cimetidine has been researched along with Disease Models, Animal in 104 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Present study was planned to estimate the gastroprotective activity of Euphorbia prostrata plant against aspirin induced gastric ulcers in male adult albino rabbits." | 7.91 | Gastroprotective and antioxidant potential of Euphorbia prostrata against aspirin induced gastric ulcers in rabbits. ( Ahmad, M; Aslam, B; Mohsin, M; Muhammad, F; Raza, A, 2019) |
| "Histamine is a biogenic amine that is widely distributed and has multiple functions, but the role it plays in acute myocardial infarction (AMI) remains unclear." | 7.81 | Histamine deficiency exacerbates myocardial injury in acute myocardial infarction through impaired macrophage infiltration and increased cardiomyocyte apoptosis. ( Chen, J; Deng, L; Ding, S; Ge, J; Hong, T; Huang, Z; Jia, J; Lin, J; Wang, TC; Yang, X; Zou, Y, 2015) |
| "The gastro-protective and antioxidant effects of methanol extract of Ficus asperifolia bark on indomethacin induced gastric ulcer were investigated in male rats." | 7.77 | Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats. ( Bolarinwa, AF; Oyeyemi, WA; Raji, Y; Shittu, ST, 2011) |
| "Combination therapy blocking both PAF and histamine markedly reduces the severity of peanut-induced anaphylaxis, and thus it may be a potential life-saving therapeutic approach in peanut and, likely, other food-induced anaphylaxis." | 7.75 | Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions. ( Arias, K; Baig, M; Chu, D; Colangelo, M; Coyle, A; Goncharova, S; Jordana, M; Vadas, P; Walker, T; Waserman, S, 2009) |
| "Oral administration for 6 days of 100 mg/kg MMK-1, an agonist peptide selective for the FPRL1 receptor, suppressed alopecia induced by the anticancer drug etoposide in neonatal rats." | 7.73 | Orally administered FPRL1 receptor agonist peptide MMK-1 inhibits etoposide-induced alopecia by a mechanism different from intraperitoneally administered MMK-1. ( Tsuruki, T; Yoshikawa, M, 2006) |
| "The present study was designed to evaluate the effects of a potassium channel opener, nicorandil, and to elucidate its possible mechanism of action in aspirin plus pylorus ligation induced and ethanol-induced gastric ulcers in rats." | 7.71 | Evaluation of the effects of nicorandil on experimentally induced gastric ulcers. ( Goswami, SG; Patel, HM; Santani, DD, 2001) |
| "We found indomethacin aggravates healed gastric ulcers (ulcer relapse) in rats." | 7.69 | Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor. ( Asano, S; Inada, I; Maeda, R; Murakami, I; Sato, F; Satoh, H; Shino, A, 1997) |
| "Daily oral administration of cimetidine or omeprazole markedly accelerated the healing of acetic acid-induced gastric ulcers in rats with a limited food intake time." | 7.69 | Cimetidine and omeprazole accelerate gastric ulcer healing by an increase in gastrin secretion. ( Inaguma, K; Ito, M; Segami, T; Suzuki, Y, 1994) |
| "The effects of cimetidine, omeprazole and atropine sulfate on the healing of acetic acid-induced gastric ulcers in rats with limited food intake time (9:00-10:00 a." | 7.69 | Effect of cimetidine and omeprazole on gastric ulcer healing of rats with limited food intake time. ( Ito, M; Kojima, R; Segami, T; Suzuki, Y; Tsukahara, T, 1994) |
| "Healing of duodenal ulcers induced by indomethacin + histamine was investigated in rats." | 7.67 | Healing process of duodenal ulcers induced by indomethacin plus histamine in rats. ( Niida, H; Okabe, S; Okada, M; Takeuchi, K, 1989) |
| "The role of the central histaminergic system in depression was studied by using swimming despair test in mice - a behavioural model of depression." | 7.67 | Role of central histaminergic mechanism in behavioural depression (swimming despair) in mice. ( Dhawan, KN; Gulati, A; Gupta, GP; Nath, C, 1988) |
| "Insight into the pathogenesis and etiology of experimental duodenal ulceration was sought by studying the modulation of this disease in rats by selective vagotomy, chemical sympathectomy, histamine depletion, histamine H-2 receptor antagonists (eg, metiamide, cimetidine), or endocrine ablations." | 7.66 | Pathogenesis of duodenal ulceration produced by cysteamine or propionitrile: influence of vagotomy, sympathectomy, histamine depletion, H-2 receptor antagonists and hormones. ( Haith, LR; Reynolds, ES; Szabo, S, 1979) |
| "Praomys (Mastomys) natalensis, an African rodent ranging in size between a mouse and a rat, is more susceptible to the induction of duodenal ulcers by constant infusion of exogenous histamine through an osmotic minipump implanted subcutaneously than other rodent species tested such as mouse, rat, or guinea-pig." | 7.66 | Praomys (Mastomys) natalensis: animal model for study of histamine-induced duodenal ulcers. ( Hosoda, S; Ikedo, H; Saito, T, 1981) |
| " Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model." | 5.62 | Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model. ( Hassan, ZM; Jafarzadeh, A; Khorramdelazad, H; Masoumi, J; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2021) |
| "Baicalin was 72% effective versus the reference drug and 80% effective against ethanol-induced ulcers." | 5.46 | Baicalin protects against gastroduodenal ulcers via the modulation of Nrf2 expression: Experimental, biochemical, and histological analyses. ( Meng, X; Yang, D; Zhang, T, 2017) |
