cimetidine has been researched along with Heartburn in 19 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Heartburn: Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous studies have demonstrated greater efficacy for omeprazole compared with cimetidine in patients with endoscopically verified oesophagitis, but excluded the substantial group of gastro-oesophageal reflux disease (GERD) patients with reflux symptoms but without endoscopic abnormality." | 9.08 | Omeprazole is more effective than cimetidine for the relief of all grades of gastro-oesophageal reflux disease-associated heartburn, irrespective of the presence or absence of endoscopic oesophagitis. ( Axon, AT; Bate, CM; Emmas, CE; Green, JR; Murray, FE; Taylor, MD; Tildesley, G, 1997) |
| " is more effective than cimetidine 800 mg nocte in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis." | 9.08 | Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis. ( Axon, AT; Bate, CM; Emmas, C; Green, JR; Murrays, FE; Owen, SM; Taylor, MD; Tildesley, G, 1998) |
| "One hundred and twenty-five patients with symptoms of heartburn and acid regurgitation but without endoscopic abnormalities were randomized to receive 200 mg cimetidine suspension four times daily or placebo for two weeks." | 9.07 | Cimetidine suspension in patients with stage 0 gastro-oesophageal reflux disease. ( Höbel, W; Riemann, JF, 1991) |
| "The effectiveness of cimetidine for symptomatic relief in patients with chronic gastroesophageal reflux was studied in a multicenter, double blind clinical trial." | 9.04 | Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial. ( Behar, J; Brand, DL; Brown, FC; Castell, DO; Cohen, S; Crossley, RJ; Pope, CE; Winans, CS, 1978) |
| "Previous studies have demonstrated greater efficacy for omeprazole compared with cimetidine in patients with endoscopically verified oesophagitis, but excluded the substantial group of gastro-oesophageal reflux disease (GERD) patients with reflux symptoms but without endoscopic abnormality." | 5.08 | Omeprazole is more effective than cimetidine for the relief of all grades of gastro-oesophageal reflux disease-associated heartburn, irrespective of the presence or absence of endoscopic oesophagitis. ( Axon, AT; Bate, CM; Emmas, CE; Green, JR; Murray, FE; Taylor, MD; Tildesley, G, 1997) |
| " is more effective than cimetidine 800 mg nocte in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis." | 5.08 | Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis. ( Axon, AT; Bate, CM; Emmas, C; Green, JR; Murrays, FE; Owen, SM; Taylor, MD; Tildesley, G, 1998) |
| "One hundred and twenty-five patients with symptoms of heartburn and acid regurgitation but without endoscopic abnormalities were randomized to receive 200 mg cimetidine suspension four times daily or placebo for two weeks." | 5.07 | Cimetidine suspension in patients with stage 0 gastro-oesophageal reflux disease. ( Höbel, W; Riemann, JF, 1991) |
| "The effectiveness of cimetidine for symptomatic relief in patients with chronic gastroesophageal reflux was studied in a multicenter, double blind clinical trial." | 5.04 | Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial. ( Behar, J; Brand, DL; Brown, FC; Castell, DO; Cohen, S; Crossley, RJ; Pope, CE; Winans, CS, 1978) |
| " The time to onset of action and the degree of gastric acid inhibition of the H2 -RAs famotidine and cimetidine at dosage levels approved for over-the-counter use (10 mg famotidine and 200 mg cimetidine) were compared." | 2.69 | The action of 10 mg famotidine versus 200 mg cimetidine: onset and magnitude of antisecretory action within the first 2 hours after administration. ( Decktor, D; Houle, JM; Pierce, CH, 1998) |
| "Gastroesophageal reflux (GER) disease is a common, multifactorial medical condition that may be difficult to treat." | 1.27 | A critical review of current medical therapy for gastroesophageal reflux disease. ( Richter, JE, 1986) |
| "Heartburn was the major gastrointestinal symptom associated with drinking coffee in 31 subjects." | 1.26 | Pathogenesis of coffee-induced gastrointestinal symptoms. ( Cohen, S, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (68.42) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Breen, KJ | 1 |
| Desmond, PV | 1 |
| Whelan, G | 1 |
| Wu, WC | 1 |
| Castell, DO | 2 |
| Cochrane, GW | 1 |
| Swinhoe, JR | 1 |
| Blum, AL | 1 |
| Cohen, S | 3 |
| Reed, PI | 1 |
| Bate, CM | 2 |
| Green, JR | 2 |
| Axon, AT | 2 |
| Murray, FE | 1 |
| Tildesley, G | 2 |
| Emmas, CE | 1 |
| Taylor, MD | 2 |
| Murrays, FE | 1 |
| Owen, SM | 1 |
| Emmas, C | 1 |
| Decktor, D | 1 |
| Houle, JM | 1 |
| Pierce, CH | 1 |
| Behar, J | 1 |
| Brand, DL | 1 |
| Brown, FC | 1 |
| Crossley, RJ | 1 |
| Pope, CE | 1 |
| Winans, CS | 1 |
| Roufail, WM | 1 |
| Riemann, JF | 1 |
| Höbel, W | 1 |
| Palmer, RH | 1 |
| Frank, WO | 1 |
| Rockhold, FW | 1 |
| Wetherington, JD | 1 |
| Young, MD | 1 |
| Richter, JE | 1 |
| Humphries, TJ | 1 |
| Lennox, B | 1 |
| Snell, C | 1 |
| Lamb, Y | 1 |
| Galmiche, JP | 1 |
| Brandstätter, G | 1 |
| Evreux, M | 1 |
| Hentschel, E | 1 |
| Kerstan, E | 1 |
| Kratochvil, P | 1 |
| Reichel, W | 1 |
| Schütze, K | 1 |
| Soule, JC | 1 |
| Vitaux, J | 1 |
| Merlo, A | 1 |
1 review available for cimetidine and Heartburn
| Article | Year |
|---|---|
Gastroesophageal reflux.
