cimetidine has been researched along with Multiple Myeloma in 2 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of pretreatment with cimetidine (200 mg three times daily, 400 mg at night) on the pharmacokinetics of oral melphalan (10 mg) have been investigated in patients with multiple myeloma." | 5.06 | Interaction of cimetidine with oral melphalan. A pharmacokinetic study. ( Bateman, DN; Proctor, SJ; Robinson, A; Sviland, L, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Osby, E | 1 |
| Bernell, P | 1 |
| Hast, R | 1 |
| Sviland, L | 1 |
| Robinson, A | 1 |
| Proctor, SJ | 1 |
| Bateman, DN | 1 |
1 trial available for cimetidine and Multiple Myeloma
| Article | Year |
|---|---|
Interaction of cimetidine with oral melphalan. A pharmacokinetic study.
Topics: Administration, Oral; Aged; Biological Availability; Cimetidine; Clinical Trials as Topic; Double-Bl | 1987 |
1 other study available for cimetidine and Multiple Myeloma
| Article | Year |
|---|---|
Possible synergism between cimetidine and interferon in a case of resistant multiple myeloma.
Topics: Aged; Cimetidine; Drug Synergism; Humans; Interferons; Male; Multiple Myeloma | 1987 |