cimetidine and Esophageal Reflux studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Research Excerpts

Excerpt	Relevance	Reference
"We conclude that omeprazole is superior to cimetidine for the relief of all grades of heartburn in GERD, whether or not the patient has unequivocal endoscopic oesophagitis."	9.08	Omeprazole is more effective than cimetidine for the relief of all grades of gastro-oesophageal reflux disease-associated heartburn, irrespective of the presence or absence of endoscopic oesophagitis. ( Axon, AT; Bate, CM; Emmas, CE; Green, JR; Murray, FE; Taylor, MD; Tildesley, G, 1997)
" is more effective than cimetidine 800 mg nocte in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis."	9.08	Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis. ( Axon, AT; Bate, CM; Emmas, C; Green, JR; Murrays, FE; Owen, SM; Taylor, MD; Tildesley, G, 1998)
"To compare the effects of ranitidine 75 mg with those of either cimetidine 200 mg or placebo given on demand for relief of typical symptoms of gastro-oesophageal reflux disease during a 15-day period."	9.08	On-demand treatment of gastro-oesophageal reflux symptoms: a comparison of ranitidine 75 mg with cimetidine 200 mg or placebo. ( Casset-Semanza, F; Galmiche, JP; Shi, G; Simon, B; Slama, A, 1998)
"One hundred and twenty-five patients with symptoms of heartburn and acid regurgitation but without endoscopic abnormalities were randomized to receive 200 mg cimetidine suspension four times daily or placebo for two weeks."	9.07	Cimetidine suspension in patients with stage 0 gastro-oesophageal reflux disease. ( Höbel, W; Riemann, JF, 1991)
"A new chewable tablet containing cimetidine 200 mg and alginic acid 500 mg, at a dosage of one tablet four times daily, was compared in a 12 week randomised study with the standard dosage of cimetidine (400 mg four times daily) in the management of oesophageal reflux disease."	9.07	Combination of cimetidine and alginic acid: an improvement in the treatment of oesophageal reflux disease. Cooperative Oesophageal Group. ( , 1991)
"The comparative efficacy of a 12-week acute treatment with 800 and 1600 mg cimetidine daily and the effectiveness of a 400-mg single-dose maintenance treatment versus placebo lasting 6 months were studied in a double-blind fashion in 30 and 24 patients, respectively, with gastroesophageal reflux (GER) disease."	9.06	Gastroesophageal reflux disease. Acute and maintenance treatments with cimetidine. ( Erichsen, H; Fjøsne, U; Grette, K; Halvorsen, T; Kaul, B; Myrvold, HE; Petersen, H, 1986)
"In a double-blind, randomized, comparative trial of the prokinetic drug cisapride and the H2-blocker cimetidine, mucosal healing and changes in symptoms of gastroesophageal reflux were evaluated in patients with erosive reflux esophagitis."	9.06	Double-blind comparison of cisapride and cimetidine in treatment of reflux esophagitis. ( Evreux, M; Filoche, B; Fournet, J; Fraitag, B; Galmiche, JP; Soule, JC; Vitaux, J; Zeitoun, P, 1990)
"In a Canadian multicenter trial, a new dosing regimen of cimetidine (Tagamet)-600 mg given twice a day-was compared with the standard regimen of 300 mg four times a day in 118 evaluable patients with endoscopically proved esophagitis."	9.05	Cimetidine therapy for gastroesophageal reflux disease. ( Archambault, AP; Cleator, IG; Farley, A; Hershfield, NB; Navert, H; Prokipchuk, EJ; Thomson, AB, 1985)
"Thirty three children aged 2 to 42 months (mean 9 months) with gastro-oesophageal reflux and peptic oesophagitis took part in a treatment trial comparing cimetidine (20 mg/kg/day) with an intensive regimen of antacids (Maalox, 700 mmol (mEq)/1 X 73 m2/day)."	9.05	Antacids and cimetidine treatment for gastro-oesophageal reflux and peptic oesophagitis. ( Auricchio, S; Capobianco, S; Cucchiara, S; Romaniello, G; Staiano, A, 1984)
"Using a method described earlier, an investigation of the gastro-oesophageal region was made on duodenal ulcer patients before and during cimetidine treatment."	9.05	The influence of cimetidine on the acid gastro-oesophageal reflux in duodenal ulcer patients. ( Wallin, L, 1980)
"The effectiveness of cimetidine for symptomatic relief in patients with chronic gastroesophageal reflux was studied in a multicenter, double blind clinical trial."	9.04	Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial. ( Behar, J; Brand, DL; Brown, FC; Castell, DO; Cohen, S; Crossley, RJ; Pope, CE; Winans, CS, 1978)
"Famotidine, a potent and long-acting H2-receptor antagonist, has been evaluated in patients with gastroesophageal reflux disease (GERD)."	8.78	Famotidine in gastroesophageal reflux disease (GERD). ( Wesdorp, IC, 1992)
"15-hour intra-oesophageal pH monitoring and symptom scores were used to compare the effect of cimetidine, 1 or 2 g daily with placebo on patients with acid gastro-oesophageal reflux."	7.66	Cimetidine in gastro-oesophageal reflux. ( Bennett, JR; Buckton, G; Martin, HD, 1983)
"Gastroesophageal reflux (GER) is a common episode in pediatric patients with severe motor and intellectual disabilities (SMID) and occasionally leads to a severe clinical state accompanied with nausea, hematemesis, melena, wheezing, pneumonia, anemia and/or failure to thrive."	5.32	Treatment of gastric hemorrhage by pulverized omeprazole and antacid--concomitant administration via a nasogastric tube. ( Kinoshita, E; Mukai, S; Ohtani, H; Sawada, Y; Yamaguchi, T, 2004)
"We conclude that omeprazole is superior to cimetidine for the relief of all grades of heartburn in GERD, whether or not the patient has unequivocal endoscopic oesophagitis."	5.08	Omeprazole is more effective than cimetidine for the relief of all grades of gastro-oesophageal reflux disease-associated heartburn, irrespective of the presence or absence of endoscopic oesophagitis. ( Axon, AT; Bate, CM; Emmas, CE; Green, JR; Murray, FE; Taylor, MD; Tildesley, G, 1997)
" is more effective than cimetidine 800 mg nocte in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis."	5.08	Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis. ( Axon, AT; Bate, CM; Emmas, C; Green, JR; Murrays, FE; Owen, SM; Taylor, MD; Tildesley, G, 1998)
"To compare the effects of ranitidine 75 mg with those of either cimetidine 200 mg or placebo given on demand for relief of typical symptoms of gastro-oesophageal reflux disease during a 15-day period."	5.08	On-demand treatment of gastro-oesophageal reflux symptoms: a comparison of ranitidine 75 mg with cimetidine 200 mg or placebo. ( Casset-Semanza, F; Galmiche, JP; Shi, G; Simon, B; Slama, A, 1998)
"One hundred and twenty-five patients with symptoms of heartburn and acid regurgitation but without endoscopic abnormalities were randomized to receive 200 mg cimetidine suspension four times daily or placebo for two weeks."	5.07	Cimetidine suspension in patients with stage 0 gastro-oesophageal reflux disease. ( Höbel, W; Riemann, JF, 1991)
