cimetidine has been researched along with Muscle Contraction in 112 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to evaluate the antiulcer activity of Linum usitatissimum fixed oil against aspirin-, indomethacin-, ethanol-, reserpine-, serotonin- and stress-induced gastric ulceration in rats and histamine-induced gastric ulceration in guinea pigs." | 3.76 | Evaluation of antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action. ( Kaithwas, G; Majumdar, DK, 2010) |
| "The pharmacological effects of the beta-hydroxylated histamine, 4(5)-(2-amino-1-hydroxyethyl)-imidazole, on smooth muscle contraction of the ileum (H1-receptor activity) and gastric acid secretion (H2-receptor activity) of the guinea-pig were investigated and compared with those of histamine." | 3.67 | Pharmacological properties of the hydroxylated histamine, (+/-)-4(5)-(2-amino-1-hydroxyethyl)-imidazole. ( Ishikawa, T; Itoh, T; Kamisaki, Y, 1989) |
| "Electrophysiological studies of the effects of histamine on the smooth muscles in the guinea-pig main pulmonary artery revealed that this amine produced muscle contraction with an associated depolarization of the membrane." | 3.66 | Direct and indirect effects of histamine on the smooth muscle cells of the guinea-pig main pulmonary artery. ( Kou, K; Suzuki, H, 1983) |
| "The regular dosage of cimetidine showed an inhibitory effect on the motility of SO, while famotidine had no obvious effects otherwise." | 2.73 | Choledochoscope manometry about different drugs on the Sphincter of Oddi. ( Chen, JZ; Kong, J; Li, ZS; Shi, G; Wang, W; Wu, SD; Zhang, XB, 2008) |
| "Histamine is a vasoactive amine which is endogenously produced in many organs including the penis." | 1.29 | Characterization and function of histamine receptors in corpus cavernosum. ( Carson, CC; Davies, MG; Hagen, PO; Kim, YC; Lee, TH, 1995) |
| " In the guinea pig ileum, millimolar concentrations of cimetidine and famotidine shifted the dose-response curve of the contractile response to acetylcholine rightward." | 1.29 | Comparative effects of cimetidine and famotidine on the vagally stimulated acid secretion in the isolated mouse whole stomach. ( Kanaoka, S; Watanabe, K; Yamamoto, M; Yano, S, 1993) |
| "Succinylcholine was administered as a bolus and constant-rate infusion to maintain 49." | 1.28 | Interaction between succinylcholine and cimetidine in rats. ( Mishra, Y; Ramzan, I, 1992) |
| " In aortic ring segments, precontracted by norepinephrine, three types of dose-response curves were found: relaxation (rat), contraction (guinea-pig, cat, mouse) and relaxation followed by contraction at higher doses (rabbit)." | 1.27 | Effect of histamine on aorta preparations of different species. ( Leusen, I; Van de Voorde, J, 1984) |
| " beta-Adrenoceptor antagonists produced a bell-shaped dose-response curve on histamine contractions in cat isolated lung parenchyma strip." | 1.27 | The response of cat airways to histamine in vivo and in vitro. ( Blaber, LC; Fryer, AD, 1985) |
| "Mifentidine appeared to be a specific and competitive antagonist of several histamine-mediated responses." | 1.27 | Pharmacology of mifentidine, a novel H2-receptor antagonist. ( Brambilla, A; Ciprandi, C; Giachetti, A; Micheletti, R; Montagna, E; Pagani, F; Schiavone, A, 1985) |
| " ORF 17910 retains 43 and 37% of its antisecretory potency 16 hr after dosing in dogs and rats, respectively, suggesting a long duration of action, whereas ranitidine is either inactive (rats) or loses 97% of its potency (dogs) at this time." | 1.27 | Pharmacological comparison of ORF 17910, a potent, long-acting histamine H2-receptor antagonist, to cimetidine and ranitidine. ( Katz, LB; Scott, CK; Shriver, DA, 1986) |
| " However, when the preparations were precontracted with histamine (10(-5)M), dose-response curves for relaxation were shifted to the right, and low-concentrations of all three histamine H2-antagonists augmented histamine-induced tone." | 1.27 | Direct effects of H2-receptor antagonists on airway smooth muscle and on responses mediated by H1- and H2-receptors. ( Hashimoto, Y; Iwatsuki, N; Koga, Y, 1987) |
