cimetidine has been researched along with Cystic Fibrosis of Pancreas in 32 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Enteric-coated microspheres of pancreatin were compared with non-enteric-coated pancreatin combined with cimetidine taken 40 min before meals in the treatment of patients with cystic fibrosis." | 9.06 | Treatment of steatorrhoea in cystic fibrosis: a comparison of enteric-coated microspheres of pancreatin versus non-enteric-coated pancreatin and adjuvant cimetidine. ( Hodson, ME; Skypala, I; Stead, RJ, 1988) |
| "A prospective, randomized double-blind study of 38 children with cystic fibrosis (CF) was designed to evaluate the effectiveness of cimetidine in improving fat absorption and clinical condition." | 9.05 | Long-term cimetidine in children with cystic fibrosis: a randomized double-blind study. ( Kläy, MP; Kraemer, R; Lentze, MJ; Mordasini, RC; Riesen, WF; Rossi, E; Ruedeberg, A; Schöni, M, 1984) |
| "Under controlled clinical observation we administered Cimetidine (600 mg/m2/day) in 10 children with cystic fibrosis." | 9.05 | Cimetidine and fat malabsorption in children with cystic fibrosis. ( Kraemer, R; Rossi, E; Schöni, M, 1981) |
| "Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination." | 9.05 | Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980) |
| "The bentiromide test for exocrine pancreatic function was carried out in normal volunteers, patients with cystic fibrosis (CF) without clinical evidence of pancreatic dysfunction, and CF patients with clinically significant exocrine pancreatic insufficiency." | 7.67 | Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease. ( Egge, AC; Hubbard, VS; Lester, LA; Wolf, RO, 1984) |
| "The pharmacokinetics and metabolism of cimetidine were studied in five cystic fibrosis patients (mean age 12." | 7.67 | The bioavailability and pharmacokinetics of cimetidine and its metabolites in juvenile cystic fibrosis patients: age related differences as compared to adults. ( Assael, BM; Padoan, R; Schentag, JJ; Ziemniak, JA, 1984) |
| "The effects of two doses orally administered Cimetidine on gastric and acid production and on intestinal absorption in 13 patients with cystic fibrosis who were treated with pancreatin supplementation were studied." | 7.66 | Cimetidine as an adjunct to oral enzymes in the treatment of malabsorption due to cystic fibrosis. ( de Biéville, F; Fernandes, J; Kerrebijn, KF; Neijens, HJ; van Caillie, M, 1981) |
| "A child with cystic fibrosis was given cimetidine in addition to pancreatic extract." | 7.66 | Meconium ileus equivalent in a child with cystic fibrosis taking cimetidine. ( Elliott, RB; Mitchell, EA; White, PR, 1980) |
| "The effectiveness and safety of the use of cimetidine as an adjunct to pancreatic enzymes was evaluated in eight patients with cystic fibrosis having pancreatic insufficiency." | 7.66 | Effectiveness of cimetidine as an adjunct to supplemental pancreatic enzymes in patients with cystic fibrosis. ( Dunn, GD; Hubbard, VS; Lester, LA, 1980) |
| "Ten patients (6 to 27 years of age) who had severe pancreatic exocrine insufficiency due to cystic fibrosis were studied to determine whether cimetidine would improve dietary fat and nitrogen absorption." | 7.66 | The effect of cimetidine on maldigestion in cystic fibrosis. ( Cox, KL; Dooley, RR; Isenberg, JN; Osher, AB, 1979) |
| "Cimetidine was effective in reducing acid secretion in such patients and led to small improvements in fat absorption." | 6.65 | The effect of cimetidine on meal-stimulated gastric function and exogenous pancreatic enzymes in cystic fibrosis. ( Cameron, DJ; Ghale, GK; Harries, JT; Matthew, DJ; Milla, PJ; More, J; Pitcher-Wilmott, R, 1982) |
