cimetidine and Hemorrhage, Peptic Ulcer studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Research Excerpts

Excerpt	Relevance	Reference
" infusion of cimetidine, a histamine-2 (H2) receptor antagonist, is needed to prevent upper gastrointestinal (GI) hemorrhage when compared with placebo and if that usage is associated with an increased risk of nosocomial pneumonia."	9.07	Continuous intravenous cimetidine decreases stress-related upper gastrointestinal hemorrhage without promoting pneumonia. ( Booth, FV; Bowman, SC; D'Ambrosio, CA; Hampsey, J; Jacobs, DM; Karlstadt, RG; Martin, LF; Rockhold, FW; Silverstein, JH, 1993)
"In a double-blind, prospective, randomized trial, the healing effect of somatostatin was compared with that of cimetidine in 67 patients with endoscopically confirmed duodenal ulcer with active bleeding (33 patients were treated with somatostatin, 34 with cimetidine)."	9.06	Somatostatin versus cimetidine in the treatment of actively bleeding duodenal ulcer: a prospective, randomized, controlled trial. ( Bodnár, A; Gupta, R; Papp, J; Tulassay, Z, 1989)
" Fifty-five patients with acute bleeding from chronic duodenal ulcers with SRH completed a randomized double-blind trial to assess the effect of administration of cimetidine (800 mg daily intravenously for 2 days, then 1000 mg daily orally for 10 days in divided doses) versus placebo on rebleeding and need for emergency surgery."	9.05	Cimetidine reduces the risk of rebleeding from duodenal ulcers displaying signs of recent haemorrhage. ( Barnes, PR; Byth, K; Heap, TR; Ruppin, DC; Stiel, D, 1984)
"We report the case of a patient with peptic ulcer disease who developed cimetidine-induced thrombocytopenia."	7.68	Cimetidine and ranitidine may not cross-react to cause thrombocytopenia. ( Seror, D; Shalev, O, 1991)
"The efficacy of prophylactic therapy with cimetidine or antacids combined with early enteral feeding to prevent gastrointestinal bleeding in patients with severe burns was evaluated."	7.67	Prevention of gastrointestinal bleeding in burns: the effects of cimetidine or antacids combined with early enteral feeding. ( Hirshowitz, B; Jacobs, R; Kaufman, T; Moscona, R, 1985)
"Preliminary results of endoscopic electrocoagulation combined with Cimetidine are reported in a prospective series of 60 consecutive patients presenting with active bleeding from gastroduodenal ulcer."	7.66	Endoscopic electrocoagulation combined with cimetidine. A pilot study of the applicability in active bleeding from gastroduodenal ulcer. ( Amdrup, E; Højsgaard, A; Wara, P, 1980)
"The authors here present a work dealing pith two groups of subjects, both groups having the diagnose of bleeding duodenal ulcer; one group using therapy antacid alone, the other using cimetidine and antacid."	7.66	[Short-term effects of cimetidine in patients with bleeding duodenal ulcer. Presentation of cases]. ( Monti, G; Rumi, A; Testone, G; Uggeri, G, 1983)
"This paper presents clinical observations on the preventive effect of cimetidine for stress ulcer bleeding in severe burns."	7.66	Prevention of stress ulcer bleeding with cimetidine in severe burns. ( Liu, YL; Yuan, KJ, 1983)
"Treatment of renal transplant patients with the H2-antagonist cimetidine has previously been assumed to be of reasonable prophylactic value in controlling the incidence of the postoperative complications of gastric or duodenal ulceration."	7.66	Failure of cimetidine to prevent gastroduodenal ulceration and bleeding after renal transplantation. ( Pinggera, W; Piza, F; Schiessel, R; Schmidt, P; Schwarz, S; Starlinger, M; Wagner, O; Wolf, A; Zazgornik, J, 1981)
"Bleeding gastric ulcers were a major cause of morbidity and mortality in young swine subjected to surgery, chronic catheterization, and daily experimental manipulation."	5.26	Cimetidine prophylaxis for gastric ulcers in laboratory swine. ( Anderson, LC; Bohr, DF; Mitchell, J; Ringler, DH, 1981)
" In a prospective clinical trial, primed infusions of different dosages of omeprazole (8 or 4 mg/h) after a bolus (40 mg) produced consistently high intragastric pH values in patients with bleeding duodenal ulcer."	5.09	Effect of intragastric pH on control of peptic ulcer bleeding. ( Dai, S; Jia, L; Li, Y; Nie, Y; Sha, W; She, Q; Wu, H; Yu, W, 2000)
" infusion of cimetidine, a histamine-2 (H2) receptor antagonist, is needed to prevent upper gastrointestinal (GI) hemorrhage when compared with placebo and if that usage is associated with an increased risk of nosocomial pneumonia."	5.07	Continuous intravenous cimetidine decreases stress-related upper gastrointestinal hemorrhage without promoting pneumonia. ( Booth, FV; Bowman, SC; D'Ambrosio, CA; Hampsey, J; Jacobs, DM; Karlstadt, RG; Martin, LF; Rockhold, FW; Silverstein, JH, 1993)
"In a double-blind, prospective, randomized trial, the healing effect of somatostatin was compared with that of cimetidine in 67 patients with endoscopically confirmed duodenal ulcer with active bleeding (33 patients were treated with somatostatin, 34 with cimetidine)."	5.06	Somatostatin versus cimetidine in the treatment of actively bleeding duodenal ulcer: a prospective, randomized, controlled trial. ( Bodnár, A; Gupta, R; Papp, J; Tulassay, Z, 1989)
"Of 113 patients in whom endoscopy revealed a bleeding gastric or duodenal ulcer 55 were randomly allocated to receive endoscopic sclerosis (ES) (injections of adrenaline/polidocanol) plus cimetidine while 58 received cimetidine alone as controls."	5.06	Controlled trial of endoscopic sclerosis in bleeding peptic ulcers. ( Forné, M; Garau, J; Garcia-Olivares, E; Marco, C; Panés, J; Viver, J, 1987)
"We studied the effects of tranexamic acid (an antifibrinolytic agent) and cimetidine on acute upper-gastrointestinal-tract bleeding in a double-blind randomized placebo-controlled trial in 775 patients with hematemesis or melena or both."	5.05	Cimetidine and tranexamic acid in the treatment of acute upper-gastrointestinal-tract bleeding. ( Atkinson, M; Barer, D; Coggon, D; Dronfield, M; Ellis, S; French, S; Henry, D; Langman, M; Ogilvie, A, 1983)
" Fifty-five patients with acute bleeding from chronic duodenal ulcers with SRH completed a randomized double-blind trial to assess the effect of administration of cimetidine (800 mg daily intravenously for 2 days, then 1000 mg daily orally for 10 days in divided doses) versus placebo on rebleeding and need for emergency surgery."	5.05	Cimetidine reduces the risk of rebleeding from duodenal ulcers displaying signs of recent haemorrhage. ( Barnes, PR; Byth, K; Heap, TR; Ruppin, DC; Stiel, D, 1984)
"During a period of 12 months, 88 patients with severe haemorrhage from gastric or duodenal ulcers or from erosive gastritis completed a double-blind trial of either cimetidine or placebo."	5.05	Cimetidine for severe gastroduodenal haemorrhage: a randomized controlled trial. ( Backer, O; Bülow, S; Carstensen, HE; Hansen, OH; Jakobsen, BH; Krarup, T; Pedersen, T; Raahave, D; Svendsen, LB, 1980)
"To assess the efficacy of cimetidine versus sucralfate in terminating or preventing further bleeding of peptic ulcers, patients presenting with bleeding from duodenal or gastric ulcers were openly randomized to receive cimetidine 1800 mg/day or sucralfate 8 g/day for a 1-wk period."	5.05	A comparison of cimetidine and sucralfate in the treatment of bleeding peptic ulcers. ( Czaja, MJ; Goldfarb, JP, 1985)
" The histamine H2-receptor antagonist cimetidine has in one large study been demonstrated to reduce mortality in ulcer haemorrhage, and in other studies beneficial effects have been found in elderly patients; above all in elderly gastric ulcer patients."	4.77	Role of histamine H2 receptor antagonists in nonoperative management of gastroduodenal ulcer haemorrhage. ( Haglund, U, 1987)
"SST has no effect on the outcome of acute pancreatitis, and experience with SST in treating intestinal fistulas is very limited."	3.75	[Somatostatin in gastroenterological therapy]. ( Gyr, K; Kayasseh, L; Stalder, GA, 1985)
"We report the case of a patient with peptic ulcer disease who developed cimetidine-induced thrombocytopenia."	3.68	Cimetidine and ranitidine may not cross-react to cause thrombocytopenia. ( Seror, D; Shalev, O, 1991)
"The efficacy of prophylactic therapy with cimetidine or antacids combined with early enteral feeding to prevent gastrointestinal bleeding in patients with severe burns was evaluated."	3.67	Prevention of gastrointestinal bleeding in burns: the effects of cimetidine or antacids combined with early enteral feeding. ( Hirshowitz, B; Jacobs, R; Kaufman, T; Moscona, R, 1985)
"The authors here present a work dealing pith two groups of subjects, both groups having the diagnose of bleeding duodenal ulcer; one group using therapy antacid alone, the other using cimetidine and antacid."	3.66	[Short-term effects of cimetidine in patients with bleeding duodenal ulcer. Presentation of cases]. ( Monti, G; Rumi, A; Testone, G; Uggeri, G, 1983)
"This paper presents clinical observations on the preventive effect of cimetidine for stress ulcer bleeding in severe burns."	3.66	Prevention of stress ulcer bleeding with cimetidine in severe burns. ( Liu, YL; Yuan, KJ, 1983)
" The histamine HI-receptor antagonist, cimetidine, was used in 27 patients with erosive gastritis, and bleeding ceased in 24."	3.66	Symposium on intensive care: 3. Upper gastrointestinal bleeding in the intensive care unit. ( Badley, BW; Freeman, AN; Holland, SG; MacDonald, AS; Pyne, DA, 1978)
"Treatment of renal transplant patients with the H2-antagonist cimetidine has previously been assumed to be of reasonable prophylactic value in controlling the incidence of the postoperative complications of gastric or duodenal ulceration."	3.66	Failure of cimetidine to prevent gastroduodenal ulceration and bleeding after renal transplantation. ( Pinggera, W; Piza, F; Schiessel, R; Schmidt, P; Schwarz, S; Starlinger, M; Wagner, O; Wolf, A; Zazgornik, J, 1981)
"A 67-year-old man with a bleeding ulcer developed fever, thrombocytopenia, and neutropenia with eosinophilia coincidental to receiving 3600 mg of cimetidine."	3.66	Cimetidine and hematologic suppression: things are not always as they appear. ( Castell, DO; Gerhardt, DC; Pasquale, DN; Richter, JE, 1980)
"Preliminary results of endoscopic electrocoagulation combined with Cimetidine are reported in a prospective series of 60 consecutive patients presenting with active bleeding from gastroduodenal ulcer."	3.66	Endoscopic electrocoagulation combined with cimetidine. A pilot study of the applicability in active bleeding from gastroduodenal ulcer. ( Amdrup, E; Højsgaard, A; Wara, P, 1980)
"On the basis of favorable results recently reported in literature with cimetidine in the prevention and therapy of upper gastrointestinal haemorrhages, the Authors have treated a patient with severe haemorrhage from acute gastric ulcer arised after jejunum-ileal massive resection for mesenteric infarction."	3.65	[Preliminary experiences with the use of cimetidine in the treatment of acute hemorrhages in the upper gastrointestinal tract]. ( Agosti, A; Pettenati, V; Pouchè, A, 1977)
"A double-blind controlled trial was conducted in which the efficacy of cimetidine in a dosage of 20 mg/kg/24 h in preventing upper gastrointestinal hemorrhage was tested in 34 critically ill patients on assisted ventilation."	2.66	Prevention of stress-induced upper gastrointestinal bleeding by cimetidine in patients on assisted ventilation. ( van Blankenstein, M; van den Berg, B, 1985)
"Cimetidine was highly effective in preventing stress ulceration in severe polytrauma patients, but mortality was the same in the cimetidine and in the placebo group."	2.65	[A randomized clinical study of stress ulcer prophylaxis with cimeytidine in severe multiple injuries]. ( Fischer, M; Lorenz, W; Rohde, H, 1980)
"Cimetidine prophylaxis was not shown to reduce the incidence of these lesions in this study but did diminish their severity and the likelihood that they would complicate the management of these patients."	2.65	Prevention of acute gastrointestinal complications after severe head injury: a controlled trial of cimetidine prophylaxis. ( Gayle, WE; Halloran, LG; Miller, JD; Wheeler, CB; Zfass, AM, 1980)
"5 cimetidine-treated patients developed cholestasis, and 5 additional central nervous system problems."	2.65	[Ranitidine and cimetidine in the prevention of stress: ulcer hemorrhage a prospective comparative multicenter study]. ( Barth, HO; Berg, P; Brunner, G; Dammann, HG; Franken, FH; Friedl, W; Greiner, L; Groitl, J; Möckel, W; Müller, P, 1984)
"Especially patients with severe sepsis or septic shock are prone to develop lesions of the upper gastrointestinal tract with consecutive bleeding."	1.35	[Stress ulcer prophylaxis in septic patients. Evidence-based overview]. ( Elke, G; Schädler, D; Scholz, J; Weiler, N; Zick, G, 2008)
"In patients without maintenance treatment, relapse was markedly higher (50/78 group I, 529/742 group II), but group II still bled significantly less (20% group I vs."	1.30	The outcome of bleeding duodenal ulcer in the era of H2 receptor antagonist therapy. ( Bardhan, KD; Nayyar, AK; Royston, C, 1998)
"Bleeding gastric ulcer is associated with a relatively low long-term recurrence rate, except in a few patients with a history of previous bleeding ulcer, who have an increased risk of recurrence."	1.29	Late outcome of bleeding gastric ulcer. Five to eight years' follow-up. ( Fischer, L; Rørbaek-Madsen, M; Thomsen, H; Wara, P, 1994)
" The 12 month report noted that cimetidine was being given, knowingly or unknowingly, in the late stages of many diseases and also to counter the adverse gastric effects of other drugs used in the treatment of serious disorders."	1.27	Postmarketing surveillance of the safety of cimetidine: mortality during second, third, and fourth years of follow up. ( Colin-Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1985)
"Cimetidine was able to stop less extensive bleedings, but did not show any therapeutic effect in case of bleeding which led to a significant fall in hemoglobin concentration."	1.26	[Prevention and therapy of gastroduodenal stress bleeding with cimetidine]. ( Inthorn, D; Teichmann, RK; Zumtobel, V, 1980)
"Cimetidine therapy was not effective in preventing restricture of the esophagus."	1.26	Barrett's ulcer and treatment with cimetidine. ( Kalra, TM; Kothari, T; Mangla, JC, 1980)
"Bleeding gastric ulcers were a major cause of morbidity and mortality in young swine subjected to surgery, chronic catheterization, and daily experimental manipulation."	1.26	Cimetidine prophylaxis for gastric ulcers in laboratory swine. ( Anderson, LC; Bohr, DF; Mitchell, J; Ringler, DH, 1981)
"Cimetidine has proved to be of value in conservative treatment of stress induced ulcer haemorrhage and is used increasingly prophylactically."	1.26	[Cimetidine for treatment of stress-induced ulcer haemorrhage (author's transl)]. ( Schiessel, R; Schulz, F, 1979)

