cimetidine has been researched along with Metastase in 25 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cimetidine has been shown to have beneficial effects in colorectal cancer patients." | 9.10 | Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells. ( Imaeda, Y; Kobayashi, K; Matsumoto, S; Okamoto, T; Suzuki, H; Umemoto, S, 2002) |
| "Administration of cimetidine after curative surgery can improve prognosis of patients with colorectal cancer." | 7.73 | [Can the survival of patients with recurrent disease after curative resection of colorectal cancer be prolonged by the administration of cimetidine?]. ( Fujimoto, T; Ishibashi, K; Matsumoto, A; Ogawa, K; Osawa, G; Otani, T; Umehara, A; Watanabe, K; Yokomizo, H; Yoshida, K; Yoshimatsu, K, 2006) |
| "In vitro synergism between interferons (IFNs) and chemotherapeutic drugs has been demonstrated, and an enhancement of IFN's antiproliferative effects when combined with cimetidine has been suggested in melanoma patients." | 7.67 | Combination of fibroblast interferon (HuIFN beta), carboxamide (DTIC), and cimetidine for advanced malignant melanoma. ( Abdi, EA; McPherson, TA; Tan, YH, 1986) |
| "Cimetidine has been shown to have beneficial effects in colorectal cancer patients." | 5.10 | Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells. ( Imaeda, Y; Kobayashi, K; Matsumoto, S; Okamoto, T; Suzuki, H; Umemoto, S, 2002) |
| "Administration of cimetidine after curative surgery can improve prognosis of patients with colorectal cancer." | 3.73 | [Can the survival of patients with recurrent disease after curative resection of colorectal cancer be prolonged by the administration of cimetidine?]. ( Fujimoto, T; Ishibashi, K; Matsumoto, A; Ogawa, K; Osawa, G; Otani, T; Umehara, A; Watanabe, K; Yokomizo, H; Yoshida, K; Yoshimatsu, K, 2006) |
| "In vitro synergism between interferons (IFNs) and chemotherapeutic drugs has been demonstrated, and an enhancement of IFN's antiproliferative effects when combined with cimetidine has been suggested in melanoma patients." | 3.67 | Combination of fibroblast interferon (HuIFN beta), carboxamide (DTIC), and cimetidine for advanced malignant melanoma. ( Abdi, EA; McPherson, TA; Tan, YH, 1986) |
| "Paclitaxel Css values were not significantly different in individual patients when either cimetidine or famotidine preceded paclitaxel (p = 0." | 2.68 | Pretreatment H2 receptor antagonists that differ in P450 modulation activity: comparative effects on paclitaxel clearance rates and neutropenia. ( Bowling, MK; Chen, TL; Donehower, RC; McGuire, WP; Rowinsky, EK; Slichenmyer, WJ, 1995) |
| "Docetaxel is active for metastatic breast cancer." | 2.68 | Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer. ( Balmaceda, C; Baselga, J; Bruno, R; Crown, JP; Currie, V; Freilich, R; Gilewski, TA; Gollub, M; Hakes, TB; Hudis, CA; Lebwohl, DE; Norton, L; Raptis, G; Robles, M; Seidman, AD, 1996) |
