cimetidine has been researched along with Melanoma in 38 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen evaluable patients with metastatic malignant melanoma who had received no prior chemotherapy were treated with high-dose cimetidine orally, 600 mg q." | 9.07 | Phase II trial of cimetidine in metastatic melanoma. A Hoosier Oncology Group trial. ( Einhorn, LH; Mandanas, R; Schultz, S; Scullin, D, 1991) |
| "We conducted parallel phase II trials of cimetidine as a single agent and the combination N-phosphonacetyl-L-aspartate (PALA) plus L-alanosine among 40 previously untreated patients with biopsy-proven, measurable disseminated malignant melanoma." | 9.06 | Phase II studies of single-agent cimetidine and the combination N-phosphonacetyl-L-aspartate (NSC-224131) plus L-alanosine (NSC-153353) in advanced malignant melanoma. ( Chang, M; Creagan, ET; Cullinan, SA; Ebbert, L; Mailliard, JA; Morton, RF; Veeder, MH, 1987) |
| "Human melanoma cells were treated in culture with the histamine (H2) agonist S-(3-(N-N-dimethylamino)propyl)isothiourea (dimaprit), a partial agonist, S-(2-(N,N-dimethylamino)ethyl)-isothiourea (nordimaprit), and two analogues of nordimaprit, S-(2-(N,N-diethylamino)ethyl)isothiourea (DENOR) and S-(2-(N,N-diisopropylamino)ethyl)isothiourea (DINOR), to investigate the effects on toxicity and tyrosinase activity." | 7.68 | Antiproliferative and depigmenting effects of the histamine (H2) agonist dimaprit and its derivatives on human melanoma cells. ( Fechner, GA; Jacobs, JJ; McEwan, MT; Parsons, PG; Takahashi, H, 1992) |
| "Sixty-two patients with biopsy-proven, measurable disseminated malignant melanoma received either the combination IFN-alpha 2A with BCNU (30 patients) or the combination cimetidine with BCNU (32 patients) in parallel noncomparative Phase II trials." | 7.68 | Phase II trial of recombinant leukocyte A interferon (IFN-alpha 2A) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and the combination cimetidine with BCNU in patients with disseminated malignant melanoma. ( Creagan, ET; Kardinal, CG; McCormack, GW; McHale, MS; Morton, RF; Schaid, DJ; Wiesenfeld, M, 1991) |
| "Cimetidine, an H2 histamine antagonist, was used in the clinical management of progressive, multifocal melanomatosis in 3 adult gray horses." | 7.68 | Cimetidine for treatment of melanomas in three horses. ( Goetz, TE; Johnson, PJ; Keegan, KG; Ogilvie, GK, 1990) |
| "Based on previous results demonstrating that coumarin and cimetidine render objective tumor regressions in renal cell carcinoma, we conducted a pilot study to determine whether these drugs possess activity against malignant melanoma." | 7.67 | Treatment of advanced malignant melanoma with coumarin and cimetidine: a pilot study. ( Butler, K; Cantrell, J; Marshall, ME; Mendelsohn, L; Wiseman, C, 1989) |
| "Histamine induced a concentration-dependent increase in intracellular cyclic-AMP of the two human melanoma cell lines SK23 and DX3." | 7.67 | Demonstration of histamine H2 receptors on human melanoma cells. ( Evanson, JM; Hart, IR; Taylor, DJ; Whitehead, RJ; Woolley, DE, 1988) |
| "The effect of cimetidine, an H-2 receptor antagonist, on activation of PBL from both normal individuals and melanoma patients was studied." | 7.67 | The effect of cimetidine on PBL from healthy donors and melanoma patients: augmentation of T cell responses to TCGF mitogens and alloantigens and of TCGF production. ( Adler, A; Eisenthal, A; Monselise, J; Zinger, R, 1986) |
| "Following recent reports suggesting that the addition of cimetidine to interferon may enhance response rates in patients with metastatic malignant melanoma, we have completed a Phase II study of the use of recombinant alpha 2 interferon and cimetidine in patients with advanced malignant melanoma and who had progressive disease following interferon therapy alone." | 7.67 | Role of recombinant interferon alpha 2 and cimetidine in patients with advanced malignant melanoma. ( Mughal, TI; Robinson, WA; Spiegel, R; Thomas, MR, 1988) |