Research

Studies (190)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Number of Blood Units Transfused Within 30 Days

Number of Blood Units Transfused Within 72 Hours

Number of Patients With Endoscopic Re-treatment Within 30 Days

Number of Patients With Endoscopic Re-treatment Within 72 Hours

Number of Patients With Surgery Due to Rebleeding Within 30 Days

Number of Patients With Surgery Due to Rebleeding Within 72 Hours

Rate of Clinically Significant Rebleeding During 30 Days

Timeframe	Studies, this research(%)	All Research%
pre-1990	161 (84.74)	18.7374
1990's	21 (11.05)	18.2507
2000's	6 (3.16)	29.6817
2010's	2 (1.05)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Bai, Y	1
Chen, DF	1
Wang, RQ	1
Chen, YX	1
Shi, RH	1
Tian, DA	1
Chen, H	1
Eklund, S	1
Li, ZS	1
Lin, PC	1
Chang, CH	1
Hsu, PI	1
Tseng, PL	1
Huang, YB	1
Bardhan, KD	2
Nayyar, AK	2
Royston, C	2
Denavit, MF	1
Guerin, J	1
Caldera, R	1
Rossier, A	1
Lin, HJ	1
Lo, WC	1
Cheng, YC	1
Perng, CL	1
Uedo, N	1
Takeuchi, Y	1
Yamada, T	1
Ishihara, R	1
Ogiyama, H	1
Yamamoto, S	2
Kato, M	1
Tatsumi, K	1
Masuda, E	1
Tamai, C	1
Higashino, K	1
Iishi, H	1
Tatsuta, M	1
Janicki, T	1
Stewart, S	1
Elke, G	1
Schädler, D	1
Zick, G	1
Scholz, J	1
Weiler, N	1
Hotz, J	1
Thomson, AB	1
Maguire, T	1
Wensel, RH	1
Sherbaniuk, RW	1
Bailey, RJ	1
Kirdeikis, P	1
Kayasseh, L	3
Gyr, K	5
Keller, U	2
Stalder, GA	3
Wall, M	1
Galmiche, JP	3
Veyrac, M	1
Colin, R	3
Thomas, RJ	1
Forbes, JF	1
Limberg, B	1
Kommerell, B	1
Mikhailidis, DP	1
Mikhailidis, AM	1
Dandona, P	1
Sharpe, PC	1
Flind, AC	1
Simon, B	2
Müller, P	3
Kather, H	1
Khokholia, VP	1
Khil'chenko, EA	1
Holtermüller, KH	2
Ebener, B	1
Kühl, HJ	1
Rolfs, A	1
Londong, W	1
Carella, G	1
Basile, M	1
Celi, S	1
Parisi, A	1
Castiglione, N	1
Parisi, S	1
Cassigneul, J	1
Faivre, J	1
Tranvouez, JL	1
Ouvry, D	1
Pascal, JP	1
Klepping, C	1
Read, AE	1
Fimmel, CJ	1
Sabbatini, F	1
Pace, F	1
Caradonna, P	1
Blum, AL	2
Stabile, BE	1
Passaro, E	1
Dammann, HG	2
Barth, HO	1
Berg, P	2
Brunner, G	1
Friedl, W	1
Franken, FH	1
Greiner, L	1
Groitl, J	1
Möckel, W	1
Darle, N	2
Almskog, B	1
Bergegårdh, S	1
Falk, A	2
Faxén, A	1
Ivarsson, LE	1
Jivegård, L	1
Karlström, L	1
Bright-Asare, P	1
Whiten, JT	1
Barer, D	1
Ogilvie, A	1
Henry, D	1
Dronfield, M	1
Coggon, D	1
French, S	1
Ellis, S	1
Atkinson, M	1
Langman, M	2
Babb, RR	1
Carr-Locke, DL	1
Taverner, D	1
Wicks, AC	1
Baltás, B	3
Döbrönte, Z	2
Hencz, P	1
Tekulics, P	1
Stiel, D	1
Barnes, PR	1
Ruppin, DC	1
Byth, K	1
Heap, TR	1
Tryba, M	3
Zevounou, F	1
Grabhoefer, P	1
Seifert, V	1
Török, M	1
Fiddian-Green, RG	1
McGough, E	1
Pittenger, G	1
Rothman, E	1
Sommers, LS	1
Cunningham, E	1
Cohen, EM	1
Aron, JM	1
Marrone, GC	1
Silen, W	1
Gullo, A	1
Romano, E	1
Cassio, S	1
Pancrazio, F	1
Iadanza, L	1
Fassiolo, S	1
Vacri, A	1
Morón, F	1
Mózsik, G	1
Nagy, L	1
Patty, I	1
Tárnok, F	1
Jávor, T	1
Vadra, JE	1
Kischinefsky, JS	1
Altrudi, RD	1
Tolia, V	1
Dubois, RS	1
Kratzsch, KH	1
Stibenz, J	1
Kubisch, H	1
Kang, JY	3
Ng, SK	1
Guan, R	1
Uggeri, G	1
Monti, G	1
Rumi, A	1
Testone, G	1
Nagasue, N	1
Yukaya, H	1
Ogawa, Y	1
Sasaki, Y	1
Hirose, S	1
Wexler, MJ	1
Williams, JG	1
Romankiewicz, JA	1
Reidenberg, MM	1
Frankel, DH	1
Blackstone, MO	1
Foco, A	3
Garbarini, A	3
Bertoldo, U	1
Serenthà, U	1
Enrichens, F	2
Colombo, R	1
Festa, T	1
Sciascia, C	1
Mao, P	1
Rozzio, G	1
Ferraudo, G	1
Balique, JG	1
Dufraisse, G	1
Bayon, MC	1
Berger, JL	1
Espalieu, P	1
Cuilleret, J	1
Saga, T	1
Iemura, J	1
Noritake, S	1
Oku, H	1
Kawai, A	1
Liu, YL	1
Yuan, KJ	1
Wynne, GA	1
Bär, U	1
Hausamen, TU	1
Lingenberg, G	1
Pfleiderer, T	1
Raedsch, R	1
Saeger, HD	1
Sailer, S	1
Schwigon, CD	1
Seidel, G	1
Stiehl, A	1
Martin, J	1
Cano, N	1
Di Costanzo, J	1
Richieri, JP	1
Salomon, M	1
Deveze, JL	1
Courbier, R	1
Halloran, LG	1
Zfass, AM	1
Gayle, WE	1
Wheeler, CB	1
Miller, JD	1
Carstensen, HE	2
Bülow, S	2
Hansen, OH	2
Jakobsen, BH	2
Krarup, T	2
Pedersen, T	2
Raahave, D	1
Svendsen, LB	2
Backer, O	2
Rohde, H	1
Lorenz, W	3
Fischer, M	1
Hetzel, D	1
Snodgrass, PJ	1
Schiessel, R	3
Starlinger, M	1
Wolf, A	1
Pinggera, W	1
Zazgornik, J	1
Schmidt, P	1
Wagner, O	1
Schwarz, S	1
Piza, F	1
Stuart, FP	1
Reckard, CR	1
Schulak, JA	1
Ketel, BL	1
Fleshler, B	1
Olivero, S	1
Sigaudo, G	1
Vottero, G	1
Checchini, P	1
Benvenuti, C	1
Domján, L	1
Rothmund, M	3
Wagner, PK	2
Düsel, W	1
Lehmann, L	1
Rietbrock, I	1
Seez, P	1
Huchzermeyer, H	1
Pahlow, J	1
Hüsch, M	1
Van Leeuwen, P	1
Bröcker, JS	1
Bax, NM	1
Molenaar, JC	1
Wylie, CM	1
Anderson, LC	1
Mitchell, J	1
Ringler, DH	1
Bohr, DF	1
Menguy, R	1
Chhattriwalla, Y	1
Colon, AR	1
Scanlon, JW	1
Kitchens, CS	1
Kothari, T	1
Mangla, JC	1
Kalra, TM	1
Luk, GD	1
Räf, L	1
Zumtobel, V	2
Teichmann, RK	2
Inthorn, D	2
Siedek, M	1
Rommelsheim, K	1
Haag, A	1
Minchom, PE	1
Wheeler, MH	1
Sibert, JR	1
Adler, LE	1
Sadja, L	1
Wilets, G	1
Wehr, M	1
Schäfer, K	1
Bode, JC	1
Elashoff, JD	1
Richter, JE	1
Gerhardt, DC	1
Pasquale, DN	1
Castell, DO	1
Hetzel, DJ	1
Hecker, R	1
Shearman, DJ	1
Wara, P	2
Højsgaard, A	1
Amdrup, E	1
Rørbaek-Madsen, M	1
Fischer, L	1
Thomsen, H	1
Katschinski, B	1
Logan, R	1
Davies, J	1
Faulkner, G	1
Pearson, J	1
Dubracić, D	1
Pulanić, R	1
Katicić, M	1
Car, D	1
Georgijević, A	1
Cvitanović, B	1
Martin, LF	3
Booth, FV	2
Karlstadt, RG	1
Silverstein, JH	1
Jacobs, DM	1
Hampsey, J	1
Bowman, SC	1
D'Ambrosio, CA	1
Rockhold, FW	1
Fabian, TC	1
Boucher, BA	1
Croce, MA	1
Kuhl, DA	1
Janning, SW	1
Coffey, BC	1
Kudsk, KA	1
Zeltsman, D	1
Rowland, M	1
Shanavas, Z	1
Kerstein, MD	1
Raff, T	1
Germann, G	1
Hartmann, B	1
Grabarević, Z	1
Rotkvić, I	1
Sikirić, P	1
Seiwerth, S	1
Dzaja, P	1
Perić, J	1
Kos, J	1
Eloubeidi, M	1
Rockey, DC	1
Li, Y	1
Sha, W	1
Nie, Y	1
Wu, H	1
She, Q	1
Dai, S	1
Jia, L	1
Yu, W	1
MacDonald, AS	1
Pyne, DA	1
Freeman, AN	1
Holland, SG	1
Badley, BW	1
Ahonen, J	1
Eklund, B	1
Lindfors, O	1
Kuhlbäck, B	1
Lindström, BL	1
Mignon, M	1
Gislon, J	1
Bonfils, S	1
Staloch, DK	1
Simonowitz, DA	1
Dellinger, EP	1
Max, MH	1
Morris, T	1
Rhodes, J	1
Esposito, R	1
Hoste, P	1
Ingels, J	1
Elewaut, A	1
Barbier, F	1
Voget, E	1
Schollmeyer, P	1
Zulli, P	1
Di Nisio, Q	1
Hussey, JL	1
Belzer, FO	1
Hoare, AM	1
Bradby, GV	1
Hawkins, CF	2
Dykes, PW	2
Macklon, AF	1
Roberts, SH	1
James, O	1
Siegel, JH	1
Candido, FM	1
Rosenthal, WS	1
Procacciante, F	1
Citone, G	1
Montesani, C	1
Giannoni, F	1
Ribotta, G	1
Hoare, A	1
Mills, JG	1
Delchier, JC	1
Soule, JC	1
Bader, JP	1
Hecketsweiler, P	1
Le Grix, A	1
Métayer, P	1
Le Bihan, M	1
Ténière, P	1
Geffroy, Y	1
Marti, MC	1
Suter, P	1
Dubouloz, M	1
Simonian, SJ	1
Soroff, HS	1
Curtis, LE	1
La Brooy, SJ	1
Misiewicz, JJ	2
Edwards, J	1
Smith, PM	1
Haggie, SJ	1
Libman, L	1
Sarner, M	1
Wyllie, JH	1
Croker, J	1
Cotton, P	1
Råhave, D	1
Ewers, HR	1
Sircus, W	1
Schulz, F	1
Iskander, F	1
Abulata, NA	1
Galal, S	1
Pouchè, A	1
Agosti, A	1
Pettenati, V	1
Siewert, JR	1
Halter, F	1
Lauterbach, HH	1
Mattes, P	1
Bennett, JR	1
Nagler, J	1
Matsumoto, T	1
Kaibara, N	1
Sugimachi, K	1
Kawarada, Y	1
Mühe, E	1
Langman, MJ	4
Reines, HD	1
Deysach, LG	1
Kochman, RL	1
Erhardt, LJ	1
Geis, GS	1
Arora, A	3
Tandon, RK	3
Schäfer, U	1
Lindlar, R	1
Dietz, W	1
Stinner, B	1
Acharya, SK	2
Tandon, BN	2
Wolfe, MM	1
Janisch, HD	1
Shalev, O	1
Seror, D	1
Tulassay, Z	2
Bodnár, A	2
Szathmári, M	1
Papp, J	2
Farkas, I	1
Meier, R	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Multi-center, Randomised, Double-blind, Parallel-group Phase III Study to Assess High Dose Esomeprazole Na i.v. Treatment (Bolus Infusion of 80 mg Followed by a Continuous Infusion of 8 mg Per Hour Administered for 72 Hours) for Prevention of Rebleeding[NCT01757275]	Phase 3	239 participants (Actual)	Interventional	2013-02-28	Completed
Effects of Enteral Nutrition on Stress Ulcer Hemorrage. Multicenter Randomized Controlled[NCT03098537]		500 participants (Anticipated)	Interventional	2016-08-01	Recruiting
Comparison of High Dose Infusion and Low Dose Bolus Intravenous Omeprazole for Treatment of Bleeding Ulcer With Adherent Clot[NCT02536989]	Phase 4	40 participants (Actual)	Interventional	2009-03-31	Completed
Clinical Impact of Second-look Endoscopy After Endoscopic Submucosal Dissection of Gastric Neoplasm[NCT02005809]	Phase 3	268 participants (Anticipated)	Interventional	2013-03-31	Recruiting
Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit[NCT00633035]	Phase 4	60 participants (Actual)	Interventional	2007-09-30	Completed
Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis in Patients After Major Abdominal Surgery[NCT00839488]	Phase 4	6 participants (Actual)	Interventional	2008-04-30	Terminated (stopped due to the chief of GS left the hopsital and the successor did't want to keep on this study)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	blood units (Number)
Esomeprazole	18
Cimetidine	21

Intervention	blood units (Number)
Esomeprazole	14
Cimetidine	21

Intervention	participants (Number)
	No re-treatment	Re-treatment
Cimetidine	106	1
Esomeprazole	106	2

Intervention	participants (Number)
	No re-treatment	Re-treatment
Cimetidine	106	1
Esomeprazole	108	0

Intervention	participants (Number)
	No surgery	Surgery
Cimetidine	106	1
Esomeprazole	108	0

Intervention	participants (Number)
	No surgery	Surgery
Cimetidine	107	0
Esomeprazole	108	0

"Diagnostic criteria for clinically significant rebleeding based on either A, B or C:~A) Endoscopy - initiated by clinical signs of bleeding defined as one of B1 or B2 or B3 and endoscopic verification, ie one of A1 or A2.~A1: Blood in stomach (this criteria cannot be used during the first 6 hours after primary endoscopic haemostasis). A2: A verified active bleeding from a peptic ulcer (Forrest Ia, Ib).~B) A true clinically based definition, at least two of B1 and/or B2 and/or B3. B1: Vomiting of fresh blood or fresh blood in a gastric tube or haematochezia or melaena after a normal stool. B2: Decrease in Hb >20g/L (or Hct >6%) during 24 hours or an increase in Hb <10g/L (or Hct <3%) despite ≥2 units of blood has been transfused during 24hours. B3: Unstable circulation systolic blood pressure ≤ 90 mmHg or pulse ≥110/min (after have had a stable circulation).~C) Haematemesis. Vomiting significant amounts (>200 ml) of fresh blood as estimated by the investigator." (NCT01757275)
Timeframe: 30 days

Rate of Clinically Significant Rebleeding During 7 Days

Intervention	participants (Number)
	No rebleeding	Rebleeding
Cimetidine	101	6
Esomeprazole	105	3

