Compounds > cimetidine
Page last updated: 2024-10-25

cimetidine and Interstitial Nephritis

cimetidine has been researched along with Interstitial Nephritis in 25 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Research Excerpts

ExcerptRelevanceReference
"We present a case of acute tubulointerstitial nephritis (ATIN) that developed in a 63-year-old man who had been taking cimetidine for treatment of a gastric ulcer."7.70A case of cimetidine-induced acute tubulointerstitial nephritis associated with antineutrophil cytoplasmic antibody. ( Hirato, J; Hiromura, K; Kitahara, T; Maezawa, A; Naruse, T; Nojima, Y; Sato, S; Sugawara, M; Ueki, K; Yano, S, 1999)
"A biopsy-proved case of acute interstitial nephritis related to the use of cimetidine in duodenal ulcer disease is presented."7.66Acute interstitial nephritis related to cimetidine therapy. ( McGowan, WR; Vermillion, SE, 1980)
"Acute tubulointerstitial nephritis (ATIN), which is often drug-induced, is a frequent cause of kidney injury."6.72Acute tubulointerstitial nephritis associated with antineutrophil cytoplasmic antibody following cimetidine treatment: a case report. ( Kanzaki, G; Koike, K; Maruyama, Y; Matsuo, N; Morimoto, K; Niikura, T; Tsuboi, N; Yokoo, T, 2021)
"Cimetidine is a histamine H2-receptor antagonist."6.38[A case of acute interstitial nephritis and nonoliguria acute renal failure induced by cimetidine]. ( Koarada, S; Nagano, Y; Sakemi, T; Syouno, Y; Watanabe, T, 1992)
"The cimetidine titer was positive, at 2,537 cpm."5.33Cimetidine-induced tubulointerstitial nephritis with both MPO-ANCA and PR3-ANCA. ( Imanishi, Y; Inaba, M; Ishimura, E; Jono, S; Matsumoto, N; Nishizawa, Y; Tsuchida, T; Ueda, H; Yunoki, T, 2005)
" Although mild elevation of serum creatinine level following the administration of cimetidine is relatively common, acute interstitial nephritis (AIN) is a rare hypersensitivity reaction."4.81Nephrotoxicity and hepatotoxicity of histamine H2 receptor antagonists. ( Fisher, AA; Le Couteur, DG, 2001)
"We present a case of acute tubulointerstitial nephritis (ATIN) that developed in a 63-year-old man who had been taking cimetidine for treatment of a gastric ulcer."3.70A case of cimetidine-induced acute tubulointerstitial nephritis associated with antineutrophil cytoplasmic antibody. ( Hirato, J; Hiromura, K; Kitahara, T; Maezawa, A; Naruse, T; Nojima, Y; Sato, S; Sugawara, M; Ueki, K; Yano, S, 1999)
"A biopsy-proved case of acute interstitial nephritis related to the use of cimetidine in duodenal ulcer disease is presented."3.66Acute interstitial nephritis related to cimetidine therapy. ( McGowan, WR; Vermillion, SE, 1980)
"Acute tubulointerstitial nephritis (ATIN), which is often drug-induced, is a frequent cause of kidney injury."2.72Acute tubulointerstitial nephritis associated with antineutrophil cytoplasmic antibody following cimetidine treatment: a case report. ( Kanzaki, G; Koike, K; Maruyama, Y; Matsuo, N; Morimoto, K; Niikura, T; Tsuboi, N; Yokoo, T, 2021)
"Cimetidine is a histamine H2-receptor antagonist."2.38[A case of acute interstitial nephritis and nonoliguria acute renal failure induced by cimetidine]. ( Koarada, S; Nagano, Y; Sakemi, T; Syouno, Y; Watanabe, T, 1992)
"The cimetidine titer was positive, at 2,537 cpm."1.33Cimetidine-induced tubulointerstitial nephritis with both MPO-ANCA and PR3-ANCA. ( Imanishi, Y; Inaba, M; Ishimura, E; Jono, S; Matsumoto, N; Nishizawa, Y; Tsuchida, T; Ueda, H; Yunoki, T, 2005)
"Pain was predominant in the hip area, disappeared within a few days after withdrawal and recurred three weeks after resuming therapy."1.27Recurrent myalgias associated with cimetidine. ( Cabanne, JF; Dubot, P; Labeeuw, M, 1986)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199018 (72.00)18.7374
1990's3 (12.00)18.2507
2000's3 (12.00)29.6817
2010's0 (0.00)24.3611
2020's1 (4.00)2.80