| " In an apparently all-or-none manner, both caused a sinistral shift in dose-response curves for the phasic component of the contractile response to histamine at H1 receptors on the ileum." | 1.27 | Metronidazole and 5-aminosalicylic acid enhance the contractile activity of histaminergic agonists on the guinea-pig isolated ileum. ( Barker, LA; Winbery, SL, 1986) |
| " Dose-response curves were constructed and characterized in terms of the EC50, slope and maximal response attainable relative to histamine." | 1.27 | Histamine-induced inositol phospholipid breakdown in the longitudinal smooth muscle of guinea-pig ileum. ( Donaldson, J; Hill, SJ, 1985) |
| "Treatment with cimetidine potentiated contraction in the strips with intact and damaged endothelium to a similar extent and attenuated relaxation." | 1.27 | Mechanism of histamine actions in human coronary arteries. ( Toda, N, 1987) |
| " Cimetidine shifted the dose-response curve for histamine to the right, but chlorpheniramine did not alter the response." | 1.27 | Mechanisms of histamine-induced relaxation in isolated monkey and dog coronary arteries. ( Toda, N, 1986) |
| " Pretreatment of parenchymal strips with cimetidine or YM-11170, H2-receptor antagonists, resulted in a parallel shift of the dimaprit dose-response curve to the right." | 1.26 | Effects of histamine H2-receptor agonists and antagonists on isolated guinea-pig airway muscles. ( Tomioka, K; Yamada, T, 1982) |
| "7 Cimetidine was without effect on histamine sensitivity in young guinea-pigs after propranolol treatment but significantly reduced airway sensitivity to histamine in old guinea-pigs." | 1.26 | Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development. ( Brink, C; Douglas, JS; Duncan, PG, 1982) |
| " Cumulative dose-response contraction curves were constructed." | 1.26 | A dual action of histamine on isolated human pulmonary arteries. ( Boe, J; Boe, MA; Simonsson, BG, 1980) |
| "Treatment with propranolol, atropine, hexamethonium, cocaine, aminophylline, cimetidine, or ouabain failed to alter the relaxing effect of AII." | 1.26 | Angiotensin-induced relaxation in isolated dog renal and cerebral arteries. ( Miyazaki, M; Toda, N, 1981) |
| "A histaminergic pathway is an attractive possibility to explain the excitatory response, because both pyrilamine and cimetidine inhibit the thyrotropin-releasing hormone induced response and the peptide has no further influence on antral motility after the tissue is exposed to a supramaximal concentration of histamine." | 1.26 | Histaminergic involvement in thyrotropin-releasing hormone stimulation of antral tissue in the rat. ( Behsudi, FM; Bruce, LA; Fawcett, CP, 1979) |
| "Cimetidine was weaker than burimamide and did not fulfil the requirements for competitive antagonism of noradrenaline." | 1.26 | Effects of the histamine H2-receptor blocking drugs burimamide and cimetidine on noradrenergic transmission in the isolated aorta of the rabbit and atria of the guinea-pig. ( McCulloch, MW; Medgett, IC; Rand, MJ, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 77 (68.75) | 18.7374 |
| 1990's | 28 (25.00) | 18.2507 |
| 2000's | 4 (3.57) | 29.6817 |
| 2010's | 2 (1.79) | 24.3611 |
| 2020's | 1 (0.89) | 2.80 |
| Authors | Studies |
|---|---|
| Oesterlin, R | 1 |
| Bell, MR | 1 |
| McGarry, RH | 1 |
| Hlavac, AG | 1 |
| Bradford, JC | 1 |
| Rozitis, J | 1 |
| Hirschfeld, J | 1 |
| Buschauer, A | 2 |
| Elz, S | 1 |
| Schunack, W | 2 |
| Ruat, M | 1 |
| Traiffort, E | 1 |
| Schwartz, JC | 1 |
| Lumma, WC | 1 |
| Anderson, PS | 1 |
| Baldwin, JJ | 1 |
| Bolhofer, WA | 1 |
| Habecker, CN | 1 |
| Hirshfield, JM | 1 |
| Pietruszkiewicz, AM | 1 |
| Randall, WC | 1 |
| Torchiana, ML | 1 |
| Britcher, SF | 1 |
| Clineschmidt, BV | 1 |
| Denny, GH | 1 |
| Hirschmann, R | 1 |
| Hoffman, MJ | 1 |
| Phillips, BT | 1 |
| Streeter, KB | 1 |
| Aneesha, VA | 1 |
| Gopi, RP | 1 |
| Kumawat, S | 1 |
| Susanth, VS | 1 |
| Vineetha, S | 1 |
| Kumar, D | 1 |
| Yao, QY | 1 |
| Chen, DP | 1 |
| Ye, DM | 1 |
| Diao, YP | 1 |
| Lin, Y | 1 |
| Kong, J | 1 |
| Wu, SD | 1 |
| Zhang, XB | 1 |
| Li, ZS | 1 |
| Shi, G | 1 |
| Wang, W | 1 |
| Chen, JZ | 1 |
| Bozarov, A | 1 |
| Wang, YZ | 2 |
| Yu, JG | 1 |
| Wunderlich, J | 1 |
| Hassanain, HH | 1 |
| Alhaj, M | 1 |
| Cooke, HJ | 2 |
| Grants, I | 1 |
| Ren, T | 1 |
| Christofi, FL | 1 |
| Kaithwas, G | 1 |
| Majumdar, DK | 1 |
| Koutsoviti-Papadopoulou, M | 2 |
| Nikolaidis, E | 1 |
| Kounenis, G | 2 |
| Pangalis, A | 1 |
