cimetidine has been researched along with Gynecomastia in 25 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Gynecomastia: Enlargement of the BREAST in the males, caused by an excess of ESTROGENS. Physiological gynecomastia is normally observed in NEWBORNS; ADOLESCENT; and AGING males.
| Excerpt | Relevance | Reference |
|---|---|---|
| " e) The gynaecomastia, galactorrhoea, amenorrhoea and impotence--reported only after long-term cimetidine treatment--can probably be attributed to the specific antiandrogen receptor property of CMT." | 4.77 | [Dysfunction of the hypothalamo-hypophyseal-gonadal axis induced by histamine H2 antagonists. Review of the literature and personal observations]. ( Biagi, P; Milani, G, 1985) |
| "Cimetidine has been associated with gynecomastia as a side effect." | 3.66 | Cimetidine is an antiandrogen in the rat. ( Banks, JL; Loriaux, DL; Winters, SJ, 1979) |
| "Sixty-one cases of the Zollinger-Ellison syndrome, encountered over a 2-year period, have been treated with cimetidine, half of them for over 1 year." | 3.66 | Report on the United States experience with cimetidine in Zollinger-Ellision syndrome and other hypersecretory states. ( McCarthy, DM, 1978) |
| " A strong dose-response relation was present among cimetidine users." | 1.29 | Risk of gynaecomastia associated with cimetidine, omeprazole, and other antiulcer drugs. ( García Rodríguez, LA; Jick, H, 1994) |
| " The scheme successfully detected and quantified some already known adverse effects of cimetidine and did not detect any new effects." | 1.27 | Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report. ( Colin Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (84.00) | 18.7374 |
| 1990's | 2 (8.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stratakis, CA | 1 |
| Batista, D | 1 |
| Sabnis, G | 1 |
| Brodie, A | 1 |
| Ivey, KJ | 1 |
| Domschke, S | 1 |
| Domschke, W | 1 |
| Brassinne, A | 1 |
| Simon, B | 1 |
| Müller, P | 1 |
| Bertermann, O | 1 |
| Kather, H | 1 |
| De Martiis, M | 1 |
| D'Ottavi, R | 1 |
| Patrizi, P | 1 |
| Jensen, RT | 2 |
| Collen, MJ | 2 |
| McArthur, KE | 1 |
| Howard, JM | 1 |
| Maton, PN | 1 |
| Cherner, JA | 1 |
| Gardner, JD | 2 |
| Humphries, TJ | 1 |
| Myerson, RM | 1 |
| Gifford, LM | 1 |
| Aeugle, ME | 1 |
| Josie, ME | 1 |
| Wood, SL | 1 |
| Tannenbaum, PJ | 1 |
| Pandol, SJ | 1 |
| Allende, HD | 1 |
| Raufman, JP | 1 |
| Bissonnette, BM | 1 |
| Duncan, WC | 1 |
| Durgin, PL | 1 |
| Gillin, JC | 1 |
| Peden, NR | 1 |
| Wormsley, KG | 1 |
| Pomier-Layrargues, G | 1 |
| Cuilleret, G | 1 |
| Bories, P | 1 |
| Champ, C | 1 |
| Orsetti, A | 1 |
| Michel, H | 1 |
| García Rodríguez, LA | 1 |
| Jick, H | 1 |
| Satoh, T | 1 |
| Fujita, KI | 1 |
| Munakata, H | 1 |
| Itoh, S | 2 |
| Nakamura, K | 1 |
| Kamataki, T | 1 |
| Yoshizawa, I | 1 |
| Voget, E | 1 |
| Schollmeyer, P | 1 |
| Winters, SJ | 1 |
| Banks, JL | 1 |
| Loriaux, DL | 1 |
| Spence, RW | 1 |
| Celestin, LR | 1 |
| Bezuidenhout, DJ | 1 |
| McCarthy, DM | 1 |
| Barth, JA | 1 |
| Lamers, CB | 1 |
| Jauhari, J | 1 |
| Long, JP | 1 |
| Smyth, PP | 1 |
| Culliton, M | 1 |
| Cunningham, S | 1 |
| O'Donoghue, DP | 1 |
| Fitzgerald, O | 1 |
| McKenna, TJ | 1 |
| Biagi, P | 1 |
| Milani, G | 1 |
| Colin Jones, DG | 1 |
| Langman, MJ | 1 |
| Lawson, DH | 1 |
| Vessey, MP | 1 |
| Lardinois, CK | 1 |
| Mazzaferri, EL | 1 |
6 reviews available for cimetidine and Gynecomastia
| Article | Year |
|---|---|
H2-receptor antagonists.
Topics: Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cimetidine; Gastric Mucosa; G | 1980 |
New histamine H2-receptor antagonists.
Topics: Animals; Anticoagulants; Chemical Phenomena; Chemistry; Cimetidine; Confusion; Dogs; Drug Interactio | 1980 |
[Cimetidine treatment. Current state of the question].