| "Cimetidine treatment significantly decreased creatinine, BUN, K, Na, SBP and creatine kinase and increased GFR and urine volume compared to group II." | 5.42 | A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats. ( Eissa, H; Elattar, S; Estaphan, S; Farouk, M; Rashed, L, 2015) |
| "Cimetidine treatment completely or partially reversed all the IR-mediated changes, while ranitidine was ineffective." | 5.36 | Effects of cytochrome p450 inhibition by cimetidine on the warm hepatic ischemia-reperfusion injury in rats. ( Mehvar, R; Shaik, IH, 2010) |
| " Chronic administration of hydrocortisone sodium phosphate resulted in a significant delay of ulcer healing induced by acetic acid." | 5.28 | Effects of sucralfate, lansoprazole, and cimetidine on the delayed healing by hydrocortisone sodium phosphate of chronic gastric ulcers in the rat. ( Eastwood, GL; Kuwayama, H; Matsuo, Y, 1991) |
| " According to the two dosing schedules adopted to evaluate the duration of action, mifentidine, compared to cimetidine and ranitidine, required considerably lower oral dosages to display its protective effect." | 5.27 | Cimetidine, ranitidine and mifentidine in specific gastric and duodenal ulcer models. ( Cereda, E; Del Soldato, P; Donetti, A; Ghiorzi, A, 1985) |
| "Histamine is known to lead to arrhythmias in the human heart." | 4.02 | Human histamine H ( Gergs, U; Griethe, K; Kirchhefer, U; Mißlinger, N; Neumann, J; Weisgut, J, 2021) |
| "Present study was planned to estimate the gastroprotective activity of Euphorbia prostrata plant against aspirin induced gastric ulcers in male adult albino rabbits." | 3.91 | Gastroprotective and antioxidant potential of Euphorbia prostrata against aspirin induced gastric ulcers in rabbits. ( Ahmad, M; Aslam, B; Mohsin, M; Muhammad, F; Raza, A, 2019) |
| "Histamine is a biogenic amine that is widely distributed and has multiple functions, but the role it plays in acute myocardial infarction (AMI) remains unclear." | 3.81 | Histamine deficiency exacerbates myocardial injury in acute myocardial infarction through impaired macrophage infiltration and increased cardiomyocyte apoptosis. ( Chen, J; Deng, L; Ding, S; Ge, J; Hong, T; Huang, Z; Jia, J; Lin, J; Wang, TC; Yang, X; Zou, Y, 2015) |
| "The gastro-protective and antioxidant effects of methanol extract of Ficus asperifolia bark on indomethacin induced gastric ulcer were investigated in male rats." | 3.77 | Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats. ( Bolarinwa, AF; Oyeyemi, WA; Raji, Y; Shittu, ST, 2011) |
| "Combination therapy blocking both PAF and histamine markedly reduces the severity of peanut-induced anaphylaxis, and thus it may be a potential life-saving therapeutic approach in peanut and, likely, other food-induced anaphylaxis." | 3.75 | Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions. ( Arias, K; Baig, M; Chu, D; Colangelo, M; Coyle, A; Goncharova, S; Jordana, M; Vadas, P; Walker, T; Waserman, S, 2009) |
| " Amatoxin, a peptide contained in several mushroom species, accounts for the majority of severe mushroom poisonings by binding to RNA polymerase II irreversibly, leading to severe hepatonecrosis." | 3.74 | Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model. ( Betten, DP; Clark, RF; Favata, M; Hernandez, M; Richardson, WH; Riffenburgh, RH; Tanen, DA; Tong, TC, 2007) |
| "Oral administration for 6 days of 100 mg/kg MMK-1, an agonist peptide selective for the FPRL1 receptor, suppressed alopecia induced by the anticancer drug etoposide in neonatal rats." | 3.73 | Orally administered FPRL1 receptor agonist peptide MMK-1 inhibits etoposide-induced alopecia by a mechanism different from intraperitoneally administered MMK-1. ( Tsuruki, T; Yoshikawa, M, 2006) |
| "The effects of beta-cyclodextrin (betaCD) inclusion complexation on the ability of violacein to prevent gastric ulceration in mice were studied." | 3.72 | Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with beta-cyclodextrin. ( Almeida, AB; Brito, AR; De Azevedo, MB; Durán, N; Haun, M; Justo, GZ; Melo, PS, 2003) |
| "Puromycin aminonucleoside (PAN)-induced glomerular injury in rats mimics minimal-change nephrotic syndrome (NS) in humans." | 3.72 | Role of cytochrome P450 2B1 in puromycin aminonucleoside-induced cytotoxicity to glomerular epithelial cells. ( Baliga, M; Baliga, R; Bigler, SA; Liu, H, 2003) |
| "The protective effect of a whey protein concentrate (WPC) was studied in three models of stomach ulcerative lesions induction: subcutaneous injection of indomethacin, and stress induced by either intraperitoneal injection of reserpine, or immobilization and holding in the cold (4 degrees C, 2 hours)." | 3.72 | Protective effect of bovine milk whey protein concentrate on the ulcerative lesions caused by subcutaneous administration of indomethacin. ( Antônio, MA; Bighetti, AE; Carvalho, JE; Rosaneli, CF; Sgarbieri, VC, 2004) |
| "The present study was designed to evaluate the effects of a potassium channel opener, nicorandil, and to elucidate its possible mechanism of action in aspirin plus pylorus ligation induced and ethanol-induced gastric ulcers in rats." | 3.71 | Evaluation of the effects of nicorandil on experimentally induced gastric ulcers. ( Goswami, SG; Patel, HM; Santani, DD, 2001) |