| "Histamine was perfectly tolerated up to 4 mg/day." | 2.66 | Clinical improvement in advanced cancer disease after treatment combining histamine and H2-antihistaminics (ranitidine or cimetidine). ( Bernard, P; Burtin, C; Galoppin, L; Noirot, C; Sabolovic, D; Scheinmann, P, 1988) |
| "Cimetidine has been shown to have anti-metastatic activity and improves the survival of patients with colorectal cancer." | 1.37 | Cimetidine inhibits the adhesion of gastric cancer cells expressing high levels of sialyl Lewis x in human vascular endothelial cells by blocking E-selectin expression. ( Jiang, CG; Li, F; Li, JB; Li, YS; Liu, FR, 2011) |
| "Three metastatic breast cancer cell lines (1590, KM22, ZE) were studied." | 1.37 | Breast cancer cell-derived cytokines, macrophages and cell adhesion: implications for metastasis. ( Bischofs, E; Brodt, P; Bruckner, T; Eichbaum, C; Eichbaum, MH; Meyer, AS; Sohn, C; Steinborn, A; Wang, N, 2011) |
| "tumor growth, secondary lung metastasis and splenocyte cytotoxicity against YAC-1 lymphoma cells (51Cr release assay)." | 1.29 | Effects of histamine type-2 receptor antagonists on indomethacin and IL-2 immunotherapy of metastasis. ( Khoo, NK; Lala, PK; Saarloos, MN, 1993) |
| "All patients had bone metastases." | 1.28 | Treatment of hormone-refractory stage D carcinoma of prostate with coumarin (1,2-benzopyrone) and cimetidine: a pilot study. ( Butler, K; Hermansen, D; Marshall, ME, 1990) |
| "Forty-five patients with metastatic renal cell carcinoma were treated with coumarin (1,2-benzopyrone) and cimetidine." | 1.27 | Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: a pilot study. ( Butler, K; Cantrell, J; Macdonald, JS; Marshall, ME; Mendelsohn, L; Riley, L; Taylor, R; Wiseman, C, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (40.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kawase, J | 1 |
| Ozawa, S | 1 |
| Kobayashi, K | 2 |
| Imaeda, Y | 2 |
| Umemoto, S | 2 |
| Matsumoto, S | 2 |
| Ueda, M | 1 |
| Liu, FR | 1 |
| Jiang, CG | 1 |
| Li, YS | 1 |
| Li, JB | 1 |
| Li, F | 1 |
| Eichbaum, C | 1 |
| Meyer, AS | 1 |
| Wang, N | 1 |
| Bischofs, E | 1 |
| Steinborn, A | 1 |
| Bruckner, T | 1 |
| Brodt, P | 1 |
| Sohn, C | 1 |
| Eichbaum, MH | 1 |
| Bobek, V | 1 |
| Boubelik, M | 1 |
| Kovarík, J | 1 |
| Taltynov, O | 1 |
| Dillman, RO | 1 |
| Soori, G | 1 |
| DePriest, C | 1 |
| Nayak, SK | 1 |
| Beutel, LD | 1 |
| Schiltz, PM | 1 |
| de Leon, C | 1 |
| O'Connor, AA | 1 |
| Tozawa, K | 1 |
| Okamoto, T | 2 |
| Kawai, N | 1 |
| Hashimoto, Y | 1 |
| Hayashi, Y | 1 |
| Kohri, K | 1 |
| Walker, PR | 1 |
| Khuder, SA | 1 |
| Quan, WD | 1 |
| Yoshimatsu, K | 1 |
| Ishibashi, K | 1 |
| Yokomizo, H | 1 |
| Umehara, A | 1 |
| Yoshida, K | 1 |
| Fujimoto, T | 1 |
| Watanabe, K | 1 |
| Otani, T | 1 |
| Matsumoto, A | 1 |
| Osawa, G | 1 |
| Ogawa, K | 1 |
| Osband, ME | 2 |
| Hamilton, D | 1 |
| Shen, YJ | 1 |
| Cohen, E | 1 |
| Shlesinger, M | 1 |
| Lavin, P | 1 |
