cimetidine has been researched along with Melena in 3 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Melena: The black, tarry, foul-smelling FECES that contain degraded blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the effects of tranexamic acid (an antifibrinolytic agent) and cimetidine on acute upper-gastrointestinal-tract bleeding in a double-blind randomized placebo-controlled trial in 775 patients with hematemesis or melena or both." | 5.05 | Cimetidine and tranexamic acid in the treatment of acute upper-gastrointestinal-tract bleeding. ( Atkinson, M; Barer, D; Coggon, D; Dronfield, M; Ellis, S; French, S; Henry, D; Langman, M; Ogilvie, A, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barer, D | 1 |
| Ogilvie, A | 1 |
| Henry, D | 1 |
| Dronfield, M | 1 |
| Coggon, D | 1 |
| French, S | 1 |
| Ellis, S | 1 |
| Atkinson, M | 1 |
| Langman, M | 2 |
| Norfleet, RG | 1 |
| Rhodes, RA | 1 |
| Katschinski, B | 1 |
| Logan, R | 1 |
| Davies, J | 1 |
| Faulkner, G | 1 |
| Pearson, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of High Dose Infusion and Low Dose Bolus Intravenous Omeprazole for Treatment of Bleeding Ulcer With Adherent Clot[NCT02536989] | Phase 4 | 40 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for cimetidine and Melena
| Article | Year |
|---|---|
Cimetidine and tranexamic acid in the treatment of acute upper-gastrointestinal-tract bleeding.
Topics: Acute Disease; Aged; Cimetidine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Double-Blind | 1983 |
Prognostic factors in upper gastrointestinal bleeding.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Duodenal Ulcer; Female | 1994 |
1 other study available for cimetidine and Melena
| Article | Year |
|---|---|
Cimetidine therapy does not affect fecal occult blood testing.
Topics: Adolescent; Adult; Cimetidine; False Positive Reactions; Feces; Female; Gastric Juice; Guanidines; H | 1982 |