Rate of Clinically Significant Rebleeding Within 72 Hours

Article	Year
The efficacy and safety of proton pump inhibitors vs histamine-2 receptor antagonists for stress ulcer bleeding prophylaxis among critical care patients: a meta-analysis. Critical care medicine, 2010, Volume: 38, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Cimetidine; Critical Care; Histamine H2 Antagonists; Humans	2010
Stress-ulcer prophylaxis for general medical patients: a review of the evidence. Journal of hospital medicine, 2007, Volume: 2, Issue:2 Topics: Aluminum Hydroxide; Antacids; Anti-Ulcer Agents; Cimetidine; Humans; Magnesium Hydroxide; Peptic Ulc	2007
[Diagnosis, treatment and prevention of acute gastroduodenal ulcers (review of the literature)]. Vrachebnoe delo, 1981, Issue:6 Topics: Cimetidine; Electrocoagulation; Embolization, Therapeutic; Histamine H2 Antagonists; Humans; Peptic	1981
[Clinical importance of antagonists of histamine H2 receptors in gastroenterology]. La Clinica terapeutica, 1984, Mar-31, Volume: 108, Issue:6 Topics: Cimetidine; Drug Resistance; Duodenal Ulcer; Gastroesophageal Reflux; Histamine H2 Antagonists; Huma	1984
[New ulcer drugs: is cimetidine out of date?]. Therapeutische Umschau. Revue therapeutique, 1982, Volume: 39, Issue:11 Topics: Aluminum; Anti-Ulcer Agents; Cimetidine; Duodenal Ulcer; Esophagitis, Peptic; Furans; Guanidines; Hu	1982
Cimetidine in preventing or treating acute upper gastrointestinal tract hemorrhage. The Western journal of medicine, 1984, Volume: 140, Issue:3 Topics: Antacids; Cimetidine; Clinical Trials as Topic; Gastric Acid; Gastric Juice; Gastrointestinal Hemorr	1984
Pathogenesis, diagnosis and treatment of acute gastric mucosal lesions. Clinics in gastroenterology, 1984, Volume: 13, Issue:2 Topics: Antacids; Cimetidine; Endoscopy; Gastrectomy; Gastric Acid; Gastric Mucosa; Humans; Hydrogen-Ion Con	1984
The impact of cimetidine on the treatment of acid-peptic disease. Primary care, 1981, Volume: 8, Issue:2 Topics: Cimetidine; Duodenal Ulcer; Esophagitis, Peptic; Gastritis; Gastrointestinal Hemorrhage; Guanidines;	1981
Antacids and peptic ulcer--a reappraisal. Gut, 1979, Volume: 20, Issue:6 Topics: Aluminum Hydroxide; Antacids; Calcium Carbonate; Cimetidine; Clinical Trials as Topic; Double-Blind	1979
[The therapeutic importance of cimetidine (Tagamet) (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1978, Nov-03, Volume: 120, Issue:44 Topics: Adult; Cimetidine; Diarrhea; Female; Galactorrhea; Gastritis; Guanidines; Gynecomastia; Headache; Hu	1978
[Cimetidine. Clinical pharmacology and toxicity (author's transl)]. La Nouvelle presse medicale, 1978, May-20, Volume: 7, Issue:20 Topics: Cimetidine; Gastric Juice; Gastrins; Gastrointestinal Hemorrhage; Guanidines; Humans; Peptic Ulcer;	1978
Recent advances in the pathogenesis and control of massive upper gastrointestinal hemorrhage. Surgery annual, 1979, Volume: 11 Topics: Anticoagulants; Cimetidine; Clinical Trials as Topic; Evaluation Studies as Topic; Gastrectomy; Gast	1979
[Acid reducing drugs for prevention of stress ulcer: cause for the development of nosocomial pneumonia? Arguments pro]. Zeitschrift fur Gastroenterologie, 1991, Volume: 29 Suppl 1 Topics: Anti-Ulcer Agents; Cimetidine; Colony Count, Microbial; Critical Care; Cross Infection; Gastric Acid	1991
[Octreotide in the treatment of peptic hemorrhages]. Zeitschrift fur Gastroenterologie, 1990, Volume: 28 Suppl 2 Topics: Cimetidine; Clinical Trials as Topic; Double-Blind Method; Humans; Octreotide; Peptic Ulcer Hemorrha	1990
[Hemorrhagic gastroduodenal ulcer: contribution of new medical treatments]. Annales de chirurgie, 1989, Volume: 43, Issue:1 Topics: Antacids; Cimetidine; Duodenoscopy; Electrocoagulation; Gastroscopy; Humans; Injections; Lasers; Lig	1989
[Somatostatin in gastroenterological therapy]. Schweizerische medizinische Wochenschrift. Supplementum, 1985, Volume: 19 Topics: Acute Disease; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Esophageal and Gastric Var	1985
Role of histamine H2 receptor antagonists in nonoperative management of gastroduodenal ulcer haemorrhage. Scandinavian journal of gastroenterology. Supplement, 1987, Volume: 137 Topics: Acute Disease; Cimetidine; Histamine H2 Antagonists; Humans; Peptic Ulcer Hemorrhage; Stomach Ulcer	1987
[Treatment of recurrent ulcers after vagotomy]. Vestnik khirurgii imeni I. I. Grekova, 1987, Volume: 138, Issue:1 Topics: Cimetidine; Gastrectomy; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Peptic Ulcer Perforation; Po	1987
[Recent state of therapy of peptic disease]. Harefuah, 1985, Nov-15, Volume: 109, Issue:10 Topics: Antacids; Anti-Ulcer Agents; Cimetidine; Gastric Acid; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage	1985
Stress-ulcers. A review. Acta anaesthesiologica Belgica, 1985, Volume: 36, Issue:4 Topics: Acute Disease; Antacids; Cimetidine; Drug Therapy, Combination; Humans; Peptic Ulcer; Peptic Ulcer H	1985