| "In vitro synergism between interferons (IFNs) and chemotherapeutic drugs has been demonstrated, and an enhancement of IFN's antiproliferative effects when combined with cimetidine has been suggested in melanoma patients." | 7.67 | Combination of fibroblast interferon (HuIFN beta), carboxamide (DTIC), and cimetidine for advanced malignant melanoma. ( Abdi, EA; McPherson, TA; Tan, YH, 1986) |
| "Immunostimulant therapy with coumarin and cimetidine was evaluated in 17 patients with advanced malignant melanoma." | 7.67 | Combined treatment of advanced malignant melanoma with coumarin and cimetidine. A phase II study. ( Langvad, E; Pedersen, L; Rose, C, 1987) |
| "Thirty-five eligible patients with disseminated malignant melanoma received intramuscular recombinant leukocyte interferon (IFN-rA), 50 X 10(6) U/m2 three times weekly (TIW) for an intended duration of 12 weeks concomitant with daily oral cimetidine, 1,200 mg/d in four divided doses." | 7.67 | Phase II study of recombinant leukocyte A interferon (IFN-rA) plus cimetidine in disseminated malignant melanoma. ( Ahmann, DL; Creagan, ET; Frytak, S; Green, SJ; Itri, LM; Long, HJ, 1985) |
| "With the aim of potentiating the anti-tumour effect of interferon in metastatic malignant melanoma by concomitant inhibition of suppressor T cells, oral cimetidine (histamine-2 receptor antagonist) medication was added to interferon (HuIFN-alpha(Le] therapy in a series of 20 patients." | 7.66 | Metastatic malignant melanoma: regression induced by combined treatment with interferon [HuIFN-alpha(Le)] and cimetidine. ( Borgström, S; Flodgren, P; Jönsson, PE; Lindström, C; Sjögren, HO, 1983) |
| "Histamine treatment accelerated tumor growth, but only in normal animals and had little effect on tumor growth in immunocompromised hosts." | 5.27 | The effect of histamine, antihistamines, and a mast cell stabilizer on the growth of cloudman melanoma cells in DBA/2 mice. ( Askenase, PW; Nordlund, JJ, 1983) |
| "Fifteen evaluable patients with metastatic malignant melanoma who had received no prior chemotherapy were treated with high-dose cimetidine orally, 600 mg q." | 5.07 | Phase II trial of cimetidine in metastatic melanoma. A Hoosier Oncology Group trial. ( Einhorn, LH; Mandanas, R; Schultz, S; Scullin, D, 1991) |
| "Ninety-six patients with advanced malignant melanoma received thrice weekly im recombinant leukocyte A interferon (Roferon-A) in three consecutive phase II trials utilizing doses of 12 X 10(6) U/m2, 50 X 10(6) U/m2, and 50 X 10(6) U/m2 plus cimetidine." | 5.06 | Phase II trials of recombinant leukocyte A interferon in disseminated malignant melanoma: results in 96 patients. ( Ahmann, DL; Chang, MN; Creagan, ET; Frytak, S; Itri, LM; Long, HJ, 1986) |
| "We conducted parallel phase II trials of cimetidine as a single agent and the combination N-phosphonacetyl-L-aspartate (PALA) plus L-alanosine among 40 previously untreated patients with biopsy-proven, measurable disseminated malignant melanoma." | 5.06 | Phase II studies of single-agent cimetidine and the combination N-phosphonacetyl-L-aspartate (NSC-224131) plus L-alanosine (NSC-153353) in advanced malignant melanoma. ( Chang, M; Creagan, ET; Cullinan, SA; Ebbert, L; Mailliard, JA; Morton, RF; Veeder, MH, 1987) |
| "Human melanoma cells were treated in culture with the histamine (H2) agonist S-(3-(N-N-dimethylamino)propyl)isothiourea (dimaprit), a partial agonist, S-(2-(N,N-dimethylamino)ethyl)-isothiourea (nordimaprit), and two analogues of nordimaprit, S-(2-(N,N-diethylamino)ethyl)isothiourea (DENOR) and S-(2-(N,N-diisopropylamino)ethyl)isothiourea (DINOR), to investigate the effects on toxicity and tyrosinase activity." | 3.68 | Antiproliferative and depigmenting effects of the histamine (H2) agonist dimaprit and its derivatives on human melanoma cells. ( Fechner, GA; Jacobs, JJ; McEwan, MT; Parsons, PG; Takahashi, H, 1992) |
