cimetidine and Kidney Diseases studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Research Excerpts

Excerpt	Relevance	Reference
"Puromycin aminonucleoside (PAN)-induced glomerular injury in rats mimics minimal-change nephrotic syndrome (NS) in humans."	3.72	Role of cytochrome P450 2B1 in puromycin aminonucleoside-induced cytotoxicity to glomerular epithelial cells. ( Baliga, M; Baliga, R; Bigler, SA; Liu, H, 2003)
"Amlodipine, a dihydropyridine calcium antagonist, was synthesized in an attempt to develop a compound with a pharmacokinetic profile characteristic of this class, which would also have an increased oral bioavailability and extended clearance time."	2.38	The pharmacokinetic profile of amlodipine. ( Abernethy, DR, 1989)
" Coexisting disease states, such as renal or hepatic dysfunction, may require individualized dosing of these agents."	2.37	Individualization of calcium entry-blocker dosage for systemic hypertension. ( Piepho, RW, 1985)
" The only risk factor for ranitidine was for patients who did not have their dosage corrected for renal function ("overdose"); these patients were twice as likely to experience a PADR compared with patients who received the correct dosage as determined by their renal function."	1.29	Risk for adverse events among patients receiving intravenous histamine2-receptor antagonists. ( Ben-Joseph, R; Russell, WL; Segal, R, 1993)
" Also, no difference in efficacy of either drug was observed and changes in dosing of digoxin were not required."	1.27	Drug interaction studies and encainide use in renal and hepatic impairment. ( Gallo, DG; Quart, BD; Sami, MH; Wood, AJ, 1986)
"Cimetidine did not enhance cyclosporine nephrotoxicity."	1.27	Effect of phenobarbital and cimetidine on experimental cyclosporine nephrotoxicity: preliminary observations. ( Benner, KE; Bennett, WM; Houghton, DC; Sasaki, AW; Schwass, DE, 1986)
" It appears that both dosage and underlying disease state are important factors determining the nature and severity of cimetidine-associated mental status changes."	1.26	Mental status, the intensive care unit, and cimetidine. ( Cerra, FB; Fitzgerald, GC; Karwande, SV; Leising, M; McMillen, M; Schentag, JJ, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (53.66)	18.7374
1990's	12 (29.27)	18.2507
2000's	5 (12.20)	29.6817
2010's	2 (4.88)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Avdeef, A	1
Tam, KY	1
Maillard, N	1
Mehdi, M	1
Thibaudin, L	1
Berthoux, F	1
Alamartine, E	1
Mariat, C	1
Liu, H	1
Baliga, M	1
Bigler, SA	1
Baliga, R	1
Hellerstein, S	4
Berenbom, M	3
Erwin, P	2
Wilson, N	2
DiMaggio, S	2
Mainra, R	1
Gallo, K	1
Moist, L	1
Work, DF	1
Schwartz, GJ	1
Mariani, L	1
Minora, T	1
Tsekova, D	1
Belovezhdov, N	1
Klimenko, VS	1
Osipov, SG	1
Masenko, VP	1
Titov, VN	1
Maher, JF	1
Vatn, MH	1
Schrumpf, E	1
Talseth, T	1
Berg, MJ	1
Lantz, RK	1
Schentag, JJ	2
Vern, BA	1
Freston, JW	1
Jenike, MA	1
Seville, P	1
Cerra, FB	1
McMillen, M	1
Karwande, SV	1
Fitzgerald, GC	1
Leising, M	1
Sperk, G	1
Ratzenhofer, E	1
Simbruner, G	1
Coradello, H	1
Pollak, A	1
Lubec, G	1
Russell, WL	2
Lopez, LM	1
Payne, RB	1
Hilbrands, LB	1
Wetzels, JF	1
Koene, RA	1
Agarwal, R	1
van Acker, BA	2
Koomen, GC	2
Koopman, MG	2
de Waart, DR	2
Arisz, L	2
Choi, KC	1
Lee, J	1
Kim, SW	1
Kim, NH	1
Moon, KH	1
Park, KK	1
Bom, HS	1
Kang, YJ	1
Ben-Joseph, R	1
Segal, R	1
Alon, U	1
Blowey, D	1
Kaplan, R	1
Warady, BA	2
Alon, US	1
Ahmad, S	1
Sutton, EL	1