| " In a thromboplastin-induced thromboembolism model, administration of 30 mg/kg YM-75466 or 3 mg/kg warfarin significantly improved the lethality ratio." | 3.70 | Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice. ( Hirayama, F; Iizumi, Y; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y, 1998) |
| "We investigated the effect of probucol, a lipid-lowering agent with antioxidant properties, on HCl plus ethanol-induced gastric mucosal injury and on the healing of acetic acid-induced gastric ulcers in rats." | 3.70 | Anti-ulcer effects of antioxidants: effect of probucol. ( Ishihara, M; Ito, M; Suzuki, Y, 1998) |
| "The effects of cimetidine, omeprazole and atropine sulfate on the healing of acetic acid-induced gastric ulcers in rats with limited food intake time (9:00-10:00 a." | 3.69 | Effect of cimetidine and omeprazole on gastric ulcer healing of rats with limited food intake time. ( Ito, M; Kojima, R; Segami, T; Suzuki, Y; Tsukahara, T, 1994) |
| "Daily oral administration of cimetidine or omeprazole markedly accelerated the healing of acetic acid-induced gastric ulcers in rats with a limited food intake time." | 3.69 | Cimetidine and omeprazole accelerate gastric ulcer healing by an increase in gastrin secretion. ( Inaguma, K; Ito, M; Segami, T; Suzuki, Y, 1994) |
| "We found indomethacin aggravates healed gastric ulcers (ulcer relapse) in rats." | 3.69 | Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor. ( Asano, S; Inada, I; Maeda, R; Murakami, I; Sato, F; Satoh, H; Shino, A, 1997) |
| "We investigated the effect of sucralfate on angiogenesis in granulation tissue of gastric ulcers induced by acetic acid in rats using the carmine dye method." | 3.68 | Short report: effect of sucralfate on angiogenesis in granulation tissue of acetic acid-induced gastric ulcers in rats. ( Arisawa, T; Goto, H; Hase, S; Niwa, Y; Tsuchida, T; Tsukamoto, Y, 1993) |
| "Trimipramine, a tricyclic antidepressant, significantly inhibited the development of experimental gastric ulcers induced by various methods like stress, drug (aspirin, reserpine) and Shay's pyloric ligation in an inbred strain of albino rats." | 3.67 | Antiulcer effects of trimipramine using various laboratory models. ( Aguwa, CN; Ramanujam, TR, 1984) |
| "Healing of duodenal ulcers induced by indomethacin + histamine was investigated in rats." | 3.67 | Healing process of duodenal ulcers induced by indomethacin plus histamine in rats. ( Niida, H; Okabe, S; Okada, M; Takeuchi, K, 1989) |
| "The role of the central histaminergic system in depression was studied by using swimming despair test in mice - a behavioural model of depression." | 3.67 | Role of central histaminergic mechanism in behavioural depression (swimming despair) in mice. ( Dhawan, KN; Gulati, A; Gupta, GP; Nath, C, 1988) |
| "The effects of three typical antisecretory agents: cimetidine, atropine and prostaglandin E2 were compared on an acute rat gastric ulcer model which consisted of perfusing the stomach continuously, at a high intraluminal pressure (120 mm H2O), with a simulated gastric juice (0." | 3.66 | Effects of cimetidine, atropine and prostaglandin E2 on rat mucosal erosions produced by intragastric distension. ( Aliño, SF; Esplugues, J; Lloris, JM; Marti-Bonmati, E, 1980) |
| "Praomys (Mastomys) natalensis, an African rodent ranging in size between a mouse and a rat, is more susceptible to the induction of duodenal ulcers by constant infusion of exogenous histamine through an osmotic minipump implanted subcutaneously than other rodent species tested such as mouse, rat, or guinea-pig." | 3.66 | Praomys (Mastomys) natalensis: animal model for study of histamine-induced duodenal ulcers. ( Hosoda, S; Ikedo, H; Saito, T, 1981) |
| "Insight into the pathogenesis and etiology of experimental duodenal ulceration was sought by studying the modulation of this disease in rats by selective vagotomy, chemical sympathectomy, histamine depletion, histamine H-2 receptor antagonists (eg, metiamide, cimetidine), or endocrine ablations." | 3.66 | Pathogenesis of duodenal ulceration produced by cysteamine or propionitrile: influence of vagotomy, sympathectomy, histamine depletion, H-2 receptor antagonists and hormones. ( Haith, LR; Reynolds, ES; Szabo, S, 1979) |
| "The "cimetidine + ibuprofen"-treated mice displayed greater T-bet expression than the un-treated mice (P<0." | 1.72 | Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer. ( Hassan, ZM; Jafarzadeh, A; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2022) |
| " Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model." | 1.62 | Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model. ( Hassan, ZM; Jafarzadeh, A; Khorramdelazad, H; Masoumi, J; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2021) |
| "Baicalin was 72% effective versus the reference drug and 80% effective against ethanol-induced ulcers." | 1.46 | Baicalin protects against gastroduodenal ulcers via the modulation of Nrf2 expression: Experimental, biochemical, and histological analyses. ( Meng, X; Yang, D; Zhang, T, 2017) |
| "Cimetidine treatment significantly decreased creatinine, BUN, K, Na, SBP and creatine kinase and increased GFR and urine volume compared to group II." | 1.42 | A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats. ( Eissa, H; Elattar, S; Estaphan, S; Farouk, M; Rashed, L, 2015) |
| " Protective effect of ginger extract (GE) against ulcer is well documented, but therapeutic use is compromised due to poor bioavailability and physicochemical properties." | 1.37 | Development and evaluation of a gastro-retentive delivery system for improved antiulcer activity of ginger extract (Zingiber officinale). ( Kumar Singh, P; Pal Kaur, I, 2011) |