| "B16-C3 murine melanoma, A375P human melanotic melanoma, and C32 human amelanotic melanoma cells were incubated in the presence of (0-4 mM) H2-antagonists, ranitidine and cimetidine." | 3.68 | The effects of histamine H2 receptor antagonists on melanogenesis and cellular proliferation in melanoma cells in culture. ( Uçar, K, 1991) |
| "Sixty-two patients with biopsy-proven, measurable disseminated malignant melanoma received either the combination IFN-alpha 2A with BCNU (30 patients) or the combination cimetidine with BCNU (32 patients) in parallel noncomparative Phase II trials." | 3.68 | Phase II trial of recombinant leukocyte A interferon (IFN-alpha 2A) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and the combination cimetidine with BCNU in patients with disseminated malignant melanoma. ( Creagan, ET; Kardinal, CG; McCormack, GW; McHale, MS; Morton, RF; Schaid, DJ; Wiesenfeld, M, 1991) |
| "Cimetidine, an H2 histamine antagonist, was used in the clinical management of progressive, multifocal melanomatosis in 3 adult gray horses." | 3.68 | Cimetidine for treatment of melanomas in three horses. ( Goetz, TE; Johnson, PJ; Keegan, KG; Ogilvie, GK, 1990) |
| "Based on previous results demonstrating that coumarin and cimetidine render objective tumor regressions in renal cell carcinoma, we conducted a pilot study to determine whether these drugs possess activity against malignant melanoma." | 3.67 | Treatment of advanced malignant melanoma with coumarin and cimetidine: a pilot study. ( Butler, K; Cantrell, J; Marshall, ME; Mendelsohn, L; Wiseman, C, 1989) |
| "Histamine induced a concentration-dependent increase in intracellular cyclic-AMP of the two human melanoma cell lines SK23 and DX3." | 3.67 | Demonstration of histamine H2 receptors on human melanoma cells. ( Evanson, JM; Hart, IR; Taylor, DJ; Whitehead, RJ; Woolley, DE, 1988) |
| "The effect of cimetidine, an H-2 receptor antagonist, on activation of PBL from both normal individuals and melanoma patients was studied." | 3.67 | The effect of cimetidine on PBL from healthy donors and melanoma patients: augmentation of T cell responses to TCGF mitogens and alloantigens and of TCGF production. ( Adler, A; Eisenthal, A; Monselise, J; Zinger, R, 1986) |
| "In vitro synergism between interferons (IFNs) and chemotherapeutic drugs has been demonstrated, and an enhancement of IFN's antiproliferative effects when combined with cimetidine has been suggested in melanoma patients." | 3.67 | Combination of fibroblast interferon (HuIFN beta), carboxamide (DTIC), and cimetidine for advanced malignant melanoma. ( Abdi, EA; McPherson, TA; Tan, YH, 1986) |
| "Immunostimulant therapy with coumarin and cimetidine was evaluated in 17 patients with advanced malignant melanoma." | 3.67 | Combined treatment of advanced malignant melanoma with coumarin and cimetidine. A phase II study. ( Langvad, E; Pedersen, L; Rose, C, 1987) |
| "The histamine-2 receptor antagonist cimetidine (10(-5)M) and the prostaglandin synthesis inhibitor indomethacin (10(-8)M) augmented natural killer cell activity in the majority of healthy controls and patients with advanced melanoma and in a lower frequency of patients with colorectal carcinoma." | 3.67 | Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon. ( Flodgren, P; Sjögren, HO, 1985) |
| "With the aim of potentiating the anti-tumour effect of interferon in metastatic malignant melanoma by concomitant inhibition of suppressor T cells, oral cimetidine (histamine-2 receptor antagonist) medication was added to interferon (HuIFN-alpha(Le] therapy in a series of 20 patients." | 3.66 | Metastatic malignant melanoma: regression induced by combined treatment with interferon [HuIFN-alpha(Le)] and cimetidine. ( Borgström, S; Flodgren, P; Jönsson, PE; Lindström, C; Sjögren, HO, 1983) |
