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cimetidine and Heartburn

cimetidine has been researched along with Heartburn in 19 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Heartburn: Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.

Research Excerpts

ExcerptRelevanceReference
"Previous studies have demonstrated greater efficacy for omeprazole compared with cimetidine in patients with endoscopically verified oesophagitis, but excluded the substantial group of gastro-oesophageal reflux disease (GERD) patients with reflux symptoms but without endoscopic abnormality."9.08Omeprazole is more effective than cimetidine for the relief of all grades of gastro-oesophageal reflux disease-associated heartburn, irrespective of the presence or absence of endoscopic oesophagitis. ( Axon, AT; Bate, CM; Emmas, CE; Green, JR; Murray, FE; Taylor, MD; Tildesley, G, 1997)
" is more effective than cimetidine 800 mg nocte in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis."9.08Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis. ( Axon, AT; Bate, CM; Emmas, C; Green, JR; Murrays, FE; Owen, SM; Taylor, MD; Tildesley, G, 1998)
"One hundred and twenty-five patients with symptoms of heartburn and acid regurgitation but without endoscopic abnormalities were randomized to receive 200 mg cimetidine suspension four times daily or placebo for two weeks."9.07Cimetidine suspension in patients with stage 0 gastro-oesophageal reflux disease. ( Höbel, W; Riemann, JF, 1991)
"The effectiveness of cimetidine for symptomatic relief in patients with chronic gastroesophageal reflux was studied in a multicenter, double blind clinical trial."9.04Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial. ( Behar, J; Brand, DL; Brown, FC; Castell, DO; Cohen, S; Crossley, RJ; Pope, CE; Winans, CS, 1978)
"Previous studies have demonstrated greater efficacy for omeprazole compared with cimetidine in patients with endoscopically verified oesophagitis, but excluded the substantial group of gastro-oesophageal reflux disease (GERD) patients with reflux symptoms but without endoscopic abnormality."5.08Omeprazole is more effective than cimetidine for the relief of all grades of gastro-oesophageal reflux disease-associated heartburn, irrespective of the presence or absence of endoscopic oesophagitis. ( Axon, AT; Bate, CM; Emmas, CE; Green, JR; Murray, FE; Taylor, MD; Tildesley, G, 1997)
" is more effective than cimetidine 800 mg nocte in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis."5.08Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis. ( Axon, AT; Bate, CM; Emmas, C; Green, JR; Murrays, FE; Owen, SM; Taylor, MD; Tildesley, G, 1998)
"One hundred and twenty-five patients with symptoms of heartburn and acid regurgitation but without endoscopic abnormalities were randomized to receive 200 mg cimetidine suspension four times daily or placebo for two weeks."5.07Cimetidine suspension in patients with stage 0 gastro-oesophageal reflux disease. ( Höbel, W; Riemann, JF, 1991)
"The effectiveness of cimetidine for symptomatic relief in patients with chronic gastroesophageal reflux was studied in a multicenter, double blind clinical trial."5.04Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial. ( Behar, J; Brand, DL; Brown, FC; Castell, DO; Cohen, S; Crossley, RJ; Pope, CE; Winans, CS, 1978)
" The time to onset of action and the degree of gastric acid inhibition of the H2 -RAs famotidine and cimetidine at dosage levels approved for over-the-counter use (10 mg famotidine and 200 mg cimetidine) were compared."2.69The action of 10 mg famotidine versus 200 mg cimetidine: onset and magnitude of antisecretory action within the first 2 hours after administration. ( Decktor, D; Houle, JM; Pierce, CH, 1998)
"Gastroesophageal reflux (GER) disease is a common, multifactorial medical condition that may be difficult to treat."1.27A critical review of current medical therapy for gastroesophageal reflux disease. ( Richter, JE, 1986)
"Heartburn was the major gastrointestinal symptom associated with drinking coffee in 31 subjects."1.26Pathogenesis of coffee-induced gastrointestinal symptoms. ( Cohen, S, 1980)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199013 (68.42)18.7374
1990's6 (31.58)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Breen, KJ1
Desmond, PV1
Whelan, G1
Wu, WC1
Castell, DO2
Cochrane, GW1
Swinhoe, JR1
Blum, AL1
Cohen, S3
Reed, PI1
Bate, CM2
Green, JR2
Axon, AT2
Murray, FE1
Tildesley, G2
Emmas, CE1
Taylor, MD2
Murrays, FE1
Owen, SM1
Emmas, C1
Decktor, D1
Houle, JM1
Pierce, CH1
Behar, J1
Brand, DL1
Brown, FC1
Crossley, RJ1
Pope, CE1
Winans, CS1
Roufail, WM1
Riemann, JF1
Höbel, W1
Palmer, RH1
Frank, WO1
Rockhold, FW1
Wetherington, JD1
Young, MD1
Richter, JE1
Humphries, TJ1
Lennox, B1
Snell, C1
Lamb, Y1
Galmiche, JP1
Brandstätter, G1
Evreux, M1
Hentschel, E1
Kerstan, E1
Kratochvil, P1
Reichel, W1
Schütze, K1
Soule, JC1
Vitaux, J1
Merlo, A1

Reviews

1 review available for cimetidine and Heartburn

ArticleYear
Gastroesophageal reflux.
    Comprehensive therapy, 1983, Volume: 9, Issue:11

    Topics: Antacids; Cimetidine; Esophagogastric Junction; Gastroesophageal Reflux; Heartburn; Humans; Metoclop