| "Cholestasis was induced by ligation of the main bile duct using two ligatures and transsection of the duct at the midpoint between them." | 1.37 | Two histamine H2 receptor antagonists, zolantidine and cimetidine, modulate nociception in cholestatic rats. ( Hasanein, P, 2011) |
| "Membranous nephropathy is a disease that affects the filtering units of the kidney, the glomeruli, and results in proteinuria accompanied by loss of kidney function." | 1.36 | Cytochrome P450 2B1 mediates complement-dependent sublytic injury in a model of membranous nephropathy. ( Arany, I; Baliga, R; Bigler, SA; Liu, H; Shah, SV; Tian, N; Waxman, DJ, 2010) |
| "Omeprazole (100 mg/kg) was given p." | 1.36 | Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats. ( Amagase, K; Kato, S; Ochi, A; Sugihara, T; Takeuchi, K, 2010) |
| "Cimetidine treatment completely or partially reversed all the IR-mediated changes, while ranitidine was ineffective." | 1.36 | Effects of cytochrome p450 inhibition by cimetidine on the warm hepatic ischemia-reperfusion injury in rats. ( Mehvar, R; Shaik, IH, 2010) |
| " Furthermore, the use of antidotes that reduced the toxic insult was also recorded using this technique." | 1.35 | Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum. ( Galanopoulou, P; Giannioti, K; Liapi, C; Mikros, E; Papalois, A; Theocharis, S; Zira, A, 2009) |
| "Histamine plays significant roles in the early-phase swelling via H1 receptors, and the late-phase swelling via H3/H4 receptors in this TPA-modified allergic dermatitis model." | 1.35 | Modification of the picryl chloride-induced allergic dermatitis model in mouse ear lobes by 12-O-tetradecanoylphorbol 13-acetate, and analysis of the role of histamine in the modified model. ( Hirasawa, N; Hong, J; Ishihara, K; Katoh, G; Ohsawa, Y; Ohuchi, K; Seyama, T; Shibata, K; Tamura, S, 2009) |
| " Because a) the mechanism of action of improgan remains unknown and b) this drug may indirectly activate cannabinoid CB(1) receptors, the effects of the CB(1) antagonist/inverse agonist rimonabant (SR141716A) and 3 congeners with varying CB(1) potencies were studied on improgan antinociception after intracerebroventricular (icv) dosing in rats." | 1.34 | Significance of cannabinoid CB1 receptors in improgan antinociception. ( Abood, ME; Gehani, NC; Hough, LB; Martin, BR; Nalwalk, JW; Razdan, RK; Sun, X; Wentland, M, 2007) |
| "Cimetidine is a powerful H2 receptor antagonist that eliminates histamine's effects on chemotaxis, phagocytosis, and superoxide anion production by phagocytes." | 1.33 | Topical H2 antagonist prevents periodontitis in a rabbit model. ( Andry, C; Ebrahimi, N; Hasturk, H; Holick, M; Jones, VL; Kantarci, A; Van Dyke, TE, 2006) |
| " The primary constituent, R-(+)-pulegone, is metabolized via hepatic cytochrome P450 to toxic intermediates." | 1.32 | Mitigation of pennyroyal oil hepatotoxicity in the mouse. ( Bond, GR; Goetz, RJ; Lindsell, CJ; Otten, EJ; Sztajnkrycer, MD, 2003) |
| "However, their changes in chronic renal failure (CRF) are poorly understood." | 1.31 | Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. ( Inui, K; Ji, L; Masuda, S; Saito, H, 2002) |
| "These data support the view that hyperalgesia induced by the magnesium-depleted diet is not a consequence of the inflammatory process." | 1.31 | Assessment of the relationship between hyperalgesia and peripheral inflammation in magnesium-deficient rats. ( Alloui, A; Begon, S; Dubray, C; Eschalier, A; Mazur, A; Rayssiguier, Y, 2002) |
| "Cimetidine was effective at oral doses of over 45." | 1.29 | Healing-promoting action of the zinc-cimetidine complex on acetic acid-induced gastric ulcers in rats. ( Inaguma, K; Ito, M; Segami, T; Suzuki, Y, 1995) |
| "The present study evaluated the therapeutic effects of rebamipide alone and in combination with cimetidine on experimental gastritis established by the administration of 5 mM sodium taurocholate (TCA) for 6 months in rats." | 1.28 | Therapeutic effects of oral rebamipide and in combination with cimetidine on experimental gastritis in rats. ( Fujimura, J; Haruma, K; Kajiyama, G; Kishimoto, S; Kobayashi, H; Machino, H; Sakurai, K; Shimamoto, T; Shimizu, S; Yamasaki, K, 1992) |
| "Necrosis was assessed on the seventh postoperative day." | 1.28 | The dorsal rat flap: a discussion of the model and the salutary effect of cimetidine on flap survival. ( Amiss, LR; Angel, MF; Bardakjian, V; Morgan, RF; Wanebo, J, 1990) |
| " Chronic administration of hydrocortisone sodium phosphate resulted in a significant delay of ulcer healing induced by acetic acid." | 1.28 | Effects of sucralfate, lansoprazole, and cimetidine on the delayed healing by hydrocortisone sodium phosphate of chronic gastric ulcers in the rat. ( Eastwood, GL; Kuwayama, H; Matsuo, Y, 1991) |
| " According to the two dosing schedules adopted to evaluate the duration of action, mifentidine, compared to cimetidine and ranitidine, required considerably lower oral dosages to display its protective effect." | 1.27 | Cimetidine, ranitidine and mifentidine in specific gastric and duodenal ulcer models. ( Cereda, E; Del Soldato, P; Donetti, A; Ghiorzi, A, 1985) |