| "Histamine treatment accelerated tumor growth, but only in normal animals and had little effect on tumor growth in immunocompromised hosts." | 1.27 | The effect of histamine, antihistamines, and a mast cell stabilizer on the growth of cloudman melanoma cells in DBA/2 mice. ( Askenase, PW; Nordlund, JJ, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (65.79) | 18.7374 |
| 1990's | 10 (26.32) | 18.2507 |
| 2000's | 3 (7.89) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Szincsák, N | 2 |
| Hegyesi, H | 2 |
| Hunyadi, J | 2 |
| Martin, G | 1 |
| Lázár-Molnár, E | 1 |
| Kovács, P | 1 |
| Rivera, E | 1 |
| Falus, A | 2 |
| Juhász, I | 2 |
| Thornes, RD | 2 |
| Lynch, G | 2 |
| Sheehan, MV | 2 |
| Creagan, ET | 6 |
| Ahmann, DL | 4 |
| Green, SJ | 2 |
| Long, HJ | 4 |
| Rubin, J | 1 |
| Schutt, AJ | 1 |
| Dziewanowski, ZE | 1 |
| Flodgren, P | 3 |
| Borgström, S | 2 |
| Jönsson, PE | 1 |
| Lindström, C | 1 |
| Sjögren, HO | 3 |
| Hill, NO | 1 |
| Pardue, A | 1 |
| Khan, A | 1 |
| Hill, RW | 1 |
| Aleman, C | 1 |
| Hilario, R | 1 |
| Hill, JM | 1 |
| Osther, K | 1 |
| Nordlund, JJ | 1 |
| Askenase, PW | 1 |
| von Eyben, FE | 1 |
| Axelsson, B | 1 |
| Adler, A | 2 |
| Schachter, J | 1 |
| Barenholz, Y | 1 |
| Bar, LK | 1 |
| Klein, T | 1 |
| Korytnaya, R | 1 |
| Sulkes, A | 1 |
| Michowiz, R | 1 |
| Cohen, Y | 1 |
| Kedar, I | 2 |
| Hellstrand, K | 1 |
| Hermodsson, S | 1 |
| Naredi, P | 1 |
| Mellqvist, UH | 1 |
| Brune, M | 1 |
| Piura, B | 1 |
| Meirovitz, M | 1 |
| Schmidt, H | 1 |
| Geertsen, PF | 1 |
| Fode, K | 1 |
| Rytter, C | 1 |
| Bastholt, L | 1 |
| von der Maase, H | 1 |
| Frytak, S | 3 |
| Chang, MN | 2 |
| Itri, LM | 3 |
| Bajorin, DF | 1 |
| Chapman, PB | 1 |
| Wong, GY | 1 |
| Cody, BV | 1 |
| Cordon-Cardo, C | 1 |
| Dantes, L | 1 |
| Templeton, MA | 1 |
| Scheinberg, D | 1 |
| Oettgen, HF | 1 |
| Houghton, AN | 1 |
| Fechner, GA | 1 |
| Parsons, PG | 1 |
| McEwan, MT | 1 |
| Jacobs, JJ | 1 |
| Takahashi, H | 1 |
| Uçar, K | 1 |
| Mandanas, R | 1 |
| Schultz, S | 1 |
| Scullin, D | 1 |
| Einhorn, LH | 1 |
| Weiss, RB | 1 |
| Donehower, RC | 1 |
| Wiernik, PH | 2 |
| Ohnuma, T | 1 |
| Gralla, RJ | 1 |
| Trump, DL | 1 |
| Baker, JR | 1 |
| Van Echo, DA | 1 |
| Von Hoff, DD | 1 |
| Leyland-Jones, B | 1 |
| Morton, RF | 2 |
| Schaid, DJ | 1 |
| Kardinal, CG | 1 |
| McCormack, GW | 1 |
| McHale, MS | 1 |
| Wiesenfeld, M | 1 |
| Goetz, TE | 1 |
| Ogilvie, GK | 1 |
| Keegan, KG | 1 |
| Johnson, PJ | 1 |
| Harland, CC | 1 |
| Saihan, EM | 1 |
| Marshall, ME | 1 |
| Butler, K | 1 |
| Cantrell, J | 1 |
| Wiseman, C | 1 |
| Mendelsohn, L | 1 |
| Timm, EG | 1 |
| Rozek, SL | 1 |
| Whitehead, RJ | 1 |
| Taylor, DJ | 1 |
| Evanson, JM | 1 |
| Hart, IR | 1 |
| Woolley, DE | 1 |
| Schwartz, EL | 1 |
| Einzig, A | 1 |
| Strauman, JJ | 1 |
| Lipton, RB | 1 |
| Dutcher, JP | 1 |
| Eisenthal, A | 1 |
| Monselise, J | 1 |
| Zinger, R | 1 |
| Steiner, A | 2 |
| Wolf, C | 1 |
| Pehamberger, H | 2 |
| McLeod, GR | 1 |
| Mughal, TI | 1 |
| Robinson, WA | 1 |
| Thomas, MR | 1 |
| Spiegel, R | 1 |
| Cullinan, SA | 1 |
| Mailliard, JA | 1 |
| Ebbert, L | 1 |
| Veeder, MH | 1 |
| Chang, M | 1 |
| Abdi, EA | 1 |
| McPherson, TA | 1 |
| Tan, YH | 1 |
| Pedersen, L | 1 |
| Rose, C | 1 |
| Langvad, E | 1 |
| Wolff, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Feasibility of a Randomized Controlled Clinical Trial Comparing the Use of Cetirizine to Replace Diphenhydramine in the Prevention of Reactions Related to Paclitaxel[NCT04237090] | Phase 3 | 27 participants (Actual) | Interventional | 2020-02-14 | Completed | ||
| Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for cimetidine and Melanoma
| Article | Year |
|---|---|
Histamine and cytokine therapy.
