cimetidine has been researched along with Experimental Neoplasms in 17 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histamine treatment accelerated tumor growth, but only in normal animals and had little effect on tumor growth in immunocompromised hosts." | 5.27 | The effect of histamine, antihistamines, and a mast cell stabilizer on the growth of cloudman melanoma cells in DBA/2 mice. ( Askenase, PW; Nordlund, JJ, 1983) |
| " Schedule dependency and dose-response evaluations involving Taxol were studied in the SC M109 model." | 1.29 | Taxol-based combination chemotherapy and other in vivo preclinical antitumor studies. ( Rose, WC, 1993) |
| "Histamine treatment accelerated tumor growth, but only in normal animals and had little effect on tumor growth in immunocompromised hosts." | 1.27 | The effect of histamine, antihistamines, and a mast cell stabilizer on the growth of cloudman melanoma cells in DBA/2 mice. ( Askenase, PW; Nordlund, JJ, 1983) |
| "N-Nitrosocimetidine (NCM) is a nitrosation product of cimetidine, a commonly-prescribed pharmaceutical agent." | 1.27 | N-nitrosocimetidine as a modifier of chemically-initiated tumors in mice. ( Anderson, LM; Giner-Sorolla, A; Hagiwara, A; Kovatch, RM; Rehm, S; Rice, JM; Riggs, CW, 1988) |
| "Cimetidine was administered in the drinking water to C57BL/6 mice after an intraperitoneal injection of an LD90 dose of EL4 tumor cells." | 1.26 | Cimetidine protection against lethal tumor challenge in mice. ( Ferguson, RM; Gifford, RR; Voss, BV, 1981) |
| "Cimetidine is a histamine H2-antagonist." | 1.26 | No evidence of carcinogenicity of N-nitrosocimetidine in rats. ( Eisenbrand, G; Habs, H; Habs, M; Schmähl, D, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (82.35) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takahashi, K | 1 |
| Tanaka, S | 1 |
| Furuta, K | 1 |
| Ichikawa, A | 1 |
| Osband, ME | 1 |
| Hamilton, D | 1 |
| Shen, YJ | 1 |
| Cohen, E | 1 |
| Shlesinger, M | 1 |
| Lavin, P | 1 |
| Brown, A | 1 |
| McCaffrey, R | 1 |
| Gifford, RR | 3 |
| Ferguson, RM | 3 |
| Voss, BV | 3 |
| Collins, M | 1 |
| Hellmann, K | 1 |
| Nordlund, JJ | 1 |
| Askenase, PW | 1 |
| Hannant, D | 1 |
| James, K | 1 |
| Bolton, RE | 1 |
| Robertson, MD | 1 |
| Milne, I | 1 |
| Habs, M | 1 |
| Eisenbrand, G | 1 |
| Habs, H | 1 |
| Schmähl, D | 1 |
| Leslie, GB | 1 |
| Noakes, DN | 1 |
| Pollitt, FD | 1 |
| Roe, FJ | 1 |
| Walker, TF | 1 |
| Wysocki, J | 1 |
| Kłuciński, P | 1 |
| Rose, WC | 1 |
| Tutton, PJ | 1 |
| Steel, GG | 1 |
| Schmidtke, JR | 1 |
| Anderson, LM | 2 |
| Hagiwara, A | 1 |
| Giner-Sorolla, A | 2 |
| Kovatch, RM | 1 |
| Rehm, S | 1 |
| Riggs, CW | 1 |
| Rice, JM | 1 |
| Magee, PN | 1 |
| Haller, IM | 1 |
| Budinger, JM | 1 |
2 reviews available for cimetidine and Experimental Neoplasms
| Article | Year |
|---|---|
[Immunoregulating properties of histamine H2 receptor antagonists].
Topics: Animals; Cimetidine; Histamine H2 Antagonists; Humans; Immune System; Neoplasms, Experimental; Ranit | 1993 |
Role of pharmacokinetics and DNA dosimetry in relating in vitro to in vivo actions of N-nitroso compounds.
Topics: Animals; Biotransformation; Cell Transformation, Neoplastic; Cimetidine; DNA, Neoplasm; Dose-Respons | 1985 |
15 other studies available for cimetidine and Experimental Neoplasms
| Article | Year |
|---|---|
Histamine H(2) receptor-mediated modulation of local cytokine expression in a mouse experimental tumor model.
Topics: Animals; Cell Division; Cimetidine; Cytokines; Histamine; Histidine Decarboxylase; Interferon-gamma; | 2002 |
Successful tumour immunotherapy with cimetidine in mice.
Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Guanidines; Immunotherapy; Male; Mice; Mice, | 1981 |
Cimetidine reduction of tumour formation in mice.
Topics: Animals; Cimetidine; Female; Fibrosarcoma; Guanidines; Immunotherapy; Lymphocytes; Lymphoma; Mice; M | 1981 |
Cimetidine, the immune system, and cancer.
Topics: Adjuvants, Immunologic; Animals; Cimetidine; Guanidines; Humans; Lymphocytes; Mice; Neoplasms, Exper | 1981 |
Histamine receptor antagonism and anti-tumour activity.
Topics: Animals; Antineoplastic Agents; Cimetidine; Drug Synergism; Female; Furans; Histamine H2 Antagonists | 1982 |
Cimetidine protection against lethal tumor challenge in mice.
Topics: Animals; Cimetidine; Female; Guanidines; Immunity, Cellular; Lymphoma; Mice; Mice, Inbred C57BL; Neo | 1981 |
The effect of histamine, antihistamines, and a mast cell stabilizer on the growth of cloudman melanoma cells in DBA/2 mice.
Topics: Animals; Chromones; Cimetidine; Histamine; Histamine Antagonists; Immunosuppression Therapy; Male; M | 1983 |
Cimetidine and therapy of rodent tumours.
Topics: Animals; Cimetidine; Fibrosarcoma; Guanidines; Male; Mesothelioma; Mice; Mice, Inbred Strains; Neopl | 1982 |
No evidence of carcinogenicity of N-nitrosocimetidine in rats.
Topics: Animals; Cimetidine; Female; Follow-Up Studies; Guanidines; Male; Methylnitronitrosoguanidine; Neopl | 1982 |
A two-year study with cimetidine in the rat: assessment for chronic toxicity and carcinogenicity.
Topics: Animals; Carcinogens; Cimetidine; Female; Guanidines; Leydig Cell Tumor; Liver; Male; Neoplasms, Exp | 1981 |
Taxol-based combination chemotherapy and other in vivo preclinical antitumor studies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Dexamethasone; Dose-Response Re | 1993 |
Influence of biogenic amines on the growth of xenografted human colorectal carcinomas.
Topics: Adrenergic Agonists; Animals; Biogenic Amines; Cimetidine; Colonic Neoplasms; Female; Humans; Mice; | 1979 |
Histamine type-2 receptor antagonist immune modulation. I. Increased cell-mediated cytotoxicity in normal and in down-regulated systems.
Topics: Animals; Cells, Cultured; Cimetidine; Cytotoxicity Tests, Immunologic; Lymphoma, Non-Hodgkin; Mice; | 1988 |
N-nitrosocimetidine as a modifier of chemically-initiated tumors in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cimetidine; Cocarcinogenesis; Lung Neoplasms; Mice; Neopl | 1988 |
Effects of cimetidine, nitrite, cimetidine plus nitrite, and nitrosocimetidine on tumors in mice following transplacental plus chronic lifetime exposure.
Topics: Animals; Body Weight; Cimetidine; Dose-Response Relationship, Drug; Female; Fetus; Lung Neoplasms; M | 1985 |