cimetidine has been researched along with Liver Dysfunction in 42 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The models of experimental liver dysfunction included bile duct ligation (with sham-operated controls), alpha-naphthylisothiocyanate-induced intrahepatic cholestasis and galactosamine-induced diffuse hepatocellular necrosis." | 7.68 | The effect of liver dysfunction on colchicine pharmacokinetics in the rat. ( Bay, MK; Johnson, RF; Leighton, JA; Maldonado, AL; Schenker, S; Speeg, KV, 1990) |
| "A 43-yr-old man with abdominal fullness was treated with oral cimetidine during remission of acute intermittent porphyria." | 7.67 | Clinical usefulness of cimetidine for the treatment of acute intermittent porphyria--a preliminary report. ( Hirayama, C; Horie, Y; Udagawa, M, 1987) |
| " The models of experimental liver dysfunction included bile duct ligation (with sham-operated controls), alpha-naphthylisothiocyanate-induced intrahepatic cholestasis and galactosamine-induced diffuse hepatocellular necrosis." | 3.68 | The effect of liver dysfunction on colchicine pharmacokinetics in the rat. ( Bay, MK; Johnson, RF; Leighton, JA; Maldonado, AL; Schenker, S; Speeg, KV, 1990) |
| "A 43-yr-old man with abdominal fullness was treated with oral cimetidine during remission of acute intermittent porphyria." | 3.67 | Clinical usefulness of cimetidine for the treatment of acute intermittent porphyria--a preliminary report. ( Hirayama, C; Horie, Y; Udagawa, M, 1987) |
| "The tolerability and metabolism of cimetidine administered for over 7 days were studied in 30 patients with liver diseases and 19 control subjects who had peptic ulcers." | 3.67 | Pharmacokinetic studies of cimetidine in patients with liver disease. ( Arima, T; Nagashima, H; Yamasaki, H, 1987) |
| " Coexisting disease states, such as renal or hepatic dysfunction, may require individualized dosing of these agents." | 2.37 | Individualization of calcium entry-blocker dosage for systemic hypertension. ( Piepho, RW, 1985) |
| " The primary constituent, R-(+)-pulegone, is metabolized via hepatic cytochrome P450 to toxic intermediates." | 1.32 | Mitigation of pennyroyal oil hepatotoxicity in the mouse. ( Bond, GR; Goetz, RJ; Lindsell, CJ; Otten, EJ; Sztajnkrycer, MD, 2003) |
| "Cimetidine was the individual anti-ulcer drug with the highest risk of developing symptomatic acute liver disease." | 1.30 | The risk of acute liver injury associated with cimetidine and other acid-suppressing anti-ulcer drugs. ( García Rodríguez, LA; Stricker, BH; Wallander, MA, 1997) |
| " Most of the early excess in mortality was attributable to cimetidine being given in the late stages of many diseases, often to counter adverse gastric effects of other drugs." | 1.28 | Postmarketing surveillance of the safety of cimetidine: 10 year mortality report. ( Colin-Jones, DG; Langman, MJ; Lawson, DH; Logan, RF; Paterson, KR; Vessey, MP, 1992) |
| " So far as can be assessed, however, none of these drug-disease associations represented adverse effects of cimetidine treatment; on the contrary, they resulted from cimetidine being used, knowingly or unknowingly, for treating the symptoms of various diseases or for alleviating adverse effects of other agents such as corticosteroids, non-steroidal anti-inflammatory drugs, and radiotherapy." | 1.27 | Postmarketing surveillance of the safety of cimetidine: 12 month mortality report. ( Colin-Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1983) |
