cimetidine has been researched along with Glioblastoma in 3 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This short note presents previous research data supporting a pilot study of metronomic dapsone during the entire course of glioblastoma treatment." | 8.02 | Research Supporting a Pilot Study of Metronomic Dapsone during Glioblastoma Chemoirradiation. ( Kast, RE, 2021) |
| "Cimetidine added to temozolomide compared with temozolomide alone induced survival benefits in nude mice with U373 human glioblastoma multiforme (GBM) cells orthotopically xenografted in the brain." | 7.73 | Combined cimetidine and temozolomide, compared with temozolomide alone: significant increases in survival in nude mice bearing U373 human glioblastoma multiforme orthotopic xenografts. ( Brotchi, J; Camby, I; Darro, F; Gabius, J; Gaussin, JF; James, S; Kiss, R; Lefranc, F, 2005) |
| "This short note presents previous research data supporting a pilot study of metronomic dapsone during the entire course of glioblastoma treatment." | 4.02 | Research Supporting a Pilot Study of Metronomic Dapsone during Glioblastoma Chemoirradiation. ( Kast, RE, 2021) |
| "Cimetidine added to temozolomide compared with temozolomide alone induced survival benefits in nude mice with U373 human glioblastoma multiforme (GBM) cells orthotopically xenografted in the brain." | 3.73 | Combined cimetidine and temozolomide, compared with temozolomide alone: significant increases in survival in nude mice bearing U373 human glioblastoma multiforme orthotopic xenografts. ( Brotchi, J; Camby, I; Darro, F; Gabius, J; Gaussin, JF; James, S; Kiss, R; Lefranc, F, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kast, RE | 1 |
| Lefranc, F | 2 |
| James, S | 1 |
| Camby, I | 1 |
| Gaussin, JF | 1 |
| Darro, F | 1 |
| Brotchi, J | 2 |
| Gabius, J | 1 |
| Kiss, R | 2 |
| Yeaton, P | 1 |
1 review available for cimetidine and Glioblastoma
| Article | Year |
|---|---|
Cimetidine, an unexpected anti-tumor agent, and its potential for the treatment of glioblastoma (review).
Topics: Antineoplastic Agents; Brain Neoplasms; Cimetidine; Clinical Trials as Topic; Colonic Neoplasms; Gli | 2006 |
2 other studies available for cimetidine and Glioblastoma
| Article | Year |
|---|---|
Research Supporting a Pilot Study of Metronomic Dapsone during Glioblastoma Chemoirradiation.
Topics: Cimetidine; Dapsone; Glioblastoma; Humans; Interleukin-8; Pemphigoid, Bullous; Pharmaceutical Prepar | 2021 |
Combined cimetidine and temozolomide, compared with temozolomide alone: significant increases in survival in nude mice bearing U373 human glioblastoma multiforme orthotopic xenografts.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cimetidine; Dac | 2005 |