| "Pretreatment with cimetidine caused a significant reduction in gastric mucosal injury in stressed animals receiving gastric mucosal barrier breakers." | 1.26 | Cimetidine protects against stress-induced gastric injury augmented by mucosal barrier breakers. ( Levine, BA; Pruitt, BA; Sirinek, KR, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (21.15) | 18.7374 |
| 1990's | 23 (22.12) | 18.2507 |
| 2000's | 26 (25.00) | 29.6817 |
| 2010's | 27 (25.96) | 24.3611 |
| 2020's | 6 (5.77) | 2.80 |
| Authors | Studies |
|---|---|
| Ohtsuki, S | 1 |
| Kikkawa, T | 1 |
| Mori, S | 1 |
| Hori, S | 1 |
| Takanaga, H | 1 |
| Otagiri, M | 1 |
| Terasaki, T | 1 |
| Liu, H | 3 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Avdeef, A | 1 |
| Tam, KY | 1 |
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Xue, ST | 1 |
| Zhang, L | 1 |
| Xie, ZS | 1 |
| Jin, J | 1 |
| Guo, HF | 1 |
| Yi, H | 1 |
| Liu, ZY | 1 |
| Li, ZR | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Turcu, AL | 1 |
| Companys-Alemany, J | 1 |
| Phillips, MB | 1 |
| Patel, DS | 1 |
| Griñán-Ferré, C | 1 |
| Loza, MI | 1 |
| Brea, JM | 1 |
| Pérez, B | 1 |
| Soto, D | 1 |
| Sureda, FX | 1 |
| Kurnikova, MG | 1 |
| Johnson, JW | 1 |
| Pallàs, M | 1 |
| Vázquez, S | 1 |
| Taghipour, F | 2 |
| Oladpour, O | 2 |
| Rezayati, MT | 2 |
| Khorramdelazad, H | 1 |
| Nemati, M | 2 |
| Taghipour, Z | 2 |
| Masoumi, J | 1 |
| Hassan, ZM | 2 |
| Jafarzadeh, A | 2 |
| Gergs, U | 1 |
| Weisgut, J | 1 |
| Griethe, K | 1 |
| Mißlinger, N | 1 |
| Kirchhefer, U | 1 |
| Neumann, J | 1 |
| Zhang, T | 1 |
| Yang, D | 1 |
| Meng, X | 1 |
| Sharma, HS | 1 |
| Patnaik, R | 1 |
| Muresanu, DF | 1 |
| Lafuente, JV | 1 |
| Ozkizilcik, A | 1 |
| Tian, ZR | 1 |
| Nozari, A | 1 |
| Sharma, A | 1 |
| Ahmad, M | 1 |
| Aslam, B | 1 |
| Muhammad, F | 1 |
| Mohsin, M | 1 |
| Raza, A | 1 |
| Satoh, H | 2 |
| Amagase, K | 2 |
| Takeuchi, K | 3 |
| Longhini, R | 1 |
| Aparecida de Oliveira, P | 1 |
| Sasso-Cerri, E | 1 |
| Cerri, PS | 1 |
| Duplancic, B | 1 |
| Stambolija, V | 1 |
| Holjevac, J | 1 |
| Zemba, M | 1 |
| Balenovic, I | 1 |
| Drmic, D | 1 |
| Suran, J | 1 |
| Radic, B | 1 |
| Filipovic, M | 1 |
| Blagaic, AB | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Skin Barrier Dysfunction and the Role of Skin Barrier Restoration on Cutaneous and Systemic Inflammation in the Aged Population[NCT03728569] | Early Phase 1 | 14 participants (Actual) | Interventional | 2018-05-16 | Terminated (stopped due to Enrollment and interactions/interventions paused due to COVID-19. Not expected to resume in the future. This is not a suspension of IRB approval) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for cimetidine and Disease Models, Animal
| Article | Year |
|---|---|
[The effect of H2-receptor blockers (cimetidine and ranitidin) on parotid gland secretion and salivary carbonic anhydrase activity in the rat].
Topics: Animals; Carbonic Anhydrase Inhibitors; Cimetidine; Disease Models, Animal; Esophagitis, Peptic; Gas | 1993 |
[Experimental aspects of pathogenesis and prophylaxis of gastric stress ulcers (author's transl)].
Topics: Animals; Cimetidine; Disease Models, Animal; Peptic Ulcer; Regional Blood Flow; Shock, Hemorrhagic; | 1978 |
1 trial available for cimetidine and Disease Models, Animal
| Article | Year |
|---|---|
Pharmacological effects of aqueous-ethanolic extract of Hibiscus rosasinensis on volume and acidity of stimulated gastric secretion.
Topics: Animals; Anti-Ulcer Agents; Calcium Channel Blockers; Carbachol; Cimetidine; Disease Models, Animal; | 2011 |
101 other studies available for cimetidine and Disease Models, Animal
| Article | Year |
|---|---|
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Ma | 2004 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological | 2010 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Respo | 2020 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Recepto | 2022 |
Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model.
Topics: Animals; Biomarkers; Breast Neoplasms; Cell Line, Tumor; Cimetidine; Disease Models, Animal; Female; | 2021 |
Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer.
Topics: Animals; Cimetidine; Disease Models, Animal; Forkhead Transcription Factors; Ibuprofen; Mice; Mice, | 2022 |
Human histamine H
Topics: Animals; Arrhythmias, Cardiac; Cimetidine; Dimaprit; Disease Models, Animal; Heart Atria; Heart Vent | 2021 |
Baicalin protects against gastroduodenal ulcers via the modulation of Nrf2 expression: Experimental, biochemical, and histological analyses.
Topics: Animals; Anti-Ulcer Agents; Blotting, Western; Cimetidine; Disease Models, Animal; Dose-Response Rel | 2017 |
Histaminergic Receptors Modulate Spinal Cord Injury-Induced Neuronal Nitric Oxide Synthase Upregulation and Cord Pathology: New Roles of Nanowired Drug Delivery for Neuroprotection.
Topics: Animals; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems | 2017 |
Gastroprotective and antioxidant potential of Euphorbia prostrata against aspirin induced gastric ulcers in rabbits.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Cimetidine; Cytoprotection; Disease Models, Anima | 2019 |
The role of food for the formation and prevention of gastrointestinal lesions induced by aspirin in cats.
Topics: Administration, Oral; Animals; Aspirin; Cats; Cimetidine; Diet; Dietary Fiber; Disease Models, Anima | 2013 |
Cimetidine reduces alveolar bone loss in induced periodontitis in rat molars.
