cimetidine has been researched along with Delayed Hypersensitivity in 35 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of an H1 antihistamine, an H2 antihistamine, and the combination of the two drugs on both histamine-induced bronchoconstriction and dermal whealing was examined in five patients with mild asthma." | 9.05 | A comparison of the actions of H1 and H2 antihistamines on histamine-induced bronchoconstriction and cutaneous wheal response in asthmatic patients. ( Nathan, RA; Schocket, AL; Segall, N, 1981) |
| "Oral cimetidine for the treatment of verruca continues to be a topic of discussion and controversy." | 8.80 | Cimetidine and a delayed hypersensitivity reaction. ( Donohoe, S; Eberly, M; Evans, RD; Yoho, R, 2000) |
| "Cimetidine prevents suppression of delayed hypersensitivity in this model." | 7.71 | Cimetidine prevents suppression of delayed hypersensitivity in an animal model of haemorrhagic shock. ( Armstrong, N; Bowrey, P; Cherian, M; Hewitt, PM; Morris, DL, 2002) |
| "The immunomodulatory potency of cimetidine, a histamine H2 receptor antagonist, was investigated in 33 AIDS-related complex (ARC) patients performing detailed immunological and clinical evaluations." | 7.67 | Immunomodulatory properties of cimetidine in ARC patients. ( Brockmeyer, NH; Chalabi, N; Goos, M; Kirch, W; Kreuzfelder, E; Mertins, L; Ohnhaus, EE; Scheiermann, N, 1988) |
| "The in vivo pharmacological effects of cimetidine on delayed hypersensitivity reactions in healthy volunteers were studied using the tuberculin skin test as parameter." | 5.06 | Cimetidine as modulator of the cell-mediated immune response in vivo using the tuberculin skin test as parameter. ( Meyer, EC; Schoeman, HS; Snyman, JR, 1990) |
| "The effect of an H1 antihistamine, an H2 antihistamine, and the combination of the two drugs on both histamine-induced bronchoconstriction and dermal whealing was examined in five patients with mild asthma." | 5.05 | A comparison of the actions of H1 and H2 antihistamines on histamine-induced bronchoconstriction and cutaneous wheal response in asthmatic patients. ( Nathan, RA; Schocket, AL; Segall, N, 1981) |
| "Two-well conducted double blind studies have shown that cimetidine is not better than placebo in healing of duodenal ulcers at the end of the 6 weeks." | 5.05 | A second look at cimetidine. ( Mangla, JC, 1981) |
| "Oral cimetidine for the treatment of verruca continues to be a topic of discussion and controversy." | 4.80 | Cimetidine and a delayed hypersensitivity reaction. ( Donohoe, S; Eberly, M; Evans, RD; Yoho, R, 2000) |
| "Cimetidine prevents suppression of delayed hypersensitivity in this model." | 3.71 | Cimetidine prevents suppression of delayed hypersensitivity in an animal model of haemorrhagic shock. ( Armstrong, N; Bowrey, P; Cherian, M; Hewitt, PM; Morris, DL, 2002) |
| "The immunomodulatory potency of cimetidine, a histamine H2 receptor antagonist, was investigated in 33 AIDS-related complex (ARC) patients performing detailed immunological and clinical evaluations." | 3.67 | Immunomodulatory properties of cimetidine in ARC patients. ( Brockmeyer, NH; Chalabi, N; Goos, M; Kirch, W; Kreuzfelder, E; Mertins, L; Ohnhaus, EE; Scheiermann, N, 1988) |
| "4." | 1.29 | The influence of antigen digestion on orally induced immunity and tolerance. ( Jain, SL; Michael, JG, 1995) |
| "Cimetidine was administered orally in a daily doses of 1,600 mg during the first three weeks of evaluation." | 1.28 | The immunomodulatory potency of cimetidine in healthy volunteers. ( Brockmeyer, NH; Chalabi, N; Goos, M; Keinecke, HO; Kreuzfelder, E; Ohnhaus, EE; Scheiermann, N, 1989) |