Article	Year
Intravenous Esomeprazole for Prevention of Peptic Ulcer Rebleeding: A Randomized Trial in Chinese Patients. Advances in therapy, 2015, Volume: 32, Issue:11 Topics: Adult; Aged; China; Cimetidine; Double-Blind Method; Esomeprazole; Female; Gastrointestinal Agents;	2015
Role of intravenous omeprazole in patients with high-risk peptic ulcer bleeding after successful endoscopic epinephrine injection: a prospective randomized comparative trial. The American journal of gastroenterology, 2006, Volume: 101, Issue:3 Topics: Adult; Aged; Anti-Ulcer Agents; Blood Transfusion; Cimetidine; Drug Administration Schedule; Electro	2006
Effect of a proton pump inhibitor or an H2-receptor antagonist on prevention of bleeding from ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial. The American journal of gastroenterology, 2007, Volume: 102, Issue:8 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Cimetidi	2007
Ranitidine versus cimetidine in the management of acute upper gastrointestinal tract bleeding. Journal of clinical gastroenterology, 1984, Volume: 6, Issue:4 Topics: Acute Disease; Adult; Aged; Blood Transfusion; Cimetidine; Clinical Trials as Topic; Double-Blind Me	1984
Somatostatin and cimetidine in peptic-ulcer haemorrhage. A randomised controlled trial. Lancet (London, England), 1980, Apr-19, Volume: 1, Issue:8173 Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Female; Guanidines; Hormones; Hum	1980
Somatostatin in peptic ulcer. Lancet (London, England), 1980, Jun-14, Volume: 1, Issue:8181 Topics: Cimetidine; Double-Blind Method; Guanidines; Humans; Peptic Ulcer Hemorrhage; Somatostatin	1980
Somatostatin in peptic ulcer bleeding. Lancet (London, England), 1980, Jul-26, Volume: 2, Issue:8187 Topics: Cimetidine; Clinical Trials as Topic; Humans; Peptic Ulcer Hemorrhage; Somatostatin	1980
[Somatostatin and cimetidine in peptic ulcer hemorrhage. A randomized controlled study]. Zeitschrift fur Gastroenterologie, 1980, Volume: 18, Issue:6 Topics: Cimetidine; Female; Guanidines; Humans; Male; Peptic Ulcer Hemorrhage; Random Allocation; Somatostat	1980
Therapy and prevention of gastroduodenal ulcer bleeding by somatostatin, secretin or cimetidine. Hepato-gastroenterology, 1981, Volume: 28, Issue:6 Topics: Cimetidine; Clinical Trials as Topic; Guanidines; Humans; Peptic Ulcer Hemorrhage; Secretin; Somatos	1981
Somatostatin in the treatment of severe gastrointestinal bleeding from peptic origin. A multicentric controlled trial. The Italian journal of surgical sciences, 1984, Volume: 14, Issue:1 Topics: Acute Disease; Adolescent; Adult; Aged; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Female	1984
Somatostatin in peptic ulcer bleeding--results of a double-blind controlled trial. International journal of clinical pharmacology research, 1983, Volume: 3, Issue:5 Topics: Age Factors; Aged; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male;	1983
[Ranitidine and cimetidine in the prevention of stress: ulcer hemorrhage a prospective comparative multicenter study]. Langenbecks Archiv fur Chirurgie, 1984, Volume: 362, Issue:2 Topics: Adolescent; Adult; Aged; Cimetidine; Clinical Trials as Topic; Female; Germany, West; Humans; Intens	1984
Treatment of acute massive gastroduodenal haemorrhage with cimetidine in elderly patients. Annales chirurgiae et gynaecologiae, 1984, Volume: 73, Issue:2 Topics: Acute Disease; Aged; Blood Transfusion; Cimetidine; Double-Blind Method; Female; Gastrointestinal He	1984
Cimetidine and tranexamic acid in the treatment of acute upper-gastrointestinal-tract bleeding. The New England journal of medicine, 1983, Jun-30, Volume: 308, Issue:26 Topics: Acute Disease; Aged; Cimetidine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Double-Blind	1983
Cimetidine in preventing or treating acute upper gastrointestinal tract hemorrhage. The Western journal of medicine, 1984, Volume: 140, Issue:3 Topics: Antacids; Cimetidine; Clinical Trials as Topic; Gastric Acid; Gastric Juice; Gastrointestinal Hemorr	1984
Cimetidine therapy does not prevent rebleeding from peptic ulceration. Postgraduate medical journal, 1984, Volume: 60, Issue:704 Topics: Aged; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Female; Humans; Mal	1984
Randomized prospective trial of cimetidine in the treatment of acute upper gastrointestinal haemorrhage. Acta chirurgica Hungarica, 1984, Volume: 25, Issue:3 Topics: Acute Disease; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Female; Gastrointestinal H	1984
[Cimetidine therapy of stress ulcer caused by life-threatening illnesses in children]. Orvosi hetilap, 1984, Aug-12, Volume: 125, Issue:33 Topics: Adolescent; Child; Child, Preschool; Cimetidine; Clinical Trials as Topic; Humans; Infant; Peptic Ul	1984
Cimetidine reduces the risk of rebleeding from duodenal ulcers displaying signs of recent haemorrhage. Scandinavian journal of gastroenterology, 1984, Volume: 19, Issue:6 Topics: Cimetidine; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Female; Humans; Male; Mid	1984
[Prevention of acute stress hemorrhages of the upper gastrointestinal tract with pirenzepine and antacids. A controlled comparison between pirenzepine and cimetidine]. Anasthesie, Intensivtherapie, Notfallmedizin, 1984, Volume: 19, Issue:5 Topics: Antacids; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Critical Care;	1984
Prophylaxis of upper gastrointestinal bleeding with cimetidine in patients undergoing partial hepatectomy. Annales chirurgiae et gynaecologiae, 1984, Volume: 73, Issue:1 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Female; Hepatectomy; Humans; Liver	1984
Emergency management of upper gastrointestinal bleeding. Comprehensive therapy, 1982, Volume: 8, Issue:8 Topics: Cimetidine; Clinical Trials as Topic; Emergencies; Esophageal and Gastric Varices; Gastrointestinal	1982
[Comparative treatment of gastroduodenal haemorrhage with secretin and cimetidine]. Deutsche medizinische Wochenschrift (1946), 1982, Dec-03, Volume: 107, Issue:48 Topics: Adult; Cimetidine; Female; Gastrointestinal Hemorrhage; Guanidines; Humans; Male; Mathematics; Pepti	1982
Prevention of acute gastrointestinal complications after severe head injury: a controlled trial of cimetidine prophylaxis. American journal of surgery, 1980, Volume: 139, Issue:1 Topics: Adolescent; Adult; Brain Injuries; Child; Cimetidine; Clinical Trials as Topic; Double-Blind Method;	1980
Cimetidine for severe gastroduodenal haemorrhage: a randomized controlled trial. Scandinavian journal of gastroenterology, 1980, Volume: 15, Issue:1 Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Emergencies;	1980
[A randomized clinical study of stress ulcer prophylaxis with cimeytidine in severe multiple injuries]. Zeitschrift fur Gastroenterologie, 1980, Volume: 18, Issue:6 Topics: Cimetidine; Clinical Trials as Topic; Guanidines; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Ran	1980
Prevention or cure for stress-induced gastrointestinal bleeding? British medical journal, 1980, Nov-15, Volume: 281, Issue:6251 Topics: Animals; Antacids; Cimetidine; Clinical Trials as Topic; Guanidines; Humans; Peptic Ulcer Hemorrhage	1980
Proven clinical uses of cimetidine. The Journal of the Indiana State Medical Association, 1980, Volume: 73, Issue:11 Topics: Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Esophagitis, Peptic; Guanidines; Humans; Pepti	1980
[Double-blind evaluation of the effectiveness of cimetidine in the arrest of hemorrhages due to gastroduodenal peptic lesions]. Minerva chirurgica, 1981, Oct-15, Volume: 36, Issue:19 Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Female; Guanidines; Humans;	1981
[Cimetidine therapy of hemorrhage caused by acute ulcerative lesions]. Orvosi hetilap, 1982, Feb-07, Volume: 123, Issue:6 Topics: Acute Disease; Cimetidine; Clinical Trials as Topic; Guanidines; Humans; Peptic Ulcer Hemorrhage; Pr	1982
[Effect of cimetidine and secretin on acute bleedings from gastroduodenal ulcers and erosions: a prospective study (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1982, Feb-19, Volume: 107, Issue:7 Topics: Cimetidine; Guanidines; Humans; Peptic Ulcer Hemorrhage; Prospective Studies; Recurrence; Secretin;	1982
Prognostic factors in upper gastrointestinal bleeding. Digestive diseases and sciences, 1994, Volume: 39, Issue:4 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Duodenal Ulcer; Female	1994
Continuous intravenous cimetidine decreases stress-related upper gastrointestinal hemorrhage without promoting pneumonia. Critical care medicine, 1993, Volume: 21, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cimetidine; Critical Care; Cross Infection; Double-Blind	1993
Continuous intravenous cimetidine decreases stress-related upper gastrointestinal hemorrhage without promoting pneumonia. Critical care medicine, 1993, Volume: 21, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cimetidine; Critical Care; Cross Infection; Double-Blind	1993
