cimetidine has been researched along with Leucocythaemia in 7 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A presumed cimetidine-induced granulocytopenia in a 6-year-old male with acute lymphocytic leukemia (ALL) prompted an investigation of the effects of cimetidine on in vitro bone marrow granulocyte colony growth (CFU-C) in normal individuals and ALL patients either on maintenance chemotherapy or off all therapy for at least 1 year." | 3.67 | Cimetidine suppression of CFU-C in males. ( Gross, S; Worthington-White, DA, 1984) |
| "A patient with multiple gastroduodenal ulcers and gastric hypersecretion due to histamine excess associated with basophilic leukemia is described." | 3.66 | Basophilic leukemia presenting as gastroduodenal ulceration: effect of H-2-receptor blockade. ( Halloran, G; Mueller, JM; Swisher, RW, 1978) |
| " So far as can be assessed, however, none of these drug-disease associations represented adverse effects of cimetidine treatment; on the contrary, they resulted from cimetidine being used, knowingly or unknowingly, for treating the symptoms of various diseases or for alleviating adverse effects of other agents such as corticosteroids, non-steroidal anti-inflammatory drugs, and radiotherapy." | 1.27 | Postmarketing surveillance of the safety of cimetidine: 12 month mortality report. ( Colin-Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Colin-Jones, DG | 1 |
| Langman, MJ | 1 |
| Lawson, DH | 1 |
| Vessey, MP | 1 |
| Gross, S | 1 |
| Worthington-White, DA | 1 |
| Błasińska, MJ | 1 |
| Jodłowska, E | 1 |
| Mirossay, L | 1 |
| Chastre, E | 1 |
| Callebert, J | 1 |
| Launay, JM | 1 |
| Housset, B | 1 |
| Zimber, A | 1 |
| Abita, JP | 1 |
| Gespach, C | 1 |
| Swisher, RW | 1 |
| Mueller, JM | 1 |
| Halloran, G | 1 |
| Douer, D | 1 |
| Kneller, A | 1 |
| Ben-Bassat, I | 1 |
| Chitayat, SD | 1 |
| Shaked, N | 1 |
| Salzberg, S | 1 |
| Ramot, B | 1 |
| Takahashi, T | 1 |
| Miura, I | 1 |
| Takatsu, H | 1 |
| Fukushima, Y | 1 |
| Fukuda, M | 1 |
| Yoshida, K | 1 |
| Yamaguchi, A | 1 |
| Miura, AB | 1 |
7 other studies available for cimetidine and Leucocythaemia
| Article | Year |
|---|---|
Postmarketing surveillance of the safety of cimetidine: 12 month mortality report.
Topics: Aged; Alcohol Drinking; Cimetidine; Colonic Neoplasms; England; Esophageal Neoplasms; Evaluation Stu | 1983 |
Cimetidine suppression of CFU-C in males.
Topics: Adolescent; Adult; Bone Marrow Cells; Child; Child, Preschool; Cimetidine; Colony-Forming Units Assa | 1984 |
Effect of histamine on E and EAC rosettes formation of normal and leukemic human lymphocytes.
Topics: Adult; Aged; Cimetidine; Dose-Response Relationship, Drug; Female; Histamine; Humans; Leukemia; Lymp | 1980 |
Histamine H2 receptors and histidine decarboxylase in normal and leukemic human monocytes and macrophages.
Topics: Adenylyl Cyclases; Binding Sites; Cimetidine; Cyclic AMP; Enzyme Activation; Gene Expression; Histam | 1994 |
Basophilic leukemia presenting as gastroduodenal ulceration: effect of H-2-receptor blockade.
Topics: Adult; Basophils; Cimetidine; Diagnosis, Differential; Gastric Juice; Gastric Mucosa; Guanidines; Hi | 1978 |
Effect of alpha interferon on growth of leukemic and normal hematopoietic progenitors. Synergism with H2 histamine receptor antagonists.
Topics: 2',5'-Oligoadenylate Synthetase; Cell Division; Cell Line; Cimetidine; Colony-Forming Units Assay; D | 1989 |
Antileukemic effect of cimetidine in vitro.
Topics: Cells, Cultured; Cimetidine; Colony-Forming Units Assay; Humans; Leukemia; Neoplastic Stem Cells; Tu | 1985 |