cimetidine has been researched along with Hypoxia in 13 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histamine was tested during hypoxic vasoconstriction." | 5.29 | Histamine induced pulmonary vasodilatation in the rat: site of action and changes in chronic hypoxia. ( Barer, GR; Howard, P; Russell, PC; Wright, CE, 1994) |
| "Cimetidine blunted this increase in all the regions of the brain except the pons and bulb." | 5.27 | Cimetidine inhibits the hypoxia-induced increase in cerebral blood flow in dogs. ( Amend, P; Clozel, JP; Hartemann, D; Saunier, C, 1985) |
| " During pentobarbital anesthesia, 2 pulmonary hemodynamic studies were conducted on each dog with a sequence of baseline, hypoxia with FlO2 = 10%, hyperoxia with FlO2 = 100%, a second baseline, treatment with either diphenhydramine (D) or cimetidine (C), and another hypoxia." | 3.68 | Postadulticide pulmonary hypertension of canine heartworm disease: successful treatment with oxygen and failure of antihistamines. ( Rawlings, CA; Tackett, RL, 1990) |
| "Histamine was tested during hypoxic vasoconstriction." | 1.29 | Histamine induced pulmonary vasodilatation in the rat: site of action and changes in chronic hypoxia. ( Barer, GR; Howard, P; Russell, PC; Wright, CE, 1994) |
| "Cimetidine was administered to six of the animals (group 1)." | 1.29 | Poor in vivo reproducibility of gastric intramucosal pH determined by saline-filled balloon tonometry. ( Kruse, JA; Oud, L, 1996) |
| "Histamine was infused at 1." | 1.28 | Developmental changes in effects of histamine on segmental pulmonary vascular resistances. ( Chu, K; Clément de Cléty, S; Gordon, JB, 1991) |
| "Cimetidine blunted this increase in all the regions of the brain except the pons and bulb." | 1.27 | Cimetidine inhibits the hypoxia-induced increase in cerebral blood flow in dogs. ( Amend, P; Clozel, JP; Hartemann, D; Saunier, C, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dutschmann, M | 1 |
| Bischoff, AM | 1 |
| Büsselberg, D | 1 |
| Richter, DW | 1 |
| Hughes, MJ | 1 |
| Bone, RC | 1 |
| Lauterbach, HH | 1 |
| Lehmann, E | 1 |
| Escobar-Jimenez, F | 1 |
| Mattes, P | 1 |
| Raptis, S | 1 |
| Russell, PC | 1 |
| Wright, CE | 1 |
| Barer, GR | 1 |
| Howard, P | 1 |
| Kuint, J | 1 |
| Linder, N | 1 |
| Reichman, B | 1 |
| Oud, L | 1 |
| Kruse, JA | 1 |
| Gordon, JB | 2 |
| Clément de Cléty, S | 2 |
| Chu, K | 2 |
| Rawlings, CA | 1 |
| Tackett, RL | 1 |
| Nakazawa, S | 2 |
| Segawa, K | 1 |
| Tsukamoto, Y | 2 |
| Okada, M | 1 |
| Kobayashi, E | 1 |
| Yamaguchi, H | 1 |
| Goto, H | 1 |
| Kurita, Y | 1 |
| Fukui, A | 1 |
| Matsui, T | 1 |
| Clozel, JP | 1 |
| Amend, P | 1 |
| Saunier, C | 1 |
| Hartemann, D | 1 |
13 other studies available for cimetidine and Hypoxia
| Article | Year |
|---|---|
Histaminergic modulation of the intact respiratory network of adult mice.
Topics: Animals; Cimetidine; Histamine; Histamine Agonists; Histamine Antagonists; Histamine H1 Antagonists; | 2003 |
A reduction in the histamine response of atria from rabbits acclimatized to hypobaric hypoxia.
Topics: Acclimatization; Altitude; Animals; Atmospheric Pressure; Cimetidine; Heart; Histamine; Hypoxia; In | 1983 |
Treatment of severe hypoxemia due to the adult respiratory distress syndrome.
Topics: Cimetidine; Humans; Hypoxia; Monitoring, Physiologic; Oxygen; Positive-Pressure Respiration; Pressur | 1980 |
Behavior of secretion in the hypoxia-immobilisation stress on the rat.
Topics: Animals; Cimetidine; Duodenum; Hypoxia; Intestinal Mucosa; Male; Rats; Restraint, Physical; Secretin | 1980 |
Histamine induced pulmonary vasodilatation in the rat: site of action and changes in chronic hypoxia.
Topics: Animals; Chronic Disease; Cimetidine; Histamine; Hypoxia; In Vitro Techniques; Lung; Male; p-Methoxy | 1994 |
Hypoxemia associated with cimetidine therapy in a newborn infant.
Topics: Adrenergic alpha-Antagonists; Adult; Cimetidine; Female; Fetal Diseases; Gastrointestinal Hemorrhage | 1996 |
Poor in vivo reproducibility of gastric intramucosal pH determined by saline-filled balloon tonometry.
Topics: Animals; Bicarbonates; Carbon Dioxide; Cimetidine; Dogs; Gastric Mucosa; Hydrogen-Ion Concentration; | 1996 |
Developmental changes in effects of histamine on segmental pulmonary vascular resistances.
Topics: Aging; Animals; Animals, Newborn; Chlorpheniramine; Cimetidine; Histamine; Histamine H1 Antagonists; | 1991 |
Developmental changes in vascular responses to histamine in normoxic and hypoxic lamb lungs.
Topics: Animals; Animals, Newborn; Blood Pressure; Cimetidine; Histamine; Hypoxia; Indomethacin; Lung; Pulmo | 1991 |
Postadulticide pulmonary hypertension of canine heartworm disease: successful treatment with oxygen and failure of antihistamines.
Topics: Animals; Arsenamide; Blood Pressure; Cimetidine; Diphenhydramine; Dirofilariasis; Dog Diseases; Dogs | 1990 |
The effect of cimetidine and hypoxia on the gastric macromolecular glycoprotein in rat.
Topics: Animals; Chromatography, Gel; Cimetidine; Gastric Acid; Gastric Mucosa; Glycoproteins; Hypoxia; Macr | 1986 |
[Effects of cimetidine and a PGE1 derivative on the gastric mucosal blood flow in rats under hypoxia].
Topics: Acute Disease; Alprostadil; Animals; Cimetidine; Gastric Mucosa; Hypoxia; Male; Rats; Rats, Inbred S | 1986 |
Cimetidine inhibits the hypoxia-induced increase in cerebral blood flow in dogs.
Topics: Animals; Cerebrovascular Circulation; Cimetidine; Dogs; Hypoxia; Hypoxia, Brain; Random Allocation; | 1985 |