Topics: Antacids; Cimetidine; Esophagogastric Junction; Gastroesophageal Reflux; Heartburn; Humans; Metoclop | 1983 |
9 trials available for cimetidine and Heartburn
| Article | Year |
|---|---|
Treatment of reflux oesophagitis. A randomized, controlled evaluation of cimetidine.
Topics: Adult; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Esophagitis, Peptic; Esophagoscopy | 1983 |
Omeprazole is more effective than cimetidine for the relief of all grades of gastro-oesophageal reflux disease-associated heartburn, irrespective of the presence or absence of endoscopic oesophagitis.
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Cimetidine; Double-Blind Method; Esophagitis; Female; Ga | 1997 |
Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis.
Topics: Administration, Oral; Anti-Ulcer Agents; Chi-Square Distribution; Cimetidine; Double-Blind Method; E | 1998 |
The action of 10 mg famotidine versus 200 mg cimetidine: onset and magnitude of antisecretory action within the first 2 hours after administration.
Topics: Administration, Oral; Adult; Anti-Ulcer Agents; Cimetidine; Cross-Over Studies; Drug Monitoring; Fam | 1998 |
Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial.
Topics: Adult; Aged; Antacids; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Esophagoscopy; Fem | 1978 |
Cimetidine suspension in patients with stage 0 gastro-oesophageal reflux disease.
Topics: Adolescent; Adult; Aged; Cimetidine; Double-Blind Method; Female; Gastroesophageal Reflux; Heartburn | 1991 |
Cimetidine 800 mg twice daily for healing erosions and ulcers in gastroesophageal reflux disease.
Topics: Adult; Aged; Aged, 80 and over; Cimetidine; Double-Blind Method; Drug Administration Schedule; Femal | 1990 |
Response of heartburn symptoms to a new cimetidine/alginate combination compared with an alginic acid/antacid.
Topics: Adult; Aged; Alginates; Antacids; Cimetidine; Drug Combinations; Female; Gastroesophageal Reflux; Gl | 1988 |
Combined therapy with cisapride and cimetidine in severe reflux oesophagitis: a double blind controlled trial.
Topics: Adult; Aged; Cimetidine; Cisapride; Clinical Trials as Topic; Double-Blind Method; Drug Combinations | 1988 |
9 other studies available for cimetidine and Heartburn
| Article | Year |
|---|---|
Heartburn in pregnancy.
Topics: Cimetidine; Female; Heartburn; Humans; Pregnancy; Pregnancy Complications | 1982 |
[Gastroesophageal reflux: indications and limitations of medical therapy and function tests].
Topics: Cimetidine; Eructation; Gastroesophageal Reflux; Heartburn; Humans; Manometry | 1981 |
Pathogenesis of coffee-induced gastrointestinal symptoms.
Topics: Adult; Aged; Cimetidine; Coffee; Digestive System; Esophagogastric Junction; Female; Gastric Juice; | 1980 |
Oesophageal reflux.
Topics: Aged; Alginates; Antacids; Cimetidine; Esophagogastric Junction; Gastroesophageal Reflux; Heartburn; | 1980 |
Over-the-counter H2-receptor antagonists for heartburn.
Topics: Cimetidine; Drug Interactions; Gastroesophageal Reflux; Heartburn; Histamine H2 Antagonists; Humans; | 1995 |
Medical management of patients with reflux esophagitis.
Topics: Alginates; Antacids; Bethanechol Compounds; Cimetidine; Esophagitis, Peptic; Heartburn; Humans; Meto | 1978 |
A critical review of current medical therapy for gastroesophageal reflux disease.
Topics: Alginates; Antacids; Barrett Esophagus; Bethanechol; Bethanechol Compounds; Cimetidine; Gastroesopha | 1986 |
Effects of long-term medical treatment with cimetidine and bethanechol in patients with esophagitis and Barrett's esophagus.
Topics: Adult; Barrett Esophagus; Bethanechol; Bethanechol Compounds; Cimetidine; Esophageal Diseases; Esoph | 1987 |
Gastroesophageal reflux. Evaluation and current treatment.
Topics: Antacids; Cimetidine; Drug Administration Schedule; Esophagogastric Junction; Gastric Emptying; Gast | 1987 |