| "Enteric-coated microspheres of pancreatin were compared with non-enteric-coated pancreatin combined with cimetidine taken 40 min before meals in the treatment of patients with cystic fibrosis." | 5.06 | Treatment of steatorrhoea in cystic fibrosis: a comparison of enteric-coated microspheres of pancreatin versus non-enteric-coated pancreatin and adjuvant cimetidine. ( Hodson, ME; Skypala, I; Stead, RJ, 1988) |
| "A prospective, randomized double-blind study of 38 children with cystic fibrosis (CF) was designed to evaluate the effectiveness of cimetidine in improving fat absorption and clinical condition." | 5.05 | Long-term cimetidine in children with cystic fibrosis: a randomized double-blind study. ( Kläy, MP; Kraemer, R; Lentze, MJ; Mordasini, RC; Riesen, WF; Rossi, E; Ruedeberg, A; Schöni, M, 1984) |
| "Under controlled clinical observation we administered Cimetidine (600 mg/m2/day) in 10 children with cystic fibrosis." | 5.05 | Cimetidine and fat malabsorption in children with cystic fibrosis. ( Kraemer, R; Rossi, E; Schöni, M, 1981) |
| "Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination." | 5.05 | Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980) |
| "The bentiromide test for exocrine pancreatic function was carried out in normal volunteers, patients with cystic fibrosis (CF) without clinical evidence of pancreatic dysfunction, and CF patients with clinically significant exocrine pancreatic insufficiency." | 3.67 | Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease. ( Egge, AC; Hubbard, VS; Lester, LA; Wolf, RO, 1984) |
| "The pharmacokinetics and metabolism of cimetidine were studied in five cystic fibrosis patients (mean age 12." | 3.67 | The bioavailability and pharmacokinetics of cimetidine and its metabolites in juvenile cystic fibrosis patients: age related differences as compared to adults. ( Assael, BM; Padoan, R; Schentag, JJ; Ziemniak, JA, 1984) |
| " Cimetidine used in the ulcer therapy shows a certain antiandrogenic effect and after a longer time may evoke impotence and other undesirable andrological side-effects which we, however, did not realize in 4 weeks treatment periods." | 3.66 | [Andrologic anomalies in various gastrointestinal diseases]. ( Szarvas, F, 1983) |
| "The effects of two doses orally administered Cimetidine on gastric and acid production and on intestinal absorption in 13 patients with cystic fibrosis who were treated with pancreatin supplementation were studied." | 3.66 | Cimetidine as an adjunct to oral enzymes in the treatment of malabsorption due to cystic fibrosis. ( de Biéville, F; Fernandes, J; Kerrebijn, KF; Neijens, HJ; van Caillie, M, 1981) |
| "A child with cystic fibrosis was given cimetidine in addition to pancreatic extract." | 3.66 | Meconium ileus equivalent in a child with cystic fibrosis taking cimetidine. ( Elliott, RB; Mitchell, EA; White, PR, 1980) |
| "The effectiveness and safety of the use of cimetidine as an adjunct to pancreatic enzymes was evaluated in eight patients with cystic fibrosis having pancreatic insufficiency." | 3.66 | Effectiveness of cimetidine as an adjunct to supplemental pancreatic enzymes in patients with cystic fibrosis. ( Dunn, GD; Hubbard, VS; Lester, LA, 1980) |
| "Ten patients (6 to 27 years of age) who had severe pancreatic exocrine insufficiency due to cystic fibrosis were studied to determine whether cimetidine would improve dietary fat and nitrogen absorption." | 3.66 | The effect of cimetidine on maldigestion in cystic fibrosis. ( Cox, KL; Dooley, RR; Isenberg, JN; Osher, AB, 1979) |
| " With Pancrease, the number of daily dosage units is decreased even when fat intake is increased." | 2.66 | Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages. ( Ansaldi-Balocco, N; Santini, B; Sarchi, C, 1988) |
| "Cimetidine was effective in reducing acid secretion in such patients and led to small improvements in fat absorption." | 2.65 | The effect of cimetidine on meal-stimulated gastric function and exogenous pancreatic enzymes in cystic fibrosis. ( Cameron, DJ; Ghale, GK; Harries, JT; Matthew, DJ; Milla, PJ; More, J; Pitcher-Wilmott, R, 1982) |