| Giala, M | 1 |
| Mironidou, M | 1 |
| Papadakis, E | 1 |
| Crassaris, L | 1 |
| Paradelis, AG | 1 |
| Pinelli, A | 1 |
| Colombo, R | 1 |
| Trivulzio, S | 1 |
| Berti, F | 1 |
| Tofanetti, O | 1 |
| Caimi, BR | 1 |
| Vohra, MM | 3 |
| Cade, JF | 1 |
| Clancy, RL | 1 |
| Walker, SE | 1 |
| Pain, MC | 1 |
| Kenakin, TP | 1 |
| Beek, D | 1 |
| MacIntosh, CM | 1 |
| Oriowo, MA | 1 |
| Barker, LA | 2 |
| Tomioka, K | 1 |
| Yamada, T | 1 |
| Re, L | 1 |
| Cingolani, ML | 1 |
| Concettoni, C | 1 |
| Rossini, L | 1 |
| Vincenc, K | 1 |
| Black, J | 1 |
| Shaw, J | 1 |
| Calvete, JA | 1 |
| Donegan, JL | 1 |
| Hayes, RJ | 1 |
| Oates, NS | 1 |
| Sloan, TP | 1 |
| Taniyama, K | 1 |
| Kusunoki, M | 1 |
| Tanaka, C | 1 |
| Duncan, PG | 2 |
| Brink, C | 3 |
| Adolphson, RL | 1 |
| Douglas, JS | 2 |
| Nakanishi, H | 1 |
| Fukui, K | 1 |
| Kanke, M | 1 |
| Sakuma, T | 1 |
| Winquist, RJ | 1 |
| Baskin, EP | 1 |
| Tenner, TE | 1 |
| Mantovani, P | 1 |
| Santicioli, P | 1 |
| Di Donato, M | 1 |
| Senaratne, M | 1 |
| Kappagoda, T | 1 |
| Suzuki, H | 2 |
| Kou, K | 1 |
| Godfraind, T | 1 |
| Miller, RC | 1 |
| Van de Voorde, J | 2 |
| Leusen, I | 2 |
| Carrier, GO | 1 |
| White, RE | 1 |
| Kirby, ML | 1 |
| Tsuru, H | 1 |
| Iwata, M | 1 |
| Shigei, T | 1 |
| Ebeigbe, AB | 1 |
| Gantzos, RD | 1 |
| Webb, RC | 1 |
| Pries, JM | 1 |
| Clanachan, AS | 1 |
| Courtney, DF | 1 |
| Scott, GW | 1 |
| Fosbraey, P | 1 |
| Johnson, ES | 1 |
| Mckay, FF | 1 |
| Vyas, S | 1 |
| Verma, SC | 1 |
| Biancani, P | 1 |
| CiCalzi, LK | 1 |
| McCallum, RW | 1 |
| Casteels, R | 2 |
| Nakazawa, S | 1 |
| Ichikawa, T | 1 |
| Naito, Y | 1 |
| Tsukamoto, Y | 1 |
| Quirion, R | 1 |
| Regoli, D | 1 |
| Rioux, F | 1 |
| St-Pierre, S | 1 |
| Boe, J | 1 |
| Boe, MA | 1 |
| Simonsson, BG | 1 |
| Toda, N | 3 |
| Miyazaki, M | 1 |
| Griffiths, MJ | 1 |
| Messent, M | 1 |
| MacAllister, RJ | 1 |
| Evans, TW | 1 |
| Gwee, MC | 1 |
| Cheah, LS | 1 |
| Shoon, ML | 1 |
| Iwase, M | 1 |
| Kanamaru, M | 1 |
| Homma, I | 1 |
| Kim, YC | 1 |
| Davies, MG | 1 |
| Lee, TH | 1 |
| Hagen, PO | 1 |
| Carson, CC | 1 |
| Rogers, R | 1 |
| Watanabe, K | 1 |
| Yano, S | 1 |
| Yamamoto, M | 1 |
| Kanaoka, S | 1 |
| KAMEI, CH | 1 |
| Jansen-Olesen, I | 1 |
| Ottosson, A | 1 |
| Cantera, L | 1 |
| Strunk, S | 1 |
| Lassen, LH | 1 |
| Olesen, J | 1 |
| Mortensen, A | 1 |
| Engel, U | 1 |
| Edvinsson, L | 1 |
| Khodorova, AB | 1 |
| Nechaeva, MV | 1 |
| Turpaev, TM | 1 |
| O'Dowd, A | 1 |
| Miller, DJ | 1 |
| Izzo, AA | 1 |
| Costa, M | 1 |
| Mascolo, N | 1 |
| Capasso, F | 1 |
| Strapkova, A | 1 |
| Nosalova, G | 1 |
| Franova, S | 1 |
| Adamicova, K | 1 |
| Bytautiene, E | 1 |
| Vedernikov, YP | 1 |
| Saade, GR | 1 |
| Romero, R | 1 |
| Garfield, RE | 1 |
| Takayanagi, I | 1 |
| Iwayama, Y | 1 |
| Kasuya, Y | 1 |
| Gadacz, TR | 1 |
| Andersson, RG | 2 |
| Lindgren, BR | 2 |
| Colldahl, H | 1 |
| Bruce, LA | 1 |
| Behsudi, FM | 1 |
| Fawcett, CP | 1 |
| Eyre, P | 2 |
| Besner, RN | 1 |
| McCulloch, MW | 1 |
| Medgett, IC | 1 |
| Rand, MJ | 1 |
| Chand, N | 1 |
| Wikberg, J | 1 |
| Mishra, Y | 1 |
| Ramzan, I | 1 |
| Elezoglou, A | 1 |
| Voutsas, A | 1 |
| Marthan, R | 1 |
| Crevel, H | 1 |
| Guénard, H | 1 |
| Savineau, JP | 1 |
| Ortiz, JL | 2 |
| Labat, C | 1 |
| Norel, X | 1 |
| Gorenne, I | 1 |
| Verley, J | 1 |
| Obi, T | 1 |
| Matsumoto, M | 1 |
| Nishio, A | 1 |
| Vassilev, P | 1 |
| Mutafova-Yambolieva, V | 1 |
| Staneva-Stoytcheva, D | 1 |
| Todorov, S | 1 |
| Onodera, S | 1 |
| Yoshinaga, M | 1 |
| Takenaga, K | 1 |
| Toyoshima, A | 1 |
| Uchiyama, T | 1 |
| Shibata, M | 1 |
| Yamaura, T | 1 |
| Sekine, A | 1 |
| Nishikawa, M | 1 |
| Chida, Y | 1 |
| Ohnishi, H | 1 |
| Cruz, MA | 1 |
| González, C | 1 |
| Sepúlveda, WH | 1 |
| Rudolph, MI | 1 |
| Nishat, TA | 1 |
| Bossa, R | 1 |
| Efstathiu, G | 1 |
| Galatulas, I | 1 |
| Ninci, MA | 1 |
| Nishimoto, T | 1 |
| Yokoyama, M | 1 |
| Fukuzaki, H | 1 |
| Norman, BJ | 1 |
| Leathard, HL | 1 |
| Keitoku, M | 1 |
| Maruyama, Y | 1 |
| Takishima, T | 1 |
| Liu, SF | 1 |
| Yacoub, M | 1 |
| Barnes, PJ | 1 |
| Trevethick, MA | 1 |
| Feniuk, W | 1 |
| Humphrey, PP | 1 |
| Holzer, P | 1 |
| Holzer-Petsche, U | 1 |
| Leander, S | 1 |
| Grundström, N | 1 |
| Ishikawa, T | 1 |
| Kamisaki, Y | 1 |
| Itoh, T | 1 |
| Cortijo, J | 1 |
| Sanz, C | 1 |
| Perpiñá, M | 1 |