Authors

AuthorsStudies
Morimoto, K1
Kanzaki, G1
Niikura, T1
Koike, K1
Matsuo, N1
Maruyama, Y1
Tsuboi, N1
Yokoo, T1
Ueda, H1
Ishimura, E1
Yunoki, T1
Tsuchida, T1
Matsumoto, N1
Jono, S1
Imanishi, Y1
Inaba, M1
Nishizawa, Y1
Kaye, M1
Gagnon, RF1
Watson, AJ1
Dalbow, MH1
Stachura, I1
Fragola, JA1
Rubin, MF1
Watson, RM1
Bourke, E1
Potter, PH1
Westby, RG1
Tsekova, D1
Belovezhdov, N1
Santoro, JJ2
Pitone, JM2
Biondi, RJ2
Chiesa, JC2
Pecora, AA2
Kaye, WA1
Passero, MA1
Solomon, RJ1
Johnson, LA1
Davis, TG1
Pickett, DL1
Schlosser, JH1
Rudnick, MR1
Bastl, CP1
Elfenbein, IB1
Sirota, RA1
Yudis, M1
Narins, RG1
Hake, DH1
Richman, AV1
Narayan, JL1
Hirschfield, JS1
Handa, SP2
McGowan, WR1
Vermillion, SE1
Kitahara, T1
Hiromura, K1
Sugawara, M1
Hirato, J1
Sato, S1
Ueki, K1
Maezawa, A1
Yano, S1
Nojima, Y1
Naruse, T1
Fisher, AA1
Le Couteur, DG1
Koarada, S1
Nagano, Y1
Sakemi, T1
Syouno, Y1
Watanabe, T1
Mullen, PJ1
Ozawa, TT1
Smith, P1
Vance, D1
Moore, N1
Lackey, L1
Ma, KW1
Labeeuw, M1
Cabanne, JF1
Dubot, P1
Ali, N1
Hamilton, DV1
Pryor, JS1
O'Regan, M1
Roberts, PF1
Seidelin, R1

Reviews

4 reviews available for cimetidine and Interstitial Nephritis

ArticleYear
Acute tubulointerstitial nephritis associated with antineutrophil cytoplasmic antibody following cimetidine treatment: a case report.
    BMC nephrology, 2021, 08-30, Volume: 22, Issue:1

    Topics: Adult; Aged; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutrophil

2021
[Cimetidine and the kidneys].
    Vutreshni bolesti, 1983, Volume: 22, Issue:5

    Topics: beta 2-Microglobulin; Cimetidine; Creatinine; Dose-Response Relationship, Drug; Gastric Mucosa; Glom

1983
Nephrotoxicity and hepatotoxicity of histamine H2 receptor antagonists.
    Drug safety, 2001, Volume: 24, Issue:1

    Topics: Cimetidine; Creatinine; Duodenal Ulcer; Histamine; Histamine H2 Antagonists; Humans; Liver Failure;

2001
[A case of acute interstitial nephritis and nonoliguria acute renal failure induced by cimetidine].
    Nihon Jinzo Gakkai shi, 1992, Volume: 34, Issue:11

    Topics: Acute Kidney Injury; Cimetidine; Female; Humans; Kidney; Middle Aged; Nephritis, Interstitial

1992

Trials

1 trial available for cimetidine and Interstitial Nephritis

ArticleYear
Evaluation of a worldwide spontaneous reporting system with cimetidine.
    JAMA, 1980, May-16, Volume: 243, Issue:19

    Topics: Anticoagulants; Cimetidine; Clinical Trials as Topic; Confusion; Drug Synergism; Guanidines; Humans;

1980

Other Studies

20 other studies available for cimetidine and Interstitial Nephritis

ArticleYear
Cimetidine-induced tubulointerstitial nephritis with both MPO-ANCA and PR3-ANCA.
    Clinical and experimental nephrology, 2005, Volume: 9, Issue:4

    Topics: Aged; Anti-Ulcer Agents; Antibodies, Antineutrophil Cytoplasmic; Cimetidine; Humans; Male; Myeloblas

2005
Acute allergic interstitial nephritis and eosinophiluria.
    Kidney international, 2008, Volume: 73, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Drug Hypersensitivity; Eosinophilia; Histamine

2008
Immunologic studies in cimetidine-induced nephropathy and polymyositis.
    The New England journal of medicine, 1983, Jan-20, Volume: 308, Issue:3

    Topics: Adult; B-Lymphocytes; Biopsy; Cell Migration Inhibition; Cimetidine; Drug Hypersensitivity; Guanidin

