cimetidine has been researched along with Leukemia in 7 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A presumed cimetidine-induced granulocytopenia in a 6-year-old male with acute lymphocytic leukemia (ALL) prompted an investigation of the effects of cimetidine on in vitro bone marrow granulocyte colony growth (CFU-C) in normal individuals and ALL patients either on maintenance chemotherapy or off all therapy for at least 1 year." | 3.67 | Cimetidine suppression of CFU-C in males. ( Gross, S; Worthington-White, DA, 1984) |
| "A patient with multiple gastroduodenal ulcers and gastric hypersecretion due to histamine excess associated with basophilic leukemia is described." | 3.66 | Basophilic leukemia presenting as gastroduodenal ulceration: effect of H-2-receptor blockade. ( Halloran, G; Mueller, JM; Swisher, RW, 1978) |
| " So far as can be assessed, however, none of these drug-disease associations represented adverse effects of cimetidine treatment; on the contrary, they resulted from cimetidine being used, knowingly or unknowingly, for treating the symptoms of various diseases or for alleviating adverse effects of other agents such as corticosteroids, non-steroidal anti-inflammatory drugs, and radiotherapy." | 1.27 | Postmarketing surveillance of the safety of cimetidine: 12 month mortality report. ( Colin-Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Colin-Jones, DG | 1 |
| Langman, MJ | 1 |
| Lawson, DH | 1 |
| Vessey, MP | 1 |
| Gross, S | 1 |
| Worthington-White, DA | 1 |
| Błasińska, MJ | 1 |
| Jodłowska, E | 1 |
| Mirossay, L | 1 |
| Chastre, E | 1 |
| Callebert, J | 1 |
| Launay, JM | 1 |
| Housset, B | 1 |
| Zimber, A | 1 |
| Abita, JP | 1 |
| Gespach, C | 1 |
| Swisher, RW | 1 |
| Mueller, JM | 1 |
| Halloran, G | 1 |
| Douer, D | 1 |
| Kneller, A | 1 |
| Ben-Bassat, I | 1 |
| Chitayat, SD | 1 |
| Shaked, N | 1 |
| Salzberg, S | 1 |
| Ramot, B | 1 |
| Takahashi, T | 1 |
| Miura, I | 1 |
| Takatsu, H | 1 |
| Fukushima, Y | 1 |
| Fukuda, M | 1 |
| Yoshida, K | 1 |
| Yamaguchi, A | 1 |
| Miura, AB | 1 |
7 other studies available for cimetidine and Leukemia
| Article | Year |
|---|---|
Postmarketing surveillance of the safety of cimetidine: 12 month mortality report.
Topics: Aged; Alcohol Drinking; Cimetidine; Colonic Neoplasms; England; Esophageal Neoplasms; Evaluation Stu | 1983 |
Cimetidine suppression of CFU-C in males.
Topics: Adolescent; Adult; Bone Marrow Cells; Child; Child, Preschool; Cimetidine; Colony-Forming Units Assa | 1984 |
Effect of histamine on E and EAC rosettes formation of normal and leukemic human lymphocytes.
Topics: Adult; Aged; Cimetidine; Dose-Response Relationship, Drug; Female; Histamine; Humans; Leukemia; Lymp | 1980 |
Histamine H2 receptors and histidine decarboxylase in normal and leukemic human monocytes and macrophages.
Topics: Adenylyl Cyclases; Binding Sites; Cimetidine; Cyclic AMP; Enzyme Activation; Gene Expression; Histam | 1994 |
Basophilic leukemia presenting as gastroduodenal ulceration: effect of H-2-receptor blockade.
Topics: Adult; Basophils; Cimetidine; Diagnosis, Differential; Gastric Juice; Gastric Mucosa; Guanidines; Hi | 1978 |
Effect of alpha interferon on growth of leukemic and normal hematopoietic progenitors. Synergism with H2 histamine receptor antagonists.
Topics: 2',5'-Oligoadenylate Synthetase; Cell Division; Cell Line; Cimetidine; Colony-Forming Units Assay; D | 1989 |
Antileukemic effect of cimetidine in vitro.
Topics: Cells, Cultured; Cimetidine; Colony-Forming Units Assay; Humans; Leukemia; Neoplastic Stem Cells; Tu | 1985 |