| " Also, no difference in efficacy of either drug was observed and changes in dosing of digoxin were not required." | 1.27 | Drug interaction studies and encainide use in renal and hepatic impairment. ( Gallo, DG; Quart, BD; Sami, MH; Wood, AJ, 1986) |
| "43 l/kg) and mean half-life (2." | 1.27 | Pharmacokinetics of cimetidine in patients with liver disease. ( Arancibia, A; Chesta, J; Fajuri, M; González-Martin, G; Novoa, X, 1985) |
| " It appears that both dosage and underlying disease state are important factors determining the nature and severity of cimetidine-associated mental status changes." | 1.26 | Mental status, the intensive care unit, and cimetidine. ( Cerra, FB; Fitzgerald, GC; Karwande, SV; Leising, M; McMillen, M; Schentag, JJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (76.19) | 18.7374 |
| 1990's | 8 (19.05) | 18.2507 |
| 2000's | 2 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sztajnkrycer, MD | 1 |
| Otten, EJ | 1 |
| Bond, GR | 1 |
| Lindsell, CJ | 1 |
| Goetz, RJ | 1 |
| Tayal, V | 1 |
| Kalra, BS | 1 |
| Agarwal, S | 1 |
| Khurana, N | 1 |
| Gupta, U | 1 |
| Kolts, BE | 1 |
| Langfitt, M | 1 |
| Malè, PJ | 1 |
| Black, M | 1 |
| Scott, WE | 1 |
| Kanter, R | 1 |
| Colin-Jones, DG | 2 |
| Langman, MJ | 2 |
| Lawson, DH | 2 |
| Vessey, MP | 2 |
| Nakayama, T | 2 |
| Saitoh, M | 2 |
| Hatano, H | 2 |
| Mishima, A | 1 |
| Wada, K | 1 |
| Sugita, S | 1 |
| Tanabe, Y | 1 |
| Tsukamoto, T | 1 |
| Terabayashi, H | 1 |
| Berg, MJ | 1 |
| Lantz, RK | 1 |
| Schentag, JJ | 2 |
| Vern, BA | 1 |
| Tams, TR | 1 |
| Röllinghoff, W | 1 |
| Paumgartner, G | 1 |
| Cole, MJ | 1 |
| Shapero, TF | 1 |
| Saibil, EA | 1 |
| Brunner, G | 1 |
| Eisenburg, J | 1 |
| Ruffalo, RL | 1 |
| Thompson, JF | 1 |
| Lewis, DS | 1 |
| Beck, ER | 1 |
| Cerra, FB | 1 |
| McMillen, M | 1 |
| Karwande, SV | 1 |
| Fitzgerald, GC | 1 |
| Leising, M | 1 |
| Mitchell, MC | 1 |
| Schenker, S | 2 |
| Avant, GR | 1 |
| Speeg, KV | 2 |
| Jackson, JE | 1 |
| Russell, WL | 1 |
| Lopez, LM | 1 |
| Paliard, P | 1 |
| Partensky, C | 1 |
| Biagi, P | 1 |
| Chmel, H | 1 |
| Burkhart, KK | 1 |
| Janco, N | 1 |
| Kulig, KW | 1 |
| Rumack, BH | 1 |
| García Rodríguez, LA | 1 |
| Wallander, MA | 1 |
| Stricker, BH | 1 |
| Al-Mustafa, ZH | 1 |
| Al-Ali, AK | 1 |
| Qaw, FS | 1 |
| Abdul-Cader, Z | 1 |
| Kaufenberg, AJ | 1 |
| Shepherd, MF | 1 |
| Wienbeck, M | 1 |
| MacDougall, BR | 1 |
| Williams, R | 1 |
| Maier, KP | 1 |
| Gerok, W | 1 |
| Logan, RF | 1 |
| Paterson, KR | 1 |
| Marcus, DL | 1 |
| Nadel, H | 1 |
| Lew, G | 1 |
| Freedman, ML | 1 |
| Leighton, JA | 1 |
| Bay, MK | 1 |
| Maldonado, AL | 1 |
| Johnson, RF | 1 |
| Baccino, E | 1 |
| Lan Cheong Wah, LS | 1 |
| Bressollette, L | 1 |
| Mottier, D | 1 |
| Quart, BD | 1 |
| Gallo, DG | 1 |
| Sami, MH | 1 |
| Wood, AJ | 1 |
| Horie, Y | 1 |
| Udagawa, M | 1 |
| Hirayama, C | 1 |
| Yamasaki, H | 1 |
| Arima, T | 1 |
| Nagashima, H | 1 |
| Murase, T | 1 |
| Hazama, H | 1 |
| Okuno, H | 1 |
| Shiozaki, Y | 1 |
| Sameshima, Y | 1 |
| Piepho, RW | 1 |
| Gottlieb, JE | 1 |
| Menashe, PI | 1 |
| Cruz, E | 1 |
| Ohnishi, K | 1 |
| Saito, M | 1 |
| Nomura, F | 1 |
| Iida, S | 1 |
| Okuda, K | 1 |
| González-Martin, G | 1 |
| Arancibia, A | 1 |
| Fajuri, M | 1 |
| Chesta, J | 1 |
| Novoa, X | 1 |
| Van Steenbergen, W | 1 |
| Vanstapel, MJ | 1 |
| Desmet, V | 1 |
| Van Kerckvoorde, L | 1 |
| De Keyzer, R | 1 |
| Brijs, R | 1 |
| Fevery, J | 1 |
| De Groote, J | 1 |
2 reviews available for cimetidine and Liver Dysfunction
| Article | Year |
|---|---|
[Typical risks in the treatment of acute and chronic liver diseases].