"A new chewable tablet containing cimetidine 200 mg and alginic acid 500 mg, at a dosage of one tablet four times daily, was compared in a 12 week randomised study with the standard dosage of cimetidine (400 mg four times daily) in the management of oesophageal reflux disease."	5.07	Combination of cimetidine and alginic acid: an improvement in the treatment of oesophageal reflux disease. Cooperative Oesophageal Group. ( , 1991)
"The effectiveness of cimetidine (30-40 mg/kg/day) was evaluated in 32 children with gastroesophageal reflux disease complicated by esophagitis who entered a random double-blind trial for 12 weeks."	5.06	Cimetidine treatment of reflux esophagitis in children: an Italian multicentric study. ( Amarri, S; Astolfi, R; Balli, F; Conti-Nibali, S; Cucchiara, S; Gobio-Casali, L; Guandalini, S; Magazzú, G; Staiano, A, 1989)
"In a double-blind, randomized, comparative trial of the prokinetic drug cisapride and the H2-blocker cimetidine, mucosal healing and changes in symptoms of gastroesophageal reflux were evaluated in patients with erosive reflux esophagitis."	5.06	Double-blind comparison of cisapride and cimetidine in treatment of reflux esophagitis. ( Evreux, M; Filoche, B; Fournet, J; Fraitag, B; Galmiche, JP; Soule, JC; Vitaux, J; Zeitoun, P, 1990)
"A total of 36 patients with grade 2 or greater erosive esophagitis and an abnormal 24-h pH monitor study, were treated in a randomized, double-blind fashion to assess the efficacy of sucralfate suspension as adjunctive therapy to cimetidine for severe esophagitis secondary to gastroesophageal reflux."	5.06	Sucralfate used as adjunctive therapy in patients with severe erosive peptic esophagitis resulting from gastroesophageal reflux. ( Herrera, JL; Johnson, LF; McCabe, M; Peura, DA; Shay, SS, 1990)
"Thirty three children aged 2 to 42 months (mean 9 months) with gastro-oesophageal reflux and peptic oesophagitis took part in a treatment trial comparing cimetidine (20 mg/kg/day) with an intensive regimen of antacids (Maalox, 700 mmol (mEq)/1 X 73 m2/day)."	5.05	Antacids and cimetidine treatment for gastro-oesophageal reflux and peptic oesophagitis. ( Auricchio, S; Capobianco, S; Cucchiara, S; Romaniello, G; Staiano, A, 1984)
"Using a method described earlier, an investigation of the gastro-oesophageal region was made on duodenal ulcer patients before and during cimetidine treatment."	5.05	The influence of cimetidine on the acid gastro-oesophageal reflux in duodenal ulcer patients. ( Wallin, L, 1980)
"In a Canadian multicenter trial, a new dosing regimen of cimetidine (Tagamet)-600 mg given twice a day-was compared with the standard regimen of 300 mg four times a day in 118 evaluable patients with endoscopically proved esophagitis."	5.05	Cimetidine therapy for gastroesophageal reflux disease. ( Archambault, AP; Cleator, IG; Farley, A; Hershfield, NB; Navert, H; Prokipchuk, EJ; Thomson, AB, 1985)
"The effectiveness of cimetidine for symptomatic relief in patients with chronic gastroesophageal reflux was studied in a multicenter, double blind clinical trial."	5.04	Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial. ( Behar, J; Brand, DL; Brown, FC; Castell, DO; Cohen, S; Crossley, RJ; Pope, CE; Winans, CS, 1978)
"Famotidine, a potent and long-acting H2-receptor antagonist, has been evaluated in patients with gastroesophageal reflux disease (GERD)."	4.78	Famotidine in gastroesophageal reflux disease (GERD). ( Wesdorp, IC, 1992)
"A 78-year-old nonvegetarian white woman with symptomatic gastroesophageal reflux (GER) was started on cimetidine 300 mg 4 times daily in February 1990 and took various other antisecretory medications over the course of the next 4 1/2 years."	3.71	Vitamin B(12) deficiency associated with histamine(2)-receptor antagonists and a proton-pump inhibitor. ( Page, RL; Ruscin, JM; Valuck, RJ, 2002)
"Successful omeprazole therapy in patients with symptomatic gastroesophageal reflux (GER) refractory to treatment with H2-receptor antagonists has often been reported."	3.69	Control of gastric acid with high dose H2-receptor antagonists after omeprazole failure: report of two cases. ( Castell, DO; Just, RJ; Lagerström, PO; Leite, LP, 1995)
"Gastric acid secretion in response to a protein meal and to exogenously administered synthetic human gastrin 17-I was measured in patients with Barrett's esophagus, patients with uncomplicated gastroesophageal reflux, and normal age- and sex-matched controls."	3.67	Elevated gastric acid secretion in patients with Barrett's metaplastic epithelium. ( Levine, DS; Mulholland, MW; Reid, BJ; Rubin, CE, 1989)
"15-hour intra-oesophageal pH monitoring and symptom scores were used to compare the effect of cimetidine, 1 or 2 g daily with placebo on patients with acid gastro-oesophageal reflux."	3.66	Cimetidine in gastro-oesophageal reflux. ( Bennett, JR; Buckton, G; Martin, HD, 1983)
"Famotidine increased the lower esophagus sphincter pressure from the initial 2."	2.68	[The effect of cimetidine and famotidine on esophageal motility]. ( Paradowski, L; Salomon, A; Szelag, A, 1996)
"Twenty-seven patients with gastroesophageal reflux-related gastrointestinal symptoms, pulmonary symptoms, or both were given randomly determined doses of cimetidine."	2.67	Efficacy of cimetidine for gastric acid suppression in pediatric patients. ( Grand, RJ; Lambert, J; Mobassaleh, M, 1992)
"Cimetidine (400 mg) b."	2.67	Cimetidine improves GERD symptoms in patients selected by a validated GERD questionnaire. ( Damgaard Pedersen, NE; Joelsson, B; Johnsson, F; Roth, Y, 1993)
"We conclude that gastroesophageal reflux can play a significant role in some patients with nonallergic pulmonary disease and that its treatment can improve pulmonary symptoms and objective measurements of pulmonary function."	2.67	Medical and surgical treatment of nonallergic asthma associated with gastroesophageal reflux. ( Carrasco, E; Galleguillos, F; Larrain, A; Pope, CE; Sepulveda, R, 1991)
"Medical treatment of gastroesophageal reflux disease often results in improvement of symptoms."	2.66	24-hour esophageal pH monitoring before and after medical therapy for reflux esophagitis. ( Lieberman, DA, 1988)
"Twenty patients with bronchial asthma who also had gastro-oesophageal reflux were investigated."	2.65	Relationship between asthma and gastro-oesophageal reflux. ( Bernstein, A; Cooper, DN; Earis, JE; Goodall, RJ; Temple, JG, 1981)
"Effectiveness with gastric ulcer has been less convincing than with duodenal ulcer."	2.64	Cimetidine. H2-receptor blockade in gastrointestinal disease. ( Schlippert, W, 1978)
"Depending on the severity of the GERD manifestation, pharmacotherapy is often added."	2.41	Management of supraesophageal complications of gastroesophageal reflux disease in infants and children. ( Orenstein, SR, 2000)
