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cimetidine and Methemoglobinemia

cimetidine has been researched along with Methemoglobinemia in 9 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
" We have attempted to reduce dapsone-dependent methaemoglobinaemia formation in six dermatitis herpetiformis patients stabilised on dapsone by the co-administration of cimetidine."7.68The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients. ( Breckenridge, AM; Coleman, MD; Friedmann, PS; Park, BK; Rhodes, LE; Scott, AK; Verbov, JL, 1992)
" We have attempted to reduce dapsone-dependent methaemoglobinaemia formation in six dermatitis herpetiformis patients stabilised on dapsone by the co-administration of cimetidine."3.68The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients. ( Breckenridge, AM; Coleman, MD; Friedmann, PS; Park, BK; Rhodes, LE; Scott, AK; Verbov, JL, 1992)
" Daily dosing of mice with dapsone (50 mg kg-1, p."1.29A dapsone-induced blood dyscrasia in the mouse: evidence for the role of an active metabolite. ( Ahmadi, M; Khalaf, LF; Nicholls, PJ; Smith, HJ, 1996)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (88.89)18.2507
2000's1 (11.11)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mehta, M1
Ahmadi, M1
Khalaf, LF1
Smith, HJ1
Nicholls, PJ1
Lu, HC1
Shih, RD1
Marcus, S1
Ruck, B1
Jennis, T1
Coleman, MD6
Russell, RM1
Tingle, MD2
Park, BK6
Rhodes, LE1
Scott, AK2
Verbov, JL1
Friedmann, PS1
Breckenridge, AM4
Hoaksey, PE1
Winn, MJ1

Other Studies

9 other studies available for cimetidine and Methemoglobinemia

ArticleYear
Cimetidine and dapsone-mediated methaemoglobinaemia.
    Anaesthesia, 2007, Volume: 62, Issue:11

    Topics: Anti-Infective Agents; Cimetidine; Dapsone; Histamine H2 Antagonists; Humans; Methemoglobinemia; Pos

2007
A dapsone-induced blood dyscrasia in the mouse: evidence for the role of an active metabolite.
    The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:2

    Topics: Animals; Cimetidine; Dapsone; Enzyme Inhibitors; Female; Folic Acid Antagonists; Histamine H2 Antago

1996
Pseudomethemoglobinemia: a case report and review of sulfhemoglobinemia.
    Archives of pediatrics & adolescent medicine, 1998, Volume: 152, Issue:8

    Topics: Acetaminophen; Adolescent; Cimetidine; Diagnosis, Differential; Female; Humans; Ibuprofen; Methemogl

1998
Inhibition of dapsone-induced methaemoglobinaemia by cimetidine in the presence of trimethoprim in the rat.
    The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:2

    Topics: Acetylation; Animals; Cimetidine; Dapsone; Drug Interactions; Half-Life; Male; Methemoglobin; Methem

1992
The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients.
    British journal of clinical pharmacology, 1992, Volume: 34, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Cimetidine; Dapsone; Dermatitis Herpetiformis; Drug Therapy, Combina

1992
Inhibition of dapsone-induced methaemoglobinaemia by cimetidine in the rat during chronic dapsone administration.
    The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Cimetidine; Dapsone; Hydroxylation; Male; Methemoglob

1991
Inhibition of dapsone-induced methaemoglobinaemia in the rat isolated perfused liver.
    The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:5

    Topics: Animals; Bile; Chromatography, High Pressure Liquid; Cimetidine; Dapsone; Half-Life; Liver; Male; Me

1990
The use of cimetidine as a selective inhibitor of dapsone N-hydroxylation in man.
    British journal of clinical pharmacology, 1990, Volume: 30, Issue:5

    Topics: Adult; Cimetidine; Dapsone; Humans; Hydroxylation; Male; Methemoglobinemia

1990
Inhibition of dapsone-induced methaemoglobinaemia in the rat.
    Biochemical pharmacology, 1990, Feb-15, Volume: 39, Issue:4

    Topics: Animals; Cimetidine; Dapsone; Male; Methemoglobinemia; Piperonyl Butoxide; Rats; Rats, Inbred Strain

1990