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cimetidine and Leukemia

cimetidine has been researched along with Leukemia in 7 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"A presumed cimetidine-induced granulocytopenia in a 6-year-old male with acute lymphocytic leukemia (ALL) prompted an investigation of the effects of cimetidine on in vitro bone marrow granulocyte colony growth (CFU-C) in normal individuals and ALL patients either on maintenance chemotherapy or off all therapy for at least 1 year."3.67Cimetidine suppression of CFU-C in males. ( Gross, S; Worthington-White, DA, 1984)
"A patient with multiple gastroduodenal ulcers and gastric hypersecretion due to histamine excess associated with basophilic leukemia is described."3.66Basophilic leukemia presenting as gastroduodenal ulceration: effect of H-2-receptor blockade. ( Halloran, G; Mueller, JM; Swisher, RW, 1978)
" So far as can be assessed, however, none of these drug-disease associations represented adverse effects of cimetidine treatment; on the contrary, they resulted from cimetidine being used, knowingly or unknowingly, for treating the symptoms of various diseases or for alleviating adverse effects of other agents such as corticosteroids, non-steroidal anti-inflammatory drugs, and radiotherapy."1.27Postmarketing surveillance of the safety of cimetidine: 12 month mortality report. ( Colin-Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1983)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19906 (85.71)18.7374
1990's1 (14.29)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Colin-Jones, DG1
Langman, MJ1
Lawson, DH1
Vessey, MP1
Gross, S1
Worthington-White, DA1
Błasińska, MJ1
Jodłowska, E1
Mirossay, L1
Chastre, E1
Callebert, J1
Launay, JM1
Housset, B1
Zimber, A1
Abita, JP1
Gespach, C1
Swisher, RW1
Mueller, JM1
Halloran, G1
Douer, D1
Kneller, A1
Ben-Bassat, I1
Chitayat, SD1
Shaked, N1
Salzberg, S1
Ramot, B1
Takahashi, T1
Miura, I1
Takatsu, H1
Fukushima, Y1
Fukuda, M1
Yoshida, K1
Yamaguchi, A1
Miura, AB1

Other Studies

7 other studies available for cimetidine and Leukemia

ArticleYear
Postmarketing surveillance of the safety of cimetidine: 12 month mortality report.
    British medical journal (Clinical research ed.), 1983, May-28, Volume: 286, Issue:6379

    Topics: Aged; Alcohol Drinking; Cimetidine; Colonic Neoplasms; England; Esophageal Neoplasms; Evaluation Stu

1983
Cimetidine suppression of CFU-C in males.
    American journal of hematology, 1984, Volume: 17, Issue:3

    Topics: Adolescent; Adult; Bone Marrow Cells; Child; Child, Preschool; Cimetidine; Colony-Forming Units Assa

1984
Effect of histamine on E and EAC rosettes formation of normal and leukemic human lymphocytes.
    Archivum immunologiae et therapiae experimentalis, 1980, Volume: 28, Issue:6

    Topics: Adult; Aged; Cimetidine; Dose-Response Relationship, Drug; Female; Histamine; Humans; Leukemia; Lymp

1980
Histamine H2 receptors and histidine decarboxylase in normal and leukemic human monocytes and macrophages.
    The American journal of physiology, 1994, Volume: 267, Issue:2 Pt 2

    Topics: Adenylyl Cyclases; Binding Sites; Cimetidine; Cyclic AMP; Enzyme Activation; Gene Expression; Histam

1994
Basophilic leukemia presenting as gastroduodenal ulceration: effect of H-2-receptor blockade.
    The American journal of digestive diseases, 1978, Volume: 23, Issue:10

    Topics: Adult; Basophils; Cimetidine; Diagnosis, Differential; Gastric Juice; Gastric Mucosa; Guanidines; Hi

1978
Effect of alpha interferon on growth of leukemic and normal hematopoietic progenitors. Synergism with H2 histamine receptor antagonists.
    Experimental hematology, 1989, Volume: 17, Issue:5

    Topics: 2',5'-Oligoadenylate Synthetase; Cell Division; Cell Line; Cimetidine; Colony-Forming Units Assay; D

1989
Antileukemic effect of cimetidine in vitro.
    Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 1985, Volume: 48, Issue:4

    Topics: Cells, Cultured; Cimetidine; Colony-Forming Units Assay; Humans; Leukemia; Neoplastic Stem Cells; Tu

1985