cimetidine has been researched along with Exocrine Pancreatic Insufficiency in 21 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Exocrine Pancreatic Insufficiency: A malabsorption condition resulting from greater than 10% reduction in the secretion of pancreatic digestive enzymes (LIPASE; PROTEASES; and AMYLASE) by the EXOCRINE PANCREAS into the DUODENUM. This condition is often associated with CYSTIC FIBROSIS and with chronic PANCREATITIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination." | 9.05 | Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980) |
| "The bentiromide test for exocrine pancreatic function was carried out in normal volunteers, patients with cystic fibrosis (CF) without clinical evidence of pancreatic dysfunction, and CF patients with clinically significant exocrine pancreatic insufficiency." | 7.67 | Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease. ( Egge, AC; Hubbard, VS; Lester, LA; Wolf, RO, 1984) |
| "The effectiveness and safety of the use of cimetidine as an adjunct to pancreatic enzymes was evaluated in eight patients with cystic fibrosis having pancreatic insufficiency." | 7.66 | Effectiveness of cimetidine as an adjunct to supplemental pancreatic enzymes in patients with cystic fibrosis. ( Dunn, GD; Hubbard, VS; Lester, LA, 1980) |
| " In this controlled randomized study, 8 hospitalized patients with severe exocrine pancreatic insufficiency and considerable steatorrhoea (greater than 15 g faecal fat/day) were treated with a conventional pancreatic enzyme preparation (Pankreon 700; 3 X 3 dragees daily), with (300 mg) and without cimetidine before meals, and with a new pH-sensitive enzyme preparation (Kreon; 3 X 6 capsules daily) comprising acid-protected granules." | 5.06 | Therapy of pancreatogenic steatorrhoea: does acid protection of pancreatic enzymes offer any advantage? ( Creutzfeldt, W; Göke, B; Lankisch, PG; Lembcke, B, 1986) |
| "Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination." | 5.05 | Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980) |
| "A 20-month-old German shepherd with primary pancreatic acinar atrophy and exocrine pancreatic insufficiency that was treated with pancreatic enzyme supplementation, vitamin B12, and cimetidine developed oral bleeding." | 3.73 | Oral ulceration and bleeding associated with pancreatic enzyme supplementation in a German shepherd with pancreatic acinar atrophy. ( Snead, E, 2006) |
| "The bentiromide test for exocrine pancreatic function was carried out in normal volunteers, patients with cystic fibrosis (CF) without clinical evidence of pancreatic dysfunction, and CF patients with clinically significant exocrine pancreatic insufficiency." | 3.67 | Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease. ( Egge, AC; Hubbard, VS; Lester, LA; Wolf, RO, 1984) |
| "The effect of the addition of sodium bicarbonate, aluminum hydroxide, magnesium hydroxide, calcium carbonate, or cimetidine to supplemental pancreatic enzyme therapy was investigated in patients with severe exocrine pancreatic insufficiency." | 3.66 | Pancreatic enzyme replacement: the effect of antacids or cimetidine. ( Graham, DY, 1982) |
| "The effectiveness and safety of the use of cimetidine as an adjunct to pancreatic enzymes was evaluated in eight patients with cystic fibrosis having pancreatic insufficiency." | 3.66 | Effectiveness of cimetidine as an adjunct to supplemental pancreatic enzymes in patients with cystic fibrosis. ( Dunn, GD; Hubbard, VS; Lester, LA, 1980) |
| " Even under long-term administration no severe organic side effect occured with the drug which generally is well tolerated." | 2.36 | [Review: cimetidine: mode of action and clinical efficacy in various gastrointestinal diseases (author's transl)]. ( Hotz, J, 1980) |
| "Pretreatment with Cimetidine did not increase the enzyme concentrations further." | 1.27 | Exocrine pancreatic substitution: facts and controversies. ( Worning, H, 1986) |
| " However, the patients' compliance is just as important; the dosage must be individualized." | 1.27 | Enzyme substitution in pancreatic disease. ( Andrén-Sandberg, A, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (85.71) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Snead, E | 1 |
| Hotz, J | 2 |
| Gugler, R | 1 |
| Musch, E | 1 |
| Hubbard, VS | 2 |
| Wolf, RO | 1 |
| Lester, LA | 2 |
| Egge, AC | 1 |
| Graham, DY | 2 |
| Lankisch, PG | 2 |
| Lembcke, B | 2 |
| Isenberg, JN | 1 |
| Hendrix, PY | 1 |
| Cox, KL | 1 |
| Pidgeon, G | 2 |
| Strombeck, DR | 1 |
| DiMagno, EP | 1 |
| Auricchio, S | 1 |
| Durie, PR | 1 |
| Bell, L | 1 |
| Linton, W | 1 |
| Corey, ML | 1 |
| Forstner, GG | 1 |
| Dunn, GD | 1 |
| Bruno, MJ | 1 |
| Rauws, EA | 1 |
| Hoek, FJ | 1 |
| Tytgat, GN | 1 |
| Mundlos, S | 1 |
| Kühnelt, P | 1 |
| Adler, G | 1 |
| Worning, H | 1 |
| Göke, B | 1 |
| Creutzfeldt, W | 1 |
| Andrén-Sandberg, A | 1 |
| Pilsworth, RC | 1 |
| Lehner, RP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pancreatic Enzyme Replacement Therapy (PERT) for Treatment of Exocrine Pancreatic Insufficiency in Patients With Unresectable Pancreatic Cancer[NCT02985801] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2016-12-31 | Terminated (stopped due to Study was terminated due to difficulty in recruiting subjects.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for cimetidine and Exocrine Pancreatic Insufficiency
| Article | Year |
|---|---|
[Review: cimetidine: mode of action and clinical efficacy in various gastrointestinal diseases (author's transl)].