"Second, hiatal hernia, capable of promoting GERD by several mechanisms, is more prevalent among the obese."	2.41	Gastro-oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations. ( Barak, N; Ehrenpreis, ED; Harrison, JR; Sitrin, MD, 2002)
"Gastro-oesophageal reflux disease (GORD) is a very common disorder of upper gastro-intestinal motility, differing widely in severity and prognosis."	2.39	Pharmacokinetic optimisation in the treatment of gastro-oesophageal reflux disease. ( Berstad, A; Hatlebakk, JG, 1996)
" There is insufficient information on the long-term paediatric use of famotidine to validate its use in children, and the endocrinological side effects associated with cimetidine therapy in adults essentially preclude its long-term use in children."	2.39	Do H2 receptor antagonists have a therapeutic role in childhood? ( Kelly, DA, 1994)
" While very safe, clinicians need to know correct dosing guidelines, drug interactions, and side effect profiles."	2.38	The clinical use of histamine-2 receptor antagonists. ( Michocki, RJ; Richardson, JP, 1992)
"Useful indications are treatment of gastric ulcer and pnacreatic insufficiency."	2.36	H2-receptor antagonists in perspective. ( Cortot, A; Malagelada, JR, 1978)
" Even under long-term administration no severe organic side effect occured with the drug which generally is well tolerated."	2.36	[Review: cimetidine: mode of action and clinical efficacy in various gastrointestinal diseases (author's transl)]. ( Hotz, J, 1980)
"Gastroesophageal reflux (GER) is a common episode in pediatric patients with severe motor and intellectual disabilities (SMID) and occasionally leads to a severe clinical state accompanied with nausea, hematemesis, melena, wheezing, pneumonia, anemia and/or failure to thrive."	1.32	Treatment of gastric hemorrhage by pulverized omeprazole and antacid--concomitant administration via a nasogastric tube. ( Kinoshita, E; Mukai, S; Ohtani, H; Sawada, Y; Yamaguchi, T, 2004)
"In refractory cases of GERD, eosinophilic esophagitis must be considered before any surgical measure."	1.32	Eosinophilic infiltration of the esophagus: gastroesophageal reflux versus eosinophilic esophagitis in children--discussion on daily practice. ( Cury, EK; Faintuch, S; Schraibman, V, 2004)
"Indications for the studies were upper airway obstruction (UAO) and congenital choanal atresia (CCA)."	1.29	Proximal pH-metry for diagnosis of upper airway complications of gastroesophageal reflux. ( Beste, DJ; Conley, SF; Werlin, SL, 1995)
"Although gastro-esophageal reflux (GER) is one of the major causes of chronic persistent cough (CPC) in the USA and in Europe, it is a rare cause of CPC in Japan."	1.29	[A case of chronic persistent cough caused by gastro-esophageal reflux]. ( Amemiya, T; Fujimura, M; Matsuda, T; Mizuguchi, M; Nishi, K; Ooka, T, 1995)
"Chest pain was associated with an episode of GER in three patients (43%)."	1.28	Esophageal chest pain in children with asthma. ( Berezin, S; Glassman, MS; Medow, MS; Newman, LJ, 1991)
"Omeprazole was well tolerated, and the incidence of clinical and laboratory adverse experiences was similar in patients receiving omeprazole, placebo, cimetidine, or ranitidine."	1.28	Comparative tolerability profile of omeprazole in clinical trials. ( Bradstreet, DC; Simon, TJ, 1991)
"Recent data describe the acid aspiration syndrome (AAS) as the cause of 25% of maternal deaths associated with anaesthesia and 19% of all deaths totally attributable to anaesthesia (DHSS, 1982; Lunn and Mushin, 1982)."	1.27	Aspiration of gastric contents. ( Nimmo, WS, 1985)
"Gastroesophageal reflux (GER) disease is a common, multifactorial medical condition that may be difficult to treat."	1.27	A critical review of current medical therapy for gastroesophageal reflux disease. ( Richter, JE, 1986)
"We conclude that severe gastroesophageal reflux disease in children causes esophageal motor dysfunction, resulting from esophageal inflammation."	1.27	Esophageal motor abnormalities in children with gastroesophageal reflux and peptic esophagitis. ( Andreotti, MR; Auricchio, S; Cucchiara, S; D'Ambrosio, R; De Filippo, P; Di Lorenzo, C; Prato, M; Staiano, A, 1986)
"Cimetidine 200 mg was given i."	1.26	Cimetidine in the prevention of the pulmonary acid aspiration (Mendelson's) syndrome. ( Dobb, G; Jordan, MJ; Williams, JG, 1979)
"Gastro-esophageal reflux is discussed with reference to pathogenetic factors and therapy."	1.26	[Therapy of gastro-esophageal reflux disease]. ( Güller, R, 1980)
"The diagnosis of gastroesophageal reflux (GER) was made in 28 of the basis of reflux (grade III) on upper gastrointestinal series and the presence of esophagitis either grossly at endoscopy or on esophageal biopsy."	1.26	Gastroesophageal reflux in the severely retarded who vomit: criteria for and results of surgical intervention in twenty-two patients. ( Ashcraft, E; Byrne, WJ; Euler, AR; Golladay, ES; Nash, DG; Seibert, JJ, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	71 (58.68)	18.7374
1990's	40 (33.06)	18.2507
2000's	8 (6.61)	29.6817
2010's	1 (0.83)	24.3611
2020's	1 (0.83)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Long Term Effects of Laparoscopic Roux-en-Y Gastric Bypass on Gastro-esophageal Reflux: Clinical Impact of Weakly Acidic Reflux[NCT02618044]				86 participants (Actual)	Observational	2006-05-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Pharmacologic treatment of GERD: Where we are now, and where are we going? Annals of the New York Academy of Sciences, 2020, Volume: 1482, Issue:1 Topics: Cimetidine; Esomeprazole; Esophageal Mucosa; Gastroesophageal Reflux; Humans; Lansoprazole; Omeprazo	2020
Gastro-oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations. Obesity reviews : an official journal of the International Association for the Study of Obesity, 2002, Volume: 3, Issue:1 Topics: Body Composition; Carcinoma; Cimetidine; Esophageal Neoplasms; Gastroesophageal Reflux; Hernia, Hiat	2002
[Bronchial asthma and gastroesophageal reflux disease: are they interrelated by chance?]. Klinicheskaia meditsina, 2005, Volume: 83, Issue:1 Topics: Adult; Algorithms; Anti-Ulcer Agents; Asthma; Bronchodilator Agents; Cimetidine; Controlled Clinical	2005
[Review: cimetidine: mode of action and clinical efficacy in various gastrointestinal diseases (author's transl)]. Zeitschrift fur Gastroenterologie, 1980, Volume: 18, Issue:7 Topics: Acute Disease; Cimetidine; Duodenal Ulcer; Exocrine Pancreatic Insufficiency; Gastric Acid; Gastroes	1980
Cimetidine and related drugs in anesthesia. Anesthesia and analgesia, 1982, Volume: 61, Issue:7 Topics: Anesthesia, Obstetrical; Child; Cimetidine; Drug Administration Schedule; Emergencies; Female; Gastr	1982