1983
Interstitial nephritis after cimetidine but not ranitidine.
    JAMA, 1983, Jan-21, Volume: 249, Issue:3

    Topics: Aged; Cimetidine; Esophagitis, Peptic; Furans; Guanidines; Humans; Male; Nephritis, Interstitial; Ra

1983
Cimetidine-induced acute renal failure.
    British medical journal (Clinical research ed.), 1982, Oct-02, Volume: 285, Issue:6346

    Topics: Acute Kidney Injury; Aged; Cimetidine; Female; Guanidines; Humans; Nephritis, Interstitial

1982
Cimetidine-induced interstitial nephritis with response to prednisone therapy.
    Archives of internal medicine, 1983, Volume: 143, Issue:4

    Topics: Acute Disease; Aged; Cimetidine; Dyspepsia; Female; Guanidines; Humans; Nephritis, Interstitial; Pre

1983
Cimetidine-induced acute renal failure.
    Annals of internal medicine, 1982, Volume: 96, Issue:2

    Topics: Acute Kidney Injury; Aged; Cimetidine; Guanidines; Humans; Male; Middle Aged; Nephritis, Interstitia

1982
Cimetidine-induced acute interstitial nephritis.
    The American journal of gastroenterology, 1982, Volume: 77, Issue:3

    Topics: Aged; Cimetidine; Creatinine; Female; Guanidines; Humans; Nephritis, Interstitial

1982
Interstitial nephritis and cimetidine.
    Annals of internal medicine, 1981, Volume: 94, Issue:3

    Topics: Cimetidine; Fever; Guanidines; Humans; Male; Middle Aged; Nephritis, Interstitial; Recurrence

1981
Acute interstitial nephritis and acute renal failure associated with cimetidine therapy.
    The American journal of medicine, 1981, Volume: 70, Issue:6

    Topics: Acute Kidney Injury; Aged; Biopsy; Cimetidine; Eosinophils; Guanidines; Humans; Kidney; Male; Nephri

1981
Interstitial nephritis induced by cimetidine.
    Canadian Medical Association journal, 1981, Oct-01, Volume: 125, Issue:7

    Topics: Adult; Cimetidine; Guanidines; Humans; Male; Nephritis, Interstitial

1981
Acute interstitial nephritis related to cimetidine therapy.
    Gastroenterology, 1980, Volume: 79, Issue:4

    Topics: Adult; Biopsy; Cimetidine; Drug Hypersensitivity; Duodenal Ulcer; Guanidines; Humans; Kidney; Male;

1980
A case of cimetidine-induced acute tubulointerstitial nephritis associated with antineutrophil cytoplasmic antibody.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1999, Volume: 33, Issue:2

    Topics: Anti-Ulcer Agents; Antibodies, Antineutrophil Cytoplasmic; Cimetidine; Humans; Kidney; Male; Middle

1999
Polyuria and weight-loss associated with cimetidine.
    Postgraduate medical journal, 1992, Volume: 68, Issue:803

    Topics: Cimetidine; Humans; Male; Middle Aged; Nephritis, Interstitial; Polyuria; Weight Loss

1992
Acute interstitial nephritis induced by cimetidine.
    Journal of the Tennessee Medical Association, 1987, Volume: 80, Issue:7

    Topics: Acute Disease; Cimetidine; Humans; Male; Middle Aged; Nephritis, Interstitial

1987
Cimetidine and the kidney.
    The International journal of artificial organs, 1986, Volume: 9, Issue:2

    Topics: Acute Kidney Injury; Cimetidine; Graft Rejection; Humans; Kidney Diseases; Nephritis, Interstitial

1986
Recurrent myalgias associated with cimetidine.
    International journal of clinical pharmacology, therapy, and toxicology, 1986, Volume: 24, Issue:7

    Topics: Cimetidine; Duodenal Ulcer; Female; Humans; Middle Aged; Muscles; Nephritis, Interstitial; Pain; Rec

1986
Drug-induced acute interstitial nephritis: report of 10 cases.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1986, Dec-01, Volume: 135, Issue:11

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Allopurinol; Anti-Bacterial Agents; Anti-Inflammatory

1986
Safety of cimetidine.
    British medical journal (Clinical research ed.), 1985, Nov-16, Volume: 291, Issue:6506

    Topics: Aged; Cimetidine; Female; Humans; Nephritis, Interstitial

1985
Safety of cimetidine.
    British medical journal (Clinical research ed.), 1985, Dec-14, Volume: 291, Issue:6510

    Topics: Adult; Cimetidine; Female; Humans; Nephritis, Interstitial; Urologic Diseases

1985