| Orón, JD | 1 |
| Esplugues, J | 1 |
| Morcillo, EJ | 1 |
| Lau, LC | 1 |
| Adaikan, PG | 1 |
| Ratnam, SS | 1 |
| Blaber, LC | 1 |
| Fryer, AD | 1 |
| Pagani, F | 1 |
| Micheletti, R | 1 |
| Brambilla, A | 1 |
| Schiavone, A | 1 |
| Montagna, E | 1 |
| Ciprandi, C | 1 |
| Giachetti, A | 1 |
| Bertaccini, G | 1 |
| Coruzzi, G | 1 |
| Poli, E | 1 |
| Black, JW | 1 |
| Shankley, NP | 1 |
| Trzeciakowski, JP | 2 |
| Frye, GD | 1 |
| Aono, M | 1 |
| Moriga, M | 1 |
| Mizuta, K | 1 |
| Narusawa, H | 1 |
| Katz, LB | 1 |
| Scott, CK | 1 |
| Shriver, DA | 1 |
| Koga, Y | 1 |
| Iwatsuki, N | 1 |
| Hashimoto, Y | 1 |
| Winbery, SL | 1 |
| Donaldson, J | 1 |
| Hill, SJ | 1 |
| Cole, S | 1 |
| Goldie, RG | 1 |
| Papadimitriou, JM | 1 |
| Paterson, JW | 1 |
| Rigby, PJ | 1 |
| Self, HM | 1 |
| Spina, D | 1 |
| Allescher, HD | 1 |
| Berezin, I | 1 |
| Jury, J | 1 |
| Daniel, EE | 1 |
| Yamanaka, K | 1 |
| Kitamura, K | 1 |
| Schmidt, G | 1 |
| Kannisto, P | 1 |
| Owman, C | 1 |
| Sjöberg, NO | 1 |
| Doss, NW | 1 |
| Estafan, MY | 1 |
| Costas, CE | 1 |
| Abadir, AR | 1 |
| Gintautas, J | 1 |
| Hashimoto, T | 1 |
| Hirata, M | 1 |
| Ito, Y | 1 |
| Letts, LG | 1 |
| Cirino, M | 1 |
| Banning, JW | 1 |
| Griffith, RK | 1 |
| Dipietro, RA | 1 |
1 review available for cimetidine and Muscle Contraction
| Article | Year |
|---|---|
Vascular actions of leukotrienes.
Topics: Aminophylline; Animals; Atropine; Blood Platelets; Blood Vessels; Capillary Permeability; Cimetidine | 1985 |
1 trial available for cimetidine and Muscle Contraction
| Article | Year |
|---|---|
Choledochoscope manometry about different drugs on the Sphincter of Oddi.
Topics: Adult; Aged; Aged, 80 and over; Benzamides; Cholecystectomy; Cimetidine; Domperidone; Endoscopes; Fa | 2008 |
110 other studies available for cimetidine and Muscle Contraction
| Article | Year |
|---|---|
Experimental antiulcer drugs. 2. 2-Substituted 2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-4-carboxamides.
Topics: Animals; Anti-Ulcer Agents; Depression, Chemical; Dogs; Gastric Juice; Guinea Pigs; Heart Rate; In V | 1977 |
Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor.
Topics: Aniline Compounds; Animals; Atrial Function; Azides; Guanidines; Guinea Pigs; Heart Atria; Heart Rat | 1992 |
Inhibitors of gastric acid secretion: 3,4-diamino-1,2,5-thiadiazole 1-oxides and 1,1-dioxides as urea equivalents in a series of histamine H2-receptor antagonists.
Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry; Cimetidine; Dihydrotestosterone; Dogs; | 1982 |
Histamine receptors mediate contraction of reticular groove smooth muscle of adult goats.
Topics: Animals; Blotting, Western; Cimetidine; Cyproheptadine; Dose-Response Relationship, Drug; Goats; His | 2020 |
Modulatory effects of taurine on jejunal contractility.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Calcium Channel Blocke | 2014 |
Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.
Topics: Adenosine; Animals; Chlorides; Cimetidine; Colon; Dihydropyridines; Dimaprit; Dose-Response Relation | 2009 |
Evaluation of antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action.
Topics: Acetylcholine; Animals; Aspirin; Atropine; Cholinergic Antagonists; Cimetidine; Ethanol; Flax; Gastr | 2010 |
Enhancing and inhibitory effects of H2-receptor antagonists on the GABA and the GABAA-agonist muscimol responses of the isolated guinea pig ileum: a pharmacodynamic interaction.
Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Famotidine; Female; GABA A | 2003 |
Interaction of aminoglycoside antibiotics with H2-blockers and calcium channel blockers in isolated smooth muscles of rat aorta.
Topics: Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Calcium Channel Blockers; Cimetidine; His | 1989 |
Inhibitory effects of 2-guanidinebenzimidazole and 1-phenylbiguanide on gastric acid secretion in rats.
Topics: Animals; Biguanides; Cats; Cimetidine; Female; Ganglia, Sympathetic; Gastric Acid; Gastrointestinal | 1984 |
Species differences in the contractile response to two specific histamine H1-receptor agonists: 2-(2-pyridyl)-ethylamine and 2-(2-aminoethyl)-thiazole.
Topics: Animals; Cimetidine; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, | 1981 |
Slow-reacting substance from alveolar macrophages--a mechanism of asthma?