Continuous intravenous cimetidine decreases stress-related upper gastrointestinal hemorrhage without promoting pneumonia. Critical care medicine, 1993, Volume: 21, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cimetidine; Critical Care; Cross Infection; Double-Blind	1993
Continuous intravenous cimetidine decreases stress-related upper gastrointestinal hemorrhage without promoting pneumonia. Critical care medicine, 1993, Volume: 21, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cimetidine; Critical Care; Cross Infection; Double-Blind	1993
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis. Archives of surgery (Chicago, Ill. : 1960), 1993, Volume: 128, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I	1993
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis. Archives of surgery (Chicago, Ill. : 1960), 1993, Volume: 128, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I	1993
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis. Archives of surgery (Chicago, Ill. : 1960), 1993, Volume: 128, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I	1993
Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis. Archives of surgery (Chicago, Ill. : 1960), 1993, Volume: 128, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; I	1993
A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcers after successful endoscopic therapy. Gastrointestinal endoscopy, 1999, Volume: 50, Issue:2 Topics: Administration, Oral; Anti-Ulcer Agents; Cimetidine; Combined Modality Therapy; Dose-Response Relati	1999
Effect of intragastric pH on control of peptic ulcer bleeding. Journal of gastroenterology and hepatology, 2000, Volume: 15, Issue:2 Topics: Adolescent; Adult; Aged; Animals; Anti-Ulcer Agents; Cimetidine; Duodenal Ulcer; Female; Gastric Aci	2000
Antacids and peptic ulcer--a reappraisal. Gut, 1979, Volume: 20, Issue:6 Topics: Aluminum Hydroxide; Antacids; Calcium Carbonate; Cimetidine; Clinical Trials as Topic; Double-Blind	1979
Cimetidine in renal-transplant recipients. Lancet (London, England), 1979, May-19, Volume: 1, Issue:8125 Topics: Cimetidine; Drug Evaluation; Female; Guanidines; Humans; Kidney Transplantation; Male; Peptic Ulcer;	1979
Cimetidine in bleeding peptic ulcer. Lancet (London, England), 1979, Sep-29, Volume: 2, Issue:8144 Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Female; Follow-Up Studies; Guanid	1979
Cimetidine in bleeding peptic ulcer. Lancet (London, England), 1979, Nov-24, Volume: 2, Issue:8152 Topics: Aged; Chlorpheniramine; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Guanidines; Humans; Pe	1979
Treatment of acute upper gastro-intestinal bleeding with cimetidine. Scottish medical journal, 1977, Volume: 22, Issue:4 Topics: Acute Disease; Adult; Cimetidine; Clinical Trials as Topic; Drug Evaluation; Duodenal Ulcer; Guanidi	1977
[Treatment of bleeding due to peptic ulcer with cimetidine. A double blind trial (author's transl)]. Gastroenterologie clinique et biologique, 1978, Volume: 2, Issue:10 Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Female; Guanidines; Hemostas	1978
[Cimetidine prevention of stress ulcers]. Schweizerische medizinische Wochenschrift, 1979, Apr-21, Volume: 109, Issue:16 Topics: Antacids; Cimetidine; Clinical Trials as Topic; Drug Evaluation; Guanidines; Humans; Peptic Ulcer; P	1979
[Prevention and therapy of gastroduodenal stress hemorrhage in intensive care patients using the histamine H2-receptor antagonist cimetidine]. Chirurgisches Forum fur experimentelle und klinische Forschung, 1979 Topics: Cimetidine; Clinical Trials as Topic; Drug Evaluation; Gastrointestinal Hemorrhage; Guanidines; Huma	1979
Recent advances in the pathogenesis and control of massive upper gastrointestinal hemorrhage. Surgery annual, 1979, Volume: 11 Topics: Anticoagulants; Cimetidine; Clinical Trials as Topic; Evaluation Studies as Topic; Gastrectomy; Gast	1979
Controlled trial of cimetidine in upper gastrointestinal haemorrhage. Gut, 1979, Volume: 20, Issue:10 Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Female; Gastrointestinal Hem	1979
[Cimetidine treatment of bleeding ulcer. A controlled randomized study]. Ugeskrift for laeger, 1979, Nov-26, Volume: 141, Issue:48 Topics: Cimetidine; Clinical Trials as Topic; Double-Blind Method; Female; Guanidines; Humans; Male; Peptic	1979
Stress ulcers and organ failure in intubated patients in surgical intensive care units. Annals of surgery, 1992, Volume: 215, Issue:4 Topics: Cause of Death; Cimetidine; Critical Care; Double-Blind Method; Female; Follow-Up Studies; Gastrosco	1992
Treating bleeding peptic ulcer with sustained achlorhydria. Gastroenterologia Japonica, 1991, Volume: 26 Suppl 3 Topics: Adult; Antacids; Cimetidine; Drug Therapy, Combination; Female; Gastric Acid; Gastric Acidity Determ	1991
The role of sustained achlorhydria in bleeding peptic ulcer. Journal of clinical gastroenterology, 1991, Volume: 13, Issue:2 Topics: Adult; Aluminum Hydroxide; Antacids; Cimetidine; Drug Combinations; Female; Humans; Infusions, Paren	1991
[Secretin versus cimetidine in the therapy of active bleeding from peptic gastroduodenal lesions. A prospective, randomized, double-blind, multicentric study]. Wiener medizinische Wochenschrift (1946), 1990, Jul-15, Volume: 140, Issue:13 Topics: Adolescent; Adult; Aged; Cimetidine; Double-Blind Method; Humans; Middle Aged; Multicenter Studies a	1990
Somatostatin versus cimetidine in the treatment of actively bleeding duodenal ulcer: a prospective, randomized, controlled trial. The American journal of gastroenterology, 1989, Volume: 84, Issue:1 Topics: Aged; Cimetidine; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Peptic Ulcer Hemorrhage; Prospe	1989
Histamine2-receptor antagonists in gastroduodenal ulcer haemorrhage. Scandinavian journal of gastroenterology. Supplement, 1985, Volume: 110 Topics: Aged; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Histamine H2 Antagonists; Humans; Male;	1985
[Somatostatin in gastroenterological therapy]. Schweizerische medizinische Wochenschrift. Supplementum, 1985, Volume: 19 Topics: Acute Disease; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Esophageal and Gastric Var	1985
Somatostatin in the treatment of severe upper gastrointestinal bleeding: a multicentre controlled trial. The British journal of surgery, 1986, Volume: 73, Issue:10 Topics: Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans	1986
Controlled trial of endoscopic sclerosis in bleeding peptic ulcers. Lancet (London, England), 1987, Dec-05, Volume: 2, Issue:8571 Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Endoscopy; Epinephrine; Humans; M	1987
Somatostatin compared with cimetidine in the treatment of bleeding peptic ulcer without visible vessel. Alimentary pharmacology & therapeutics, 1988, Volume: 2, Issue:2 Topics: Aged; Cimetidine; Double-Blind Method; Female; Humans; Male; Middle Aged; Peptic Ulcer; Peptic Ulcer	1988
Intragastric pH monitoring in acute upper gastrointestinal bleeding and the effect of intravenous cimetidine and ranitidine. Alimentary pharmacology & therapeutics, 1987, Volume: 1, Issue:1 Topics: Aged; Cimetidine; Duodenal Ulcer; Female; Gastric Acidity Determination; Humans; Injections, Intrave	1987
Cimetidine prophylaxis for gastrointestinal bleeding in an intensive care unit. Gut, 1986, Volume: 27, Issue:2 Topics: Adolescent; Adult; Aged; Cimetidine; Double-Blind Method; Female; Gastrointestinal Hemorrhage; Human	1986
Prophylactic therapy for stress ulcer bleeding: a reappraisal. Annals of internal medicine, 1987, Volume: 106, Issue:4 Topics: Antacids; Cimetidine; Clinical Trials as Topic; Humans; Peptic Ulcer Hemorrhage; Prospective Studies	1987
[Prevention of stress ulcers with cimetidine and ranitidine. Comparative studies within the scope of cardiosurgical interventions]. Wiener medizinische Wochenschrift (1946), 1986, Sep-30, Volume: 136, Issue:18 Topics: Cimetidine; Critical Care; Duodenal Ulcer; Female; Gastric Acidity Determination; Heart Diseases; Hu	1986
A comparison of cimetidine and sucralfate in the treatment of bleeding peptic ulcers. The American journal of gastroenterology, 1985, Volume: 80, Issue:1 Topics: Aluminum; Blood Transfusion; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Humans; Peptic Ul	1985
Prophylaxis for acute stress ulcers. Antacids or cimetidine. The American surgeon, 1985, Volume: 51, Issue:9 Topics: Acute Disease; Antacids; Cimetidine; Clinical Trials as Topic; Humans; Intubation, Gastrointestinal;	1985
Prevention of stress-induced upper gastrointestinal bleeding by cimetidine in patients on assisted ventilation. Digestion, 1985, Volume: 31, Issue:1 Topics: Adult; Aged; Cimetidine; Critical Care; Double-Blind Method; Female; Gastric Acidity Determination;	1985