Dean, JA	1
Wallenberg, BG	1
Caliendo, TM	1
Hatano, M	1
Shaheen, RA	1
Zazgornik, J	1
Kuska, J	1
Kokot, F	1
Schneider, J	1
Abernethy, DR	1
Ishigami, M	1
Sezai, Y	1
Shimada, Y	1
Maeda, T	1
Yabuki, S	1
Quart, BD	1
Gallo, DG	1
Sami, MH	1
Wood, AJ	1
Jarowenko, MV	1
Van Buren, CT	1
Kramer, WG	1
Lorber, MI	1
Flechner, SM	1
Kahan, BD	1
Ma, KW	1
Schwass, DE	1
Sasaki, AW	1
Houghton, DC	1
Benner, KE	1
Bennett, WM	1
Lanes, SF	1
Delzell, E	1
Dreyer, NA	1
Rothman, KJ	1
Piepho, RW	1

Article	Year
Estimating and measuring glomerular filtration rate in children. Current opinion in nephrology and hypertension, 2008, Volume: 17, Issue:3 Topics: Biomarkers; Child; Cimetidine; Creatinine; Cystatin C; Cystatins; Glomerular Filtration Rate; Humans	2008
[Cimetidine and the kidneys]. Vutreshni bolesti, 1983, Volume: 22, Issue:5 Topics: beta 2-Microglobulin; Cimetidine; Creatinine; Dose-Response Relationship, Drug; Gastric Mucosa; Glom	1983
[Diagnostic value of a study of beta 2-microglobulin in the blood serum and urine]. Terapevticheskii arkhiv, 1984, Volume: 56, Issue:5 Topics: Aminoglycosides; Anti-Bacterial Agents; beta 2-Microglobulin; Cimetidine; Creatinine; Diabetic Nephr	1984
Clinicopathologic spectrum of drug nephrotoxicity. Advances in internal medicine, 1984, Volume: 30 Topics: Aminoglycosides; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antineoplastic Agents;	1984
Cimetidine: II. Adverse reactions and patterns of use. Annals of internal medicine, 1982, Volume: 97, Issue:5 Topics: Cardiovascular Diseases; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Ci	1982
Side effects of cimetidine. Southern medical journal, 1979, Volume: 72, Issue:5 Topics: Acute Disease; Aged; Agranulocytosis; Burns; Central Nervous System; Cimetidine; Female; Glucose; Gu	1979
The pharmacokinetic profile of amlodipine. American heart journal, 1989, Volume: 118, Issue:5 Pt 2 Topics: Administration, Oral; Aging; Amlodipine; Angina Pectoris; Animals; Biological Availability; Calcium	1989
Individualization of calcium entry-blocker dosage for systemic hypertension. The American journal of cardiology, 1985, Dec-06, Volume: 56, Issue:16 Topics: Adult; Age Factors; Aged; Calcium Channel Blockers; Child; Cimetidine; Diabetes Complications; Digox	1985

Article	Year
Creatinine-based GFR predicting equations in renal transplantation: reassessing the tubular secretion effect. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:9 Topics: Adult; Aged; Anti-Ulcer Agents; Cimetidine; Creatinine; Diet; Female; Glomerular Filtration Rate; Hu	2010
Effect of cimetidine on intrinsic factor secretion stimulated by different doses of pentagastrin in patients with impaired renal function. Scandinavian journal of gastroenterology, 1983, Volume: 18, Issue:8 Topics: Adult; Cimetidine; Dose-Response Relationship, Drug; Gastric Acid; Humans; Intrinsic Factor; Kidney	1983
Creatinine clearance following cimetidine for estimation of glomerular filtration rate. Pediatric nephrology (Berlin, Germany), 1998, Volume: 12, Issue:1 Topics: Adolescent; Adult; Child; Child, Preschool; Chromium; Cimetidine; Creatinine; Female; Glomerular Fil	1998

Article	Year
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological	2010
Role of cytochrome P450 2B1 in puromycin aminonucleoside-induced cytotoxicity to glomerular epithelial cells. Nephron. Experimental nephrology, 2003, Volume: 94, Issue:1 Topics: Animals; Cells, Cultured; Cimetidine; Cytochrome P-450 CYP2B1; Disease Models, Animal; Dose-Response	2003