Topics: Animals; Asthma; Atropine; Autacoids; Chromones; Cimetidine; Ethers; Guinea Pigs; Indomethacin; Macr | 1981 |
A quantitative analysis of histamine H2-receptor-mediated relaxation of rabbit trachea.
Topics: Animals; Cimetidine; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Male; Muscle Contract | 1982 |
Pharmacological characterization of histamine receptors in the mouse seminal vesicle: sensitivity to H1- and H2-receptor agonists and antagonists.
Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Electric Stimulation; Histamine; Histamine H1 | 1981 |
An inhibitory effect of histamine on the rat anococcygeus muscle.
Topics: Acetylcholine; Animals; Carbachol; Cimetidine; Dimaprit; Drug Interactions; Guanidines; Histamine; I | 1982 |
Histamine H1- and muscarinic receptor antagonist activity of cimetidine and tiotidine in the guinea pig isolated ileum.
Topics: Animals; Carbachol; Cimetidine; Guanidines; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; | 1981 |
Effects of histamine H2-receptor agonists and antagonists on isolated guinea-pig airway muscles.
Topics: Airway Resistance; Animals; Cimetidine; Dimaprit; Drug Interactions; Guinea Pigs; Histamine H2 Antag | 1982 |
Cholinergic effects of cimetidine and ranitidine.
Topics: Acetylcholine; Animals; Anura; Atropine; Bethanechol; Bethanechol Compounds; Cimetidine; Drug Synerg | 1983 |
Relaxation and contraction responses to histamine in the human lung parenchymal strip.
Topics: Cimetidine; Dose-Response Relationship, Drug; Histamine; Histamine H1 Antagonists; Histamine H2 Anta | 1984 |
Genetic heterogeneity of histamine H2-receptors in the mouse vas deferens.
Topics: Animals; Calcium; Cimetidine; Electric Stimulation; Genetic Variation; Histamine H2 Antagonists; In | 1984 |
Inhibitory histamine H2-receptor in the guinea-pig urinary bladder.
Topics: Acetylcholine; Animals; Calcium; Choline; Cimetidine; Diphenhydramine; Electric Stimulation; Female; | 1984 |
Cyclic nucleotides and contraction/relaxation in airway muscle: H1 and H2 agonists and antagonists.
Topics: Animals; Cimetidine; Cyclic AMP; Cyclic GMP; Ethylamines; Female; Guinea Pigs; Histamine; Histamine | 1980 |
Histamine receptor in the rabbit vas deferens.
Topics: Animals; Cimetidine; Diphenhydramine; Electric Stimulation; Histamine; In Vitro Techniques; Male; Mu | 1982 |
Calcium channels resistant to organic calcium entry blockers in a rabbit vein.
Topics: Animals; Benzazepines; Calcium; Cimetidine; Diltiazem; Dose-Response Relationship, Drug; Face; Hista | 1983 |
Comparison of H2 receptor agonists in rabbit atria and aorta.
Topics: Animals; Aorta; Cimetidine; Dimaprit; Dose-Response Relationship, Drug; Female; Guanidines; Heart At | 1981 |
Further experiments on the pharmacological actions of ergometrine.
Topics: Animals; Cattle; Cimetidine; Coronary Vessels; Dimaprit; Ergonovine; Gastric Acid; Guinea Pigs; Hist | 1981 |
Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development.
Topics: Aging; Airway Resistance; Animals; Bronchi; Cimetidine; Dimaprit; Female; Guanidines; Guinea Pigs; H | 1982 |
Tetrodotoxin-resistant relaxation to transmural nerve stimulation in isolated saphenous vein.
Topics: Aminophylline; Animals; Biomechanical Phenomena; Cimetidine; Cyproheptadine; Dogs; Drug Resistance; | 1984 |
Direct and indirect effects of histamine on the smooth muscle cells of the guinea-pig main pulmonary artery.
Topics: Action Potentials; Animals; Cimetidine; Female; Guinea Pigs; Histamine; Male; Muscle Contraction; Mu | 1983 |
Effects of histamine and the histamine antagonists mepyramine and cimetidine on human coronary arteries in vitro.
Topics: Adolescent; Adult; Aged; Aminopyridines; Child; Cimetidine; Coronary Vessels; Histamine; Humans; In | 1983 |
Effect of histamine on aorta preparations of different species.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cats; Cimetidine; Guinea Pigs; Histamine; In Vitro Techniqu | 1984 |
Histamine-induced relaxation of rat aorta. Importance of H1 receptor and vascular endothelium.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Cimetidine; Diphenhydramine; Endothelium; Histamine; | 1984 |
Relaxation of isolated rabbit veins mediated by latent histamine H2-receptors.
Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Histamine; Male; Muscle Contraction; Muscle R | 1983 |
Relaxation of rat tail artery to electrical stimulation.
Topics: Animals; Arteries; Calcium; Cimetidine; Dose-Response Relationship, Drug; Electric Stimulation; Hist | 1983 |
Vascular endothelium and the relaxation effect of histamine on aorta of the rat.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Atropine; Cimetidine; Endothelium; Histamine; In Vitro Tech | 1982 |
Coping with reflux esophagitis in the aged.
Topics: Aged; Aging; Antacids; Cimetidine; Esophagitis, Peptic; Esophagogastric Junction; Esophagoscopy; Gas | 1982 |
Stimulatory and inhibitory histamine receptors in canine cystic duct.
Topics: Animals; Cimetidine; Cystic Duct; Diphenhydramine; Dogs; Female; Hemodynamics; Male; Muscle Contract | 1982 |
Inhibition of electrically induced twitch responses of the guinea-pig ileum by histamine.
Topics: Acetylcholine; Animals; Cimetidine; Electric Stimulation; Guinea Pigs; Histamine; Ileum; In Vitro Te | 1980 |
The direct excitatory effects of cimetidine on the smooth muscle of guinea pig ileum.