| " Dosage requirements vary according to age and clinical condition, and children require a relatively higher drug dosage (mg/kg) than adults." | 2.39 | Do H2 receptor antagonists have a therapeutic role in childhood? ( Kelly, DA, 1994) |
| "Cystic fibrosis is a recessive, fatal genetic disease involving multiple organ systems, in which patients develop pancreatic insufficiency, malabsorption, and repeated pulmonary infections." | 2.38 | Pharmacologic management of cystic fibrosis. ( Hall, M; Kuhn, RJ; Wallace, CS, 1993) |
| " Changes in [Ca2+]i and inositol phosphate production exhibit a similar dose-response relationship for histamine (maximal effect at 10(-4) M), with both phenomena being blocked by the H1 antagonist mepyramine and being insensitive to pertussis toxin treatment." | 1.29 | Histamine activates phospholipase C in human airway epithelial cells via a phorbol ester-sensitive pathway. ( Barzanti, F; Gruenert, DC; Hrelia, S; Rugolo, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (84.38) | 18.7374 |
| 1990's | 3 (9.38) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, WJ | 1 |
| Goeckeler-Fried, JL | 1 |
| Havasi, V | 1 |
| Chiang, A | 1 |
| Rowe, SM | 1 |
| Plyler, ZE | 1 |
| Hong, JS | 1 |
| Mazur, M | 1 |
| Piazza, GA | 1 |
| Keeton, AB | 1 |
| White, EL | 1 |
| Rasmussen, L | 1 |
| Weissman, AM | 1 |
| Denny, RA | 1 |
| Brodsky, JL | 1 |
| Sorscher, EJ | 1 |
| Gow, R | 1 |
| Bradbear, R | 1 |
| Francis, P | 1 |
| Shepherd, R | 1 |
| Hubbard, VS | 2 |
| Wolf, RO | 1 |
| Lester, LA | 2 |
| Egge, AC | 1 |
| Schöni, M | 2 |
| Kraemer, R | 2 |
| Ruedeberg, A | 1 |
| Lentze, MJ | 1 |
| Mordasini, RC | 1 |
| Riesen, WF | 1 |
| Kläy, MP | 1 |
| Rossi, E | 2 |
| Isenberg, JN | 2 |
| Hendrix, PY | 1 |
| Cox, KL | 2 |
| Szarvas, F | 1 |
| Ziemniak, JA | 1 |
| Assael, BM | 1 |
| Padoan, R | 1 |
| Schentag, JJ | 1 |
| de Biéville, F | 1 |
| Neijens, HJ | 1 |
| Fernandes, J | 1 |
| van Caillie, M | 1 |
| Kerrebijn, KF | 1 |
| Cameron, DJ | 1 |
| Pitcher-Wilmott, R | 1 |
| Milla, PJ | 1 |
| More, J | 1 |
| Ghale, GK | 1 |
| Matthew, DJ | 1 |
| Harries, JT | 1 |
| Mitchell, EA | 2 |
| White, PR | 1 |
| Elliott, RB | 2 |
| Ansaldi, N | 1 |
| Auricchio, S | 1 |
| Bendig, DW | 1 |
| Seilheimer, DK | 1 |
| Wagner, ML | 1 |
| Ferry, GD | 1 |
| Barrison, GM | 1 |
| Chase, HP | 1 |
| Welch, NN | 1 |
| Rabaglia, ME | 1 |
| Dupont, J | 1 |
| Wesley, AW | 1 |
| Bradbear, RA | 1 |
| Shepherd, RW | 1 |
| McGuffie, C | 1 |
| Grice, J | 1 |
| Roberts, RK | 1 |
| Boyle, BJ | 1 |
| Long, WB | 1 |
| Balistreri, WF | 1 |
| Widzer, SJ | 1 |
| Huang, N | 1 |
| Durie, PR | 1 |
| Bell, L | 1 |
| Linton, W | 1 |
| Corey, ML | 1 |
| Forstner, GG | 1 |
| Dunn, GD | 1 |
| Kelly, DA | 1 |
| Wallace, CS | 1 |
| Hall, M | 1 |
| Kuhn, RJ | 1 |
| Rugolo, M | 1 |
| Barzanti, F | 1 |
| Gruenert, DC | 1 |
| Hrelia, S | 1 |
| Prandota, J | 1 |
| Osher, AB | 1 |
| Dooley, RR | 1 |
| Ahuja, AS | 1 |
| Mann, NM | 1 |
| Zentler-Munro, P | 1 |
| Northfield, TC | 2 |
| Hodson, ME | 2 |
| Batten, JC | 2 |
| Stead, RJ | 1 |
| Skypala, I | 1 |
| Ansaldi-Balocco, N | 1 |
| Santini, B | 1 |
| Sarchi, C | 1 |
| Strong, HA | 1 |
| Spino, M | 1 |
| Zentler-Munro, PL | 1 |
| Fine, DR | 1 |
| Chalmers, DM | 1 |
| Brown, RC | 1 |
| Miller, MG | 1 |
| Clarke, PC | 1 |
| Kelleher, J | 1 |
| Littlewood, JM | 1 |
| Losowsky, MS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Proton Pump Inhibitors (PPI) and Fat Absorption in Subjects With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (EPI)[NCT03551691] | Phase 2 | 19 participants (Actual) | Interventional | 2018-08-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for cimetidine and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
[Nutrition problems in cystic fibrosis].