Gastroesophageal reflux. Pathogenesis, diagnosis, and therapy. Annals of internal medicine, 1982, Volume: 97, Issue:1 Topics: Alginates; Antacids; Barium Sulfate; Bethanechol; Bethanechol Compounds; Cimetidine; Esophagitis, Pe	1982
Gastroesophageal reflux and asthma. Clinical reviews in allergy, 1983, Volume: 1, Issue:1 Topics: Adolescent; Adult; Aged; Asthma; Bethanechol; Bethanechol Compounds; Child; Child, Preschool; Cimeti	1983
[Clinical importance of antagonists of histamine H2 receptors in gastroenterology]. La Clinica terapeutica, 1984, Mar-31, Volume: 108, Issue:6 Topics: Cimetidine; Drug Resistance; Duodenal Ulcer; Gastroesophageal Reflux; Histamine H2 Antagonists; Huma	1984
[Ranitidine]. Medicina clinica, 1983, Jul-02, Volume: 81, Issue:4 Topics: Anti-Ulcer Agents; Chemical Phenomena; Chemistry; Cimetidine; Duodenal Ulcer; Gastroesophageal Reflu	1983
Gastroesophageal reflux. Comprehensive therapy, 1983, Volume: 9, Issue:11 Topics: Antacids; Cimetidine; Esophagogastric Junction; Gastroesophageal Reflux; Heartburn; Humans; Metoclop	1983
[Pulmonary aspiration of gastric contents during anesthesia. Physiological and pharmacological data: applications to prevention and treatment]. Annales francaises d'anesthesie et de reanimation, 1984, Volume: 3, Issue:1 Topics: Anesthesia, General; Antiemetics; Cimetidine; Gastric Juice; Gastroesophageal Reflux; Humans; Intrao	1984
Do H2 receptor antagonists have a therapeutic role in childhood? Journal of pediatric gastroenterology and nutrition, 1994, Volume: 19, Issue:3 Topics: Adolescent; Child; Child, Preschool; Cimetidine; Cystic Fibrosis; Drug Interactions; Famotidine; Gas	1994
[The effect of H2-receptor blockers (cimetidine and ranitidin) on parotid gland secretion and salivary carbonic anhydrase activity in the rat]. Fogorvosi szemle, 1993, Volume: 86, Issue:8 Topics: Animals; Carbonic Anhydrase Inhibitors; Cimetidine; Disease Models, Animal; Esophagitis, Peptic; Gas	1993
[Is remission of Barrett esophagus possible?]. Gastroenterologie clinique et biologique, 1994, Volume: 18, Issue:1 Pt 2 Topics: Antacids; Barrett Esophagus; Bethanechol Compounds; Cimetidine; Drug Therapy, Combination; Gastroeso	1994
Efficacy of omeprazole in lower grades of gastro-oesophageal reflux disease. Scandinavian journal of gastroenterology. Supplement, 1994, Volume: 201 Topics: Cimetidine; Clinical Trials as Topic; Double-Blind Method; Gastroesophageal Reflux; Humans; Omeprazo	1994
Barrett's esophagus: new definitions and approaches in children. Journal of pediatric gastroenterology and nutrition, 1993, Volume: 16, Issue:4 Topics: Adenocarcinoma; Adolescent; Adult; Aged; Barrett Esophagus; Child; Child, Preschool; Cimetidine; End	1993
Pharmacokinetic optimisation in the treatment of gastro-oesophageal reflux disease. Clinical pharmacokinetics, 1996, Volume: 31, Issue:5 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Antacids; Benzimidazoles; Cimetidine; Cisapride; Domperidon	1996
Does medical antireflux therapy improve asthma in asthmatics with gastroesophageal reflux?: a critical review of the literature. Chest, 1998, Volume: 114, Issue:1 Topics: Antacids; Anti-Asthmatic Agents; Anti-Ulcer Agents; Asthma; Cimetidine; Circadian Rhythm; Cisapride;	1998
[25 years of gastric acid blockers]. Nederlands tijdschrift voor geneeskunde, 1999, Dec-11, Volume: 143, Issue:50 Topics: Anti-Ulcer Agents; Cimetidine; Dyspepsia; Gastroesophageal Reflux; Histamine H2 Antagonists; Humans;	1999
Management of supraesophageal complications of gastroesophageal reflux disease in infants and children. The American journal of medicine, 2000, Mar-06, Volume: 108 Suppl 4a Topics: Bethanechol; Child; Child, Preschool; Cimetidine; Cisapride; Fundoplication; Gastroesophageal Reflux	2000
H2-receptor antagonists in perspective. Mayo Clinic proceedings, 1978, Volume: 53, Issue:3 Topics: Cimetidine; Double-Blind Method; Duodenal Ulcer; Gastroesophageal Reflux; Gastrointestinal Hemorrhag	1978
[Cimetidine: a review (author's transl)]. Revista medica de Chile, 1979, Volume: 107, Issue:3 Topics: Cimetidine; Esophagitis, Peptic; Gastroesophageal Reflux; Gastrointestinal Hemorrhage; Guanidines; H	1979
Drug therapy: Cimetidine. The New England journal of medicine, 1978, Nov-02, Volume: 299, Issue:18 Topics: Acute Disease; Aged; Antacids; Cimetidine; Clinical Trials as Topic; Drug Evaluation; Duodenal Ulcer	1978
Abdominal surgery (first of three parts). The New England journal of medicine, 1979, Mar-22, Volume: 300, Issue:12 Topics: Abdomen; Aged; Appendicitis; Cimetidine; Crohn Disease; Duodenal Ulcer; Gastrectomy; Gastroesophagea	1979
Famotidine in gastroesophageal reflux disease (GERD). Hepato-gastroenterology, 1992, Volume: 39 Suppl 1 Topics: Cimetidine; Esophagitis, Peptic; Famotidine; Gastroesophageal Reflux; Humans; Ranitidine	1992
The clinical use of histamine-2 receptor antagonists. Maryland medical journal (Baltimore, Md. : 1985), 1992, Volume: 41, Issue:5 Topics: Cimetidine; Drug Evaluation; Famotidine; Gastroesophageal Reflux; Humans; Nizatidine; Peptic Ulcer;	1992
[Asthma and gastroesophageal reflux. Outcome of asthma after longterm medical treatment of the reflux]. Anales espanoles de pediatria, 1990, Volume: 33, Issue:4 Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Asthma; Child; Child, Preschool; Cimetidine; E	1990
Barrett's esophagus. The New England journal of medicine, 1986, Aug-07, Volume: 315, Issue:6 Topics: Adenocarcinoma; Antacids; Barrett Esophagus; Bethanechol; Bethanechol Compounds; Cimetidine; Epithel	1986
The medical therapy of reflux oesophagitis. Bailliere's clinical gastroenterology, 1987, Volume: 1, Issue:4 Topics: Antacids; Bethanechol; Bethanechol Compounds; Cimetidine; Cisapride; Domperidone; Esophagitis, Pepti	1987
Aspiration pneumonitis: predisposing conditions and prevention. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1986, Volume: 44, Issue:5 Topics: Atropine; Cimetidine; Citrates; Citric Acid; Duodenal Ulcer; Esophagogastric Junction; Gastric Acid;	1986

Article	Year
Comparative study of the speed of acid-suppressing effects of oral administration of cimetidine and famotidine. Journal of gastroenterology and hepatology, 2005, Volume: 20, Issue:7 Topics: Adult; Chromatography, High Pressure Liquid; Cimetidine; Cross-Over Studies; Famotidine; Follow-Up S	2005
Ranitidine, cimetidine, antacids, and gastro-oesophageal reflux: results of a 20-hour oesophageal pH study. International journal of clinical pharmacology research, 1984, Volume: 4, Issue:3 Topics: Adult; Aged; Aluminum Hydroxide; Antacids; Cimetidine; Esophagus; Female; Gastroesophageal Reflux; H	1984
