cimetidine has been researched along with Leukopenia in 21 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Leukopenia: A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The relationship of silver sulfadiazine therapy to leukopenia has been controversial." | 9.05 | Leukopenia and silver sulfadiazine. ( Bingham, HG; Caffee, HH, 1982) |
| "A case of leukopenia associated with cimetidine therapy is reported." | 7.66 | Leukopenia with cimetidine. ( Chandrasekhara, KL; Iyer, SK, 1980) |
| "The relationship of silver sulfadiazine therapy to leukopenia has been controversial." | 5.05 | Leukopenia and silver sulfadiazine. ( Bingham, HG; Caffee, HH, 1982) |
| "A case of leukopenia associated with cimetidine therapy is reported." | 3.66 | Leukopenia with cimetidine. ( Chandrasekhara, KL; Iyer, SK, 1980) |
| "Docetaxel is active for metastatic breast cancer." | 2.68 | Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer. ( Balmaceda, C; Baselga, J; Bruno, R; Crown, JP; Currie, V; Freilich, R; Gilewski, TA; Gollub, M; Hakes, TB; Hudis, CA; Lebwohl, DE; Norton, L; Raptis, G; Robles, M; Seidman, AD, 1996) |
| "A patient with chronic myelogenous leukemia was treated with cimetidine and antibiotics after pneumonectomy." | 1.26 | Prolonged WBC depression after cimetidine in a patient with chronic myelogenous leukemia. ( Gadacz, TR; Linhardt, GE, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (90.48) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keller, HJ | 1 |
| Kirste, G | 1 |
| Wilms, H | 1 |
| Khokhar, N | 1 |
| Akavaram, NR | 1 |
| Linhardt, GE | 1 |
| Gadacz, TR | 1 |
| Collen, MJ | 1 |
| Caffee, HH | 1 |
| Bingham, HG | 1 |
| Mar, DD | 1 |
| Brandstetter, RD | 1 |
| Miskovitz, PF | 1 |
| Fotino, M | 1 |
| Chandrasekhara, KL | 2 |
| Iyer, SK | 2 |
| Macchia, RJ | 1 |
| Hudis, CA | 1 |
| Seidman, AD | 1 |
| Crown, JP | 1 |
| Balmaceda, C | 1 |
| Freilich, R | 1 |
| Gilewski, TA | 1 |
| Hakes, TB | 1 |
| Currie, V | 1 |
| Lebwohl, DE | 1 |
| Baselga, J | 1 |
| Raptis, G | 1 |
| Gollub, M | 1 |
| Robles, M | 1 |
| Bruno, R | 1 |
| Norton, L | 1 |
| López-Luque, A | 1 |
| Rodriguez-Cuartero, A | 1 |
| Pérez-Gálvez, N | 1 |
| Pomores Mora, J | 1 |
| Pena-Yanez, A | 1 |
| James, C | 1 |
| Prout, BJ | 1 |
| Chang, HK | 1 |
| Morrison, SL | 1 |
| Corbett, CL | 1 |
| Holdsworth, CD | 1 |
| Gouffier, E | 1 |
| Schnurmann, D | 1 |
| Durepaire, H | 1 |
| Vernant, JB | 1 |
| Rodríguez Cuartero, A | 1 |
| González Martínez, F | 1 |
| Rodríguez Cuartero, F | 1 |
| Lim, HW | 1 |
| Young, L | 1 |
| Hagan, M | 1 |
| Gigli, I | 1 |
| Wiernik, PH | 1 |
| Schwartz, EL | 1 |
| Strauman, JJ | 1 |
| Dutcher, JP | 1 |
| Lipton, RB | 1 |
| Paietta, E | 1 |
| Porter, JB | 1 |
| Beard, K | 1 |
| Walker, AM | 1 |
| Lawson, DH | 1 |
| Jick, H | 1 |
| Kellaway, GS | 1 |
| Fernández Rodríguez, R | 1 |
| Moreno Sánchez, D | 1 |
| de Cuenca Morón, B | 1 |
| Martínez Fernández, R | 1 |
| Hess, WA | 1 |
| Kornblith, PL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for cimetidine and Leukopenia
| Article | Year |
|---|---|
Leukopenia and silver sulfadiazine.