Topics: Caseins; Celiac Disease; Cimetidine; Cystic Fibrosis; Humans; Linoleic Acids; Malabsorption Syndrome | 1981 |
[Therapy of digestive insufficiency in cystic fibrosis].
Topics: Antacids; Bile Acids and Salts; Celiac Disease; Cimetidine; Cystic Fibrosis; Exocrine Pancreatic Ins | 1981 |
Do H2 receptor antagonists have a therapeutic role in childhood?
Topics: Adolescent; Child; Child, Preschool; Cimetidine; Cystic Fibrosis; Drug Interactions; Famotidine; Gas | 1994 |
Pharmacologic management of cystic fibrosis.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Bronchodilator Agents; Child; Cimetidine; Cystic Fibrosis; | 1993 |
Unusual distribution, pharmacokinetics, and metabolism of some drugs and their implications to pharmacotherapy.
Topics: Amphotericin B; Anti-Bacterial Agents; Anti-Ulcer Agents; Cimetidine; Colistin; Cystic Fibrosis; Hum | 2000 |
10 trials available for cimetidine and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Comparative study of varying regimens to improve steatorrhoea and creatorrhoea in cystic fibrosis: Effectiveness of an enteric-coated preparation with and without antacids and cimetidine.
Topics: Adolescent; Antacids; Celiac Disease; Child; Cimetidine; Clinical Trials as Topic; Cystic Fibrosis; | 1981 |
Long-term cimetidine in children with cystic fibrosis: a randomized double-blind study.
Topics: Adolescent; Child; Cimetidine; Clinical Trials as Topic; Cystic Fibrosis; Dietary Fats; Double-Blind | 1984 |
The effect of cimetidine on meal-stimulated gastric function and exogenous pancreatic enzymes in cystic fibrosis.
Topics: Adolescent; Child; Child, Preschool; Cimetidine; Cystic Fibrosis; Double-Blind Method; Gastric Acid; | 1982 |
Cimetidine and fat malabsorption in children with cystic fibrosis.
Topics: Adolescent; Child; Cimetidine; Clinical Trials as Topic; Cystic Fibrosis; Dietary Fats; Feces; Femal | 1981 |
Effect of cimetidine and pancreatic enzymes on serum and fecal bile acids and fat absorption in cystic fibrosis.
Topics: Adolescent; Adult; Bile Acids and Salts; Celiac Disease; Cimetidine; Cystic Fibrosis; Diet; Drug Com | 1980 |
Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.
Topics: Adolescent; Bicarbonates; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; Dietary Fats; Drug The | 1980 |
Treatment of steatorrhoea in cystic fibrosis: a comparison of enteric-coated microspheres of pancreatin versus non-enteric-coated pancreatin and adjuvant cimetidine.
Topics: Adult; Celiac Disease; Cimetidine; Cystic Fibrosis; Drug Therapy, Combination; Female; Humans; Male; | 1988 |
Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages.
Topics: Adolescent; Age Factors; Celiac Disease; Child; Child, Preschool; Cimetidine; Clinical Trials as Top | 1988 |
Effect of cimetidine on enzyme inactivation, bile acid precipitation, and lipid solubilisation in pancreatic steatorrhoea due to cystic fibrosis.