Topics: Animals; Antineoplastic Agents; Cimetidine; Combined Modality Therapy; Histamine; Humans; Immunother | 1998 |
6 trials available for cimetidine and Melanoma
| Article | Year |
|---|---|
Allogeneic human liposomal melanoma vaccine with or without IL-2 in metastatic melanoma patients: clinical and immunobiological effects.
Topics: Adult; Aged; Antigens, Neoplasm; Antigens, Surface; Cimetidine; Combined Modality Therapy; Cytotoxic | 1995 |
Subcutaneous interleukin-2 and interferon-alpha plus cisplatin with and without prophylactic cimetidine in patients with metastatic malignant melanoma: a phase II study.
Topics: Adjuvants, Immunologic; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; | 2000 |
Three consecutive phase II studies of recombinant interferon alfa-2a in advanced malignant melanoma. Updated analyses.
Topics: Adjuvants, Immunologic; Antibodies; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Prot | 1987 |
Phase II trial of cimetidine in metastatic melanoma. A Hoosier Oncology Group trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Cimetidine; Drug Administration Schedule; Drug | 1991 |
Phase II trials of recombinant leukocyte A interferon in disseminated malignant melanoma: results in 96 patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Clinical Trials as Topic; DNA, Recombina | 1986 |
Phase II studies of single-agent cimetidine and the combination N-phosphonacetyl-L-aspartate (NSC-224131) plus L-alanosine (NSC-153353) in advanced malignant melanoma.
Topics: Alanine; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cimetidine; Drug Evaluation; | 1987 |
31 other studies available for cimetidine and Melanoma
| Article | Year |
|---|---|
Cimetidine and a tamoxifen derivate reduce tumour formation in SCID mice xenotransplanted with a human melanoma cell line.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autocrine Communication; Cell Division; Cim | 2002 |
Different h2 receptor antihistamines dissimilarly retard the growth of xenografted human melanoma cells in immunodeficient mice.
Topics: Aged; Animals; Benzhydryl Compounds; Cell Division; Cimetidine; Ethylamines; Histamine H2 Antagonist | 2002 |
Cimetidine and coumarin therapy of melanoma.
Topics: Adult; Aged; Cimetidine; Coumarins; Drug Antagonism; Drug Therapy, Combination; Female; Guanidines; | 1982 |
Combination of cimetidine with other drugs for treatment of cancer.
Topics: Aged; Animals; Cimetidine; Coumarins; Female; Guanidines; Histamine; Humans; Interferons; Male; Mela | 1983 |
Phase II study of recombinant leukocyte A interferon (rIFN-alpha A) in disseminated malignant melanoma.
Topics: Adult; Aged; Cimetidine; Drug Evaluation; Female; Humans; Interferon Type I; Male; Melanoma; Middle | 1984 |
Metastatic malignant melanoma: regression induced by combined treatment with interferon [HuIFN-alpha(Le)] and cimetidine.
Topics: Adult; Aged; Cimetidine; Combined Modality Therapy; Female; Humans; Interferon Type I; Lung Neoplasm | 1983 |
Coumarin and cimetidine in malignant melanoma.
Topics: Adult; Aged; Cimetidine; Coumarins; Female; Guanidines; Humans; Male; Melanoma; Middle Aged | 1983 |
Interferon and cimetidine for malignant melanoma.
Topics: Cimetidine; Guanidines; Humans; Interferon Type I; Melanoma | 1983 |
The effect of histamine, antihistamines, and a mast cell stabilizer on the growth of cloudman melanoma cells in DBA/2 mice.
Topics: Animals; Chromones; Cimetidine; Histamine; Histamine Antagonists; Immunosuppression Therapy; Male; M | 1983 |
Human leukocyte interferon and cimetidine for metastatic melanoma.
