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cimetidine and Exocrine Pancreatic Insufficiency

cimetidine has been researched along with Exocrine Pancreatic Insufficiency in 21 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Exocrine Pancreatic Insufficiency: A malabsorption condition resulting from greater than 10% reduction in the secretion of pancreatic digestive enzymes (LIPASE; PROTEASES; and AMYLASE) by the EXOCRINE PANCREAS into the DUODENUM. This condition is often associated with CYSTIC FIBROSIS and with chronic PANCREATITIS.

Research Excerpts

ExcerptRelevanceReference
"Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination."9.05Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980)
"The bentiromide test for exocrine pancreatic function was carried out in normal volunteers, patients with cystic fibrosis (CF) without clinical evidence of pancreatic dysfunction, and CF patients with clinically significant exocrine pancreatic insufficiency."7.67Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease. ( Egge, AC; Hubbard, VS; Lester, LA; Wolf, RO, 1984)
"The effectiveness and safety of the use of cimetidine as an adjunct to pancreatic enzymes was evaluated in eight patients with cystic fibrosis having pancreatic insufficiency."7.66Effectiveness of cimetidine as an adjunct to supplemental pancreatic enzymes in patients with cystic fibrosis. ( Dunn, GD; Hubbard, VS; Lester, LA, 1980)
" In this controlled randomized study, 8 hospitalized patients with severe exocrine pancreatic insufficiency and considerable steatorrhoea (greater than 15 g faecal fat/day) were treated with a conventional pancreatic enzyme preparation (Pankreon 700; 3 X 3 dragees daily), with (300 mg) and without cimetidine before meals, and with a new pH-sensitive enzyme preparation (Kreon; 3 X 6 capsules daily) comprising acid-protected granules."5.06Therapy of pancreatogenic steatorrhoea: does acid protection of pancreatic enzymes offer any advantage? ( Creutzfeldt, W; Göke, B; Lankisch, PG; Lembcke, B, 1986)
"Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination."5.05Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980)
"A 20-month-old German shepherd with primary pancreatic acinar atrophy and exocrine pancreatic insufficiency that was treated with pancreatic enzyme supplementation, vitamin B12, and cimetidine developed oral bleeding."3.73Oral ulceration and bleeding associated with pancreatic enzyme supplementation in a German shepherd with pancreatic acinar atrophy. ( Snead, E, 2006)
"The bentiromide test for exocrine pancreatic function was carried out in normal volunteers, patients with cystic fibrosis (CF) without clinical evidence of pancreatic dysfunction, and CF patients with clinically significant exocrine pancreatic insufficiency."3.67Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease. ( Egge, AC; Hubbard, VS; Lester, LA; Wolf, RO, 1984)
"The effect of the addition of sodium bicarbonate, aluminum hydroxide, magnesium hydroxide, calcium carbonate, or cimetidine to supplemental pancreatic enzyme therapy was investigated in patients with severe exocrine pancreatic insufficiency."3.66Pancreatic enzyme replacement: the effect of antacids or cimetidine. ( Graham, DY, 1982)
"The effectiveness and safety of the use of cimetidine as an adjunct to pancreatic enzymes was evaluated in eight patients with cystic fibrosis having pancreatic insufficiency."3.66Effectiveness of cimetidine as an adjunct to supplemental pancreatic enzymes in patients with cystic fibrosis. ( Dunn, GD; Hubbard, VS; Lester, LA, 1980)
" Even under long-term administration no severe organic side effect occured with the drug which generally is well tolerated."2.36[Review: cimetidine: mode of action and clinical efficacy in various gastrointestinal diseases (author's transl)]. ( Hotz, J, 1980)
"Pretreatment with Cimetidine did not increase the enzyme concentrations further."1.27Exocrine pancreatic substitution: facts and controversies. ( Worning, H, 1986)
" However, the patients' compliance is just as important; the dosage must be individualized."1.27Enzyme substitution in pancreatic disease. ( Andrén-Sandberg, A, 1987)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199018 (85.71)18.7374
1990's2 (9.52)18.2507
2000's1 (4.76)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Snead, E1
Hotz, J2
Gugler, R1
Musch, E1
Hubbard, VS2
Wolf, RO1
Lester, LA2
Egge, AC1
Graham, DY2
Lankisch, PG2
Lembcke, B2
Isenberg, JN1
Hendrix, PY1
Cox, KL1
Pidgeon, G2
Strombeck, DR1
DiMagno, EP1
Auricchio, S1
Durie, PR1
Bell, L1
Linton, W1
Corey, ML1
Forstner, GG1
Dunn, GD1
Bruno, MJ1
Rauws, EA1
Hoek, FJ1
Tytgat, GN1
Mundlos, S1
Kühnelt, P1
Adler, G1
Worning, H1
Göke, B1
Creutzfeldt, W1
Andrén-Sandberg, A1
Pilsworth, RC1
Lehner, RP1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pancreatic Enzyme Replacement Therapy (PERT) for Treatment of Exocrine Pancreatic Insufficiency in Patients With Unresectable Pancreatic Cancer[NCT02985801]Phase 1/Phase 216 participants (Actual)Interventional2016-12-31Terminated (stopped due to Study was terminated due to difficulty in recruiting subjects.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for cimetidine and Exocrine Pancreatic Insufficiency