Antacids and cimetidine treatment for gastro-oesophageal reflux and peptic oesophagitis. Archives of disease in childhood, 1984, Volume: 59, Issue:9 Topics: Aluminum Hydroxide; Antacids; Child, Preschool; Cimetidine; Clinical Trials as Topic; Drug Combinati	1984
Cimetidine and metoclopramide in oesophageal reflux disease. British medical journal (Clinical research ed.), 1983, Jun-11, Volume: 286, Issue:6381 Topics: Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Gastro	1983
The influence of cimetidine on the acid gastro-oesophageal reflux in duodenal ulcer patients. Scandinavian journal of gastroenterology, 1980, Volume: 15, Issue:2 Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Esophagogastric Junction; Female;	1980
Cimetidine, metoclopramide, or placebo in the treatment of symptomatic gastroesophageal reflux. Journal of clinical gastroenterology, 1980, Volume: 2, Issue:2 Topics: Adult; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Female; Gastroesophageal Reflux; G	1980
Cimetidine for the treatment of symptomatic gastro-oesophageal reflux. The British journal of clinical practice, 1981, Volume: 35, Issue:1 Topics: Cimetidine; Clinical Trials as Topic; Double-Blind Method; Female; Gastroesophageal Reflux; Guanidin	1981
Relationship between asthma and gastro-oesophageal reflux. Thorax, 1981, Volume: 36, Issue:2 Topics: Adult; Aged; Asthma; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Female; Gastroesopha	1981
Cimetidine improves GERD symptoms in patients selected by a validated GERD questionnaire. Alimentary pharmacology & therapeutics, 1993, Volume: 7, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Cimetidine; Double-Blind Method; Female; Gastroesophageal Reflux; Hu	1993
Effect of alginate and alginate-cimetidine combination therapy on stimulated postprandial gastro-oesophageal reflux. The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:11 Topics: Adult; Alginates; Cimetidine; Cross-Over Studies; Drug Therapy, Combination; Gastroesophageal Reflux	1995
[The effect of cimetidine and famotidine on esophageal motility]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1996, Volume: 51, Issue:14-18 Topics: Adult; Cimetidine; Duodenal Ulcer; Esophagus; Famotidine; Female; Gastroesophageal Reflux; Histamine	1996
Omeprazole is more effective than cimetidine for the relief of all grades of gastro-oesophageal reflux disease-associated heartburn, irrespective of the presence or absence of endoscopic oesophagitis. Alimentary pharmacology & therapeutics, 1997, Volume: 11, Issue:4 Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Cimetidine; Double-Blind Method; Esophagitis; Female; Ga	1997
Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis. Alimentary pharmacology & therapeutics, 1998, Volume: 12, Issue:1 Topics: Administration, Oral; Anti-Ulcer Agents; Chi-Square Distribution; Cimetidine; Double-Blind Method; E	1998
On-demand treatment of gastro-oesophageal reflux symptoms: a comparison of ranitidine 75 mg with cimetidine 200 mg or placebo. Alimentary pharmacology & therapeutics, 1998, Volume: 12, Issue:9 Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Cimetidine; Double-Blind Method; Female; Gastroesophagea	1998
Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial. Gastroenterology, 1978, Volume: 74, Issue:2 Pt 2 Topics: Adult; Aged; Antacids; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Esophagoscopy; Fem	1978
Drug therapy: Cimetidine. The New England journal of medicine, 1978, Nov-02, Volume: 299, Issue:18 Topics: Acute Disease; Aged; Antacids; Cimetidine; Clinical Trials as Topic; Drug Evaluation; Duodenal Ulcer	1978
Response to cimetidine of gastric outlet obstruction due to peptic ulcer disease. Boletin de la Asociacion Medica de Puerto Rico, 1978, Volume: 70, Issue:6 Topics: Adult; Cimetidine; Clinical Trials as Topic; Drug Evaluation; Duodenal Ulcer; Gastric Emptying; Gast	1978
[Comparative clinical trial of trithiozine and cimetidine in duodenal ulcer]. La Clinica terapeutica, 1979, May-15, Volume: 89, Issue:3 Topics: Adult; Cimetidine; Clinical Trials as Topic; Drug Tolerance; Duodenal Ulcer; Female; Gastroesophagea	1979
Cimetidine. H2-receptor blockade in gastrointestinal disease. Archives of internal medicine, 1978, Volume: 138, Issue:8 Topics: Animals; Cimetidine; Dogs; Duodenal Ulcer; Gastroesophageal Reflux; Gastrointestinal Diseases; Guani	1978
Efficacy of cimetidine for gastric acid suppression in pediatric patients. The Journal of pediatrics, 1992, Volume: 120, Issue:3 Topics: Administration, Oral; Child; Cimetidine; Double-Blind Method; Gastric Acid; Gastric Acidity Determin	1992
Intragastric pH rise with effervescent citrate-cimetidine. Lancet (London, England), 1991, Feb-16, Volume: 337, Issue:8738 Topics: Antacids; Bicarbonates; Cimetidine; Citrates; Citric Acid; Drug Therapy, Combination; Gastroesophage	1991
Combination of cimetidine and alginic acid: an improvement in the treatment of oesophageal reflux disease. Cooperative Oesophageal Group. Gut, 1991, Volume: 32, Issue:7 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alginates; Cimetidine; Drug Combinations; Female; Gastro	1991
Cimetidine suspension in patients with stage 0 gastro-oesophageal reflux disease. Alimentary pharmacology & therapeutics, 1991, Volume: 5, Issue:2 Topics: Adolescent; Adult; Aged; Cimetidine; Double-Blind Method; Female; Gastroesophageal Reflux; Heartburn	1991
Medical and surgical treatment of nonallergic asthma associated with gastroesophageal reflux. Chest, 1991, Volume: 99, Issue:6 Topics: Adult; Asthma; Cimetidine; Female; Forced Expiratory Volume; Gastroesophageal Reflux; Humans; Male;	1991
A double-blind controlled study of the efficacy of cimetidine in the treatment of the cervical symptoms of gastroesophageal reflux. The Journal of otolaryngology, 1990, Volume: 19, Issue:2 Topics: Cimetidine; Double-Blind Method; Gastroesophageal Reflux; Humans; Incidence; Pharyngitis; Randomized	1990
Sucralfate used as adjunctive therapy in patients with severe erosive peptic esophagitis resulting from gastroesophageal reflux. The American journal of gastroenterology, 1990, Volume: 85, Issue:10 Topics: Cimetidine; Double-Blind Method; Drug Therapy, Combination; Esophagitis, Peptic; Esophagoscopy; Fema	1990
Cimetidine 800 mg twice daily for healing erosions and ulcers in gastroesophageal reflux disease. Journal of clinical gastroenterology, 1990, Volume: 12 Suppl 2 Topics: Adult; Aged; Aged, 80 and over; Cimetidine; Double-Blind Method; Drug Administration Schedule; Femal	1990
Double-blind comparison of cisapride and cimetidine in treatment of reflux esophagitis. Digestive diseases and sciences, 1990, Volume: 35, Issue:5 Topics: Adult; Cimetidine; Cisapride; Double-Blind Method; Drug Evaluation; Esophagitis; Esophagoscopy; Fema	1990
