cimetidine has been researched along with Multiple Sclerosis in 2 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the analysis the presence of a peptic ulcer in patients after 1976 was taken as a proxy for cimetidine (and ranitidine) use." | 7.68 | Peptic ulcer, cimetidine, and motor neurone disease--a record linkage study. ( Goldacre, MJ; Seagroatt, V; Vessey, MP; Yeates, D, 1993) |
| " In the analysis the presence of a peptic ulcer in patients after 1976 was taken as a proxy for cimetidine (and ranitidine) use." | 3.68 | Peptic ulcer, cimetidine, and motor neurone disease--a record linkage study. ( Goldacre, MJ; Seagroatt, V; Vessey, MP; Yeates, D, 1993) |
| "Using oligodendrocytes from primary brain cultures as targets in an antibody-dependent cellular cytotoxicity (ADCC) assay, we have examined the effects of insulin and histamine on killer cells in multiple sclerosis (MS) and other neurological disease (OND) controls compared to normal healthy controls." | 3.67 | Regulation of antibody-dependent cellular cytotoxicity in multiple sclerosis by central nervous system hormones. ( Merrill, JE; Mohlstrom, C, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vessey, MP | 1 |
| Goldacre, MJ | 1 |
| Seagroatt, V | 1 |
| Yeates, D | 1 |
| Merrill, JE | 1 |
| Mohlstrom, C | 1 |
2 other studies available for cimetidine and Multiple Sclerosis
| Article | Year |
|---|---|
Peptic ulcer, cimetidine, and motor neurone disease--a record linkage study.
Topics: Cimetidine; Confidence Intervals; Humans; Medical Record Linkage; Motor Neuron Disease; Multiple Scl | 1993 |
Regulation of antibody-dependent cellular cytotoxicity in multiple sclerosis by central nervous system hormones.
Topics: Antibody-Dependent Cell Cytotoxicity; Central Nervous System; Cimetidine; Histamine; Humans; Insulin | 1987 |