ArticleYear
[Review: cimetidine: mode of action and clinical efficacy in various gastrointestinal diseases (author's transl)].
    Zeitschrift fur Gastroenterologie, 1980, Volume: 18, Issue:7

    Topics: Acute Disease; Cimetidine; Duodenal Ulcer; Exocrine Pancreatic Insufficiency; Gastric Acid; Gastroes

1980
[Therapy of digestive insufficiency in cystic fibrosis].
    La Pediatria, 1981, Sep-30, Volume: 89, Issue:3

    Topics: Antacids; Bile Acids and Salts; Celiac Disease; Cimetidine; Cystic Fibrosis; Exocrine Pancreatic Ins

1981

Trials

3 trials available for cimetidine and Exocrine Pancreatic Insufficiency

ArticleYear
Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.
    Gut, 1980, Volume: 21, Issue:9

    Topics: Adolescent; Bicarbonates; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; Dietary Fats; Drug The

1980
Comparative effects of adjuvant cimetidine and omeprazole during pancreatic enzyme replacement therapy.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:5

    Topics: Adult; Aged; Celiac Disease; Cimetidine; Double-Blind Method; Exocrine Pancreatic Insufficiency; Fem

1994
Therapy of pancreatogenic steatorrhoea: does acid protection of pancreatic enzymes offer any advantage?
    Zeitschrift fur Gastroenterologie, 1986, Volume: 24, Issue:12

    Topics: Celiac Disease; Chronic Disease; Cimetidine; Clinical Trials as Topic; Drug Therapy, Combination; Ex

1986

Other Studies

16 other studies available for cimetidine and Exocrine Pancreatic Insufficiency

ArticleYear
Oral ulceration and bleeding associated with pancreatic enzyme supplementation in a German shepherd with pancreatic acinar atrophy.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2006, Volume: 47, Issue:6

    Topics: Animals; Atrophy; Cimetidine; Dog Diseases; Dogs; Enzyme Inhibitors; Exocrine Pancreatic Insufficien

2006
[H2 receptor blockaders: domains for oral use. Indications for cimetidine and ranitidine in gastroenterology].
    Fortschritte der Medizin, 1984, Feb-23, Volume: 102, Issue:8

    Topics: Administration, Oral; Cimetidine; Duodenitis; Esophagitis, Peptic; Exocrine Pancreatic Insufficiency

1984
[Cimetidine and recent H2-receptor blocking agents in the therapy of gastrointestinal diseases].
    Die Medizinische Welt, 1982, Aug-13, Volume: 33, Issue:31-32

    Topics: Cimetidine; Exocrine Pancreatic Insufficiency; Gastrointestinal Diseases; Guanidines; Histamine H2 A