Cimetidine treatment of reflux esophagitis in children: an Italian multicentric study. Journal of pediatric gastroenterology and nutrition, 1989, Volume: 8, Issue:2 Topics: Adolescent; Child; Child, Preschool; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Esop	1989
Combined cimetidine-alginate antacid therapy versus single agent treatment for reflux oesophagitis: results of prospective double-blind randomised clinical trial. Annales chirurgiae et gynaecologiae, 1988, Volume: 77, Issue:4 Topics: Alginates; Aluminum Hydroxide; Antacids; Bicarbonates; Cimetidine; Double-Blind Method; Drug Combina	1988
Response of heartburn symptoms to a new cimetidine/alginate combination compared with an alginic acid/antacid. The British journal of clinical practice, 1988, Volume: 42, Issue:12 Topics: Adult; Aged; Alginates; Antacids; Cimetidine; Drug Combinations; Female; Gastroesophageal Reflux; Gl	1988
24-hour esophageal pH monitoring before and after medical therapy for reflux esophagitis. Digestive diseases and sciences, 1988, Volume: 33, Issue:2 Topics: Cimetidine; Esophagitis, Peptic; Female; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration	1988
Gastroesophageal reflux disease. Acute and maintenance treatments with cimetidine. Scandinavian journal of gastroenterology, 1986, Volume: 21, Issue:2 Topics: Adult; Aged; Biopsy; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Administration	1986
Effects of antireflux therapies on salivary function in normal humans. Digestive diseases and sciences, 1987, Volume: 32, Issue:6 Topics: Adult; Bethanechol Compounds; Cimetidine; Gastroesophageal Reflux; Humans; Metoclopramide; Pirenzepi	1987
Cimetidine therapy for gastroesophageal reflux disease. The Western journal of medicine, 1985, Volume: 143, Issue:5 Topics: Adult; Cimetidine; Clinical Trials as Topic; Drug Administration Schedule; Esophagitis; Esophagoscop	1985
Comparison of cimetidine and ranitidine on 24-hour intragastric acidity and serum gastrin profile in patients with esophagitis. Digestive diseases and sciences, 1985, Volume: 30, Issue:4 Topics: Adult; Aged; Cimetidine; Double-Blind Method; Eating; Esophagitis; Gastric Acid; Gastric Acidity Det	1985

Article	Year
Cimetidine-induced lactic acidosis and acute pancreatitis. Southern medical journal, 2010, Volume: 103, Issue:8 Topics: Acidosis, Lactic; Acute Disease; Cimetidine; Diabetes Mellitus, Type 2; Drug Interactions; Female; G	2010
Eosinophilic infiltration of the esophagus: gastroesophageal reflux versus eosinophilic esophagitis in children--discussion on daily practice. Journal of pediatric surgery, 2004, Volume: 39, Issue:2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Biopsy; Child; Cimetidine; Diagnosis, Differential; Enzyme	2004
Treatment of gastric hemorrhage by pulverized omeprazole and antacid--concomitant administration via a nasogastric tube. International journal of clinical pharmacology and therapeutics, 2004, Volume: 42, Issue:11 Topics: Adolescent; Antacids; Anti-Ulcer Agents; Cimetidine; Drug Therapy, Combination; Gastroesophageal Ref	2004
[A new H2-receptor antagonist in the treatment of gastrointestinal diseases]. Die Medizinische Welt, 1982, Oct-29, Volume: 33, Issue:43 Topics: Anti-Ulcer Agents; Chemical Phenomena; Chemistry; Cimetidine; Duodenal Ulcer; Furans; Gastroesophage	1982
New drugs. H2 receptor antagonists--cimetidine and ranitidine. British medical journal (Clinical research ed.), 1983, Feb-26, Volume: 286, Issue:6366 Topics: Anti-Ulcer Agents; Cimetidine; Duodenal Ulcer; Furans; Gastroesophageal Reflux; Gastrointestinal Hem	1983
[Therapy of esophageal reflux disease]. Deutsche medizinische Wochenschrift (1946), 1982, Mar-12, Volume: 107, Issue:10 Topics: Antacids; Bethanechol Compounds; Cimetidine; Esophagitis, Peptic; Furans; Gastroesophageal Reflux; H	1982
[Esophago-gastro-enteric manifestations of scleroderma. Apropos of a clinical case]. Chirurgia italiana, 1983, Volume: 35, Issue:2 Topics: Adult; Cimetidine; Diagnosis, Differential; Duodenal Ulcer; Esophageal Diseases; Gastroesophageal Re	1983
Treatment of gastroesophageal reflux. The Western journal of medicine, 1984, Volume: 140, Issue:6 Topics: Bethanechol Compounds; Cimetidine; Domperidone; Gastroesophageal Reflux; Humans; Infant; Infant, New	1984
Cimetidine in gastro-oesophageal reflux. Digestion, 1983, Volume: 26, Issue:3 Topics: Adult; Aged; Cimetidine; Female; Gastric Acid; Gastroesophageal Reflux; Guanidines; Humans; Hydrogen	1983
Management of gastro-oesophageal reflux. Australian and New Zealand journal of medicine, 1982, Volume: 12, Issue:1 Topics: Antacids; Body Weight; Cimetidine; Diagnosis, Differential; Diet, Reducing; Esophagoscopy; Gastroeso	1982
[Indications for cimetidine]. Revista espanola de las enfermedades del aparato digestivo, 1981, Volume: 59, Issue:3 Topics: Cimetidine; Duodenal Ulcer; Gastroesophageal Reflux; Gastrointestinal Hemorrhage; Guanidines; Humans	1981
Gastroesophageal reflux in the severely retarded who vomit: criteria for and results of surgical intervention in twenty-two patients. Surgery, 1982, Volume: 91, Issue:1 Topics: Adolescent; Adult; Child; Child, Preschool; Cimetidine; Female; Follow-Up Studies; Gastroesophageal	1982
Complications of gastroesophageal reflux in patients with cystic fibrosis. The Journal of pediatrics, 1982, Volume: 100, Issue:4 Topics: Adolescent; Adult; Antacids; Child; Cimetidine; Cystic Fibrosis; Esophageal Stenosis; Esophagitis, P	1982
[Gastroesophageal reflux: indications and limitations of medical therapy and function tests]. Helvetica chirurgica acta, 1981, Volume: 47, Issue:6 Topics: Cimetidine; Eructation; Gastroesophageal Reflux; Heartburn; Humans; Manometry	1981
The effect of parietal cell vagotomy on gastrooesophageal function in duodenal ulcer patients. Scandinavian journal of gastroenterology, 1981, Volume: 16, Issue:1 Topics: Adult; Cimetidine; Duodenal Ulcer; Esophagogastric Junction; Gastroesophageal Reflux; Humans; Hydrog	1981
[Pathophysiology, clinical aspects and therapy of gastro-esophageal reflux disease]. Schweizerische medizinische Wochenschrift, 1981, Apr-18, Volume: 111, Issue:16 Topics: Antacids; Barrett Esophagus; Candidiasis; Cholic Acids; Cimetidine; Diagnosis, Differential; Endosco	1981
Drugs for esophageal reflux. The Medical letter on drugs and therapeutics, 1980, Mar-21, Volume: 22, Issue:6 Topics: Antacids; Anxiety; Cimetidine; Gastroesophageal Reflux; Humans; Parasympathomimetics; Tremor	1980
Benign oesophageal stricture in the elderly--use of cimetidine and fibre-optic dilatation. Age and ageing, 1980, Volume: 9, Issue:1 Topics: Aged; Cimetidine; Dilatation; Esophageal Diseases; Female; Fiber Optic Technology; Gastroesophageal	1980
Oesophageal reflux. The Practitioner, 1980, Volume: 224, Issue:1342 Topics: Aged; Alginates; Antacids; Cimetidine; Esophagogastric Junction; Gastroesophageal Reflux; Heartburn;	1980