Topics: Androgens; Ascites; Cholestyramine Resin; Cimetidine; Disseminated Intravascular Coagulation; Diuret | 1982 |
Individualization of calcium entry-blocker dosage for systemic hypertension.
Topics: Adult; Age Factors; Aged; Calcium Channel Blockers; Child; Cimetidine; Diabetes Complications; Digox | 1985 |
1 trial available for cimetidine and Liver Dysfunction
| Article | Year |
|---|---|
H2-receptor antagonist in the prevention of acute upper gastrointestinal hemorrhage in fulminant hepatic failure: a controlled trial.
Topics: Cimetidine; Gastrointestinal Hemorrhage; Guanidines; Humans; Liver Diseases; Metiamide; Thiourea | 1978 |
39 other studies available for cimetidine and Liver Dysfunction
| Article | Year |
|---|---|
Mitigation of pennyroyal oil hepatotoxicity in the mouse.
Topics: Animals; Case-Control Studies; Cimetidine; Cyclohexane Monoterpenes; Cyclohexanones; Disease Models, | 2003 |
Hepatoprotective effect of tocopherol against isoniazid and rifampicin induced hepatotoxicity in albino rabbits.
Topics: Animals; Antioxidants; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cimetidine; Do | 2007 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
[Beta-blockers in gastroenterology and hepatology].
Topics: Adrenergic beta-Antagonists; Cimetidine; Drug Combinations; Gastrointestinal Diseases; Humans; Liver | 1984 |
Possible ranitidine hepatotoxicity.
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholangitis; Cimetidine; Diagnosis, Differential; Fem | 1984 |
Postmarketing surveillance of the safety of cimetidine: 12 month mortality report.
Topics: Aged; Alcohol Drinking; Cimetidine; Colonic Neoplasms; England; Esophageal Neoplasms; Evaluation Stu | 1983 |
[Effects of cimetidine on systemic and hepatic hemodynamics].
Topics: Adult; Blood Circulation; Cimetidine; Female; Humans; Liver Circulation; Liver Diseases; Male; Middl | 1984 |
Distribution of cimetidine in postmortem tissues.
Topics: Adipose Tissue; Adult; Aged; Autopsy; Cimetidine; Female; Humans; Kidney; Kidney Diseases; Kinetics; | 1984 |
Management of liver disease in dogs and cats.
Topics: Acetylcysteine; Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Bacterial Infections; Cat D | 1984 |
Inhibition of drug metabolism by cimetidine in man: dependence on pretreatment microsomal liver function.
Topics: Aged; Aminopyrine; Breath Tests; Chronic Disease; Cimetidine; Depression, Chemical; Female; Guanidin | 1982 |
Cimetidine and portal pressure in chronic liver disease.
Topics: Cimetidine; Guanidines; Hepatic Veins; Humans; Hypertension, Portal; Liver Diseases; Portal Vein; Ve | 1983 |
[Acute liver failure--therapeutic aspects 1982].
Topics: Acute Disease; Animals; Antithrombins; Blood Coagulation Factors; Cimetidine; Dietary Carbohydrates; | 1982 |
Cimetidine and acetylcysteine as antidote for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Cimetidine; Cytoch | 1982 |
Reversible agranulocytosis in association with cimetidine and hepatic failure.
Topics: Agranulocytosis; Cimetidine; Female; Guanidines; Humans; Liver Diseases; Middle Aged | 1982 |
Mental status, the intensive care unit, and cimetidine.
Topics: Adult; Aged; Analysis of Variance; Blood Chemical Analysis; Cimetidine; Creatinine; Critical Care; G | 1982 |
Cimetidine protects against acetaminophen hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Aminopyrine; Animals; Aspartate Aminotransferases; Chemical and | 1981 |
Cimetidine protects against acetaminophen hepatoxicity.