Timed-urine collections for renal clearance studies. Pediatric nephrology (Berlin, Germany), 2006, Volume: 21, Issue:1 Topics: Adolescent; Child; Child, Preschool; Cimetidine; Creatinine; Female; Glomerular Filtration Rate; Hum	2006
Creatinine for evaluation of glomerular filtration rate in children. Clinical pediatrics, 2006, Volume: 45, Issue:6 Topics: Adolescent; Adult; Child; Child, Preschool; Cimetidine; Creatinine; Female; Glomerular Filtration Ra	2006
Effect of N-acetylcysteine on renal function in patients with chronic kidney disease. Nephrology (Carlton, Vic.), 2007, Volume: 12, Issue:5 Topics: Acetylcysteine; Aged; Chronic Disease; Cimetidine; Creatinine; Cystatin C; Cystatins; Drug Synergism	2007
[Drug surveillance. Monitoring the collateral effects of drugs in the post-marketing phase: cimetidine. I]. La Clinica terapeutica, 1984, Apr-15, Volume: 109, Issue:1 Topics: Chemical and Drug Induced Liver Injury; Cimetidine; Endocrine System Diseases; Evaluation Studies as	1984
Distribution of cimetidine in postmortem tissues. Journal of forensic sciences, 1984, Volume: 29, Issue:1 Topics: Adipose Tissue; Adult; Aged; Autopsy; Cimetidine; Female; Humans; Kidney; Kidney Diseases; Kinetics;	1984
Cimetidine: optimal use in older patients. Geriatrics, 1983, Volume: 38, Issue:7 Topics: Adult; Aged; Cimetidine; Delirium; Drug Interactions; Guanidines; Humans; Kidney Diseases; Metabolic	1983
Cimetidine and agranulocytosis. The Medical journal of Australia, 1982, Mar-20, Volume: 1, Issue:6 Topics: Agranulocytosis; Cimetidine; Guanidines; Humans; Kidney Diseases	1982
Mental status, the intensive care unit, and cimetidine. Annals of surgery, 1982, Volume: 196, Issue:5 Topics: Adult; Aged; Analysis of Variance; Blood Chemical Analysis; Cimetidine; Creatinine; Critical Care; G	1982
Evidence of H2 receptor activity on glomerular cells. Renal physiology, 1980, Volume: 3, Issue:1-6 Topics: Animals; Binding Sites; Cimetidine; Histamine; In Vitro Techniques; Inflammation; Kidney Diseases; K	1980
Cimetidine-induced mental status changes: case report and literature review. American journal of hospital pharmacy, 1980, Volume: 37, Issue:12 Topics: Adult; Aged; Child; Cimetidine; Guanidines; Humans; Infant; Kidney Diseases; Liver Diseases; Male; M	1980
Creatinine clearance with cimetidine for measurement of GFR. Lancet (London, England), 1993, Jan-16, Volume: 341, Issue:8838 Topics: Cimetidine; Creatinine; Glomerular Filtration Rate; Humans; Kidney Diseases	1993
Creatinine clearance with cimetidine for measurement of GFR. Lancet (London, England), 1993, Jan-16, Volume: 341, Issue:8838 Topics: Cimetidine; Creatinine; Glomerular Filtration Rate; Humans; Kidney Diseases	1993
Creatinine clearance with cimetidine for measurement of GFR. Lancet (London, England), 1993, Jan-16, Volume: 341, Issue:8838 Topics: Cimetidine; Creatinine; Glomerular Filtration Rate; Humans; Kidney Diseases	1993
Creatinine clearance with cimetidine for measurement of GFR. Lancet (London, England), 1993, Apr-24, Volume: 341, Issue:8852 Topics: Cimetidine; Creatinine; Glomerular Filtration Rate; Humans; Kidney Diseases; Metabolic Clearance Rat	1993
Cimetidine improves the accuracy of creatinine clearance as an indicator for glomerular filtration rate. The Korean journal of internal medicine, 1993, Volume: 8, Issue:1 Topics: Adolescent; Adult; Aged; Cimetidine; Creatinine; Female; Glomerular Filtration Rate; Humans; Kidney	1993
