arteries; Cimetidine; Histamine; Imidazoles; Impromidine; In Vitro Techniques; Mal | 1988 |
Mechanisms of histamine-induced relaxation in isolated monkey and dog coronary arteries.
Topics: Animals; Benzoquinones; Chlorpheniramine; Cimetidine; Coronary Vessels; Dogs; Female; Histamine; Ind | 1986 |