Topics: Acetaminophen; Adolescent; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Female; Guan | 1981 |
Cimetidine-induced mental status changes: case report and literature review.
Topics: Adult; Aged; Child; Cimetidine; Guanidines; Humans; Infant; Kidney Diseases; Liver Diseases; Male; M | 1980 |
[Polycystic liver disease with abdominal pain and jaundice treated by two successive "fenestration" procedure (author's transl)].
Topics: Adult; Cholestasis; Cimetidine; Cysts; Guanidines; Humans; Liver Diseases; Male; Postoperative Perio | 1980 |
[Kinetics of BSP disappearance after a single dose of cimetidine in ulcer patients with liver disease].
Topics: Adult; Aged; Cimetidine; Female; Guanidines; Humans; Kinetics; Liver Diseases; Male; Middle Aged; Pe | 1980 |
Fatal acute hepatic necrosis due to fluconazole.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cimetidine; Fatal Outcome; Fluconazole; Human | 1995 |
Cimetidine as adjunctive treatment for acetaminophen overdose.
Topics: Acetaminophen; Adult; Cimetidine; Drug Overdose; Female; Humans; Liver Diseases; Male | 1995 |
The risk of acute liver injury associated with cimetidine and other acid-suppressing anti-ulcer drugs.
Topics: Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Anti-Ulcer Agents; Case-Control Studies; Ch | 1997 |
Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Analgesics, Non-Narcotic; | 1997 |
Role of cimetidine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Overdose; Humans; L | 1998 |
[The treatment of hepatic emergencies].
Topics: Cimetidine; Female; Gastrointestinal Hemorrhage; Hepatic Encephalopathy; Humans; Lactulose; Liver Di | 1979 |
[Therapy of acute liver failure].
Topics: Acute Disease; Cimetidine; Exchange Transfusion, Whole Blood; Glucocorticoids; Hemoperfusion; Hepati | 1978 |
Postmarketing surveillance of the safety of cimetidine: 10 year mortality report.
Topics: Cimetidine; Duodenal Neoplasms; Esophageal Neoplasms; Female; Histamine H2 Antagonists; Humans; Live | 1992 |
Cimetidine suppresses chemically induced experimental hepatic porphyria.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chemical and Drug Induced Liver Inju | 1990 |
The effect of liver dysfunction on colchicine pharmacokinetics in the rat.
Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cimetidine; Colchicine; Cytochrome P-450 Enzyme Inhi | 1990 |
Cimetidine in the treatment of acute intermittent porphyria.
Topics: Acute Disease; Adult; Cimetidine; Female; Humans; Liver Diseases; Porphyrias | 1989 |
Drug interaction studies and encainide use in renal and hepatic impairment.
Topics: Adrenergic beta-Antagonists; Adult; Amiodarone; Anilides; Anti-Arrhythmia Agents; Anticoagulants; An | 1986 |
Clinical usefulness of cimetidine for the treatment of acute intermittent porphyria--a preliminary report.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Adult; Aminolevulinic Acid; Cimetidine; Humans; Liver D | 1987 |
Pharmacokinetic studies of cimetidine in patients with liver disease.
Topics: Administration, Oral; Adult; Aged; Cimetidine; Female; Humans; Injections, Intravenous; Liver Diseas | 1987 |
Effect of H2-receptor antagonists on acetaminophen-induced hepatic injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Famotidine; Glutathione; | 1986 |
Gastrointestinal complications in critically ill patients: the intensivists' overview.
Topics: Animals; Antacids; Cholecystitis; Cimetidine; Critical Care; Gastric Acid; Gastrointestinal Diseases | 1986 |
Effects of cimetidine and ranitidine on splanchnic hemodynamics in patients with chronic liver disease.
Topics: Chronic Disease; Cimetidine; Female; Hemodynamics; Humans; Liver Circulation; Liver Diseases; Male; | 1985 |
Pharmacokinetics of cimetidine in patients with liver disease.
Topics: Adult; Aged; Cimetidine; Female; Half-Life; Humans; Kinetics; Liver Cirrhosis; Liver Diseases; Male; | 1985 |
Cimetidine-induced liver injury. Report of three cases.
Topics: Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Gastritis; Gastritis, Hypertrophic; Humans | 1985 |