Topics: Acid Phosphatase; Alveolar Bone Loss; Alveolar Process; Animals; Cimetidine; Coloring Agents; Connec | 2014 |
Pentadecapeptide BPC 157 and anaphylactoid reaction in rats and mice after intravenous dextran and white egg administration.
Topics: Administration, Intravenous; Anaphylaxis; Animals; Anti-Allergic Agents; Cimetidine; Dextrans; Disea | 2014 |
A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats.
Topics: Acute Kidney Injury; Animals; Carnitine; Cimetidine; Creatine Kinase; Creatinine; Disease Models, An | 2015 |
Histamine deficiency exacerbates myocardial injury in acute myocardial infarction through impaired macrophage infiltration and increased cardiomyocyte apoptosis.
Topics: Acute Disease; Animals; Apoptosis; Cell Line; Cimetidine; Creatine Kinase, MB Form; Disease Models, | 2015 |
A critical time window for the analgesic effect of central histamine in the partial sciatic ligation model of neuropathic pain.
Topics: Analgesics; Animals; Central Nervous System; Cimetidine; Disease Models, Animal; Drug Administration | 2016 |
Modification of the picryl chloride-induced allergic dermatitis model in mouse ear lobes by 12-O-tetradecanoylphorbol 13-acetate, and analysis of the role of histamine in the modified model.
Topics: Animals; Cell Count; Cimetidine; Cyclophosphamide; Cyclosporine; Cytokines; Dermatitis, Allergic Con | 2009 |
Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Alanine Transaminase; Animals; Antidotes; Aspartate Am | 2009 |
Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions.
Topics: Allergens; Anaphylaxis; Animals; Arachis; Cholera Toxin; Cimetidine; Disease Models, Animal; Drug Th | 2009 |
Effects of cytochrome p450 inhibition by cimetidine on the warm hepatic ischemia-reperfusion injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Catalase; Cimetidine; Cytochrome P-450 E | 2010 |
Two histamine H2 receptor antagonists, zolantidine and cimetidine, modulate nociception in cholestatic rats.
Topics: Analgesia; Animals; Benzothiazoles; Cholestasis; Cimetidine; Dimaprit; Disease Models, Animal; Hista | 2011 |
Gastroprotective activity of Trichosanthes cucumerina in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Ethanol; Female; Gastric Juice; Gast | 2010 |
Hepatoprotective, antinociceptive and antioxidant activities of cimetidine, ranitidine and famotidine as histamine H2 receptor antagonists.
Topics: Analgesics; Animals; Antioxidants; Carbon Tetrachloride; Cimetidine; Disease Models, Animal; Dose-Re | 2011 |
Gastroprotective and antisecretory effects of Ailanthus excelsa (Roxb).
Topics: Ailanthus; Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Egypt; Ethanol; Gastric A | 2010 |
Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models.
Topics: Achyrocline; Animals; Anti-Ulcer Agents; Brazil; Cimetidine; Cytoprotection; Disease Models, Animal; | 2010 |
Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats.
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Ampicillin; Animals; Anti-Bacterial Agents; Anti-Ulcer A | 2010 |
Protective effect of roxatidine against indomethacin-induced small intestinal mucosal injury in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Famotidine; Histamine H2 Antagonists | 2010 |
Cytochrome P450 2B1 mediates complement-dependent sublytic injury in a model of membranous nephropathy.
Topics: Animals; Antibodies; Cimetidine; Complement Membrane Attack Complex; Cytochrome P-450 CYP2B1; Diseas | 2010 |
Development and evaluation of a gastro-retentive delivery system for improved antiulcer activity of ginger extract (Zingiber officinale).
Topics: Alginates; Animals; Anti-Ulcer Agents; Calcium Carbonate; Cimetidine; Delayed-Action Preparations; D | 2011 |
Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Cimetidine; Cytoprotection | 2011 |
Gastro-protective effect of crude hexane leaf extract of Sesamum indicum in rabbits.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Cytoprotection; Disease Models, Animal; Dose-Response Relati | 2011 |
Topical antihistamines display potent anti-inflammatory activity linked in part to enhanced permeability barrier function.
Topics: Administration, Topical; Animals; Cell Differentiation; Cimetidine; Dermatitis, Atopic; Dermatitis, | 2013 |
Effect of Flabellaria paniculata Cav. extracts on gastric ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Female; Gastric Juice; Gastric Mucos | 2012 |
Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy.
Topics: Animals; Cimetidine; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Estradiol; Gonadal | 2002 |
Effects of sea buckthorn (Hippophaë rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats.
Topics: Animals; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hippophae; Ma | 2002 |
Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with beta-cyclodextrin.
Topics: Animals; Anti-Ulcer Agents; Cells, Cultured; Chemistry, Pharmaceutical; Cimetidine; Cyclodextrins; D | 2003 |
Role of cytochrome P450 2B1 in puromycin aminonucleoside-induced cytotoxicity to glomerular epithelial cells.
Topics: Animals; Cells, Cultured; Cimetidine; Cytochrome P-450 CYP2B1; Disease Models, Animal; Dose-Response | 2003 |
[Reduction of cardiovascular disorders by preventive perioperative antihistamine administration in general surgery: are the drugs interchangeable?].
Topics: Animals; Cardiovascular Diseases; Cimetidine; Dimethindene; Disease Models, Animal; Drug Evaluation, | 1998 |
Mitigation of pennyroyal oil hepatotoxicity in the mouse.
Topics: Animals; Case-Control Studies; Cimetidine; Cyclohexane Monoterpenes; Cyclohexanones; Disease Models, | 2003 |
Gastric antiulcer activity of Syngonanthus arthrotrichus SILVEIRA.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Bethanechol; Cimetidine; Diseas | 2004 |
[Complementary medicine. Phytotherapy in gastrointestinal ulcer].