Topics: Cimetidine; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Guanidines; Gynecomastia; Humans | 1980 |
[Side effects of ulcer treatment with cimetidine].
Topics: Androgen Antagonists; Anti-Ulcer Agents; Central Nervous System; Cimetidine; Drug Interactions; Guan | 1981 |
[The therapeutic importance of cimetidine (Tagamet) (author's transl)].
Topics: Adult; Cimetidine; Diarrhea; Female; Galactorrhea; Gastritis; Guanidines; Gynecomastia; Headache; Hu | 1978 |
[Dysfunction of the hypothalamo-hypophyseal-gonadal axis induced by histamine H2 antagonists. Review of the literature and personal observations].
Topics: Amenorrhea; Androgens; Cimetidine; Erectile Dysfunction; Female; Follicle Stimulating Hormone; Galac | 1985 |
1 trial available for cimetidine and Gynecomastia
| Article | Year |
|---|---|
Comparison of the effectiveness of ranitidine and cimetidine in inhibiting acid secretion in patients with gastric hypersecretory states.
Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, C | 1984 |
18 other studies available for cimetidine and Gynecomastia
| Article | Year |
|---|---|
Prepubertal gynaecomastia caused by medication or the aromatase excess syndrome.
Topics: Anti-Ulcer Agents; Cimetidine; Gynecomastia; Humans; Infant; Male; Parenteral Nutrition, Total | 2004 |
[Relationship between cimetidine and prolactin].
Topics: Breast Diseases; Cimetidine; Female; Galactorrhea; Guanidines; Gynecomastia; Humans; Male; Pregnancy | 1982 |
A unique postmarket outpatient surveillance program of cimetidine: report on phase II and final summary.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Cimetidine; Confusion; Drug Interactions; Female; Gastr | 1984 |
Cimetidine-induced impotence and breast changes in patients with gastric hypersecretory states.
Topics: Adult; Breast; Cimetidine; Erectile Dysfunction; Gastric Acid; Guanidines; Gynecomastia; Humans; Mal | 1983 |
Effect of cimetidine on gonadal function in man.
Topics: Cimetidine; Guanidines; Gynecomastia; Humans; Male; Testis | 1982 |
[Oral cimetidine does not induce hypersecretion of prolactin].
Topics: Adult; Aged; Cimetidine; Female; Guanidines; Gynecomastia; Humans; Male; Middle Aged; Prolactin | 1981 |
Risk of gynaecomastia associated with cimetidine, omeprazole, and other antiulcer drugs.
Topics: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Case-Control Studies; Cimetidine; Cohort Studies; | 1994 |
Studies on the interactions between drugs and estrogen: analytical method for prediction system of gynecomastia induced by drugs on the inhibitory metabolism of estradiol using Escherichia coli coexpressing human CYP3A4 with human NADPH-cytochrome P450 re
Topics: Catechols; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cyt | 2000 |
Cimetidine is an antiandrogen in the rat.
Topics: Androgen Antagonists; Animals; Binding, Competitive; Cimetidine; Dihydrotestosterone; Female; Gonado | 1979 |
Gynaecomastia associated with cimetidine.
Topics: Cimetidine; Estradiol; Guanidines; Gynecomastia; Humans; Male; Prolactin; Testosterone | 1979 |
[Gynaecomastia during treatment with cimetidine].
Topics: Cimetidine; Female; Galactorrhea; Guanidines; Gynecomastia; Humans; Male; Middle Aged; Pregnancy | 1978 |
Report on the United States experience with cimetidine in Zollinger-Ellision syndrome and other hypersecretory states.
Topics: Adult; Aged; Antacids; Cimetidine; Female; Gastric Juice; Guanidines; Gynecomastia; Histamine; Human | 1978 |
[Can ulcer treatment with cimetidine and other H2 receptor antagonists induce sexual dysfunctions (impotence) and other endocrine disorders?].
Topics: Amenorrhea; Cimetidine; Erectile Dysfunction; Female; Gynecomastia; Humans; Male; Peptic Ulcer; Risk | 1991 |
[Cimetidine or ranitidine?].
Topics: Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Esophagitis, Peptic; Gynecomastia; Humans; Male; Pep | 1986 |
Gynaecomastia, galactorrhoea and impotence--the uncommon side effects of cimetidine therapy.
Topics: Adult; Cimetidine; Erectile Dysfunction; Female; Galactorrhea; Gynecomastia; Humans; Lactation Disor | 1987 |
Prolactin and the hypothalamic-pituitary-testicular axis in cimetidine-treated men.
Topics: Adult; Cimetidine; Erectile Dysfunction; Follicle Stimulating Hormone; Gynecomastia; Humans; Hypotha | 1985 |
Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cimetidine; Drug Interactions; Erectile Dysfunctio | 1985 |
Cimetidine blocks testosterone synthesis.
Topics: Aged; Cimetidine; Female; Gynecomastia; Humans; Male; Sexual Dysfunction, Physiological; Testosteron | 1985 |