1982
Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease.
    Digestive diseases and sciences, 1984, Volume: 29, Issue:10

    Topics: 4-Aminobenzoic Acid; Adolescent; Adult; Aminobenzoates; Amylases; Child; Cimetidine; Cystic Fibrosis

1984
Pancreatic enzyme replacement: the effect of antacids or cimetidine.
    Digestive diseases and sciences, 1982, Volume: 27, Issue:6

    Topics: Adult; Aluminum Hydroxide; Antacids; Bicarbonates; Calcium Carbonate; Celiac Disease; Cimetidine; Ex

1982
[Therapy of exocrine pancreatic insufficiency].
    Deutsche medizinische Wochenschrift (1946), 1984, May-04, Volume: 109, Issue:18

    Topics: Antacids; Biological Availability; Celiac Disease; Cimetidine; Exocrine Pancreatic Insufficiency; Hu

1984
Effect of short-term cimetidine administration on fecal bile acid losses in cystic fibrosis.
    Journal of pediatric gastroenterology and nutrition, 1983, Volume: 2, Issue:3

    Topics: Adolescent; Bile Acids and Salts; Child; Cimetidine; Cystic Fibrosis; Exocrine Pancreatic Insufficie

1983
Evaluation of treatment for pancreatic exocrine insufficiency in dogs with ligated pancreatic ducts.
    American journal of veterinary research, 1982, Volume: 43, Issue:3

    Topics: Animals; Bicarbonates; Bile Acids and Salts; Cimetidine; Dog Diseases; Dogs; Exocrine Pancreatic Ins

1982
Controversies in the treatment of exocrine pancreatic insufficiency.
    Digestive diseases and sciences, 1982, Volume: 27, Issue:6

    Topics: Adult; Antacids; Celiac Disease; Child, Preschool; Cimetidine; Exocrine Pancreatic Insufficiency; Ga

1982
Effect of diet on exocrine pancreatic insufficiency in dogs.
    Journal of the American Veterinary Medical Association, 1982, Aug-01, Volume: 181, Issue:3

    Topics: Animal Feed; Animals; Antacids; Cimetidine; Dog Diseases; Dogs; Exocrine Pancreatic Insufficiency; F

1982
Effectiveness of cimetidine as an adjunct to supplemental pancreatic enzymes in patients with cystic fibrosis.
    The American journal of clinical nutrition, 1980, Volume: 33, Issue:11

    Topics: Adolescent; Adult; Body Weight; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; Drug Therapy, Co

1980
Monitoring enzyme replacement treatment in exocrine pancreatic insufficiency using the cholesteryl octanoate breath test.
    Gut, 1990, Volume: 31, Issue:11

    Topics: Breath Tests; Cholesterol Esters; Cimetidine; Exocrine Pancreatic Insufficiency; Gastric Emptying; H

1990
Treatment of steatorrhea in chronic pancreatitis.
    Hospital practice (Office ed.), 1986, Jan-15, Volume: 21, Issue:1

    Topics: Antacids; Celiac Disease; Cimetidine; Exocrine Pancreatic Insufficiency; Humans; Pancreatic Extracts

1986
Exocrine pancreatic substitution: facts and controversies.
    Scandinavian journal of gastroenterology. Supplement, 1986, Volume: 126

    Topics: Adult; Chronic Disease; Cimetidine; Drug Therapy, Combination; Exocrine Pancreatic Insufficiency; Hu

1986
Enzyme substitution in pancreatic disease.
    Digestion, 1987, Volume: 37 Suppl 1

    Topics: Chronic Disease; Cimetidine; Exocrine Pancreatic Insufficiency; Humans; Malabsorption Syndromes; Pan

1987
Use of cimetidine as an aid to the control of pancreatic insufficiency in a German shepherd bitch.
    The Veterinary record, 1986, Sep-06, Volume: 119, Issue:10

    Topics: Animals; Cimetidine; Dog Diseases; Dogs; Exocrine Pancreatic Insufficiency; Female; Pancreatic Juice

1986