Topics: Adult; Burns; Cimetidine; Drug Interactions; Guanidines; Humans; Leukopenia; Peptic Ulcer; Prospecti | 1982 |
Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cimetidine; Dexamethasone; Diphenh | 1996 |
19 other studies available for cimetidine and Leukopenia
| Article | Year |
|---|---|
[Cimetidine-induced leukopenia after kidney transplantation].
Topics: Cimetidine; Guanidines; Humans; Kidney Transplantation; Leukopenia; Male; Middle Aged | 1983 |
Cimetidine-induced leukopenia: case reports.
Topics: Aged; Bone Marrow; Cimetidine; Female; Guanidines; Humans; Leukopenia; Male; Middle Aged | 1980 |
Prolonged WBC depression after cimetidine in a patient with chronic myelogenous leukemia.
Topics: Aged; Cimetidine; Guanidines; Humans; Leukemia, Myeloid; Leukocyte Count; Leukopenia; Male | 1981 |
Cimetidine-associated thrombocytopenia and leukopenia.
Topics: Cimetidine; Guanidines; Humans; Leukopenia; Male; Middle Aged; Thrombocytopenia | 1980 |
Cimetidine-induced, immune-mediated leukopenia and thrombocytopenia.
Topics: Agglutination Tests; Agglutinins; Cimetidine; Female; Guanidines; Humans; Leukocytes; Leukopenia; Mi | 1982 |
Leucopenia and thrombocytopenia with cimetidine.
Topics: Cimetidine; Female; Guanidines; Humans; Leukopenia; Middle Aged; Thrombocytopenia | 1981 |
Leukopenia with cimetidine.
Topics: Cimetidine; Female; Guanidines; Humans; Leukopenia; Middle Aged | 1980 |
Leucopenia with cimetidine.
Topics: Adult; Cimetidine; Drug Evaluation; Duodenal Ulcer; Guanidines; Humans; Leukopenia; Male; Neutropeni | 1977 |
Cimetidine and bone-marrow toxicity.
Topics: Adult; Bone Marrow; Cimetidine; Guanidines; Humans; Leukopenia; Male | 1978 |
Marrow suppression and intravenous cimetidine.
Topics: Adult; Bone Marrow; Cimetidine; Guanidines; Humans; Injections, Intravenous; Leukopenia; Male; Throm | 1978 |
Bone-marrow suppression associated with cimetidine.
Topics: Aged; Agranulocytosis; Anemia; Bone Marrow; Cimetidine; Guanidines; Humans; Leukopenia; Male | 1979 |
Fever, abdominal pain, and leucopenia during treatment with cimetidine.
Topics: Abdomen; Adult; Cimetidine; Female; Fever; Guanidines; Humans; Leukopenia; Pain; Transaminases | 1978 |
[Transient marrow aplasia during cimetidine treatment].
Topics: Aged; Anemia, Aplastic; Cimetidine; Guanidines; Humans; Leukopenia; Male | 1978 |
[Duodenal perforation following cimetidine suppression because of leukopenia].
Topics: Cimetidine; Duodenal Diseases; Humans; Intestinal Perforation; Leukopenia; Male; Middle Aged | 1992 |
Delayed phase of hematoporphyrin-induced phototoxicity: modulation by complement, leukocytes, and antihistamines.
Topics: Animals; Cimetidine; Complement System Proteins; Diphenhydramine; Drug Therapy, Combination; Female; | 1985 |
Phase I clinical and pharmacokinetic study of taxol.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alkaloids; Alopecia; Cimetidine; Dexamethasone; Diph | 1987 |
Intensive hospital monitoring study of intravenous cimetidine.
Topics: Age Factors; Aged; Aged, 80 and over; Cimetidine; Female; Hospitals; Humans; Infusions, Intravenous; | 1986 |
[Reversible leukopenia associated with the use of cimetidine].
Topics: Cimetidine; Humans; Leukopenia; Male; Middle Aged | 1987 |
Combination of lomustine and cimetidine in the treatment of a patient with malignant glioblastoma: a case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Humans; Leukopenia; Lomustine; Male; Mid | 1985 |