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cimetidine; Clinical Trials as Topic; Disease Models, Anim | 2004 |
Protective effect of bovine milk whey protein concentrate on the ulcerative lesions caused by subcutaneous administration of indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cattle; Cimetidine; Disease Mod | 2004 |
Involvement of H2-receptors in the mechanism of analgesic action of Tyr-MIF-1.
Topics: Analgesics; Animals; Cimetidine; Dimaprit; Disease Models, Animal; Injections, Intraperitoneal; MSH | 2003 |
[Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers].
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Berberine; Cimetidine; Coptis; Disease Models, Animal; Drugs, | 2005 |
Orally administered FPRL1 receptor agonist peptide MMK-1 inhibits etoposide-induced alopecia by a mechanism different from intraperitoneally administered MMK-1.
Topics: Administration, Oral; Alopecia; Animals; Cimetidine; Disease Models, Animal; Etoposide; Female; Indo | 2006 |
Topical H2 antagonist prevents periodontitis in a rabbit model.
Topics: Administration, Topical; Animals; Bacteroidaceae Infections; Cimetidine; Disease Models, Animal; Dos | 2006 |
Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model.
Topics: Acetylcysteine; Alanine Transaminase; Amanitins; Animals; Antidotes; Aspartate Aminotransferases; Ch | 2007 |
Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Brazil; Cimetidine; Disease Mod | 2007 |
Significance of cannabinoid CB1 receptors in improgan antinociception.
Topics: Analgesics; Analysis of Variance; Animals; Cimetidine; Disease Models, Animal; Dose-Response Relatio | 2007 |
Attempts at oral infection of rats and mice with trophozoites of Entamoeba histolytica.
Topics: Amebiasis; Animals; Cimetidine; Disease Models, Animal; Disease Susceptibility; Entamoeba histolytic | 1984 |
A rat model based on the histamine H2-receptor-activation-induced gastric pathology.
Topics: Adenosine Triphosphatases; Animals; Cimetidine; Disease Models, Animal; Female; Furans; Histamine H2 | 1982 |
[Ulcer-protective effect of cimetidine and an antacid. Animal experiment study on an ulcer model with protracted histamine liberation].
Topics: Animals; Antacids; Cimetidine; Disease Models, Animal; Guinea Pigs; Histamine; Histamine Release; Ma | 1984 |
Pharmacological prevention of ocular inflammation induced by lens proteins.
Topics: Aminopyridines; Animals; Catechols; Cimetidine; Crystallins; Disease Models, Animal; Drug Therapy, C | 1984 |
Antiulcer effects of trimipramine using various laboratory models.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Dibenzazepines; Disease Models, Animal; Humans; Mal | 1984 |
Stress ulcer accompanying subarachnoid hemorrhage--a new rat model.
Topics: Animals; Cimetidine; Diazepam; Disease Models, Animal; Gastric Mucosa; Male; Pentobarbital; Phenytoi | 1983 |
[A rat's model of neurogenic stress gastric ulcer--studies on distribution of produced ulcers, and on effect of cimetidine and atropine].
Topics: Animals; Atropine; Cimetidine; Disease Models, Animal; Drug Synergism; Guanidines; Rats; Stomach Ulc | 1983 |
Cimetidine and esophageal reflux.
Topics: Animals; Cimetidine; Disease Models, Animal; Esophagitis, Peptic; Gastric Acid; Guanidines; Male; Ra | 1981 |
Effects of cimetidine, atropine and prostaglandin E2 on rat mucosal erosions produced by intragastric distension.
Topics: Animals; Atropine; Cimetidine; Disease Models, Animal; Gastric Juice; Guanidines; Male; Prostaglandi | 1980 |
Praomys (Mastomys) natalensis: animal model for study of histamine-induced duodenal ulcers.
Topics: Animals; Cimetidine; Cysteamine; Disease Models, Animal; Duodenal Ulcer; Female; Gastrins; Guinea Pi | 1981 |
Healing-promoting action of the zinc-cimetidine complex on acetic acid-induced gastric ulcers in rats.
Topics: Acetates; Acetic Acid; Animals; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug | 1995 |
Short report: effect of sucralfate on angiogenesis in granulation tissue of acetic acid-induced gastric ulcers in rats.
Topics: Animals; Carmine; Cimetidine; Disease Models, Animal; Drug Therapy, Combination; Granulation Tissue; | 1993 |
Effect of cimetidine and omeprazole on gastric ulcer healing of rats with limited food intake time.
Topics: Acetates; Acetic Acid; Administration, Oral; Analysis of Variance; Animals; Atropine; Cimetidine; Di | 1994 |
Cimetidine and omeprazole accelerate gastric ulcer healing by an increase in gastrin secretion.
Topics: Analysis of Variance; Animals; Cimetidine; Disease Models, Animal; Drug Interactions; Drug Synergism | 1994 |
Asynchrony in circadian rhythms of gastric function in the rat. A model for gastric mucosal injury.
Topics: Animals; Aspirin; Bicarbonates; Cimetidine; Circadian Rhythm; Disease Models, Animal; Epoprostenol; | 1994 |
Cimetidine prevents alcoholic hepatic injury in the intragastric feeding rat model.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Cimetidine; Cytochrome P | 1994 |
Studies on antiulcer agents. IV. Antiulcer effects of 2-benzylthio5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Epirizole; | 1995 |
Transendoscopic electrocautery-induced gastric ulcers as a model for gastric healing studies in ponies.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Electrocoagula | 1994 |
Anti-ulcer activity of higher primary alcohols of beeswax.
Topics: Administration, Oral; Alcohols; Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Etha | 1995 |
[Antiulcer properties of shosaiko-to].
Topics: Animals; Anti-Ulcer Agents; Atropine; Cimetidine; Deoxyglucose; Depression, Chemical; Disease Models | 1996 |
Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agen | 1997 |
Histamine receptor antagonists, cyclooxygenase blockade, and tumor necrosis factor during acute septic insult.
