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cimetidine and Impotence

cimetidine has been researched along with Impotence in 19 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Research Excerpts

ExcerptRelevanceReference
"Cimetidine and ranitidine are specific and potent H2-receptor antagonists widely used in the effective therapy of peptic ulcer disease."8.77Actions of cimetidine and ranitidine at some cholinergic sites: implications in toxicology and anesthesia. ( Cheah, LS; Gwee, MC, 1986)
"Cimetidine and ranitidine are specific and potent H2-receptor antagonists widely used in the effective therapy of peptic ulcer disease."4.77Actions of cimetidine and ranitidine at some cholinergic sites: implications in toxicology and anesthesia. ( Cheah, LS; Gwee, MC, 1986)
" e) The gynaecomastia, galactorrhoea, amenorrhoea and impotence--reported only after long-term cimetidine treatment--can probably be attributed to the specific antiandrogen receptor property of CMT."4.77[Dysfunction of the hypothalamo-hypophyseal-gonadal axis induced by histamine H2 antagonists. Review of the literature and personal observations]. ( Biagi, P; Milani, G, 1985)
" Cimetidine used in the ulcer therapy shows a certain antiandrogenic effect and after a longer time may evoke impotence and other undesirable andrological side-effects which we, however, did not realize in 4 weeks treatment periods."3.66[Andrologic anomalies in various gastrointestinal diseases]. ( Szarvas, F, 1983)
" The scheme successfully detected and quantified some already known adverse effects of cimetidine and did not detect any new effects."1.27Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report. ( Colin Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1985)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199018 (94.74)18.7374
1990's1 (5.26)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Beeley, L1
Jensen, RT2
Collen, MJ2
McArthur, KE1
Howard, JM1
Maton, PN1
Cherner, JA1
Gardner, JD2
Reed, M1
Strum, WB1
Szarvas, F1
Pandol, SJ1
Allende, HD1
Raufman, JP1
Bissonnette, BM1
Duncan, WC1
Durgin, PL1
Gillin, JC1
Weideman, CL1
Northcutt, RC1
Peden, NR1
Cargill, JM1
Browning, MC1
Saunders, JH1
Wormsley, KG1
Barber, SG1
Adaikan, PG1
Karim, SM1
Wolfe, MM1
Barth, JA1
Gwee, MC1
Cheah, LS1
Estrada Rodríguez, M1
Izquierdo de la Rosa, H1
González Peláez, J1
Arredondo Bruce, A1
Jauhari, J1
Niv, Y1
Long, JP1
Smyth, PP1
Culliton, M1
Cunningham, S1
O'Donoghue, DP1
Fitzgerald, O1
McKenna, TJ1
Biagi, P1
Milani, G1
Colin Jones, DG1
Langman, MJ1
Lawson, DH1
Vessey, MP1

Reviews

3 reviews available for cimetidine and Impotence

ArticleYear
Drug-induced sexual dysfunction and infertility.
    Adverse drug reactions and acute poisoning reviews, 1984,Spring, Volume: 3, Issue:1

    Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzothiadiazines; Child; Cimetidine;

1984
Actions of cimetidine and ranitidine at some cholinergic sites: implications in toxicology and anesthesia.
    Life sciences, 1986, Aug-04, Volume: 39, Issue:5

    Topics: Anesthesia; Animals; Antihypertensive Agents; Bradycardia; Cholinesterase Inhibitors; Cimetidine; Co

1986
[Dysfunction of the hypothalamo-hypophyseal-gonadal axis induced by histamine H2 antagonists. Review of the literature and personal observations].
    Minerva medica, 1985, Mar-24, Volume: 76, Issue:12

    Topics: Amenorrhea; Androgens; Cimetidine; Erectile Dysfunction; Female; Follicle Stimulating Hormone; Galac

1985

Trials

1 trial available for cimetidine and Impotence

ArticleYear
Comparison of the effectiveness of ranitidine and cimetidine in inhibiting acid secretion in patients with gastric hypersecretory states.
    The American journal of medicine, 1984, Nov-19, Volume: 77, Issue:5B

    Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, C

1984

Other Studies

15 other studies available for cimetidine and Impotence

ArticleYear
Antiandrogen effects of ulcer drug averted with experimental agent.
    JAMA, 1982, Aug-13, Volume: 248, Issue:6

