cimetidine has been researched along with Esophageal Neoplasms in 15 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gastro-oesophageal reflux disease (GERD) is common in obese patients." | 2.41 | Gastro-oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations. ( Barak, N; Ehrenpreis, ED; Harrison, JR; Sitrin, MD, 2002) |
| "The possibility exists that Barrett's esophagus may be acquired in some instances and congenital in others." | 2.36 | Barrett's esophagus. ( Berardi, RS; Devaiah, KA, 1983) |
| "These findings indicate that risk of oesophageal cancer is not increased among H-2-receptor antagonist users." | 1.30 | Histamine-2-receptor antagonists and oesophageal cancer. ( Fioretti, F; Franceschi, S; La Vecchia, C; Tavani, A, 1997) |
| " Most of the early excess in mortality was attributable to cimetidine being given in the late stages of many diseases, often to counter adverse gastric effects of other drugs." | 1.28 | Postmarketing surveillance of the safety of cimetidine: 10 year mortality report. ( Colin-Jones, DG; Langman, MJ; Lawson, DH; Logan, RF; Paterson, KR; Vessey, MP, 1992) |
| "The O/E ratio of oesophageal cancer deaths also fell over the first six years of study, from 5." | 1.28 | Post-cimetidine surveillance for up to ten years: incidence of carcinoma of the stomach and oesophagus. ( Colin-Jones, DG; Langman, MJ; Lawson, DH; Logan, RF; Paterson, KR; Vessey, MP, 1991) |
| " So far as can be assessed, however, none of these drug-disease associations represented adverse effects of cimetidine treatment; on the contrary, they resulted from cimetidine being used, knowingly or unknowingly, for treating the symptoms of various diseases or for alleviating adverse effects of other agents such as corticosteroids, non-steroidal anti-inflammatory drugs, and radiotherapy." | 1.27 | Postmarketing surveillance of the safety of cimetidine: 12 month mortality report. ( Colin-Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1983) |
| "I have reviewed Barrett's esophagus in the light of recent advances." | 1.26 | Barrett's esophagus: an old entity rediscovered. ( Mangla, JC, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barak, N | 1 |
| Ehrenpreis, ED | 1 |
| Harrison, JR | 1 |
| Sitrin, MD | 1 |
| Shiraishi-Yokoyama, H | 1 |
| Yokoyama, H | 1 |
| Matsumoto, M | 1 |
| Ishii, H | 1 |
| Berardi, RS | 1 |
| Devaiah, KA | 1 |
| Colin-Jones, DG | 3 |
| Langman, MJ | 3 |
| Lawson, DH | 3 |
| Vessey, MP | 3 |
| Sommers, LS | 1 |
| Cunningham, E | 1 |
| Cohen, EM | 1 |
| Aron, JM | 1 |
| Mangla, JC | 1 |
| Hassall, E | 1 |
| Fioretti, F | 1 |
| Tavani, A | 1 |
| La Vecchia, C | 1 |
| Franceschi, S | 1 |
| Mirvish, SS | 1 |
| Suleiman, UL | 1 |
| Harrison, M | 1 |
| Britton, A | 1 |
| McPherson, K | 1 |
| Bates, T | 1 |
| Logan, RF | 2 |
| Paterson, KR | 2 |
| Klimczak, J | 1 |
| Hennessy, TP | 1 |
| Spechler, SJ | 1 |
| Goyal, RK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Long Term Effects of Laparoscopic Roux-en-Y Gastric Bypass on Gastro-esophageal Reflux: Clinical Impact of Weakly Acidic Reflux[NCT02618044] | 86 participants (Actual) | Observational | 2006-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for cimetidine and Esophageal Neoplasms
| Article | Year |
|---|---|
Gastro-oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations.
Topics: Body Composition; Carcinoma; Cimetidine; Esophageal Neoplasms; Gastroesophageal Reflux; Hernia, Hiat | 2002 |
Barrett's esophagus.
Topics: Adenocarcinoma; Adolescent; Adult; Age Factors; Aged; Animals; Barrett Esophagus; Carcinoma, Squamou | 1983 |
Barrett's esophagus: new definitions and approaches in children.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Barrett Esophagus; Child; Child, Preschool; Cimetidine; End | 1993 |
Studies on experimental animals involving surgical procedures and/or nitrosamine treatment related to the etiology of esophageal adenocarcinoma.
Topics: Adenocarcinoma; Animals; Bile Acids and Salts; Bile Reflux; Cimetidine; Duodenogastric Reflux; Esoph | 1997 |
Barrett's oesophagus.
Topics: Adenocarcinoma; Adolescent; Adult; Barrett Esophagus; Cimetidine; Epithelium; Esophageal Diseases; E | 1985 |
Barrett's esophagus.
Topics: Adenocarcinoma; Antacids; Barrett Esophagus; Bethanechol; Bethanechol Compounds; Cimetidine; Epithel | 1986 |
9 other studies available for cimetidine and Esophageal Neoplasms
| Article | Year |
|---|---|
The existence of an NAD-dependent pathway for retinoic acid formation from vitamin A (retinol) in rat esophagus and its inhibition by ethanol and histamine 2 (H2) receptor antagonists.
Topics: Alcohol Dehydrogenase; Animals; Cimetidine; Cytosol; Enzyme Inhibitors; Esophageal Neoplasms; Esopha | 2003 |
Postmarketing surveillance of the safety of cimetidine: 12 month mortality report.
Topics: Aged; Alcohol Drinking; Cimetidine; Colonic Neoplasms; England; Esophageal Neoplasms; Evaluation Stu | 1983 |
Evaluation of cimetidine usage in a community teaching hospital.
Topics: Cimetidine; Drug Utilization; Duodenal Ulcer; Esophageal Neoplasms; Hospitals, Community; Hospitals, | 1983 |
Barrett's esophagus: an old entity rediscovered.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Barrett Esophagus; Bethanechol Compounds; Biopsy; Child; Ch | 1981 |
Histamine-2-receptor antagonists and oesophageal cancer.
Topics: Adult; Age Distribution; Aged; Case-Control Studies; Cimetidine; Confidence Intervals; Esophageal Ne | 1997 |
H2-receptor antagonists may increase the risk of cardio-oesophageal adenocarcinoma: a case-control study.
Topics: Adenocarcinoma; Adult; Age Distribution; Aged; Anti-Inflammatory Agents, Non-Steroidal; Case-Control | 2000 |
Postmarketing surveillance of the safety of cimetidine: 10 year mortality report.
Topics: Cimetidine; Duodenal Neoplasms; Esophageal Neoplasms; Female; Histamine H2 Antagonists; Humans; Live | 1992 |
Post-cimetidine surveillance for up to ten years: incidence of carcinoma of the stomach and oesophagus.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cimetidine; Cohort Studies; Esoph | 1991 |
[Use of cimetidine with histamine in 4 patients with inoperable neoplasms of the upper part of the digestive tract].
Topics: Adenocarcinoma; Aged; Carcinoma; Cimetidine; Drug Therapy, Combination; Esophageal Neoplasms; Histam | 1985 |