Topics: Animals; Bacteremia; Blood Pressure; Cardiac Output; Cimetidine; Cyclooxygenase Inhibitors; Diphenhy | 1998 |
Clinic modelling randomised trials (CMRT's) in animals as a new intermediate between biological experiments and randomised clinical trials: application to antihistamine prophylaxis in anaesthesia and surgery.
Topics: Anesthesia; Animals; Cimetidine; Dimethindene; Disease Models, Animal; Double-Blind Method; Female; | 1998 |
Anti-ulcer effects of antioxidants: effect of probucol.
Topics: Acetic Acid; Acute Disease; Animals; Anti-Ulcer Agents; Antioxidants; Chronic Disease; Cimetidine; D | 1998 |
Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Anticoagulants; Anti | 1998 |
Roles of histamine receptor in a guinea pig asthma model.
Topics: Animals; Asthma; Cimetidine; Disease Models, Animal; Guinea Pigs; Histamine Antagonists; Lung; Male; | 1998 |
Effect of cimetidine on development of gastric cancer in rats after gastrojejunostomy.
Topics: Adjuvants, Immunologic; Animals; Chi-Square Distribution; Cimetidine; Disease Models, Animal; Drug S | 1999 |
Effects of drugs acting as histamine releasers or histamine receptor blockers on an experimental anxiety model in mice.
Topics: Animals; Anxiety; Cimetidine; Disease Models, Animal; Histamine Antagonists; Histamine Release; Inje | 2000 |
Haloperidol-stomach lesions attenuation by pentadecapeptide BPC 157, omeprazole, bromocriptine, but not atropine, lansoprazole, pantoprazole, ranitidine, cimetidine and misoprostol in mice.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Atropine; Benzimidazoles; Bromo | 2001 |
Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum, on experimental gastric ulcer models in rats and mice.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce | 2001 |
Gastric antiulcer effect of Rhizophora mangle L.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Gastric Mucosa; Magnoliopsida; Male; | 2001 |
Evaluation of the effects of nicorandil on experimentally induced gastric ulcers.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Dose-Response Relationship, | 2001 |
Assessment of the relationship between hyperalgesia and peripheral inflammation in magnesium-deficient rats.
Topics: Animals; Anti-Inflammatory Agents; Astemizole; Cimetidine; Cromolyn Sodium; Dexamethasone; Disease M | 2002 |
Cimetidine, carbenoxolone sodium, and antacids for the prevention of experimental stress ulcers.
Topics: Animals; Antacids; Carbenoxolone; Cimetidine; Disease Models, Animal; Drug Therapy, Combination; Ele | 1978 |
Pathogenesis of duodenal ulceration produced by cysteamine or propionitrile: influence of vagotomy, sympathectomy, histamine depletion, H-2 receptor antagonists and hormones.
Topics: Adrenalectomy; Animals; Castration; Cimetidine; Cysteamine; Disease Models, Animal; Duodenal Ulcer; | 1979 |
Is histamine a mediator in bile-induced gastric mucosal injury?
Topics: Animals; Bile; Cimetidine; Disease Models, Animal; Dogs; Gastric Mucosa; Histamine; Histamine Releas | 1978 |
Septic induced acute gastric erosions: the role of cimetidine.
Topics: Animals; Bacteroides fragilis; Cimetidine; Disease Models, Animal; Dogs; Enterococcus faecalis; Guan | 1978 |
Cimetidine protects against stress-induced gastric injury augmented by mucosal barrier breakers.
Topics: Animals; Aspirin; Cimetidine; Disease Models, Animal; Female; Gastric Mucosa; Guanidines; Rats; Stom | 1979 |
Effect cimetidine on gastric secretory function during stress.
Topics: Animals; Cimetidine; Disease Models, Animal; Female; Gastric Juice; Guanidines; Rats; Stress, Physio | 1978 |
Therapeutic effects of oral rebamipide and in combination with cimetidine on experimental gastritis in rats.
Topics: Administration, Oral; Alanine; Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Drug | 1992 |
[Effects of FOY-305 on post-operative reflux esophagitis in rats (I). Effects of FOY-305 on reflux esophagitis after total gastrectomy in rats].
Topics: Alginates; Animals; Body Weight; Cimetidine; Disease Models, Animal; Esophagitis, Peptic; Esters; Ga | 1991 |
Effects of sucralfate, lansoprazole, and cimetidine on the delayed healing by hydrocortisone sodium phosphate of chronic gastric ulcers in the rat.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Cimetidi | 1991 |
The dorsal rat flap: a discussion of the model and the salutary effect of cimetidine on flap survival.
Topics: Animals; Cimetidine; Disease Models, Animal; Injections, Intraperitoneal; Male; Necrosis; Postoperat | 1990 |
Role of histamine in the cell turnover changes associated with experimental gastric ulceration in the mastomys.
Topics: Animals; Cell Division; Cimetidine; Clemastine; Disease Models, Animal; Female; Histamine H1 Antagon | 1985 |
Healing process of duodenal ulcers induced by indomethacin plus histamine in rats.
Topics: Animals; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Duodenum; Gastric Acid; Histamine; Hydr | 1989 |
Cimetidine, ranitidine and mifentidine in specific gastric and duodenal ulcer models.
Topics: Animals; Cimetidine; Dimaprit; Disease Models, Animal; Duodenal Ulcer; Female; Guinea Pigs; Histamin | 1985 |
Role of central histaminergic mechanism in behavioural depression (swimming despair) in mice.
Topics: Animals; Atropine; Central Nervous System; Cimetidine; Depression; Desipramine; Disease Models, Anim | 1988 |
Indomethacin-induced gastric antral ulcers in hamsters.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cricetinae; Dinoprostone; Disease Models, Animal | 1988 |