| Brown, A | 1 |
| McCaffrey, R | 1 |
| Ribera Pascuet, E | 1 |
| González Atienza, J | 1 |
| Obiols Alfonso, G | 1 |
| Mesa Manteca, J | 1 |
| Friesen, SR | 1 |
| McCarthy, DM | 2 |
| Brennan, MF | 1 |
| Jensen, RT | 1 |
| Wesley, RA | 1 |
| Doppman, JL | 1 |
| Slichenmyer, WJ | 1 |
| Donehower, RC | 1 |
| Chen, TL | 1 |
| Bowling, MK | 1 |
| McGuire, WP | 1 |
| Rowinsky, EK | 1 |
| Saarloos, MN | 1 |
| Khoo, NK | 1 |
| Lala, PK | 1 |
| Hudis, CA | 1 |
| Seidman, AD | 1 |
| Crown, JP | 1 |
| Balmaceda, C | 1 |
| Freilich, R | 1 |
| Gilewski, TA | 1 |
| Hakes, TB | 1 |
| Currie, V | 1 |
| Lebwohl, DE | 1 |
| Baselga, J | 1 |
| Raptis, G | 1 |
| Gollub, M | 1 |
| Robles, M | 1 |
| Bruno, R | 1 |
| Norton, L | 1 |
| Suzuki, H | 1 |
| Armitage, JO | 1 |
| Sidner, RD | 1 |
| de las Casas Alonso, P | 1 |
| González Hermoso, F | 1 |
| García Santos, J | 1 |
| Marrero García, N | 1 |
| Martín Herrera, A | 1 |
| Núñez Díaz, V | 1 |
| Rodríguez Torres, J | 1 |
| Soler Arocha, A | 1 |
| Bajorin, DF | 1 |
| Chapman, PB | 1 |
| Wong, GY | 1 |
| Cody, BV | 1 |
| Cordon-Cardo, C | 1 |
| Dantes, L | 1 |
| Templeton, MA | 1 |
| Scheinberg, D | 1 |
| Oettgen, HF | 1 |
| Houghton, AN | 1 |
| Lavin, PT | 1 |
| Maar, R | 1 |
| Franklin, M | 1 |
| Ross, S | 1 |
| Martin, J | 1 |
| Marshall, ME | 2 |
| Butler, K | 2 |
| Hermansen, D | 1 |
| Burtin, C | 1 |
| Noirot, C | 1 |
| Scheinmann, P | 1 |
| Galoppin, L | 1 |
| Sabolovic, D | 1 |
| Bernard, P | 1 |
| Mendelsohn, L | 1 |
| Riley, L | 1 |
| Cantrell, J | 1 |
| Wiseman, C | 1 |
| Taylor, R | 1 |
| Macdonald, JS | 1 |
| Abdi, EA | 1 |
| McPherson, TA | 1 |
| Tan, YH | 1 |
4 reviews available for cimetidine and Metastase
| Article | Year |
|---|---|
Continuous infusion interleukin-2 and antihistamines in metastatic kidney cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Agents; Cimetidine; Famotidine; Histamine; Histamine H1 Antag | 2005 |
[Current status of treatment in the Zollinger-Ellison syndrome].
Topics: Cimetidine; Gastrectomy; Gastric Acid; Humans; Neoplasm Metastasis; Neoplasm Recurrence, Local; Stre | 1983 |
Treatment of the Zollinger-Ellison syndrome. A 25 year assessment.
Topics: Cimetidine; Gastrectomy; Gastrins; Guanidines; Humans; Neoplasm Metastasis; Retrospective Studies; S | 1982 |
The place of surgery in the Zollinger-Ellison syndrome.
Topics: Cimetidine; Gastrectomy; Gastric Juice; Gastrins; Humans; Hyperplasia; Neoplasm Metastasis; Postoper | 1980 |
6 trials available for cimetidine and Metastase
| Article | Year |
|---|---|
Treatment of human solid malignancies with autologous activated lymphocytes and cimetidine: a phase II trial of the cancer biotherapy research group.
Topics: Adoptive Transfer; Adult; Aged; Cell- and Tissue-Based Therapy; Cimetidine; Combined Modality Therap | 2003 |
Pretreatment H2 receptor antagonists that differ in P450 modulation activity: comparative effects on paclitaxel clearance rates and neutropenia.