Topics: Acetylcholine; Animals; Atropine; Cimetidine; Female; Guanidines; Guinea Pigs; Ileum; In Vitro Techn | 1981 |
Mechanism of histamine-induced excitation of the cat pylorus.
Topics: Animals; Catecholamines; Cats; Cimetidine; Diphenhydramine; Histamine; Muscle Contraction; Muscle, S | 1981 |
[The effect of histamine on smooth muscle cells of the artery of the ear in rabbits].
Topics: Animals; Cimetidine; Female; Histamine; Male; Membrane Potentials; Muscle Contraction; Muscle, Smoot | 1981 |
Effect of histamine on the gastric smooth muscles of guinea pig.
Topics: Acetylcholine; Animals; Cimetidine; Guinea Pigs; Histamine; Male; Muscle Contraction; Muscle, Smooth | 1981 |
The stimulatory effects of neurotensin and related peptides in rat stomach strips and guinea-pig atria.
Topics: Animals; Cimetidine; Diphenhydramine; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitr | 1980 |
A dual action of histamine on isolated human pulmonary arteries.
Topics: Cimetidine; Dose-Response Relationship, Drug; Histamine; Histamine Antagonists; Humans; In Vitro Tec | 1980 |
Angiotensin-induced relaxation in isolated dog renal and cerebral arteries.
Topics: Aminophylline; Angiotensin II; Animals; Arteries; Aspirin; Atropine; Brain; Cimetidine; Cocaine; Dep | 1981 |
Aminoguanidine selectively inhibits inducible nitric oxide synthase.
Topics: Acetylcholine; Amino Acid Oxidoreductases; Animals; Arginine; Cimetidine; Endothelium, Vascular; End | 1993 |
Prejunctional and postjunctional inhibition of adrenergic transmission in the rat-isolated anococcygeus muscle by cimetidine.
Topics: Animals; Cimetidine; Desipramine; Electric Stimulation; Guanethidine; In Vitro Techniques; Male; Mus | 1995 |
Posterior hypothalamic control of rabbit tracheal tension and involvement of central histaminergic neurons.
Topics: Animals; Blood Pressure; Cimetidine; Electric Stimulation; Histamine; Hypothalamus, Posterior; Muscl | 1995 |
Characterization and function of histamine receptors in corpus cavernosum.
Topics: Acetylcholine; Animals; Cimetidine; Dimaprit; Dose-Response Relationship, Drug; Electric Stimulation | 1995 |
Coordination of Cl- secretion and contraction by a histamine H2-receptor agonist in guinea pig distal colon.
Topics: Animals; Chlorides; Cimetidine; Colon; Dimaprit; Electric Conductivity; Guinea Pigs; In Vitro Techni | 1993 |
Comparative effects of cimetidine and famotidine on the vagally stimulated acid secretion in the isolated mouse whole stomach.
Topics: Acetylcholine; Animals; Cimetidine; Drug Interactions; Electric Stimulation; Famotidine; Gastric Aci | 1993 |
EFFECTS OF HISTAMINE AND RELATED COMPOUNDS ON THE BOVINE IRIS DILATOR.
Topics: Analysis of Variance; Animals; Cattle; Chlorpheniramine; Cimetidine; Diphenhydramine; Dose-Response | 1996 |
Role of endothelium and nitric oxide in histamine-induced responses in human cranial arteries and detection of mRNA encoding H1- and H2-receptors by RT-PCR.
Topics: Cerebral Arteries; Cimetidine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel | 1997 |
[Possible involvement of histamine in humoral regulation of the spontaneous contractile activity of the chick embryo amnion].
Topics: Amnion; Animals; Chick Embryo; Cimetidine; Histamine; Histamine H1 Antagonists; Histamine H2 Antagon | 1997 |
Analysis of an H1 receptor-mediated, zinc-potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carnosine; Cimetidine; Drug Interactions; Histamin | 1998 |
The role of histamine H1, H2 and H3 receptors on enteric ascending synaptic transmission in the guinea pig ileum.
Topics: Animals; Cimetidine; Dimaprit; Electric Stimulation; Guinea Pigs; Histamine; Histamine Agonists; His | 1998 |
[Mechanisms of the effect of oxidants on the respiratory system].
Topics: Acetylcysteine; Animals; Cimetidine; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; | 1999 |
Endogenous mast cell degranulation modulates cervical contractility in the guinea pig.
Topics: Animals; Cell Degranulation; Cervix Uteri; Chlorpheniramine; Cimetidine; Dose-Response Relationship, | 2002 |
Narcotic antagonistic action of cimetidine on the guinea-pig ileum.
Topics: Animals; Cimetidine; Electric Stimulation; Guanidines; Guinea Pigs; Ileum; In Vitro Techniques; Male | 1978 |
Effect of an H-2 antagonist on gallbladder contraction.
Topics: Animals; Cimetidine; Diphenhydramine; Dose-Response Relationship, Drug; Gallbladder; Guinea Pigs; Hi | 1978 |
Inhibitory effects of imidazolines on histamine liberation from human leukocytes and on tracheal smooth muscle tone.
Topics: Animals; Cattle; Cimetidine; Clemastine; Clonidine; Guinea Pigs; Histamine H1 Antagonists; Histamine | 1978 |
Histaminergic involvement in thyrotropin-releasing hormone stimulation of antral tissue in the rat.
Topics: Animals; Atropine; Bethanechol Compounds; Cimetidine; Histamine; In Vitro Techniques; Male; Muscle C | 1979 |
Cimetidine fails to block functional antagonism of carbachol by histamine in rat trachea.