| "Diphenhydramine treatment alone partially inhibited the histologic intensity of LPR in a dose-dependent manner." | 1.27 | The biologic activity of mast cell granules. V. The effects of antihistamine treatment on rat cutaneous early- and late-phase allergic reactions. ( Barr, L; Guthman, DA; Kaliner, M; Lemanske, RF, 1983) |
| " Animals were then treated with the four agents in carefully defined dosage regimens, and survival was again determined on the tenth postburn day." | 1.27 | Postburn immunosuppression in an animal model. IV. Improved resistance to septic challenge with immunomodulating drugs. ( Bartle, EJ; Bender, EM; Carter, WH; Hansbrough, JF; Mansour, MA; Zapata-Sirvent, RL, 1986) |
| "Cimetidine treatment of mice who had also received suppressor cells eliminated the manifestation of suppressor cell activity as measured by the development of normal immunologic response following contact sensitization with DNFB." | 1.27 | "Immunoregulatory effects of cimetidine: inhibition of suppressor cell effector function in vivo". ( Cleveland, RP; Kumar, A, 1988) |
| "A statistically significant increase in delayed hypersensitivity responses on repeated skin testing during cimetidine hydrochloride therapy was observed." | 1.27 | In vivo anergy reversal with cimetidine in patients with cancer. ( Eisele, D; Richtsmeier, WJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (71.43) | 18.7374 |
| 1990's | 7 (20.00) | 18.2507 |
| 2000's | 2 (5.71) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| A, J | 1 |
| Zm, H | 1 |
| M, E | 1 |
| S, MH | 1 |
| T, T | 1 |
| Hewitt, PM | 1 |
| Armstrong, N | 1 |
| Bowrey, P | 1 |
| Cherian, M | 1 |
| Morris, DL | 1 |
| Lipsmeyer, EA | 2 |
| Mawhinney, H | 1 |
| Killen, M | 1 |
| Fleming, WA | 1 |
| Roy, AD | 1 |
| Nathan, RA | 1 |
| Segall, N | 1 |
| Schocket, AL | 1 |
| Descotes, J | 1 |
| Tedone, R | 1 |
| Evreux, JC | 1 |
| Lemanske, RF | 1 |
| Barr, L | 1 |
| Guthman, DA | 1 |
| Kaliner, M | 1 |
| Giacchino, F | 1 |
| Segoloni, G | 1 |
| Giachino, G | 1 |
| Jeantet, A | 1 |
| Pellerey, M | 1 |
| Vercellone, A | 1 |
| Piccoli, G | 1 |
| Mangla, JC | 1 |
| Hammershøy, O | 1 |
| Chakravarty, N | 1 |
| Afzelius, H | 1 |
| Simon, MR | 1 |
| Jain, SL | 1 |
| Michael, JG | 1 |
| Ebtekar, M | 1 |
| Hassan, ZM | 1 |
| Adler, A | 1 |
| Schachter, J | 1 |
| Barenholz, Y | 1 |
| Bar, LK | 1 |
| Klein, T | 1 |
| Korytnaya, R | 1 |
| Sulkes, A | 1 |
| Michowiz, R | 1 |
| Cohen, Y | 1 |
| Kedar, I | 1 |
| Evans, RD | 1 |
| Yoho, R | 1 |
| Eberly, M | 1 |
| Donohoe, S | 1 |
| Avella, J | 1 |
| Madsen, JE | 1 |
| Binder, HJ | 1 |
| Askenase, PW | 2 |
| Jones, FG | 1 |
| Greaves, MW | 1 |
| Goodwin, JS | 1 |
| Norval, M | 1 |
| Gilmour, JW | 1 |
| Simpson, TJ | 1 |
| Ptak, W | 1 |
| Geba, GP | 1 |
| Dexeus, FH | 1 |
| Logothetis, CJ | 1 |
| Sella, A | 1 |
| Fitz, K | 1 |
| Amato, R | 1 |
| Reuben, JM | 1 |
| Dozier, N | 1 |
| Snyman, JR | 1 |
| Meyer, EC | 1 |
| Schoeman, HS | 1 |
| Brockmeyer, NH | 2 |
| Kreuzfelder, E | 2 |
| Chalabi, N | 2 |
| Scheiermann, N | 2 |
| Keinecke, HO | 1 |
| Goos, M | 2 |
| Ohnhaus, EE | 2 |
| Griswold, DE | 1 |
| Alessi, S | 1 |
| Badger, AM | 1 |
| Poste, G | 1 |
| Hanna, N | 1 |
| Nakazawa, T | 1 |
| Umegae, Y | 1 |
| Matsui, S | 1 |
| Fueki, R | 1 |
| Kobayashi, S | 1 |
| Zapata-Sirvent, RL | 2 |
| Hansbrough, JF | 2 |
| Bender, EM | 1 |
| Bartle, EJ | 1 |
| Mansour, MA | 1 |
| Carter, WH | 1 |
| Peters, K | 1 |
| Mertins, L | 1 |
| Kirch, W | 1 |
| Kumar, A | 1 |
| Cleveland, RP | 1 |
| Sun, B | 1 |
| Liu, F | 1 |
| Li, GH | 1 |
| Richtsmeier, WJ | 1 |
| Eisele, D | 1 |
| Tasaka, K | 1 |
| Kurokawa, K | 1 |
| Nakayama, Y | 1 |
| Kakimoto, M | 1 |
| Narrod, JA | 1 |
1 review available for cimetidine and Delayed Hypersensitivity
| Article | Year |
|---|---|
Cimetidine and a delayed hypersensitivity reaction.
Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Cimetidine; Drug Eruptions; Edema; Female; Foll | 2000 |
5 trials available for cimetidine and Delayed Hypersensitivity
| Article | Year |
|---|---|
A comparison of the actions of H1 and H2 antihistamines on histamine-induced bronchoconstriction and cutaneous wheal response in asthmatic patients.
Topics: Asthma; Bronchial Provocation Tests; Bronchial Spasm; Chlorpheniramine; Cimetidine; Clinical Trials | 1981 |
A second look at cimetidine.
Topics: Animals; Bone Marrow; Brain; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Utiliza | 1981 |
Allogeneic human liposomal melanoma vaccine with or without IL-2 in metastatic melanoma patients: clinical and immunobiological effects.
Topics: Adult; Aged; Antigens, Neoplasm; Antigens, Surface; Cimetidine; Combined Modality Therapy; Cytotoxic | 1995 |
Effect of histamine H2-receptor antagonists on delayed hypersensitivity.
Topics: Cimetidine; Drug Hypersensitivity; Duodenal Ulcer; Erythema; Female; Guanidines; Humans; Hypersensit | 1978 |
Cimetidine as modulator of the cell-mediated immune response in vivo using the tuberculin skin test as parameter.
Topics: Adolescent; Adult; Cimetidine; Double-Blind Method; Female; Humans; Hypersensitivity, Delayed; Immun | 1990 |
29 other studies available for cimetidine and Delayed Hypersensitivity
| Article | Year |
|---|---|
Time-dependent changes of immunologic responses after burn injury and immunomodulation by cimetidine and pyrimethamine in an animal model.
Topics: Animals; Anti-Infective Agents; Antibody Formation; Burns; Cimetidine; Histamine H2 Antagonists; Hyp | 2010 |
Cimetidine prevents suppression of delayed hypersensitivity in an animal model of haemorrhagic shock.
Topics: Administration, Oral; Animals; Chi-Square Distribution; Cimetidine; Erythrocyte Transfusion; Histami | 2002 |
Effect of cimetidine on delayed hypersensitivity.
Topics: Animals; Cimetidine; Guanidines; Guinea Pigs; Haptens; Histamine; Histamine H2 Antagonists; Hypersen | 1980 |
The hyperimmunoglobulin E syndrome--a neutrophil chemotactic defect reversible by histamine H2 receptor blockade?
Topics: Adult; Chemotaxis, Leukocyte; Cimetidine; Histamine H2 Antagonists; Humans; Hypergammaglobulinemia; | 1980 |
Effects of cimetidine and ranitidine on delayed-type hypersensitivity.
Topics: Animals; Cimetidine; Furans; Guanidines; Histamine H2 Antagonists; Hypersensitivity, Delayed; Mice; | 1983 |
The biologic activity of mast cell granules. V. The effects of antihistamine treatment on rat cutaneous early- and late-phase allergic reactions.
Topics: Animals; Antibodies, Anti-Idiotypic; Ascitic Fluid; Capillary Permeability; Cimetidine; Cytoplasmic | 1983 |
Cimetidine does not influence cellular immunity in patients with chronic renal insufficiency.
Topics: Adult; B-Lymphocytes; Cimetidine; Complement C3; Female; Humans; Hypersensitivity, Delayed; Immunogl | 1983 |
Effect of cimetidine and indomethacin on delayed hypersensitivity.
Topics: Animals; Cimetidine; Drug Synergism; Drug Therapy, Combination; Guanidines; Guinea Pigs; Hypersensit | 1982 |
Enhancement of delayed hypersensitivity in guinea-pigs by H2-receptor antagonist.
Topics: Animals; Cimetidine; Dinitrochlorobenzene; Female; Guanidines; Guinea Pigs; Histamine; Hypersensitiv | 1982 |
Cimetidine and immunologic response.
