cimetidine has been researched along with Epilepsy in 7 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen metabolism and clearance after a single 1 gm oral dose of the drug was investigated in 12 healthy men, six of whom were cigarette smokers, and in six men who were receiving anticonvulsant drugs for epilepsy." | 3.67 | Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways. ( Attwood, J; Birkett, DJ; Miners, JO, 1984) |
| "Neurocysticercosis is the most important parasitic infection of the nervous system in countries of the third world." | 2.38 | Neurocysticercosis. An introduction with special emphasis on new developments in pharmacotherapy. ( Overbosch, D, 1992) |
| ", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
| "Cimetidine-related neurotoxicity may be characterized by signs of affective dysfunction, toxic delusional state and/or delirium, confusion and/or amnestic signs, coma, epileptic phenomena and focal neurological signs." | 1.27 | Cimetidine neurotoxicity. EEG and behaviour aspects. ( Kamphuisen, HA; Van Sweden, B, 1984) |
| "Cimetidine can cause significant changes in phenytoin serum levels which may be manifested clinically." | 1.27 | Effect of cimetidine on phenytoin serum levels. ( Breland, BD; Jordan, JE; Mishra, SK; Salem, RB, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waszkielewicz, AM | 1 |
| Gunia-Krzyżak, A | 1 |
| Powroźnik, B | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Walczak, M | 1 |
| Bednarski, M | 1 |
| Żesławska, E | 1 |
| Nitek, W | 1 |
| Marona, H | 1 |
| Phillips, P | 1 |
| Hansky, J | 1 |
| Van Sweden, B | 1 |
| Kamphuisen, HA | 1 |
| Miners, JO | 1 |
| Attwood, J | 1 |
| Birkett, DJ | 1 |
| Hetzel, DJ | 1 |
| Bochner, F | 1 |
| Hallpike, JF | 1 |
| Shearman, DJ | 1 |
| Hann, CS | 1 |
| Salem, RB | 1 |
| Breland, BD | 1 |
| Mishra, SK | 1 |
| Jordan, JE | 1 |
| Overbosch, D | 1 |
1 review available for cimetidine and Epilepsy
| Article | Year |
|---|---|
Neurocysticercosis. An introduction with special emphasis on new developments in pharmacotherapy.
Topics: Albendazole; Central Nervous System Diseases; Cimetidine; Cysticercosis; Diagnosis, Differential; Di | 1992 |
6 other studies available for cimetidine and Epilepsy
| Article | Year |
|---|---|
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
Phenytoin toxicity secondary to cimetidine administration.
Topics: Aged; Cimetidine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Peptic Ulc | 1984 |
Cimetidine neurotoxicity. EEG and behaviour aspects.
Topics: Brain; Brain Diseases; Cimetidine; Confusion; Delusions; Electroencephalography; Epilepsy; Female; H | 1984 |
Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways.
Topics: Acetaminophen; Administration, Oral; Adult; Anticonvulsants; Biotransformation; Cimetidine; Drug Int | 1984 |
Cimetidine interaction with phenytoin.
Topics: Adult; Cimetidine; Drug Interactions; Epilepsy; Guanidines; Humans; Middle Aged; Phenytoin | 1981 |
Effect of cimetidine on phenytoin serum levels.
Topics: Cimetidine; Drug Synergism; Epilepsy; Guanidines; Humans; Male; Phenytoin | 1983 |