1983

Trials

9 trials available for cimetidine and Heartburn

ArticleYear
Treatment of reflux oesophagitis. A randomized, controlled evaluation of cimetidine.
    The Medical journal of Australia, 1983, Nov-26, Volume: 2, Issue:11

    Topics: Adult; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Esophagitis, Peptic; Esophagoscopy

1983
Omeprazole is more effective than cimetidine for the relief of all grades of gastro-oesophageal reflux disease-associated heartburn, irrespective of the presence or absence of endoscopic oesophagitis.
    Alimentary pharmacology & therapeutics, 1997, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Cimetidine; Double-Blind Method; Esophagitis; Female; Ga

1997
Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis.
    Alimentary pharmacology & therapeutics, 1998, Volume: 12, Issue:1

    Topics: Administration, Oral; Anti-Ulcer Agents; Chi-Square Distribution; Cimetidine; Double-Blind Method; E

1998
The action of 10 mg famotidine versus 200 mg cimetidine: onset and magnitude of antisecretory action within the first 2 hours after administration.
    American journal of therapeutics, 1998, Volume: 5, Issue:2

    Topics: Administration, Oral; Adult; Anti-Ulcer Agents; Cimetidine; Cross-Over Studies; Drug Monitoring; Fam

1998
Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial.
    Gastroenterology, 1978, Volume: 74, Issue:2 Pt 2

    Topics: Adult; Aged; Antacids; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Esophagoscopy; Fem

1978
Cimetidine suspension in patients with stage 0 gastro-oesophageal reflux disease.
    Alimentary pharmacology & therapeutics, 1991, Volume: 5, Issue:2

    Topics: Adolescent; Adult; Aged; Cimetidine; Double-Blind Method; Female; Gastroesophageal Reflux; Heartburn

1991
Cimetidine 800 mg twice daily for healing erosions and ulcers in gastroesophageal reflux disease.
    Journal of clinical gastroenterology, 1990, Volume: 12 Suppl 2

    Topics: Adult; Aged; Aged, 80 and over; Cimetidine; Double-Blind Method; Drug Administration Schedule; Femal

1990
Response of heartburn symptoms to a new cimetidine/alginate combination compared with an alginic acid/antacid.
    The British journal of clinical practice, 1988, Volume: 42, Issue:12

    Topics: Adult; Aged; Alginates; Antacids; Cimetidine; Drug Combinations; Female; Gastroesophageal Reflux; Gl

1988
Combined therapy with cisapride and cimetidine in severe reflux oesophagitis: a double blind controlled trial.
    Gut, 1988, Volume: 29, Issue:5

    Topics: Adult; Aged; Cimetidine; Cisapride; Clinical Trials as Topic; Double-Blind Method; Drug Combinations

1988

Other Studies

9 other studies available for cimetidine and Heartburn

ArticleYear
Heartburn in pregnancy.
    British medical journal (Clinical research ed.), 1982, May-22, Volume: 284, Issue:6328

    Topics: Cimetidine; Female; Heartburn; Humans; Pregnancy; Pregnancy Complications

1982
[Gastroesophageal reflux: indications and limitations of medical therapy and function tests].
    Helvetica chirurgica acta, 1981, Volume: 47, Issue:6

    Topics: Cimetidine; Eructation; Gastroesophageal Reflux; Heartburn; Humans; Manometry

1981
Pathogenesis of coffee-induced gastrointestinal symptoms.
    The New England journal of medicine, 1980, Jul-17, Volume: 303, Issue:3

    Topics: Adult; Aged; Cimetidine; Coffee; Digestive System; Esophagogastric Junction; Female; Gastric Juice;

1980
Oesophageal reflux.
    The Practitioner, 1980, Volume: 224, Issue:1342

    Topics: Aged; Alginates; Antacids; Cimetidine; Esophagogastric Junction; Gastroesophageal Reflux; Heartburn;

1980
Over-the-counter H2-receptor antagonists for heartburn.
    The Medical letter on drugs and therapeutics, 1995, Oct-27, Volume: 37, Issue:960

    Topics: Cimetidine; Drug Interactions; Gastroesophageal Reflux; Heartburn; Histamine H2 Antagonists; Humans;

1995
Medical management of patients with reflux esophagitis.
    Southern medical journal, 1978, Volume: 71 Suppl 1

    Topics: Alginates; Antacids; Bethanechol Compounds; Cimetidine; Esophagitis, Peptic; Heartburn; Humans; Meto

1978
A critical review of current medical therapy for gastroesophageal reflux disease.
    Journal of clinical gastroenterology, 1986, Volume: 8 Suppl 1

    Topics: Alginates; Antacids; Barrett Esophagus; Bethanechol; Bethanechol Compounds; Cimetidine; Gastroesopha

1986
Effects of long-term medical treatment with cimetidine and bethanechol in patients with esophagitis and Barrett's esophagus.
    Journal of clinical gastroenterology, 1987, Volume: 9, Issue:1

    Topics: Adult; Barrett Esophagus; Bethanechol; Bethanechol Compounds; Cimetidine; Esophageal Diseases; Esoph

1987
Gastroesophageal reflux. Evaluation and current treatment.
    Postgraduate medicine, 1987, May-01, Volume: 81, Issue:6

    Topics: Antacids; Cimetidine; Drug Administration Schedule; Esophagogastric Junction; Gastric Emptying; Gast

1987