cimetidine has been researched along with Lung Diseases, Obstructive in 15 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Lung Diseases, Obstructive: Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "4 mg/kg as an intravenous infusion over 5 min (a dosage previously used to test drug interactions with cimetidine and ranitidine) were evaluated in 7 patients with chronic obstructive pulmonary disease (COPD) and peptic ulcer disease before and after 8 days' treatment with famotidine 40mg at night." | 3.68 | Famotidine and theophylline pharmacokinetics. An unexpected cimetidine-like interaction in patients with chronic obstructive pulmonary disease. ( Dal Negro, R; Pomari, C; Turco, P, 1993) |
| "Theophylline was infused after the 17th dose of each treatment." | 2.68 | Controlled study of the putative interaction between famotidine and theophylline in patients with chronic obstructive pulmonary disease. ( Bachmann, K; Jauregui, L; King, JD; Miller, K; Reese, JH; Schwartz, J; Scott, M; Stepanavage, M; Sullivan, TJ; Yeh, KC, 1995) |
| "The influence of usual regimens of the H2 blocking drugs, cimetidine, ranitidine, and nizatidine on the steady-state plasma concentrations and pharmacokinetic characteristics of theophylline was studied in seventeen patients with chronic obstructive pulmonary disease (COPD)." | 1.28 | Comparative investigation of the influence of nizatidine, ranitidine, and cimetidine on the steady-state pharmacokinetics of theophylline in COPD patients. ( Bachmann, K; Jauregui, L; Levine, L; Martin, M; Mauro, LS; Sullivan, TJ, 1992) |
| " Cimetidine significantly reduced theophylline clearance, but increased its half-life and the area under the curve (AUC) (p less than 0." | 1.27 | Pharmacokinetics of theophylline and the H2-antagonist drugs cimetidine and ranitidine. ( Carloni, C; Dal Negro, R; Pomari, C; Trevisan, F; Turco, P; Zoccatelli, O, 1984) |
| "Cimetidine was given to some patients in both groups after steady state for theophylline was achieved." | 1.27 | The influence of orally administered cimetidine and theophylline on the elimination of each drug in patients with chronic airways obstruction. ( Garton, A; Herbert, FA; Hsu, K; Legatt, D; Sproule, BJ; Tam, YK, 1984) |
| " Prescribers should be aware of this potential interaction and reduce theophylline dosage where appropriate." | 1.27 | Cimetidine-theophylline interaction in patients with chronic obstructive airways disease. ( Grice, J; McGuffie, C; Roberts, RK, 1984) |
| "To examine for a relationship between in vivo nonspecific bronchial reactivity to histamine and in vitro smooth muscle response to histamine, we performed inhalation dose-response curves prior to lung surgery in 12 patients and compared this with their bronchial smooth muscle response in vitro." | 1.27 | A comparison of in vivo and in vitro human airway reactivity to histamine. ( Armour, CL; Chan, N; Hogg, JC; Lazar, NM; Paré, PD; Schellenberg, RR; Taylor, SM, 1984) |
| "05), half-life increased 48% (6." | 1.27 | Cimetidine inhibits theophylline clearance in patients with chronic obstructive pulmonary disease: a study using stable isotope methodology during multiple oral dose administration. ( Mercer, GD; Musser, B; Thummel, KE; Vestal, RE, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (66.67) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bauman, JH | 1 |
| Kimelblatt, BJ | 1 |
| Caraccio, TR | 1 |
| Silverman, HM | 1 |
| Simon, GI | 1 |
| Beck, GJ | 1 |
| Chow, JS | 1 |
| Wang, RY | 1 |
| Wong, PH | 1 |
| Chen, WW | 1 |
| Lai, CL | 2 |
| Dal Negro, R | 2 |
| Pomari, C | 2 |
| Zoccatelli, O | 1 |
| Trevisan, F | 1 |
| Carloni, C | 1 |
| Turco, P | 2 |
| Hsu, K | 1 |
| Garton, A | 1 |
| Sproule, BJ | 1 |
| Tam, YK | 1 |
| Legatt, D | 1 |
| Herbert, FA | 1 |
| Roberts, RK | 1 |
| Grice, J | 1 |
| McGuffie, C | 1 |
| Armour, CL | 1 |
| Lazar, NM | 1 |
| Schellenberg, RR | 1 |
| Taylor, SM | 1 |
| Chan, N | 1 |
| Hogg, JC | 1 |
| Paré, PD | 1 |
| Vestal, RE | 2 |
| Thummel, KE | 2 |
| Musser, B | 2 |
| Mercer, GD | 2 |
| Jue, SG | 1 |
| Howald, WN | 1 |
| Lee, PK | 1 |
| Lok, AS | 1 |
| Tse, TF | 1 |
| Lai, KN | 1 |
| Chow, SF | 1 |
| Lam, KC | 1 |
| Bachmann, K | 2 |
| Sullivan, TJ | 2 |
| Reese, JH | 1 |
| Jauregui, L | 2 |
| Miller, K | 1 |
| Scott, M | 1 |
| Yeh, KC | 1 |
| Stepanavage, M | 1 |
| King, JD | 1 |
| Schwartz, J | 1 |
| Mauro, LS | 1 |
| Martin, M | 1 |
| Levine, L | 1 |
| Marshall, J | 1 |
| Altman, D | 1 |
| Lauber, M | 1 |
| Baylor, P | 1 |
| Boehning, W | 1 |
| Verdiani, P | 1 |
| Di Carlo, S | 1 |
| Baronti, A | 1 |
3 trials available for cimetidine and Lung Diseases, Obstructive
| Article | Year |
|---|---|
Controlled study of the putative interaction between famotidine and theophylline in patients with chronic obstructive pulmonary disease.