Topics: Candidiasis, Cutaneous; Cimetidine; Guanidines; Humans; Hypersensitivity, Delayed; Hypersensitivity, | 1980 |
The influence of antigen digestion on orally induced immunity and tolerance.
Topics: Administration, Oral; Animals; Antigens; Cimetidine; Digestion; Female; Gastric Juice; Hydrogen-Ion | 1995 |
Effect of immunomodulators pyrimethamine and cimetidine on immunosuppression induced by sulfur mustard in mice.
Topics: Animals; Antibody Formation; Cimetidine; Hypersensitivity, Delayed; Immune System; Male; Mice; Mice, | 1993 |
Cimetidine and the delayed-hypersensitivity response.
Topics: Cimetidine; Guanidines; Humans; Hypersensitivity, Delayed; Skin; Skin Tests | 1978 |
H2-receptor antagonists and delayed hypersensitivity.
Topics: Cimetidine; Guanidines; Humans; Hypersensitivity, Delayed; Receptors, Histamine; Receptors, Histamin | 1978 |
Cimetidine and delayed hypersensitivity.
Topics: Cimetidine; Duodenal Ulcer; Guanidines; Humans; Hypersensitivity, Delayed; Substance Withdrawal Synd | 1978 |
The effect of histamine receptor antagonists on immunosuppression induced by the cis-isomer of urocanic acid.
Topics: Adenosine Triphosphatases; Animals; Benzhydryl Compounds; Cell Count; Cimetidine; Female; Herpes Sim | 1990 |
Initiation of delayed-type hypersensitivity by low doses of monoclonal IgE antibody. Mediation by serotonin and inhibition by histamine.
Topics: Animals; Antibodies, Monoclonal; Cimetidine; Histamine; Hypersensitivity, Delayed; Immunoglobulin E; | 1991 |
Phase II study of coumarin and cimetidine in patients with metastatic renal cell carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coum | 1990 |
The immunomodulatory potency of cimetidine in healthy volunteers.
Topics: Adjuvants, Immunologic; Adult; Cell Division; Cimetidine; Complement System Proteins; Humans; Hypers | 1989 |
Differential sensitivity of T suppressor cell expression to inhibition by histamine type 2 receptor antagonists.
Topics: Animals; Benzenesulfonates; Cimetidine; Dermatitis, Contact; Diphenhydramine; Dose-Response Relation | 1986 |
Effect of combined H-1 and H-2 histamine receptor antagonists on late asthmatic response in an asthmatic patient.
Topics: Asthma; Candida albicans; Chlorpheniramine; Cimetidine; Drug Therapy, Combination; Histamine H1 Anta | 1987 |
Postburn immunosuppression in an animal model. IV. Improved resistance to septic challenge with immunomodulating drugs.
Topics: Animals; Anti-Infective Agents, Local; Burns; Cerium; Cimetidine; Cyclophosphamide; Dose-Response Re | 1986 |
Delayed hypersensitivity to oral cimetidine.
Topics: Administration, Oral; Adult; Cimetidine; Drug Eruptions; Humans; Hypersensitivity, Delayed; Male | 1986 |
Immunomodulatory properties of cimetidine in ARC patients.
Topics: Adjuvants, Immunologic; Adult; AIDS-Related Complex; B-Lymphocytes; Cimetidine; Complement C4; Femal | 1988 |
"Immunoregulatory effects of cimetidine: inhibition of suppressor cell effector function in vivo".
Topics: Animals; Cimetidine; Dinitrofluorobenzene; Female; Hypersensitivity, Delayed; Immunization, Passive; | 1988 |
[Immunomodulation of cimetidine in mice].
Topics: Animals; Cimetidine; Female; Hemolytic Plaque Technique; Hypersensitivity, Delayed; Lung Neoplasms; | 1988 |
In vivo anergy reversal with cimetidine in patients with cancer.
Topics: Aged; Carcinoma, Squamous Cell; Cimetidine; Head and Neck Neoplasms; Humans; Hypersensitivity, Delay | 1986 |
Effect of histamine on delayed-type hypersensitivity in mice.
Topics: Adrenalectomy; Animals; Chemotaxis; Cimetidine; Female; Histamine; Hypersensitivity, Delayed; Macrop | 1986 |
Restoration of delayed hypersensitivity in mice receiving immunosuppressive drugs by cimetidine.
Topics: Animals; Azathioprine; Cimetidine; Female; Hypersensitivity, Delayed; Immunity, Cellular; Immunosupp | 1985 |