Topics: Airway Resistance; Animals; Carbachol; Cimetidine; Guanidines; Histamine Antagonists; In Vitro Techn | 1979 |
Effects of the histamine H2-receptor blocking drugs burimamide and cimetidine on noradrenergic transmission in the isolated aorta of the rabbit and atria of the guinea-pig.
Topics: Animals; Aorta, Thoracic; Burimamide; Cimetidine; Cocaine; Female; Guanidines; Guinea Pigs; Heart At | 1979 |
An inhibitory action of histamine on the rat isolated vas deferens.
Topics: Animals; Cimetidine; Drug Interactions; Electric Stimulation; Histamine; In Vitro Techniques; Male; | 1979 |
Effect of histamine on the small arteries in the gracilis muscle of the rabbit.
Topics: Animals; Arteries; Cimetidine; Female; Histamine; Male; Membrane Potentials; Muscle Contraction; Mus | 1979 |
Spasmolytic action of histamine in airway smooth muscle of horse.
Topics: Animals; Atropine; Bronchi; Burimamide; Cimetidine; Histamine; Horses; In Vitro Techniques; Indometh | 1978 |
Differentiation between pre- and postjunctional alpha-receptors in guinea pig ileum and rabbit aorta.
Topics: Animals; Aorta, Thoracic; Cimetidine; Clonidine; Dibenzylchlorethamine; Dose-Response Relationship, | 1978 |
Interaction between succinylcholine and cimetidine in rats.
Topics: Anesthesia, Intravenous; Animals; Cimetidine; Drug Interactions; Drug Synergism; Male; Muscle Contra | 1992 |
Comparative study of the H2-receptor antagonists cimetidine, ranitidine, famotidine and nizatidine on the rabbit stomach fundus and sigmoid colon.
Topics: Acetylcholine; Animals; Cimetidine; Colon, Sigmoid; Famotidine; Female; Gastric Fundus; Histamine H2 | 1992 |
Responsiveness to histamine in human sensitized airway smooth muscle.
Topics: Aged; Analysis of Variance; Animals; Bronchi; Calcium; Cimetidine; Dose-Response Relationship, Drug; | 1992 |
Histamine receptors on human isolated pulmonary arterial muscle preparations: effects of endothelial cell removal and nitric oxide inhibitors.
Topics: Arginine; Burimamide; Chlorpheniramine; Cimetidine; Dimaprit; Endothelium, Vascular; Histamine; Huma | 1992 |
Vasomotor effect of histamine on pig and cattle coronary artery in vitro.
Topics: Animals; Cattle; Cimetidine; Coronary Vessels; Dimaprit; Diphenhydramine; Endothelium, Vascular; His | 1991 |
Involvement of calcium ions in the modulation of electrically-induced rat vas deferens contractions by histaminergic drugs.
Topics: Animals; Calcium; Cimetidine; Dimaprit; Diphenhydramine; Electric Stimulation; Histamine; In Vitro T | 1991 |
[Effects of cernitin pollen extract (CN-009) on the isolated bladder smooth muscles and the intravesical pressure].
Topics: Aging; Animals; Atropine; Cats; Cimetidine; Diphenhydramine; Dose-Response Relationship, Drug; Drug | 1991 |
Effects of FRG-8701 on gastric acid secretion, gastric mucosal lesions by necrotizing agents and experimental gastric or duodenal ulcer in rats.
Topics: Acetamides; Animals; Cimetidine; Duodenal Ulcer; Famotidine; Gastric Acid; Gastric Mucosa; Guinea Pi | 1990 |
Effect of histamine on human placental chorionic veins: interaction with serotonin.
Topics: Chorion; Cimetidine; Drug Interactions; Female; Histamine; Humans; In Vitro Techniques; Muscle Contr | 1991 |
A comparative study of the effects of verapamil and cimetidine on isolated rat stomach strip.
Topics: Acetylcholine; Animals; Cimetidine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptic | 1990 |
The effect of cimetidine on the rat sciatic nerve-gastrocnemius muscle preparation in vivo.
Topics: Animals; Cimetidine; Male; Muscle Contraction; Muscle, Smooth; Rats; Sciatic Nerve; Synaptic Transmi | 1990 |
Self suppression of phosphoinositide turnover and contraction by stimulating release of endogenous endothelium derived relaxing factor in vascular action of histamine.
Topics: Animals; Calcimycin; Calcium; Cimetidine; Cyclic GMP; Diphenhydramine; Endothelium, Vascular; Histam | 1990 |
Evidence that an atypical beta-adrenoceptor mediates the inhibition of spontaneous rhythmical contractions of rabbit isolated jejunum induced by ritodrine and salbutamol.
Topics: Albuterol; Animals; Cimetidine; Female; In Vitro Techniques; Jejunum; Male; Muscle Contraction; Musc | 1990 |
Different histamine actions in proximal and distal human coronary arteries in vitro.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Cimetidine; Coronary Vessels; Culture Tech | 1990 |
Effect of histamine on human bronchial arteries in vitro.
Topics: Adult; Bronchial Arteries; Cimetidine; Dinoprost; Histamine; Humans; In Vitro Techniques; Middle Age | 1990 |
5-Carboxamidotryptamine: a potent agonist mediating relaxation and elevation of cyclic AMP in the isolated neonatal porcine vena cava.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atropine; Cimetidine; Cocaine; Cyclic AMP; D | 1986 |
A tachykinin antagonist inhibits gastric emptying and gastrointestinal transit in the rat.
Topics: Animals; Bombesin; Cimetidine; Female; Gastric Emptying; Gastrointestinal Motility; Guanethidine; In | 1986 |
Comparison of the effects of clonidine and guanfacine on the histamine liberation from human mast cells and basophils and on the human bronchial smooth muscle activity.