    Topics: Androgen Antagonists; Cimetidine; Erectile Dysfunction; Furans; Guanidines; Humans; Male; Peptic Ulc

1982
Epigastric pain and HBP after biliary disease.
    Hospital practice (Office ed.), 1983, Volume: 18, Issue:10

    Topics: Abdomen; Biliary Tract Diseases; Cimetidine; Duodenal Ulcer; Erectile Dysfunction; Humans; Male; Mid

1983
[Andrologic anomalies in various gastrointestinal diseases].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1983, Aug-01, Volume: 38, Issue:15

    Topics: Cimetidine; Crohn Disease; Cystic Fibrosis; Erectile Dysfunction; Estradiol; Gastrointestinal Diseas

1983
Cimetidine-induced impotence and breast changes in patients with gastric hypersecretory states.
    The New England journal of medicine, 1983, Apr-14, Volume: 308, Issue:15

    Topics: Adult; Breast; Cimetidine; Erectile Dysfunction; Gastric Acid; Guanidines; Gynecomastia; Humans; Mal

1983
Endocrine aspects of impotence.
    The Urologic clinics of North America, 1981, Volume: 8, Issue:1

    Topics: Antihypertensive Agents; Cimetidine; Endocrine System Diseases; Erectile Dysfunction; Estrogens; Gon

1981
Male sexual dysfunction during treatment with cimetidine.
    British medical journal, 1979, Mar-10, Volume: 1, Issue:6164

    Topics: Adult; Cimetidine; Duodenal Ulcer; Erectile Dysfunction; Guanidines; Humans; Male; Middle Aged

1979
Male sexual dysfunction and cimetidine.
    British medical journal, 1979, Apr-28, Volume: 1, Issue:6171

    Topics: Adult; Aged; Cimetidine; Erectile Dysfunction; Guanidines; Humans; Male; Middle Aged

1979
Male sexual dysfunction during treatment with cimetidine.
    British medical journal, 1979, May-12, Volume: 1, Issue:6173

    Topics: Cimetidine; Erectile Dysfunction; Guanidines; Histamine; Humans; Male; Penis

1979
Impotence on cimetidine treatment.
    The New England journal of medicine, 1979, 01-11, Volume: 300, Issue:2

    Topics: Adult; Cimetidine; Duodenal Ulcer; Erectile Dysfunction; Guanidines; Humans; Male

1979
[Can ulcer treatment with cimetidine and other H2 receptor antagonists induce sexual dysfunctions (impotence) and other endocrine disorders?].
    Zentralblatt fur Gynakologie, 1991, Volume: 113, Issue:11

    Topics: Amenorrhea; Cimetidine; Erectile Dysfunction; Female; Gynecomastia; Humans; Male; Peptic Ulcer; Risk

1991
[Adverse clinico-humoral manifestations in ulcer patients treated with cimetidine. Our experience in 488 patients].
    Revista espanola de las enfermedades del aparato digestivo, 1988, Volume: 73, Issue:6

    Topics: Cimetidine; Drug Eruptions; Duodenal Ulcer; Erectile Dysfunction; Galactorrhea; Gastrointestinal Dis

1988
Gynaecomastia, galactorrhoea and impotence--the uncommon side effects of cimetidine therapy.
    The Journal of the Association of Physicians of India, 1987, Volume: 35, Issue:6

    Topics: Adult; Cimetidine; Erectile Dysfunction; Female; Galactorrhea; Gynecomastia; Humans; Lactation Disor

1987
Male sexual dysfunction due to cimetidine.
    Irish medical journal, 1986, Volume: 79, Issue:9

    Topics: Cimetidine; Dose-Response Relationship, Drug; Erectile Dysfunction; Humans; Male; Middle Aged

1986
Prolactin and the hypothalamic-pituitary-testicular axis in cimetidine-treated men.
    Irish medical journal, 1985, Volume: 78, Issue:2

    Topics: Adult; Cimetidine; Erectile Dysfunction; Follicle Stimulating Hormone; Gynecomastia; Humans; Hypotha

1985
Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report.
    The Quarterly journal of medicine, 1985, Volume: 54, Issue:215

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cimetidine; Drug Interactions; Erectile Dysfunctio

1985