Topics: Acute Disease; Cimetidine; Duodenal Ulcer; Exocrine Pancreatic Insufficiency; Gastric Acid; Gastroes | 1980 |
[Therapy of digestive insufficiency in cystic fibrosis].
Topics: Antacids; Bile Acids and Salts; Celiac Disease; Cimetidine; Cystic Fibrosis; Exocrine Pancreatic Ins | 1981 |
3 trials available for cimetidine and Exocrine Pancreatic Insufficiency
| Article | Year |
|---|---|
Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.
Topics: Adolescent; Bicarbonates; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; Dietary Fats; Drug The | 1980 |
Comparative effects of adjuvant cimetidine and omeprazole during pancreatic enzyme replacement therapy.
Topics: Adult; Aged; Celiac Disease; Cimetidine; Double-Blind Method; Exocrine Pancreatic Insufficiency; Fem | 1994 |
Therapy of pancreatogenic steatorrhoea: does acid protection of pancreatic enzymes offer any advantage?
Topics: Celiac Disease; Chronic Disease; Cimetidine; Clinical Trials as Topic; Drug Therapy, Combination; Ex | 1986 |
16 other studies available for cimetidine and Exocrine Pancreatic Insufficiency
| Article | Year |
|---|---|
Oral ulceration and bleeding associated with pancreatic enzyme supplementation in a German shepherd with pancreatic acinar atrophy.
Topics: Animals; Atrophy; Cimetidine; Dog Diseases; Dogs; Enzyme Inhibitors; Exocrine Pancreatic Insufficien | 2006 |
[H2 receptor blockaders: domains for oral use. Indications for cimetidine and ranitidine in gastroenterology].
Topics: Administration, Oral; Cimetidine; Duodenitis; Esophagitis, Peptic; Exocrine Pancreatic Insufficiency | 1984 |
[Cimetidine and recent H2-receptor blocking agents in the therapy of gastrointestinal diseases].
Topics: Cimetidine; Exocrine Pancreatic Insufficiency; Gastrointestinal Diseases; Guanidines; Histamine H2 A | 1982 |
Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease.
Topics: 4-Aminobenzoic Acid; Adolescent; Adult; Aminobenzoates; Amylases; Child; Cimetidine; Cystic Fibrosis | 1984 |
Pancreatic enzyme replacement: the effect of antacids or cimetidine.
Topics: Adult; Aluminum Hydroxide; Antacids; Bicarbonates; Calcium Carbonate; Celiac Disease; Cimetidine; Ex | 1982 |
[Therapy of exocrine pancreatic insufficiency].
Topics: Antacids; Biological Availability; Celiac Disease; Cimetidine; Exocrine Pancreatic Insufficiency; Hu | 1984 |
Effect of short-term cimetidine administration on fecal bile acid losses in cystic fibrosis.
Topics: Adolescent; Bile Acids and Salts; Child; Cimetidine; Cystic Fibrosis; Exocrine Pancreatic Insufficie | 1983 |
Evaluation of treatment for pancreatic exocrine insufficiency in dogs with ligated pancreatic ducts.
Topics: Animals; Bicarbonates; Bile Acids and Salts; Cimetidine; Dog Diseases; Dogs; Exocrine Pancreatic Ins | 1982 |
Controversies in the treatment of exocrine pancreatic insufficiency.
Topics: Adult; Antacids; Celiac Disease; Child, Preschool; Cimetidine; Exocrine Pancreatic Insufficiency; Ga | 1982 |
Effect of diet on exocrine pancreatic insufficiency in dogs.
Topics: Animal Feed; Animals; Antacids; Cimetidine; Dog Diseases; Dogs; Exocrine Pancreatic Insufficiency; F | 1982 |
Effectiveness of cimetidine as an adjunct to supplemental pancreatic enzymes in patients with cystic fibrosis.
Topics: Adolescent; Adult; Body Weight; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; Drug Therapy, Co | 1980 |
Monitoring enzyme replacement treatment in exocrine pancreatic insufficiency using the cholesteryl octanoate breath test.
Topics: Breath Tests; Cholesterol Esters; Cimetidine; Exocrine Pancreatic Insufficiency; Gastric Emptying; H | 1990 |
Treatment of steatorrhea in chronic pancreatitis.
Topics: Antacids; Celiac Disease; Cimetidine; Exocrine Pancreatic Insufficiency; Humans; Pancreatic Extracts | 1986 |
Exocrine pancreatic substitution: facts and controversies.
Topics: Adult; Chronic Disease; Cimetidine; Drug Therapy, Combination; Exocrine Pancreatic Insufficiency; Hu | 1986 |
Enzyme substitution in pancreatic disease.
Topics: Chronic Disease; Cimetidine; Exocrine Pancreatic Insufficiency; Humans; Malabsorption Syndromes; Pan | 1987 |
Use of cimetidine as an aid to the control of pancreatic insufficiency in a German shepherd bitch.
Topics: Animals; Cimetidine; Dog Diseases; Dogs; Exocrine Pancreatic Insufficiency; Female; Pancreatic Juice | 1986 |