Article	Year
History in our lifetime: the changing nature of refractory duodenal ulcer in the era of histamine H2 receptor antagonists. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2003, Volume: 35, Issue:8 Topics: Adult; Cimetidine; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; D	2003
[Duodenal ulcer in a newborn]. Annales de pediatrie, 1978, Volume: 25, Issue:9 Topics: Anti-Ulcer Agents; Blood Transfusion; Cesarean Section; Cimetidine; Combined Modality Therapy; Cryot	1978
[Stress ulcer prophylaxis in septic patients. Evidence-based overview]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2008, Volume: 43, Issue:5 Topics: Anti-Ulcer Agents; Cimetidine; Duodenal Ulcer; Evidence-Based Medicine; Gastric Acid; Gastrointestin	2008
[H2 receptor blockaders: domains for oral use. Indications for cimetidine and ranitidine in gastroenterology]. Fortschritte der Medizin, 1984, Feb-23, Volume: 102, Issue:8 Topics: Administration, Oral; Cimetidine; Duodenitis; Esophagitis, Peptic; Exocrine Pancreatic Insufficiency	1984
Somatostatin for cimetidine-resistant gastroduodenal haemorrhage. Lancet (London, England), 1980, Oct-25, Volume: 2, Issue:8200 Topics: Adult; Aged; Cimetidine; Drug Evaluation; Duodenal Ulcer; Female; Guanidines; Humans; Male; Middle A	1980
Cimetidine and somatostatin in gastroduodenal haemorrhage. Lancet (London, England), 1981, Apr-04, Volume: 1, Issue:8223 Topics: Cimetidine; Guanidines; Hemostasis; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Platelet Aggregat	1981
Cimetidine and somatostatin in gastroduodenal haemorrhage. Lancet (London, England), 1981, Mar-07, Volume: 1, Issue:8219 Topics: Cimetidine; Guanidines; Humans; Peptic Ulcer Hemorrhage; Platelet Aggregation; Somatostatin	1981
[Prevention of stress-induced hemorrhage of the upper gastrointestinal tract]. MMW, Munchener medizinische Wochenschrift, 1981, Jun-05, Volume: 123, Issue:23 Topics: Antacids; Cimetidine; Drug Resistance; Gastric Acidity Determination; Histamine H2 Antagonists; Huma	1981
[Stress ulcerations: pathogenesis and prevention]. Zeitschrift fur Gastroenterologie, 1983, Volume: 21 Suppl Topics: Animals; Antacids; Brain Injuries; Burns; Cimetidine; Histamine H2 Antagonists; Humans; Peptic Ulcer	1983
[Drug therapy and prevention of acute upper gastrointestinal hemorrhage]. Zeitschrift fur Gastroenterologie, 1983, Volume: 21, Issue:6 Topics: Acute Disease; Anti-Ulcer Agents; Cimetidine; Esophageal and Gastric Varices; Gastrointestinal Hemor	1983
Gastrointestinal bleeding. Postgraduate medical journal, 1984, Volume: 60, Issue:709 Topics: Acute Disease; Adult; Age Factors; Aged; Cimetidine; Duodenal Ulcer; Female; Gastrointestinal Hemorr	1984
Duodenal ulcer: a disease in evolution. Current problems in surgery, 1984, Volume: 21, Issue:1 Topics: Adult; Aged; Aluminum; Antacids; Cimetidine; Duodenal Ulcer; Female; Gastrectomy; Humans; Male; Midd	1984
[Pharmacoprophylaxis of hemorrhage in stress ulcer]. La Clinica terapeutica, 1983, Nov-15, Volume: 107, Issue:3 Topics: Aluminum Hydroxide; Antacids; Cimetidine; Drug Combinations; Humans; Magnesium Hydroxide; Peptic Ulc	1983
Prostaglandins, gastroduodenal ulcer and hemorrhagic gastritis. Clinical physiology and biochemistry, 1984, Volume: 2, Issue:2-3 Topics: Animals; Cimetidine; Dogs; Double-Blind Method; Female; Fluorouracil; Gastritis; Gastrointestinal He	1984
Predictive value of intramural pH and other risk factors for massive bleeding from stress ulceration. Gastroenterology, 1983, Volume: 85, Issue:3 Topics: Adolescent; Adult; Aged; Animals; Antacids; Bicarbonates; Carbon Dioxide; Child; Child, Preschool; C	1983
Evaluation of cimetidine usage in a community teaching hospital. QRB. Quality review bulletin, 1983, Volume: 9, Issue:8 Topics: Cimetidine; Drug Utilization; Duodenal Ulcer; Esophageal Neoplasms; Hospitals, Community; Hospitals,	1983
[Stress ulcer: role of cimetidine in the critical patient]. Minerva anestesiologica, 1984, Volume: 50, Issue:3 Topics: Adolescent; Adult; Aged; Cimetidine; Female; Humans; Male; Middle Aged; Peptic Ulcer; Peptic Ulcer H	1984
Evidence for the existence of gastric cytoprotective effect of atropine and cimetidine in humans. Acta physiologica Hungarica, 1984, Volume: 64, Issue:3-4 Topics: Adult; Atropine; Cimetidine; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastric Mucosa;	1984
[Acute bleeding digestive lesions]. Acta gastroenterologica Latinoamericana, 1983, Volume: 13, Issue:1 Topics: Acute Disease; Animals; Cimetidine; Diazepam; Dogs; Drug Therapy, Combination; Female; Gastrointesti	1983
Peptic ulcer disease in children and adolescents. A ten-year experience. Clinical pediatrics, 1983, Volume: 22, Issue:10 Topics: Adolescent; Antacids; Child; Child, Preschool; Cimetidine; Female; Humans; Infant; Infant, Newborn;	1983
[Indications for the surgical treatment of peptic ulcer from the internal medicine viewpoint]. Zeitschrift fur arztliche Fortbildung, 1983, Volume: 77, Issue:19 Topics: Aged; Antacids; Cimetidine; Diagnosis, Differential; Duodenal Ulcer; Emergencies; Female; Humans; Ma	1983
The use of one gram daily cimetidine in the treatment of peptic ulcer in Singapore. Annals of the Academy of Medicine, Singapore, 1983, Volume: 12, Issue:4 Topics: Adult; Aged; Cimetidine; Drug Evaluation; Duodenal Ulcer; Dyspepsia; Female; Humans; Male; Middle Ag	1983
[Short-term effects of cimetidine in patients with bleeding duodenal ulcer. Presentation of cases]. Chirurgia italiana, 1983, Volume: 35, Issue:5 Topics: Adult; Aged; Antacids; Cimetidine; Duodenal Ulcer; Female; Gastrectomy; Humans; Male; Middle Aged; P	1983
Management of gastrointestinal bleeding. British medical journal (Clinical research ed.), 1981, Oct-10, Volume: 283, Issue:6297 Topics: Cimetidine; Gastrointestinal Hemorrhage; Guanidines; Humans; Peptic Ulcer Hemorrhage	1981
[The present state of knowledge on the treatment of peptic diseases with cimetidine]. Der Internist, 1981, Volume: 22, Issue:12 Topics: Cimetidine; Double-Blind Method; Duodenal Ulcer; Esophagitis, Peptic; Gastric Acid; Guanidines; Half	1981
Cimetidine and antacids. Annals of internal medicine, 1983, Volume: 98, Issue:3 Topics: Antacids; Cimetidine; Guanidines; Humans; Peptic Ulcer Hemorrhage	1983
[Retrospective clinical study of the effectiveness of cimetidine in hemorrhages caused by chronic gastroduodenal peptic lesions]. Minerva chirurgica, 1983, Feb-15, Volume: 38, Issue:3 Topics: Adult; Aged; Cimetidine; Drug Evaluation; Female; Guanidines; Humans; Male; Middle Aged; Peptic Ulce	1983
[Value of sulpiride in the prevention and treatment of stress ulcer. Apropos of 3 cases]. Annales de chirurgie, 1983, Volume: 37, Issue:1 Topics: Adult; Cimetidine; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Peptic Ulcer; Pepti	1983
[Stress ulcer after open heart surgery]. Rinsho kyobu geka = Japanese annals of thoracic surgery, 1983, Volume: 3, Issue:1 Topics: Cardiac Surgical Procedures; Cimetidine; Coronary Disease; Duodenal Ulcer; Electrocoagulation; Human	1983
Prevention of stress ulcer bleeding with cimetidine in severe burns. Burns, including thermal injury, 1983, Volume: 9, Issue:5 Topics: Adolescent; Adult; Aged; Burns; Cimetidine; Gastric Acidity Determination; Guanidines; Humans; Middl	1983
Nursing care study. Peptic ulcer: bleeding on the inside. Nursing mirror, 1981, Jul-08, Volume: 153, Issue:2 Topics: Adult; Cimetidine; Duodenal Ulcer; Humans; Male; Peptic Ulcer Hemorrhage	1981
[Prevention of gastroduodenal complications in coronary surgery. Usefulness of preoperative fiberoscopy]. La Nouvelle presse medicale, 1982, Oct-09, Volume: 11, Issue:39 Topics: Antacids; Cimetidine; Coronary Artery Bypass; Coronary Disease; Duodenal Diseases; Endoscopy; Female	1982
Failure of cimetidine to prevent gastroduodenal ulceration and bleeding after renal transplantation. Surgery, 1981, Volume: 90, Issue:3 Topics: Adolescent; Adult; Cimetidine; Female; Guanidines; Humans; Kidney Failure, Chronic; Kidney Transplan	1981
Gastroduodenal complications in kidney transplant recipients. Annals of surgery, 1981, Volume: 194, Issue:3 Topics: Adult; Antacids; Cimetidine; Female; Gastric Juice; Graft Survival; Humans; Kidney Transplantation;	1981
[Cimetidine with suture ligature of ulcers - an alternative in the treatment of severe acute gastroduodenal ulcer hemorrhage]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1982, Volume: 53, Issue:10 Topics: Acute Disease; Cimetidine; Female; Germany, West; Guanidines; Humans; Ligation; Male; Middle Aged; P	1982
[Prevention of stress-induced hemorrhages with cimetidin and antacids in long-term intensive care patients]. Intensivmedizinische Praxis, 1982, Volume: 5 Topics: Antacids; Cimetidine; Drug Therapy, Combination; Guanidines; Humans; Intensive Care Units; Peptic Ul	1982
The effect of cimetidine on a bleeding peptic ulcer due to a gastrojejunostomy for duodenal atresia. Journal of pediatric surgery, 1981, Volume: 16, Issue:2 Topics: Child; Cimetidine; Duodenum; Guanidines; Humans; Intestinal Atresia; Male; Peptic Ulcer Hemorrhage;	1981