Topics: Adult; Aged; Cimetidine; Cross-Over Studies; Drug Interactions; Famotidine; Female; Humans; Infusion | 1995 |
Effect of cimetidine and ranitidine on plasma theophylline in patients with chronic obstructive airways disease treated with theophylline and corticosteroids.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cimetidine; Delayed-Action Preparations; Drug Interactio | 1990 |
Famotidine effects on theophylline pharmacokinetics in subjects affected by COPD. Comparison with cimetidine and placebo.
Topics: Aged; Cimetidine; Famotidine; Female; Half-Life; Humans; Lung Diseases, Obstructive; Male; Metabolic | 1988 |
12 other studies available for cimetidine and Lung Diseases, Obstructive
| Article | Year |
|---|---|
Cimetidine-theophylline interaction: report of four patients.
Topics: Adrenergic beta-Agonists; Aged; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Lung Dise | 1982 |
Intravenous ranitidine has no hemodynamic effects in subjects with normal lung function and patients with chronic obstructive airway disease.
Topics: Adult; Cimetidine; Hemodynamics; Humans; Injections, Intravenous; Lung; Lung Diseases, Obstructive; | 1983 |
Pharmacokinetics of theophylline and the H2-antagonist drugs cimetidine and ranitidine.
Topics: Adult; Aged; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Half-Life; Humans; Lun | 1984 |
The influence of orally administered cimetidine and theophylline on the elimination of each drug in patients with chronic airways obstruction.
Topics: Age Factors; Aged; Bronchodilator Agents; Choline; Cimetidine; Drug Interactions; Half-Life; Humans; | 1984 |
Cimetidine-theophylline interaction in patients with chronic obstructive airways disease.
Topics: Aged; Cimetidine; Drug Interactions; Female; Humans; Kinetics; Lung Diseases, Obstructive; Middle Ag | 1984 |
A comparison of in vivo and in vitro human airway reactivity to histamine.
Topics: Aged; Asthma; Bronchi; Bronchial Provocation Tests; Carbachol; Cimetidine; Dose-Response Relationshi | 1984 |
Cimetidine inhibits theophylline clearance in patients with chronic obstructive pulmonary disease: a study using stable isotope methodology during multiple oral dose administration.
Topics: Administration, Oral; Aged; Carbon Isotopes; Cimetidine; Drug Interactions; Guanidines; Humans; Lung | 1983 |
Stable isotope methodology in a pharmacokinetic study of the interaction of theophylline and cimetidine.
Topics: Carbon Isotopes; Chromatography, High Pressure Liquid; Chronic Disease; Cimetidine; Drug Interaction | 1982 |
Haemodynamic responses to intravenous cimetidine in subjects with normal lung function and in subjects with chronic airway obstruction.
Topics: Adult; Cimetidine; Guanidines; Hemodynamics; Humans; Injections, Intravenous; Lung Diseases, Obstruc | 1981 |
Famotidine and theophylline pharmacokinetics. An unexpected cimetidine-like interaction in patients with chronic obstructive pulmonary disease.
Topics: Cimetidine; Drug Interactions; Famotidine; Humans; Infusions, Intravenous; Lung Diseases, Obstructiv | 1993 |
Comparative investigation of the influence of nizatidine, ranitidine, and cimetidine on the steady-state pharmacokinetics of theophylline in COPD patients.
Topics: Administration, Oral; Aged; Cimetidine; Delayed-Action Preparations; Humans; Lung Diseases, Obstruct | 1992 |
COPD exacerbation associated with a skin rash.
Topics: Aged; Cimetidine; Diagnosis, Differential; Drug Eruptions; Humans; Larva Migrans; Lung Diseases, Obs | 1991 |