Topics: Adult; Aged; Cimetidine; Drug Therapy, Combination; Female; Guanidines; Humans; Interferon Type I; M | 1982 |
Long-term disease-free survival following surgery and active specific immunotherapy with allogeneic vaccine in a patient with high-risk malignant melanoma of the vulva.
Topics: Adult; Cancer Vaccines; Cimetidine; Disease-Free Survival; Female; Granulocyte-Macrophage Colony-Sti | 1998 |
Treatment with high dose mouse monoclonal (anti-GD3) antibody R24 in patients with metastatic melanoma.
Topics: Adult; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antigens, CD; Cimetidine; Comple | 1992 |
Antiproliferative and depigmenting effects of the histamine (H2) agonist dimaprit and its derivatives on human melanoma cells.
Topics: Cell Division; Cell Survival; Cimetidine; Dimaprit; Humans; Immunoblotting; Melanoma; Microscopy, El | 1992 |
The effects of histamine H2 receptor antagonists on melanogenesis and cellular proliferation in melanoma cells in culture.
Topics: Animals; Cell Division; Cell Line; Cimetidine; Dose-Response Relationship, Drug; Humans; Kinetics; M | 1991 |
Hypersensitivity reactions from taxol.
Topics: Adult; Aged; Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Colonic Neoplasms; Dexamethas | 1990 |
Phase II trial of recombinant leukocyte A interferon (IFN-alpha 2A) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and the combination cimetidine with BCNU in patients with disseminated malignant melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cimetidine; Drug Evaluation | 1991 |
Cimetidine for treatment of melanomas in three horses.
Topics: Animals; Cimetidine; Horse Diseases; Horses; Male; Melanoma; Skin Neoplasms | 1990 |
Regression of cutaneous metastatic malignant melanoma with topical diphencyprone and oral cimetidine.
Topics: Administration, Oral; Administration, Topical; Aged; Cimetidine; Cyclopropanes; Drug Administration | 1989 |
Treatment of advanced malignant melanoma with coumarin and cimetidine: a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarin | 1989 |
Cimetidine in malignant melanoma.
Topics: Adjuvants, Immunologic; Cimetidine; Humans; Immunity, Cellular; Killer Cells, Natural; Melanoma; T-L | 1989 |
Demonstration of histamine H2 receptors on human melanoma cells.
Topics: Adenylyl Cyclases; Cimetidine; Cyclic AMP; Dose-Response Relationship, Drug; Histamine; Humans; Mela | 1988 |
Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphenhydramine; Drug Admin | 1987 |
The effect of cimetidine on PBL from healthy donors and melanoma patients: augmentation of T cell responses to TCGF mitogens and alloantigens and of TCGF production.
Topics: Cells, Cultured; Cimetidine; Humans; Interleukin-2; Lymphocyte Activation; Lymphocyte Culture Test, | 1986 |
Comparison of the effects of three different treatment regimens of recombinant interferons (r-IFN alpha, r-IFN gamma, and r-IFN alpha + cimetidine) in disseminated malignant melanoma.
Topics: Cimetidine; Drug Evaluation; Drug Therapy, Combination; Fatigue; Female; Fever; Humans; Interferon T | 1987 |
Alpha-interferons in malignant melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Dacarbazine; Humans; Interferon Type I; | 1988 |
Role of recombinant interferon alpha 2 and cimetidine in patients with advanced malignant melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Female; Interferon Type I; Male; Melanom | 1988 |
Combination of fibroblast interferon (HuIFN beta), carboxamide (DTIC), and cimetidine for advanced malignant melanoma.
Topics: Adult; Cimetidine; Combined Modality Therapy; Dacarbazine; Female; Humans; Immunotherapy; Interferon | 1986 |
Combined treatment of advanced malignant melanoma with coumarin and cimetidine. A phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Coumarins; Drug Evaluation; | 1987 |
Recombinant leukocyte A interferon and cimetidine treatment in disseminated melanoma.
Topics: Adult; Aged; Cimetidine; Drug Therapy, Combination; Female; Humans; Interferon Type I; Male; Melanom | 1986 |
Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon.
Topics: Antibody-Dependent Cell Cytotoxicity; Carcinoma; Cimetidine; Colonic Neoplasms; Cytotoxicity, Immuno | 1985 |
Phase II study of recombinant leukocyte A interferon (IFN-rA) plus cimetidine in disseminated malignant melanoma.
Topics: Administration, Oral; Cimetidine; Combined Modality Therapy; Drug Evaluation; Female; Humans; Inject | 1985 |