The complex wane of peptic ulcer. II. Trends in duodenal and gastric ulcer admissions to 790 hospitals, 1974-1979. Journal of clinical gastroenterology, 1981, Volume: 3, Issue:4 Topics: Adolescent; Adult; Aged; Cimetidine; Duodenal Ulcer; Hospitalization; Humans; Length of Stay; Middle	1981
Cimetidine prophylaxis for gastric ulcers in laboratory swine. Laboratory animal science, 1981, Volume: 31, Issue:5 Pt 1 Topics: Animals; Cimetidine; Guanidines; Peptic Ulcer Hemorrhage; Stomach; Stomach Ulcer; Swine; Swine Disea	1981
The prophylaxis of stress ulceration. The New England journal of medicine, 1980, Feb-21, Volume: 302, Issue:8 Topics: Animals; Antacids; Burns; Cimetidine; Gastric Mucosa; Guanidines; Humans; Intestinal Mucosa; Ischemi	1980
The use of cimetidine in the newborn. Pediatrics, 1980, Volume: 65, Issue:2 Topics: Cimetidine; Esophagitis, Peptic; Guanidines; Humans; Infant, Newborn; Infant, Premature, Diseases; P	1980
Lack of antiplatelet effect of cimetidine in hemophiliacs. Southern medical journal, 1980, Volume: 73, Issue:3 Topics: Aged; Blood Platelets; Cimetidine; Duodenal Ulcer; Guanidines; Hemophilia A; Humans; Male; Middle Ag	1980
Barrett's ulcer and treatment with cimetidine. Archives of internal medicine, 1980, Volume: 140, Issue:4 Topics: Aged; Cimetidine; Esophageal Diseases; Esophageal Stenosis; Female; Guanidines; Humans; Male; Middle	1980
Prophylaxis against acute stress erosions. Southern medical journal, 1980, Volume: 73, Issue:4 Topics: Animals; Antacids; Carbenoxolone; Cimetidine; Guanidines; Humans; Peptic Ulcer; Peptic Ulcer Hemorrh	1980
[Medical treatment of bleeding ulcer]. Lakartidningen, 1980, Feb-27, Volume: 77, Issue:9 Topics: Cimetidine; Gastritis; Guanidines; Humans; Peptic Ulcer Hemorrhage; Stomach Ulcer	1980
[Complicated ulcer; prevention and therapy of upper gastrointestinal bleeding; indications for antacid therapy]. Zeitschrift fur Gastroenterologie, 1980, Volume: 18, Issue:6 Topics: Antacids; Cimetidine; Humans; Peptic Ulcer Hemorrhage	1980
[Prevention and therapy of gastroduodenal stress bleeding with cimetidine]. Zeitschrift fur Gastroenterologie, 1980, Volume: 18, Issue:6 Topics: Cimetidine; Guanidines; Humans; Peptic Ulcer Hemorrhage; Stress, Physiological	1980
[Effect of cimetidine and synthetic secretin as treatment of acute upper gastrointestinal bleeding--a prospective alternate trial (author's transl)]. Zeitschrift fur Gastroenterologie, 1980, Volume: 18, Issue:6 Topics: Cimetidine; Drug Therapy, Combination; Guanidines; Humans; Peptic Ulcer Hemorrhage; Prospective Stud	1980
[Stress-induced haemorrhages in intensive care patients (author's transl)]. Anasthesie, Intensivtherapie, Notfallmedizin, 1980, Volume: 15, Issue:4 Topics: Antacids; Cimetidine; Gastric Lavage; Humans; Intensive Care Units; Peptic Ulcer Hemorrhage; Stress,	1980
Cimetidine and peptic ulceration in a Meckel's diverticulum. Archives of disease in childhood, 1980, Volume: 55, Issue:4 Topics: Child; Cimetidine; Guanidines; Humans; Male; Meckel Diverticulum; Peptic Ulcer Hemorrhage	1980
Cimetidine toxicity manifested as paranoia and hallucinations. The American journal of psychiatry, 1980, Volume: 137, Issue:9 Topics: Cimetidine; Guanidines; Hallucinations; Humans; Male; Middle Aged; Paranoid Disorders; Peptic Ulcer	1980
[Granulocytopenia with cimetidine therapy (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1980, Nov-07, Volume: 105, Issue:45 Topics: Adult; Agranulocytosis; Bone Marrow; Cimetidine; Guanidines; Humans; Liver Cirrhosis, Alcoholic; Mal	1980
Risk factors in acute gastric mucosal bleeding. Digestive diseases and sciences, 1980, Volume: 25, Issue:11 Topics: Acute Disease; Antacids; Cimetidine; Guanidines; Humans; Liver Cirrhosis; Peptic Ulcer Hemorrhage; R	1980
Cimetidine and hematologic suppression: things are not always as they appear. Digestive diseases and sciences, 1980, Volume: 25, Issue:12 Topics: Aged; Agranulocytosis; Blood Transfusion; Cimetidine; Duodenal Ulcer; Eosinophilia; Fever; Guanidine	1980
Cimetidine and peptic ulcer. The Medical journal of Australia, 1980, Nov-29, Volume: 2, Issue:11 Topics: Cimetidine; Guanidines; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Recurrence	1980
Endoscopic electrocoagulation combined with cimetidine. A pilot study of the applicability in active bleeding from gastroduodenal ulcer. Acta chirurgica Scandinavica, 1980, Volume: 146, Issue:6 Topics: Adolescent; Adult; Aged; Cimetidine; Duodenal Ulcer; Electrocoagulation; Endoscopy; Female; Guanidin	1980
Late outcome of bleeding gastric ulcer. Five to eight years' follow-up. Scandinavian journal of gastroenterology, 1994, Volume: 29, Issue:11 Topics: Aged; Cimetidine; Electrocoagulation; Female; Follow-Up Studies; Hemostasis, Endoscopic; Humans; Mal	1994
[Hemostasis and treatment of stress hemorrhage in the upper gastrointestinal tract of trauma patients]. Acta medica Austriaca, 1993, Volume: 20, Issue:5 Topics: Cimetidine; Combined Modality Therapy; Croatia; Endoscopy, Gastrointestinal; Gastrectomy; Humans; Mi	1993
Is the incidence of hemorrhagic stress ulceration in surgical critically ill patients affected by modern antacid prophylaxis? The American surgeon, 1996, Volume: 62, Issue:12 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antacids; Anti-Ulcer Agents; Cimetidine; Critical Care;	1996
The value of early enteral nutrition in the prophylaxis of stress ulceration in the severely burned patient. Burns : journal of the International Society for Burn Injuries, 1997, Volume: 23, Issue:4 Topics: Administration, Oral; Adult; Antacids; Anti-Ulcer Agents; Burns; Cimetidine; Endoscopy, Digestive Sy	1997
Brain-mediated protective interactions of histaminergic H2 and dopaminergic systems in rats. Acta veterinaria Hungarica, 1997, Volume: 45, Issue:1 Topics: Animals; Apomorphine; Bromocriptine; Cimetidine; Domperidone; Dopamine Agonists; Dopamine Antagonist	1997
The outcome of bleeding duodenal ulcer in the era of H2 receptor antagonist therapy. QJM : monthly journal of the Association of Physicians, 1998, Volume: 91, Issue:3 Topics: Abdominal Pain; Adult; Aged; Cimetidine; Combined Modality Therapy; Duodenal Ulcer; Female; Follow-U	1998
Symposium on intensive care: 3. Upper gastrointestinal bleeding in the intensive care unit. Canadian journal of surgery. Journal canadien de chirurgie, 1978, Volume: 21, Issue:1 Topics: Antacids; Bacterial Infections; Cimetidine; Critical Care; Endoscopy; Gastritis; Histamine H2 Antago	1978
Peptic ulceration in kidney transplantation. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1977, Volume: 14 Topics: Cimetidine; Duodenal Ulcer; Gastrins; Histamine H2 Antagonists; Humans; Kidney Transplantation; Pept	1977
[Cimetidine in peptic ulcer hemorrhage and in reflux esophagitis]. Acta medica Austriaca, 1978, Volume: 5, Issue:2 Topics: Adult; Aged; Cimetidine; Drug Evaluation; Esophagitis, Peptic; Guanidines; Humans; Hydrogen-Ion Conc	1978
[Histamine H2 receptor antagonists. Pharmacology and clinical applications]. La Revue du praticien, 1978, Nov-21, Volume: 28, Issue:53 Topics: Animals; Cimetidine; Duodenal Ulcer; Esophagitis, Peptic; Gastric Juice; Gastric Mucosa; Gastritis;	1978
Failure of cimetidine prophylaxis in the critically ill. Archives of surgery (Chicago, Ill. : 1960), 1979, Volume: 114, Issue:4 Topics: Acute Kidney Injury; Bacterial Infections; Child; Cimetidine; Female; Gastric Juice; Guanidines; Hum	1979
Cimetidine and iron-deficiency anaemia. Lancet (London, England), 1977, Nov-26, Volume: 2, Issue:8048 Topics: Anemia, Hypochromic; Cimetidine; Ferrous Compounds; Guanidines; Humans; Peptic Ulcer; Peptic Ulcer H	1977
Duodenal perforation after cimetidine. Lancet (London, England), 1978, Mar-25, Volume: 1, Issue:8065 Topics: Adolescent; Cimetidine; Duodenal Ulcer; Guanidines; Humans; Male; Peptic Ulcer Hemorrhage; Peptic Ul	1978
Cimetidine treatment during pregnancy. Lancet (London, England), 1978, Oct-28, Volume: 2, Issue:8096 Topics: Administration, Oral; Adult; Cimetidine; Duodenal Ulcer; Female; Guanidines; Humans; Infant, Newborn	1978
Emergency use of cimetidine in acute gastrointestinal hemorrhage: endoscopic evaluation. The Journal of the Medical Society of New Jersey, 1979, Volume: 76, Issue:3 Topics: Cimetidine; Duodenal Ulcer; Gastroscopy; Guanidines; Humans; Male; Middle Aged; Peptic Ulcer Hemorrh	1979
[Use of cimetidine in hemorrhages of the upper gastrointestinal tract]. La Clinica terapeutica, 1979, Sep-15, Volume: 90, Issue:5 Topics: Adult; Aged; Cimetidine; Female; Gastrointestinal Hemorrhage; Guanidines; Humans; Male; Middle Aged;	1979
[Sopor during cimetidine therapy]. Deutsche medizinische Wochenschrift (1946), 1979, May-18, Volume: 104, Issue:20 Topics: Cimetidine; Cognition Disorders; Consciousness Disorders; Female; Guanidines; Humans; Kidney Failure	1979
The Andrew Melrose Lecture 1977, Part I. The enigma of peptic ulcer. Scottish medical journal, 1979, Volume: 24, Issue:1 Topics: ABO Blood-Group System; Adult; Animals; Cattle; Child; Cimetidine; Duodenal Ulcer; Ethnicity; Female	1979
[Cimetidine for treatment of stress-induced ulcer haemorrhage (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1979, Dec-28, Volume: 104, Issue:52 Topics: Adult; Aged; Cimetidine; Female; Guanidines; Humans; Male; Middle Aged; Peptic Ulcer Hemorrhage; Pro	1979