Topics: Adult; Aged; Cimetidine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Famotidine; Female; His | 1995 |
Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cimetidine; Dexamethasone; Diphenh | 1996 |
Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Biomarkers, Tumor; CA-19-9 Antig | 2002 |
Autolymphocyte therapy for metastatic renal cell carcinoma: initial clinical results from 335 patients treated in a multisite clinical practice.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell; Cimetidine; Cohort Studies; Female; Follow-Up | 1992 |
Clinical improvement in advanced cancer disease after treatment combining histamine and H2-antihistaminics (ranitidine or cimetidine).
Topics: Adult; Aged; Cimetidine; Drug Therapy, Combination; Female; Histamine; Humans; Male; Middle Aged; Ne | 1988 |
15 other studies available for cimetidine and Metastase
| Article | Year |
|---|---|
Increase in E-selectin expression in umbilical vein endothelial cells by anticancer drugs and inhibition by cimetidine.
Topics: Actins; Antineoplastic Agents; Cimetidine; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; | 2009 |
Cimetidine inhibits the adhesion of gastric cancer cells expressing high levels of sialyl Lewis x in human vascular endothelial cells by blocking E-selectin expression.
Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cimetidine; E-Selectin; Endothelial Ce | 2011 |
Breast cancer cell-derived cytokines, macrophages and cell adhesion: implications for metastasis.
Topics: Animals; Antibodies, Monoclonal; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cimetidine; Cyto | 2011 |
Inhibition of adhesion breast cancer cells by anticoagulant drugs and cimetidine.
Topics: Aged; Anticoagulants; Breast Neoplasms; Cell Adhesion; Cimetidine; Female; Humans; Killer Cells, Nat | 2003 |
Positive correlation between sialyl Lewis X expression and pathologic findings in renal cell carcinoma.
Topics: Adjuvants, Immunologic; Carcinoma, Renal Cell; Cimetidine; Humans; Immunohistochemistry; Kidney Neop | 2005 |
[Can the survival of patients with recurrent disease after curative resection of colorectal cancer be prolonged by the administration of cimetidine?].
Topics: Cimetidine; Colorectal Neoplasms; Humans; Neoplasm Metastasis; Neoplasm Recurrence, Local; Prognosis | 2006 |
Successful tumour immunotherapy with cimetidine in mice.
Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Guanidines; Immunotherapy; Male; Mice; Mice, | 1981 |
The role of surgery in patients with Zollinger-Ellison syndrome (ZES) managed medically.
Topics: Adult; Aged; Cimetidine; Female; Gastrectomy; Guanidines; Humans; Male; Middle Aged; Neoplasm Metast | 1982 |
Effects of histamine type-2 receptor antagonists on indomethacin and IL-2 immunotherapy of metastasis.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Cimetidine; Famotidine; Female; Histamine H2 Antago | 1993 |
Antitumour effect of cimetidine.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Cimetidine; Female | 1979 |
[Healing action of cimetidine in an incipient gastric cancer in its depressive variation. Apropos of a case].
Topics: Cimetidine; Gastric Mucosa; Guanidines; Humans; Intestinal Neoplasms; Male; Middle Aged; Neoplasm Me | 1979 |
Treatment with high dose mouse monoclonal (anti-GD3) antibody R24 in patients with metastatic melanoma.
Topics: Adult; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antigens, CD; Cimetidine; Comple | 1992 |
Treatment of hormone-refractory stage D carcinoma of prostate with coumarin (1,2-benzopyrone) and cimetidine: a pilot study.
Topics: Aged; Bone Neoplasms; Cimetidine; Coumarins; Drug Therapy, Combination; Humans; Male; Middle Aged; N | 1990 |
Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: a pilot study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coum | 1987 |
Combination of fibroblast interferon (HuIFN beta), carboxamide (DTIC), and cimetidine for advanced malignant melanoma.
Topics: Adult; Cimetidine; Combined Modality Therapy; Dacarbazine; Female; Humans; Immunotherapy; Interferon | 1986 |