[Gastro-esophageal reflux]. Minerva chirurgica, 1980, Jun-30, Volume: 35, Issue:12 Topics: Antacids; Bethanechol Compounds; Cimetidine; Esophagogastric Junction; Gastroesophageal Reflux; Gast	1980
[Therapy of gastro-esophageal reflux disease]. Schweizerische medizinische Wochenschrift, 1980, Oct-18, Volume: 110, Issue:42 Topics: Alginates; Antacids; Cimetidine; Esophagogastric Junction; Esophagoscopy; Gastroesophageal Reflux; H	1980
Over-the-counter H2-receptor antagonists for heartburn. The Medical letter on drugs and therapeutics, 1995, Oct-27, Volume: 37, Issue:960 Topics: Cimetidine; Drug Interactions; Gastroesophageal Reflux; Heartburn; Histamine H2 Antagonists; Humans;	1995
Control of gastric acid with high dose H2-receptor antagonists after omeprazole failure: report of two cases. The American journal of gastroenterology, 1995, Volume: 90, Issue:10 Topics: Adult; Anti-Ulcer Agents; Cimetidine; Drug Resistance; Female; Gastric Acid; Gastroesophageal Reflux	1995
[A case of chronic persistent cough caused by gastro-esophageal reflux]. Nihon Kyobu Shikkan Gakkai zasshi, 1995, Volume: 33, Issue:6 Topics: Aged; Chronic Disease; Cimetidine; Cough; Female; Gastroesophageal Reflux; Histamine H2 Antagonists;	1995
Megaoesophagus and glucocorticoid-deficient hypoadrenocorticism in a dog. The Journal of small animal practice, 1995, Volume: 36, Issue:3 Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Animals; Cimetidine; Dexamethasone; Dog Diseases	1995
[Gastroesophageal reflux and bronchial asthma]. Klinicheskaia meditsina, 1994, Volume: 72, Issue:6 Topics: Adult; Alcohol Drinking; Aminophylline; Animals; Asthma; Bronchodilator Agents; Child; Cimetidine; D	1994
Predictive factors of the long term outcome in gastro-oesophageal reflux disease: six year follow up of 107 patients. Gut, 1994, Volume: 35, Issue:1 Topics: Adult; Aged; Antacids; Cimetidine; Esophagitis, Peptic; Female; Follow-Up Studies; Gastroesophageal	1994
Proximal pH-metry for diagnosis of upper airway complications of gastroesophageal reflux. The Journal of otolaryngology, 1995, Volume: 24, Issue:5 Topics: Airway Obstruction; Antiemetics; Bethanechol; Child, Preschool; Choanal Atresia; Cimetidine; Endosco	1995
Report from the NASPGN Therapeutics Subcommittee. Cisapride and the attack of the P-450s. Journal of pediatric gastroenterology and nutrition, 1996, Volume: 23, Issue:4 Topics: Anti-Ulcer Agents; Child; Cimetidine; Cisapride; Cytochrome P-450 Enzyme System; Drug Interactions;	1996
"Infantile colic" as the sole manifestation of gastroesophageal reflux. Journal of pediatric gastroenterology and nutrition, 1997, Volume: 24, Issue:2 Topics: Administration, Oral; Anti-Ulcer Agents; Cimetidine; Cisapride; Colic; Esophagus; Female; Follow-Up	1997
Clinical and economic factors in the selection of drugs for gastroesophageal reflux disease. PharmacoEconomics, 1993, Volume: 3, Issue:2 Topics: Cimetidine; Cost-Benefit Analysis; Endoscopy; Gastroesophageal Reflux; Humans; Omeprazole; Ranitidin	1993
Therapeutic substitution of cimetidine for nizatidine was not associated with an increase in healthcare utilization. The American journal of managed care, 2000, Volume: 6, Issue:10 Topics: Aged; Cimetidine; Cost Savings; Drug Costs; Duodenal Ulcer; Formularies, Hospital as Topic; Gastroes	2000
Vitamin B(12) deficiency associated with histamine(2)-receptor antagonists and a proton-pump inhibitor. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:5 Topics: Aged; Cimetidine; Creatinine; Enzyme Inhibitors; Female; Folic Acid; Gastroesophageal Reflux; Histam	2002
Cimetidine in the prevention of the pulmonary acid aspiration (Mendelson's) syndrome. British journal of anaesthesia, 1979, Volume: 51, Issue:10 Topics: Adolescent; Adult; Aged; Anesthesia, General; Cimetidine; Female; Gastric Juice; Gastroesophageal Re	1979
Antitumour effect of cimetidine. Lancet (London, England), 1979, Apr-21, Volume: 1, Issue:8121 Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Cimetidine; Female	1979
Rational treatment of oesophagitis. Drugs, 1978, Volume: 15, Issue:3 Topics: Alginates; Antacids; Barium Sulfate; Biopsy; Cimetidine; Esophageal Stenosis; Esophagitis; Esophagos	1978
Histamine H2 antagonists. The Practitioner, 1979, Volume: 223, Issue:1336 Topics: Animals; Bismuth; Carbenoxolone; Chemical Phenomena; Chemistry; Cimetidine; Duodenal Ulcer; Gastric	1979
[Treatment of reflux disease (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1978, Aug-22, Volume: 67, Issue:34 Topics: Alginates; Antacids; Body Weight; Cimetidine; Esophagitis; Gastroesophageal Reflux; Humans; Metoclop	1978
The pathophysiology and treatment of gastroesophageal reflux disease: new concepts. Archives of internal medicine, 1978, Volume: 138, Issue:9 Topics: Bethanechol Compounds; Cimetidine; Esophagogastric Junction; Esophagus; Gastrins; Gastroesophageal R	1978
Gastrointestinal pitfalls. Australian family physician, 1978, Volume: 7, Issue:10 Topics: Cholelithiasis; Cimetidine; Diverticulum, Colon; Endoscopy; Gastroesophageal Reflux; Gastrointestina	1978
Comparative tolerability profile of omeprazole in clinical trials. Digestive diseases and sciences, 1991, Volume: 36, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Aspartate Aminotransferases; Cimet	1991
[Stomach ulcers in the horse--clinical and gastroscopic findings in 12 horses (1989-1990)]. Tierarztliche Praxis, 1991, Volume: 19, Issue:4 Topics: Animals; Bruxism; Cimetidine; Colic; Eructation; Female; Gastroesophageal Reflux; Gastroscopy; Horse	1991
Esophageal chest pain in children with asthma. Journal of pediatric gastroenterology and nutrition, 1991, Volume: 12, Issue:1 Topics: Adolescent; Antacids; Asthma; Chest Pain; Child; Cimetidine; Endoscopy, Digestive System; Esophagiti	1991
Algitec: an illogical combination? Drug and therapeutics bulletin, 1990, Sep-17, Volume: 28, Issue:19 Topics: Alginates; Cimetidine; Drug Combinations; Gastroesophageal Reflux; Glucuronic Acid; Hexuronic Acids;	1990
Sandifer syndrome reconsidered. Acta paediatrica Scandinavica, 1989, Volume: 78, Issue:5 Topics: Antacids; Child; Child, Preschool; Cimetidine; Domperidone; Dystonia; Female; Gastroesophageal Reflu	1989
Elevated gastric acid secretion in patients with Barrett's metaplastic epithelium. Digestive diseases and sciences, 1989, Volume: 34, Issue:9 Topics: Barrett Esophagus; Chronic Disease; Cimetidine; Female; Gastric Acid; Gastric Acidity Determination;	1989
[Diffuse interstitial lung disease following the use of cimetidine in a patient with severe reflux disease of the esophagus]. Medizinische Klinik (Munich, Germany : 1983), 1989, Aug-15, Volume: 84, Issue:8 Topics: Cimetidine; Gastroesophageal Reflux; Humans; Male; Middle Aged; Pulmonary Fibrosis	1989