Truncal vagotomy and pyloroplasty for bleeding peptic ulcer (analysis of 32 cases). The Journal of the Egyptian Medical Association, 1978, Volume: 61, Issue:11-12 Topics: Cimetidine; Endoscopy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Peptic Ulcer Hemorrhage	1978
[Preliminary experiences with the use of cimetidine in the treatment of acute hemorrhages in the upper gastrointestinal tract]. L'Ateneo parmense. Acta bio-medica : organo della Societa di medicina e scienze naturali di Parma, 1977, Volume: 48, Issue:6 Topics: Aged; Cimetidine; Female; Guanidines; Humans; Mesenteric Vascular Occlusion; Peptic Ulcer Hemorrhage	1977
[Ulcer therapy using cimetidine]. Deutsche medizinische Wochenschrift (1946), 1978, Jan-27, Volume: 103, Issue:4 Topics: Cimetidine; Duodenal Ulcer; Guanidines; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Peptic Ulcer	1978
Role of cimetidine in gastrointestinal disease: present status and future potential. Drugs, 1978, Volume: 15, Issue:2 Topics: Cimetidine; Duodenal Ulcer; Guanidines; Humans; Peptic Ulcer Hemorrhage; Recurrence; Stomach Ulcer	1978
[Conservative and surgical therapy of peptic ulcer]. Deutsche medizinische Wochenschrift (1946), 1978, Apr-07, Volume: 103, Issue:14 Topics: Antacids; Cimetidine; Duodenal Ulcer; Humans; Methods; Peptic Ulcer; Peptic Ulcer Hemorrhage; Peptic	1978
Effect of cimetidine, histamine H2 receptor antagonist, in the prevention of experimental stress ulcer in the rat. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1978, Volume: 10, Issue:2 Topics: Animals; Cimetidine; Gastric Mucosa; Guanidines; Male; Peptic Ulcer Hemorrhage; Rats; Stomach Ulcer;	1978
Duodenal ulcers. British medical journal, 1978, Oct-21, Volume: 2, Issue:6145 Topics: Antacids; Cimetidine; Duodenal Ulcer; Humans; Peptic Ulcer Hemorrhage	1978
Cimetidine and gastric pH. Gastroenterology, 1978, Volume: 75, Issue:4 Topics: Cimetidine; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Guanidines; Humans; Peptic	1978
Pathophysiology and management of acute gastric mucosal hemorrhage. The Japanese journal of surgery, 1978, Volume: 8, Issue:4 Topics: Acute Disease; Animals; Cimetidine; Dogs; Gastric Mucosa; Humans; Peptic Ulcer; Peptic Ulcer Hemorrh	1978
[A surgeon's experiences in the treatment of stress ulcer with cimetidine]. Acta medica Austriaca, 1978, Volume: 5, Issue:2 Topics: Cimetidine; Duodenal Ulcer; Guanidines; Humans; Infusions, Parenteral; Peptic Ulcer Hemorrhage; Pros	1978
Drugs for peptic ulcer. Journal of the Royal College of Physicians of London, 1979, Volume: 13, Issue:1 Topics: Antacids; Bismuth; Carbenoxolone; Chelating Agents; Cimetidine; Duodenal Neoplasms; Duodenal Ulcer;	1979
Medical treatment of bleeding peptic ulcer: old drugs, new regimens. Gut, 1991, Volume: 32, Issue:11 Topics: Antacids; Cimetidine; Drug Administration Schedule; Drug Therapy, Combination; Humans; Peptic Ulcer	1991
[Stress ulcer or pneumonia: effect of prevention with H2 blockers on gastric juice pH]. Klinische Wochenschrift, 1991, Volume: 69 Suppl 26 Topics: Adult; Aged; Cimetidine; Critical Care; Female; Gastric Acidity Determination; Humans; Male; Middle	1991
H2 antagonists by continuous infusion: i.v. or i.g.? Gastroenterology, 1991, Volume: 101, Issue:5 Topics: Cimetidine; Enteral Nutrition; Gastrostomy; Humans; Infusions, Intravenous; Intubation, Gastrointest	1991
[Prevention of stress ulcer with topically acting drugs: an effective and sensible therapeutic approach? Arguments contra]. Zeitschrift fur Gastroenterologie, 1991, Volume: 29 Suppl 1 Topics: Antacids; Anti-Ulcer Agents; Cimetidine; Critical Care; Drug Therapy, Combination; Gastric Acidity D	1991
Cimetidine and ranitidine may not cross-react to cause thrombocytopenia. Journal of internal medicine, 1991, Volume: 230, Issue:1 Topics: Aged; Cimetidine; Duodenal Ulcer; Humans; Male; Peptic Ulcer Hemorrhage; Ranitidine; Thrombocytopeni	1991
Use of Histodil injection in upper gastro-intestinal haemorrhages. Therapia Hungarica (English edition), 1989, Volume: 37, Issue:3 Topics: Adult; Aged; Cimetidine; Female; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Midd	1989
[Intravenous cimetidine in bleeding gastroduodenal ulcer in children with or without sclerotherapy. Which is the best alternative?]. Revista espanola de las enfermedades del aparato digestivo, 1989, Volume: 76, Issue:1 Topics: Adolescent; Child; Child, Preschool; Cimetidine; Humans; Infant; Infant, Newborn; Injections, Intrav	1989
[Our experience in the treatment of gastroduodenal hemorrhage with somatostatin]. Chirurgia italiana, 1986, Volume: 38, Issue:5 Topics: Cimetidine; Double-Blind Method; Female; Humans; Male; Peptic Ulcer; Peptic Ulcer Hemorrhage; Random	1986
[Intragastric long-term pH measurement for adjusting drug therapy of gastroduodenal ulcer hemorrhage in childhood]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1987, Volume: 135, Issue:3 Topics: Adolescent; Anti-Ulcer Agents; Child; Cimetidine; Dose-Response Relationship, Drug; Drug Therapy, Co	1987
[Traditional Chinese medicine and Western medicine therapy in treating 330 cases of upper GI tract bleeding]. Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1987, Volume: 7, Issue:11 Topics: Adolescent; Adult; Aged; Cimetidine; Drugs, Chinese Herbal; Duodenal Ulcer; Female; Gastritis; Gastr	1987
[Cimetidine and upper digestive hemorrhage: analysis of its effect in the most frequent causes. Trial in 411 patients]. Revista espanola de las enfermedades del aparato digestivo, 1987, Volume: 71, Issue:1 Topics: Cimetidine; Drug Evaluation; Duodenal Ulcer; Female; Humans; Male; Peptic Ulcer Hemorrhage; Prospect	1987
Massive gastrointestinal hemorrhage in children with posterior fossa tumors. Journal of pediatric surgery, 1987, Volume: 22, Issue:7 Topics: Antacids; Brain Neoplasms; Cerebellar Neoplasms; Cerebral Ventricle Neoplasms; Child, Preschool; Cim	1987
Peptic ulcer treatment now and tomorrow. Journal of clinical gastroenterology, 1987, Volume: 9 Suppl 2 Topics: Adult; Aged; Anti-Ulcer Agents; Cimetidine; Female; Humans; Male; Middle Aged; Peptic Ulcer; Peptic	1987
[Medical or surgical treatment of the elderly bleeding ulcer patient]. Minerva medica, 1986, May-07, Volume: 77, Issue:19 Topics: Aged; Blood Transfusion; Cimetidine; Combined Modality Therapy; Female; Humans; Male; Peptic Ulcer;	1986
[Three cases of hemorrhagic gastric ulcer and cimetidine-associated mental confusion]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1986, Volume: 83, Issue:7 Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Female; Humans; Male; Middle Aged; Peptic Ulcer He	1986
[Antacid prevention of stress lesions hinders endoscopic hemostasis]. Deutsche medizinische Wochenschrift (1946), 1985, Aug-23, Volume: 110, Issue:34 Topics: Antacids; Benzodiazepinones; Cimetidine; Drug Therapy, Combination; Endoscopy; Hemostasis, Surgical;	1985
Advances in treatment of acute upper gastrointestinal hemorrhage. Southern medical journal, 1985, Volume: 78, Issue:7 Topics: Angiography; Antacids; Barium Sulfate; Cimetidine; Combined Modality Therapy; Embolization, Therapeu	1985
Postmarketing surveillance of the safety of cimetidine: mortality during second, third, and fourth years of follow up. British medical journal (Clinical research ed.), 1985, Oct-19, Volume: 291, Issue:6502 Topics: Aged; Cimetidine; Duodenal Ulcer; Evaluation Studies as Topic; Female; Gastrointestinal Diseases; Ga	1985
[Choice of operative method in duodenal ulcer and hemophilia A]. Zentralblatt fur Chirurgie, 1985, Volume: 110, Issue:15 Topics: Adult; Blood Transfusion; Cimetidine; Combined Modality Therapy; Duodenal Ulcer; Factor VIII; Hemoph	1985
Prevention of gastrointestinal bleeding in burns: the effects of cimetidine or antacids combined with early enteral feeding. Burns, including thermal injury, 1985, Volume: 12, Issue:1 Topics: Adult; Aged; Antacids; Burns; Cimetidine; Duodenal Ulcer; Enteral Nutrition; Female; Humans; Male; M	1985
Prostaglandins. A surgeon's perspective. Digestive diseases and sciences, 1986, Volume: 31, Issue:2 Suppl Topics: Antacids; Cimetidine; Gastric Acidity Determination; Gastric Mucosa; Gastritis; Humans; Peptic Ulcer	1986
Sustained fasting achlorhydria: a comparison of medical regimens. Gastroenterology, 1985, Volume: 88, Issue:3 Topics: Adult; Aged; Antacids; Cimetidine; Duodenal Ulcer; Fasting; Female; Gastric Acid; Gastric Acidity De	1985
[Emergency surgery of complicated gastroduodenal ulcers: risk factors and results]. Schweizerische medizinische Wochenschrift, 1985, Jul-20, Volume: 115, Issue:29 Topics: Age Factors; Aged; Cimetidine; Emergencies; Humans; Middle Aged; Peptic Ulcer; Peptic Ulcer Hemorrha	1985
[Symptomless and complicated peptic ulcer as an extreme clinical form of ulcer disease: consequences for choice between conservative and surgical therapy]. Langenbecks Archiv fur Chirurgie, 1985, Volume: 366 Topics: Cimetidine; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Postoperative Complications; Prognosis; R	1985

cimetidine and Hemorrhage, Peptic Ulcer