Topics: Adolescent; Adult; Bile Acids and Salts; Celiac Disease; Chemical Precipitation; Cimetidine; Cystic | 1985 |
The influence of long-term cimetidine as an adjuvant to pancreatic enzyme therapy in cystic fibrosis.
Topics: Adolescent; Adult; Bile Acids and Salts; Child; Child, Preschool; Cimetidine; Clinical Trials as Top | 1985 |
17 other studies available for cimetidine and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu | 2016 |
Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease.
Topics: 4-Aminobenzoic Acid; Adolescent; Adult; Aminobenzoates; Amylases; Child; Cimetidine; Cystic Fibrosis | 1984 |
Effect of short-term cimetidine administration on fecal bile acid losses in cystic fibrosis.
Topics: Adolescent; Bile Acids and Salts; Child; Cimetidine; Cystic Fibrosis; Exocrine Pancreatic Insufficie | 1983 |
[Andrologic anomalies in various gastrointestinal diseases].
Topics: Cimetidine; Crohn Disease; Cystic Fibrosis; Erectile Dysfunction; Estradiol; Gastrointestinal Diseas | 1983 |
The bioavailability and pharmacokinetics of cimetidine and its metabolites in juvenile cystic fibrosis patients: age related differences as compared to adults.
Topics: Administration, Oral; Adolescent; Adult; Aging; Biological Availability; Biotransformation; Body Sur | 1984 |
Cimetidine as an adjunct to oral enzymes in the treatment of malabsorption due to cystic fibrosis.
Topics: Administration, Oral; Adolescent; Body Weight; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; D | 1981 |
Meconium ileus equivalent in a child with cystic fibrosis taking cimetidine.
Topics: Child; Cimetidine; Cystic Fibrosis; Guanidines; Humans; Infant; Infant, Newborn; Intestinal Obstruct | 1980 |
Complications of gastroesophageal reflux in patients with cystic fibrosis.
Topics: Adolescent; Adult; Antacids; Child; Cimetidine; Cystic Fibrosis; Esophageal Stenosis; Esophagitis, P | 1982 |
Linoleic acid absorption in children with cystic fibrosis.
Topics: Antacids; Child; Cimetidine; Cystic Fibrosis; Dose-Response Relationship, Drug; Enzymes; Female; Hum | 1982 |
The treatment of malabsorption in cystic fibrosis with pancreatic extracts and inhibition of gastric acidity by antacids and cimetidine.
Topics: Adolescent; Aluminum Hydroxide; Celiac Disease; Child; Child, Preschool; Cimetidine; Cystic Fibrosis | 1981 |
The kinetics of oral cimetidine in children with cystic fibrosis.
Topics: Administration, Oral; Adolescent; Child; Cimetidine; Cystic Fibrosis; Guanidines; Humans; Kinetics | 1981 |
Effectiveness of cimetidine as an adjunct to supplemental pancreatic enzymes in patients with cystic fibrosis.
Topics: Adolescent; Adult; Body Weight; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; Drug Therapy, Co | 1980 |
Histamine activates phospholipase C in human airway epithelial cells via a phorbol ester-sensitive pathway.
Topics: Calcium; Calcium-Transporting ATPases; Cell Line; Cimetidine; Cystic Fibrosis; Enzyme Activation; En | 1996 |
The effect of cimetidine on maldigestion in cystic fibrosis.
Topics: Adolescent; Adult; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; Drug Therapy, Combination; Fe | 1979 |
Cimetidine in cystic fibrosis.
Topics: Child; Child, Preschool; Cimetidine; Cystic Fibrosis; Fats; Feces; Female; Guanidines; Humans; Male | 1978 |
Management of partial intestinal obstruction in cystic fibrosis.
Topics: Cimetidine; Cystic Fibrosis; Drug Therapy, Combination; Humans; Intestinal Obstruction; Pancreatin | 1986 |
Highly sensitive determination of cimetidine and its metabolites in serum and urine by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Cimetidine; Cystic Fibrosis; Drug Stability; Humans; | 1987 |