Page last updated: 2024-10-25

cimetidine and Hepatocellular Carcinoma

cimetidine has been researched along with Hepatocellular Carcinoma in 6 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Research Excerpts

ExcerptRelevanceReference
"Cimetidine is known to have an anti-tumor effect on certain types of malignancies, though on hepatocellular carcinomas (HCCs), its effect remains unclear."7.74Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats. ( Adachi, K; Amano, Y; Furuta, K; Ishihara, S; Ishine, J; Kinoshita, Y; Miyake, T; Okamoto, E; Sato, S, 2008)
" In the current study, we clarified that cimetidine inhibits both epidermal growth factor (EGF)-induced cell proliferation and migration in hepatocellular carcinoma (HCC) cell lines."3.74Cimetidine inhibits epidermal growth factor-induced cell signaling. ( Fujikawa, T; Nakanishi, Y; Shiraha, H; Shiratori, Y; Suzuki, M; Takaoka, N; Ueda, N, 2007)
"Cimetidine is known to have an anti-tumor effect on certain types of malignancies, though on hepatocellular carcinomas (HCCs), its effect remains unclear."3.74Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats. ( Adachi, K; Amano, Y; Furuta, K; Ishihara, S; Ishine, J; Kinoshita, Y; Miyake, T; Okamoto, E; Sato, S, 2008)
" These results were consistent with the cell-level pharmacodynamic (PD) modeling analysis which leveraged the time-course effects of drugs as single agents and drug combinations."1.72Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin. ( Ait-Oudhia, S; Lesko, LJ; Mody, H; Vaidya, TR, 2022)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's1 (16.67)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Mody, H1
Vaidya, TR1
Lesko, LJ1
Ait-Oudhia, S1
Borentain, P1
Carmona, S1
Mathieu, S1
Jouve, E1
El-Battari, A1
GĂ©rolami, R1
Fujikawa, T1
Shiraha, H1
Nakanishi, Y1
Takaoka, N1
Ueda, N1
Suzuki, M1
Shiratori, Y1
Furuta, K1
Sato, S1
Miyake, T1
Okamoto, E1
Ishine, J1
Ishihara, S1
Amano, Y1
Adachi, K1
Kinoshita, Y1
Cheng, JS1
Lee, KC1
Wang, JL1
Tseng, LL1
Chou, KJ1
Tang, KY1
Jan, CR1
Ling, HY1
Wang, NZ1
Zhu, HZ1

Other Studies

6 other studies available for cimetidine and Hepatocellular Carcinoma

ArticleYear
Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin.
    Cells, 2022, 12-23, Volume: 12, Issue:1

    Topics: Carcinoma, Hepatocellular; Cimetidine; Cisplatin; Drug-Related Side Effects and Adverse Reactions; H

2022
Inhibition of E-selectin expression on the surface of endothelial cells inhibits hepatocellular carcinoma growth by preventing tumor angiogenesis.
    Cancer chemotherapy and pharmacology, 2016, Volume: 77, Issue:4

    Topics: Amiloride; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cimetidine; E-Selectin; Endotheli

2016
Cimetidine inhibits epidermal growth factor-induced cell signaling.
    Journal of gastroenterology and hepatology, 2007, Volume: 22, Issue:3

    Topics: Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cimetidine; Epidermal Growth Factor; H

2007
Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats.
    Oncology reports, 2008, Volume: 19, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cimeti

2008
Histamine-Induced increases in intracellular free Ca2+ levels in hepatoma cells.
    The Chinese journal of physiology, 2000, Dec-31, Volume: 43, Issue:4

    Topics: Biological Transport; Calcium; Carcinoma, Hepatocellular; Cimetidine; Cytosol; Extracellular Space;

2000
[Preliminary study of traditional Chinese medicine-Western medicine treatment of patients with primary liver carcinoma].
    Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1989, Volume: 9, Issue:6

    Topics: Adjuvants, Immunologic; Adult; Camptothecin; Carcinoma, Hepatocellular; Cimetidine; Drugs, Chinese H

1989