Aspiration of gastric contents. British journal of hospital medicine, 1985, Volume: 34, Issue:3 Topics: Administration, Oral; Analgesics, Opioid; Anesthesia; Anesthesia, Obstetrical; Cimetidine; Citrates;	1985
A critical review of current medical therapy for gastroesophageal reflux disease. Journal of clinical gastroenterology, 1986, Volume: 8 Suppl 1 Topics: Alginates; Antacids; Barrett Esophagus; Bethanechol; Bethanechol Compounds; Cimetidine; Gastroesopha	1986
Long-term therapy for chronic gastroesophageal reflux. Archives of internal medicine, 1987, Volume: 147, Issue:10 Topics: Chronic Disease; Cimetidine; Drug Therapy, Combination; Esophagogastric Junction; Gastroesophageal R	1987
Psychosis in association with combined cimetidine and imipramine treatment. Psychosomatics, 1987, Volume: 28, Issue:4 Topics: Adult; Cimetidine; Depressive Disorder; Drug Therapy, Combination; Female; Gastroesophageal Reflux;	1987
Gastroesophageal reflux. Evaluation and current treatment. Postgraduate medicine, 1987, May-01, Volume: 81, Issue:6 Topics: Antacids; Cimetidine; Drug Administration Schedule; Esophagogastric Junction; Gastric Emptying; Gast	1987
Esophageal motor abnormalities in children with gastroesophageal reflux and peptic esophagitis. The Journal of pediatrics, 1986, Volume: 108, Issue:6 Topics: Antacids; Child, Preschool; Cimetidine; Esophagitis, Peptic; Esophagogastric Junction; Gastroesophag	1986
Gastroesophageal reflux in children. Clinical profile, course and outcome with active therapy in 126 cases. Clinical pediatrics, 1987, Volume: 26, Issue:2 Topics: Child; Child, Preschool; Cimetidine; Endoscopy; Esophagitis, Peptic; Feeding Behavior; Female; Fiber	1987
Gastroesophageal reflux disease. Hospital practice (Office ed.), 1985, May-15, Volume: 20, Issue:5 Topics: Antacids; Cimetidine; Gastroesophageal Reflux; Hernia, Hiatal; Humans; Hydrogen-Ion Concentration; P	1985
Ambulatory esophageal pH monitoring in children as an indicator for surgery. Journal of pediatric surgery, 1986, Volume: 21, Issue:3 Topics: Antacids; Child; Child, Preschool; Cimetidine; Esophagus; Gastroesophageal Reflux; Humans; Hydrogen-	1986

cimetidine and Esophageal Reflux

Research Excerpts

Research

Studies (121)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Scarpignato, C	1
Hongo, M	1
Wu, JCY	1
Lottrup, C	1
Lazarescu, A	1
Stein, E	1
Hunt, RH	1
Boehm, KM	1
Gunaga, S	1
Barak, N	1
Ehrenpreis, ED	1
Harrison, JR	1
Sitrin, MD	1
Cury, EK	1
Schraibman, V	1
Faintuch, S	1
Yamaguchi, T	1
Mukai, S	1
Kinoshita, E	1
Ohtani, H	1
Sawada, Y	1
Paleev, NR	1
Isakov, VA	1
Ivanova, OV	1
Adachi, K	1
Komazawa, Y	1
Mihara, T	1
Azumi, T	1
Fujisawa, T	1
Katsube, T	1
Furuta, K	1
Kinoshita, Y	1
Desechalliers, JP	1
Galmiche, JP	4
Touchais, JY	1
Denis, P	1
Colin, R	1
Hotz, J	1
Manchikanti, L	1
Kraus, JW	1
Edds, SP	1
Richter, JE	2
Castell, DO	6
Senfft, U	1
Feely, J	1
Wormsley, KG	1
Shapiro, GG	1
Christie, DL	1
Carella, G	1
Rösch, W	1
Acero, D	1
Wu, WC	1
Lehot, JJ	1
Saunier, CF	1
Cucchiara, S	3
Staiano, A	3
Romaniello, G	1
Capobianco, S	1
Auricchio, S	2
Temple, JG	2
Bradby, GV	1
O'Connor, FO	1
Panesar, KS	1
Mulligan, TO	1
Robinson, TJ	1
Ward, DW	1
Modena, S	1
Crudo, V	1
Abrescia, F	1
Baratella, M	1
Bertrand, C	1
Salvagno, R	1
Vesentini, S	1
Grill, BB	1
Bennett, JR	1
Buckton, G	1
Martin, HD	1
Whelan, G	1
Pérez Blanco, FJ	1
Salmerón Escobar, J	1
Castañeda Navarro, E	1
Peña Angulo, JF	1
Wallin, L	2
Bright-Asare, P	1
El-Bassoussi, M	1
Greaney, MG	1
Irvin, TT	1
Goodall, RJ	1
Earis, JE	1
Cooper, DN	1
Bernstein, A	1
Byrne, WJ	1
Euler, AR	1
Ashcraft, E	1
Nash, DG	1
Seibert, JJ	1
Golladay, ES	1
Bendig, DW	1
Seilheimer, DK	1
Wagner, ML	1
Ferry, GD	1
Barrison, GM	1
Blum, AL	2
Fahrländer, H	1
Croker, JR	1
Vallon, AG	1
Cotton, PB	1
Reed, PI	1
Bonardi, O	1
Güller, R	1
Leite, LP	1
Just, RJ	1
Lagerström, PO	1
Nishi, K	1
Amemiya, T	1
Mizuguchi, M	1
Ooka, T	1
Fujimura, M	1
Matsuda, T	1
Whitley, NT	1
Kelly, DA	1
Parkhomenko, LK	1
Radbil', OS	1
Boros, I	1
Keszler, P	1
Szombath, D	1
Pósch, E	1
Le Rhun, M	1
Havelund, T	1
Laursen, LS	1
Lauritsen, K	1
Kuster, E	1
Ros, E	1
Toledo-Pimentel, V	1
Pujol, A	1
Bordas, JM	1
Grande, L	1
Pera, C	1
Hassall, E	1
Johnsson, F	1
Roth, Y	1
Damgaard Pedersen, NE	1
Joelsson, B	1
Conley, SF	1
Werlin, SL	1
Beste, DJ	1
Washington, N	1
Denton, G	1
Shulman, RJ	1
Paradowski, L	1
Salomon, A	1
Szelag, A	1
Berkowitz, D	1
Naveh, Y	1
Berant, M	2
Hatlebakk, JG	1
Berstad, A	1
Bate, CM	3
Green, JR	2
Axon, AT	2
Murray, FE	1
Tildesley, G	2
Emmas, CE	1
Taylor, MD	2
Field, SK	1
Sutherland, LR	1
Murrays, FE	1
Owen, SM	1
Emmas, C	1
Shi, G	1
Simon, B	1
Casset-Semanza, F	1
Slama, A	1
Richardson, PD	1
Lamers, CB	1
Orenstein, SR	1
Good, CB	1
Fultz, SL	1
Trilli, L	1
Etchason, J	1
Ruscin, JM	1
Page, RL	1
Valuck, RJ	1
Malagelada, JR	1
Cortot, A	1
Hoffenberg, P	1
Dobb, G	1
Jordan, MJ	1
Williams, JG	1
Armitage, JO	1
Sidner, RD	1
de Carle, DJ	1
Behar, J	1
Brand, DL	1
Brown, FC	1
Cohen, S	3
Crossley, RJ	1
Pope, CE	2
Winans, CS	1
Finkelstein, W	1
Isselbacher, KJ	1
Olazábal, A	1
García-Pont, PH	1
Welch, CE	1
Malt, RA	1
Ponti, V	1
Pera, A	1
Verme, G	1
Langman, MJ	1
Schlippert, W	1
Bucher, P	1
Lepsien, G	1
Weber, K	1
Giger, M	1
Sonnenberg, A	1
Snape, WJ	1
Grant, AK	1
Lambert, J	1
Mobassaleh, M	1
Grand, RJ	1
Wesdorp, IC	1
Michocki, RJ	1
Richardson, JP	1
Ström, M	1
Madsen, S	1
Norlander, B	1
Riemann, JF	1
Höbel, W	1
Simon, TJ	1
Bradstreet, DC	1
Dieckmann, M	1
Deegen, E	1
Ojeda Casas, JA	1
García Ara, MC	1
Martín Muñoz, F	1
Díaz Pena, JM	1
Añibarro Bausera, B	1
Escobar Castro, H	1
Larrain, A	1
Carrasco, E	1
Galleguillos, F	1
Sepulveda, R	1
Berezin, S	1
Medow, MS	1
Glassman, MS	1
Newman, LJ	1
Kibblewhite, DJ	1
Morrison, MD	1
Herrera, JL	1
Shay, SS	1
McCabe, M	1
Peura, DA	1
Johnson, LF	1
Palmer, RH	1
Frank, WO	1
Rockhold, FW	1
Wetherington, JD	1
Young, MD	1
Fraitag, B	1
Filoche, B	1
Evreux, M	1
Vitaux, J	1
Zeitoun, P	1
Fournet, J	1
Soule, JC	1
Mandel, H	1
Tirosh, E	1
Gobio-Casali, L	1
Balli, F	1
Magazzú, G	1
Astolfi, R	1
Amarri, S	1
Conti-Nibali, S	1
Guandalini, S	1
Mulholland, MW	1
Reid, BJ	1
Levine, DS	1
Rubin, CE	1
Höltmann, BJ	1
Schött, D	1
Ulmer, WT	1
Eriksen, CA	1
Cheadle, WG	1
Cranford, CA	1
Cuschieri, A	1
Nimmo, WS	1
Spechler, SJ	1
Goyal, RK	1
Tytgat, GN	1
Nio, CY	1
Lennox, B	1
Snell, C	1
Lamb, Y	1
Lieberman, DA	1
Miller, ME	1
Perry, CJ	1
Siris, SG	1
Kinni, ME	1
Stout, MM	1
Kaul, B	1
Petersen, H	1
Erichsen, H	1
Myrvold, HE	1
Grette, K	1
Halvorsen, T	1
Fjøsne, U	1
DeVault, KR	1
Merlo, A	1
Di Lorenzo, C	1
D'Ambrosio, R	1
Andreotti, MR	1
Prato, M	1
De Filippo, P	1
Shepherd, RW	1
Wren, J	1
Evans, S	1
Lander, M	1
Ong, TH	1
Archambault, AP	1
Farley, A	1
Cleator, IG	1
Hershfield, NB	1
Navert, H	1
Prokipchuk, EJ	1
Thomson, AB	2
Kleinman, MS	1
Evans, DF	1
Haynes, J	1
Jones, JA	1
Stower, MJ	1
Kapila, L	1
Mahachai, V	1
Walker, K	1
Zuk, L	1
Kirdeikis, P	1
Fisher, D	1
Brunet, K	1