Topics: Adrenergic alpha-Agonists; Basophils; Bronchi; Carbachol; Cimetidine; Clonidine; Electric Stimulatio | 1987 |
Pharmacological properties of the hydroxylated histamine, (+/-)-4(5)-(2-amino-1-hydroxyethyl)-imidazole.
Topics: Animals; Cimetidine; Cyclic AMP; Gastric Acid; Histamine; Ileum; In Vitro Techniques; Male; Mice; Mu | 1989 |
Responses to histamine and selective H2-receptor agonists in lung parenchymal strips from normal and sensitized guinea-pigs.
Topics: Animals; Benzimidazoles; Cimetidine; Dimaprit; Dose-Response Relationship, Drug; Guanidines; Guinea | 1989 |
Effect of histamine on human vas deferens in vitro.
Topics: Burimamide; Cimetidine; Culture Techniques; Dose-Response Relationship, Drug; Histamine; Humans; Mal | 1989 |
The response of cat airways to histamine in vivo and in vitro.
Topics: Adrenergic beta-Antagonists; Animals; Cats; Cimetidine; Female; Histamine; Histamine Antagonists; In | 1985 |
Pharmacology of mifentidine, a novel H2-receptor antagonist.
Topics: Animals; Blood Pressure; Cimetidine; Dogs; Female; Gastric Acid; Guinea Pigs; Heart Rate; Histamine | 1985 |
Histamine H2 receptor antagonists may modify dog intestinal motility independently of their primary action on the H2 receptors.
Topics: Acetylcholine; Animals; Blood Pressure; Ceruletide; Cimetidine; Dimaprit; Dogs; Female; Gastrointest | 1985 |
Pharmacological analysis of muscarinic receptors coupled to oxyntic cell secretion in the mouse stomach.
Topics: Animals; Atropine; Atropine Derivatives; Benzodiazepinones; Binding, Competitive; Cimetidine; Guinea | 1985 |
[Isocimetidine and analogs. 23. H2-antihistaminics].
Topics: Animals; Chemical Phenomena; Chemistry; Cimetidine; Guinea Pigs; Histamine; Histamine H2 Antagonists | 1985 |
Pressor responses to central injection of H2 antagonists not caused by GABA blockade.
Topics: Animals; Bicuculline; Blood Pressure; Cimetidine; Electric Stimulation; Female; Guinea Pigs; Histami | 1986 |
Cholinergic effects of histamine-H2 receptor antagonists partly through inhibition of acetylcholinesterase.
Topics: Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cimetidine; Famotidine; Guinea Pigs; Hist | 1986 |
Pharmacological comparison of ORF 17910, a potent, long-acting histamine H2-receptor antagonist, to cimetidine and ranitidine.
Topics: Androgen Antagonists; Animals; Cimetidine; Dogs; Female; Gastric Acid; Guinea Pigs; Heart Rate; Hist | 1986 |
Direct effects of H2-receptor antagonists on airway smooth muscle and on responses mediated by H1- and H2-receptors.
Topics: Animals; Cimetidine; Famotidine; Guinea Pigs; Histamine H2 Antagonists; In Vitro Techniques; Male; M | 1987 |
Metronidazole and 5-aminosalicylic acid enhance the contractile activity of histaminergic agonists on the guinea-pig isolated ileum.
Topics: Aminosalicylic Acids; Animals; Cimetidine; Computers; Dimaprit; Dose-Response Relationship, Drug; Dr | 1986 |
Histamine-induced inositol phospholipid breakdown in the longitudinal smooth muscle of guinea-pig ileum.
Topics: Animals; Cerebellum; Cimetidine; Female; Guinea Pigs; Histamine; Ileum; Imidazoles; Impromidine; In | 1985 |
Ranitidine potentiates ileum contractions caused by GABA and electrical stimulation.
Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Female; | 1986 |
Influence of the epithelium on responsiveness of guinea-pig isolated trachea to contractile and relaxant agonists.
Topics: Acetylcholine; Animals; Asthma; Autoradiography; Carbachol; Cimetidine; Colforsin; Dose-Response Rel | 1986 |
Mechanism of histamine actions in human coronary arteries.
Topics: Adult; Aged; Aged, 80 and over; Cimetidine; Coronary Vessels; Dose-Response Relationship, Drug; Endo | 1987 |
Characteristics of canine lower esophageal sphincter: a new electrophysiological tool.
Topics: Animals; Carbachol; Cimetidine; Dogs; Electric Stimulation; Electrophysiology; Esophagus; Female; Hi | 1988 |
Electrophysiological and mechanical characteristics of histamine receptors in smooth muscle cells of the guinea-pig ileum.
Topics: Animals; Cimetidine; Electrophysiology; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Membr | 1987 |
Alteration by histamine of the sympathetic nerve-mediated contractions in the bovine ovarian follicle wall in vitro.
Topics: Animals; Cattle; Cimetidine; Electrolytes; Female; Glucose; Histamine; In Vitro Techniques; Methylhi | 1987 |
Cimetidine and gastrointestinal motility in vitro.
Topics: Animals; Cimetidine; Female; Gastrointestinal Motility; In Vitro Techniques; Muscle Contraction; Rat | 1986 |
Mechanisms of histamine-induced relaxation in isolated monkey and dog coronary arteries.
Topics: Animals; Benzoquinones; Chlorpheniramine; Cimetidine; Coronary Vessels; Dogs; Female; Histamine; Ind | 1986 |
A role for inositol 1,4,5-trisphosphate in the initiation of agonist-induced contractions of dog tracheal smooth muscle.
Topics: 5-Hydroxytryptophan; Acetylcholine; Animals; Calcium; Cimetidine; Dinoprost; Dogs; Female; Histamine | 1985 |
Histamine receptor activation by unsaturated (allyl and propargyl) homologs of histamine.
Topics: Adrenergic Fibers; Animals; Cimetidine; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Il | 1985 |