cimetidine has been researched along with Hypertension in 17 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aliskiren is the first in a new class of orally effective direct renin inhibitors approved for the treatment of hypertension." | 5.13 | A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with allopurinol, celecoxib and cimetidine in healthy subjects. ( Ayalasomayajula, S; Bizot, MN; Dieterich, HA; Dole, WP; Howard, D; Tchaloyan, S; Yeh, CM, 2008) |
| "Aliskiren is the first in a new class of orally effective renin inhibitors for the treatment of hypertension." | 5.11 | Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine. ( Corynen, S; Dieterle, W; Mann, J; Vaidyanathan, S, 2005) |
| " for 6 days) on the pharmacokinetics and pharmacodynamic effects of the angiotensin II receptor antagonist, losartan (100 mg)." | 2.68 | Effects of cimetidine on pharmacokinetics and pharmacodynamics of losartan, an AT1-selective non-peptide angiotensin II receptor antagonist. ( Bradstreet, TE; Goldberg, MR; Höglund, P; Lo, MW; Ritter, MA, 1995) |
| " The interaction of nifedipine and cimetidine is thus of clinical significance because of its pharmacodynamic effect." | 2.65 | [Effect of cimetidine and ranitidine on the pharmacokinetics and anti-hypertensive effect of nifedipine]. ( Heidemann, H; Janisch, HD; Kirch, W; Ohnhaus, EE; Rämsch, K, 1983) |
| "2 Caffeine (300 mg) was given orally before any treatment and at the beginning of the last day of each treatment course." | 2.65 | Decreased systemic clearance of caffeine due to cimetidine. ( Broughton, LJ; Rogers, HJ, 1981) |
| " Coexisting disease states, such as renal or hepatic dysfunction, may require individualized dosing of these agents." | 2.37 | Individualization of calcium entry-blocker dosage for systemic hypertension. ( Piepho, RW, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kihara, K | 1 |
| Kamimura, H | 1 |
| Isayama, H | 1 |
| Fujii, Y | 1 |
| Iino, Y | 1 |
| Dieterle, W | 1 |
| Corynen, S | 1 |
| Vaidyanathan, S | 1 |
| Mann, J | 1 |
| Hannaway, PJ | 1 |
| Ayalasomayajula, S | 1 |
| Tchaloyan, S | 1 |
| Yeh, CM | 1 |
| Bizot, MN | 1 |
| Dieterich, HA | 1 |
| Howard, D | 1 |
| Dole, WP | 1 |
| Atkinson, AB | 1 |
| Brown, JJ | 1 |
| Lever, AF | 1 |
| McAreavey, D | 1 |
| Robertson, JI | 1 |
| Behan, PO | 1 |
| Melville, ID | 1 |
| Weir, AI | 1 |
| Dadkar, NK | 1 |
| Aroskar, VA | 1 |
| Gupte, RD | 1 |
| Dohadwalla, AN | 1 |
| Kirch, W | 1 |
| Janisch, HD | 1 |
| Heidemann, H | 1 |
| Rämsch, K | 1 |
| Ohnhaus, EE | 1 |
| Klimenko, VS | 1 |
| Osipov, SG | 1 |
| Masenko, VP | 1 |
| Titov, VN | 1 |
| Broughton, LJ | 1 |
| Rogers, HJ | 1 |
| Salive, ME | 1 |
| Jones, CA | 1 |
| Guralnik, JM | 1 |
| Agodoa, LY | 1 |
| Pahor, M | 1 |
| Wallace, RB | 1 |
| Goldberg, MR | 1 |
| Lo, MW | 1 |
| Bradstreet, TE | 1 |
| Ritter, MA | 1 |
| Höglund, P | 1 |
| Lada, W | 1 |
| Jones, FA | 1 |
| Hunt, T | 1 |
| Baraka, A | 1 |
| Nauphal, M | 1 |
| Arab, W | 1 |
| Shane, E | 1 |
| Barrett, RJ | 1 |
| Kau, ST | 1 |
| Piepho, RW | 1 |
4 reviews available for cimetidine and Hypertension
| Article | Year |
|---|---|
[Diagnostic value of a study of beta 2-microglobulin in the blood serum and urine].
Topics: Aminoglycosides; Anti-Bacterial Agents; beta 2-Microglobulin; Cimetidine; Creatinine; Diabetic Nephr | 1984 |
[Imidazoline receptors and use of drug blocking receptors I1].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Antihypertensive Agents; Arrhythmias, Cardi | 1996 |
Medical management of asymptomatic primary hyperparathyroidism.
Topics: Administration, Oral; Calcium; Calcium, Dietary; Cimetidine; Diphosphonates; Diuretics; Humans; Hype | 1991 |
Individualization of calcium entry-blocker dosage for systemic hypertension.
Topics: Adult; Age Factors; Aged; Calcium Channel Blockers; Child; Cimetidine; Diabetes Complications; Digox | 1985 |
5 trials available for cimetidine and Hypertension
| Article | Year |
|---|---|
Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Amides; Atenolol; Celecoxib; Cimetidine; Cross-Over | 2005 |
A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with allopurinol, celecoxib and cimetidine in healthy subjects.
Topics: Adolescent; Adult; Allopurinol; Amides; Antihypertensive Agents; Celecoxib; Cimetidine; Cyclooxygena | 2008 |
[Effect of cimetidine and ranitidine on the pharmacokinetics and anti-hypertensive effect of nifedipine].
Topics: Adult; Blood Pressure; Cimetidine; Clinical Trials as Topic; Drug Administration Schedule; Drug Inte | 1983 |
Decreased systemic clearance of caffeine due to cimetidine.
Topics: Adult; Biological Availability; Caffeine; Cimetidine; Drug Interactions; Female; Guanidines; Humans; | 1981 |
Effects of cimetidine on pharmacokinetics and pharmacodynamics of losartan, an AT1-selective non-peptide angiotensin II receptor antagonist.
Topics: Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Cimetidine; Cr | 1995 |
8 other studies available for cimetidine and Hypertension
| Article | Year |
|---|---|
[Suppression of renin-angiotensin system and cancer therapy (discussion)].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; B | 2010 |
Emergency department treatment of anaphylaxis: is epinephrine always indicated?
Topics: Aged; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Contraindications; Diphenhyd | 2006 |
Neurological dysfunction in two patients receiving captopril and cimetidine.
Topics: Captopril; Cimetidine; Female; Guanidines; Humans; Hypertension; Male; Middle Aged; Peripheral Nervo | 1980 |
Central pressor activity of cimetidine in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Brain; Cimetidine; Hydroxydopamines; Hypertension; Male; Norepinephrine; Ox | 1984 |
Serum creatinine levels in older adults: relationship with health status and medications.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Black People; Cardiovascular Agents; Cimetidine | 1995 |
Drugs for peptic ulcer.
Topics: Aged; Body Fluids; Carbenoxolone; Cimetidine; Female; Glycyrrhetinic Acid; Guanidines; Humans; Hyper | 1979 |
Cimetidine-dobutamine interaction?
Topics: Anesthesia, Intravenous; Cimetidine; Coronary Artery Bypass; Dobutamine; Drug Interactions; Humans; | 1992 |
Myocardial and vascular actions of amiloride in spontaneously hypertensive rats.
Topics: Amiloride; Animals; Atropine; Blood Pressure; Cardiovascular System; Cimetidine; Dose-Response Relat | 1986 |