Risk for adverse events among patients receiving intravenous histamine2-receptor antagonists. The Annals of pharmacotherapy, 1993, Volume: 27, Issue:12 Topics: Age Factors; Cimetidine; Drug Interactions; Famotidine; Female; Humans; Injections, Intravenous; Kid	1993
Use of serum creatinine concentration for estimation of glomerular filtration rate. American journal of diseases of children (1960), 1993, Volume: 147, Issue:7 Topics: Adolescent; Adult; Cimetidine; Creatinine; Female; Glomerular Filtration Rate; Humans; Inulin; Kidne	1993
Cimetidine in the presence of renal impairment. JAMA, 1979, Aug-10, Volume: 242, Issue:6 Topics: Cimetidine; Cognition Disorders; Guanidines; Humans; Kidney Diseases; Physostigmine	1979
Creatinine clearance during cimetidine administration for measurement of glomerular filtration rate. Lancet (London, England), 1992, Nov-28, Volume: 340, Issue:8831 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cimetidine; Creatinine; Dose-Response Relationship, Drug	1992
H2-antagonist dosing in the elderly based on renal function. The Annals of pharmacotherapy, 1992, Volume: 26, Issue:12 Topics: Aged; Aged, 80 and over; Cimetidine; Drug Administration Schedule; Evaluation Studies as Topic; Huma	1992
[Clinical study of tubular creatinine secretion in renal dysfunction]. Nihon Jinzo Gakkai shi, 1991, Volume: 33, Issue:11 Topics: Adult; Cimetidine; Creatinine; Glomerular Filtration Rate; Humans; Inulin; Kidney Diseases; Kidney T	1991
Cimetidine pharmacokinetics after oral administration of cimetidine retard in normal and impaired renal function. International journal of clinical pharmacology, therapy, and toxicology, 1990, Volume: 28, Issue:11 Topics: Administration, Oral; Adolescent; Adult; Cimetidine; Delayed-Action Preparations; Female; Humans; Ki	1990
Effects of famotidine, a new histamine H2-receptor antagonist, on renal function. Nihon Jinzo Gakkai shi, 1989, Volume: 31, Issue:6 Topics: Acetylglucosaminidase; Adult; Aged; beta 2-Microglobulin; Blood Urea Nitrogen; Cimetidine; Creatinin	1989
Drug interaction studies and encainide use in renal and hepatic impairment. The American journal of cardiology, 1986, Aug-29, Volume: 58, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Amiodarone; Anilides; Anti-Arrhythmia Agents; Anticoagulants; An	1986
Ranitidine, cimetidine, and the cyclosporine-treated recipient. Transplantation, 1986, Volume: 42, Issue:3 Topics: Blood Urea Nitrogen; Cimetidine; Creatinine; Cyclosporins; Heart Transplantation; Humans; Kidney Dis	1986
Cimetidine and the kidney. The International journal of artificial organs, 1986, Volume: 9, Issue:2 Topics: Acute Kidney Injury; Cimetidine; Graft Rejection; Humans; Kidney Diseases; Nephritis, Interstitial	1986
Effect of phenobarbital and cimetidine on experimental cyclosporine nephrotoxicity: preliminary observations. Clinical nephrology, 1986, Volume: 25 Suppl 1 Topics: Animals; Cimetidine; Creatinine; Cyclosporins; Cytochrome P-450 Enzyme System; Drug Interactions; In	1986
Analgesics and kidney disease. International journal of epidemiology, 1986, Volume: 15, Issue:4 Topics: Analgesics; Cimetidine; Female; Humans; Kidney Diseases; Phenacetin	1986

cimetidine and Kidney Diseases

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