Page last updated: 2024-10-25

cimetidine and Critical Illness

cimetidine has been researched along with Critical Illness in 6 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Critical Illness: A disease or state in which death is possible or imminent.

Research Excerpts

ExcerptRelevanceReference
"The observed effects of cimetidine and sucralfate on the incidence and severity of hemorrhage from stress-related gastritis were not significant when compared with no treatment."5.07Prophylaxis for stress-related gastric hemorrhage in the medical intensive care unit. A randomized, controlled, single-blind study. ( Ben-Menachem, T; Bresalier, RS; Divine, G; Fogel, R; Hadzijahic, N; Patel, RV; Touchette, M; Verter, J; Zarowitz, BJ, 1994)
"Cimetidine treatment decreased mucus/mucin content after 3 or 6 days of treatment."1.37H2 blockers decrease gut mucus production and lead to barrier dysfunction in vitro. ( Diebel, LN; Hall-Zimmerman, L; Liberati, DM, 2011)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lou, W1
Xia, Y1
Xiang, P1
Zhang, L1
Yu, X1
Lim, S1
Xu, M1
Zhao, L1
Rydholm, H1
Traxler, B1
Qin, X1
García-Rayado, G1
Lanas, A1
Tsai, JJ1
Lin, HJ1
Diebel, LN1
Liberati, DM1
Hall-Zimmerman, L1
Yang, YX1
Lewis, JD1
Ben-Menachem, T1
Fogel, R1
Patel, RV1
Touchette, M1
Zarowitz, BJ1
Hadzijahic, N1
Divine, G1
Verter, J1
Bresalier, RS1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Intravenous Esomeprazole Versus Cimetidine in Prevention of Stress Ulcer Prophylaxis in Chinese Seriously Ill Patients - a Randomized, Double-blind, Parallel-group Study[NCT02157376]Phase 3343 participants (Actual)Interventional2014-07-31Completed
Lactobacillus GG in the Prophylaxis of Ventilator Associated Pneumonia: A Prospective, Randomized, Placebo-controlled, Double-blind Study[NCT00613795]Phase 3125 participants (Anticipated)Interventional2004-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Proportion of Patients With Any Overt Upper-GI Bleeding (Significant and Non-significant) During the Treatment Evaluation Phase

"Criteria for a significant upper GI bleeding as described in primary outcome measure or,~Criteria for a non-significant upper GI bleeding as:~Bright red blood per NG or OG tube that clear after NG or OG tube adjustment and 5 to 10 minutes of lavage with room temperature normal saline or,~Persistent gastroccult- positive coffee ground material~During IMP treatment Day 1-2:~Persistent gastroccult - positive coffee ground material for at less than eight consecutive hours or that clear with at least 100 ml of lavage with room temperature normal saline.~During IMP treatment Day 3-14:~Persistent gastroccult - positive coffee ground material in less than three consecutive gastric aspirates within 2 to 4 hours (at least 60±20 minutes apart), or that clear with at least 100 ml of lavage with room temperature normal saline or,~Any clinical signs of hematemesis or melena or haematochezia judged (by the Investigator) to be from an upper GI source." (NCT02157376)
Timeframe: 1-14 days

Interventionproportion of participants (Number)
Esomeprazole0.109
Cimetidine0.105

The Percent of Patients With Clinically Significant Upper-GI Bleeding During the Treatment Evaluation Phase

"Criteria for a clinically significant upper GI bleeding as:~Bright red blood per NG or OG tube that did not clear after NG or OG tube adjustment and 5 to 10 minutes of at least 100 ml lavage with room temperature normal saline-or,~Persistent gastroccult- positive coffee ground material~During IMP treatment Day 1-2:~Persistent gastroccult- positive coffee ground material for at least eight consecutive hours that did not clear with at least 100 ml of lavage with room temperature normal saline.~During IMP treatment Day 3-14:~Persistent gastroccult- positive coffee ground material in at least three consecutive gastric aspirates within 2 to 4 hours (at least 60 ±20 minutes apart), that did not clear with at least 100 ml of lavage with room temperature normal saline." (NCT02157376)
Timeframe: 1-14 days

Intervention% of participants (Number)
Esomeprazole2.7
Cimetidine4.6

Reviews

1 review available for cimetidine and Critical Illness

ArticleYear
Prevention and treatment of stress ulcers in critically ill patients.
    Seminars in gastrointestinal disease, 2003, Volume: 14, Issue:1

    Topics: Aged; Anti-Ulcer Agents; Cimetidine; Critical Illness; Female; Gastric Mucosa; Gastrointestinal Hemo

2003

Trials

2 trials available for cimetidine and Critical Illness

ArticleYear
Prevention of upper gastrointestinal bleeding in critically ill Chinese patients: a randomized, double-blind study evaluating esomeprazole and cimetidine.
    Current medical research and opinion, 2018, Volume: 34, Issue:8

    Topics: Adult; Aged; Cimetidine; Critical Illness; Double-Blind Method; Esomeprazole; Female; Gastrointestin

2018
Prophylaxis for stress-related gastric hemorrhage in the medical intensive care unit. A randomized, controlled, single-blind study.
    Annals of internal medicine, 1994, Oct-15, Volume: 121, Issue:8

    Topics: Adult; Aged; Blood Transfusion; Cimetidine; Critical Illness; Cross Infection; Female; Gastritis; Ga

1994

Other Studies

3 other studies available for cimetidine and Critical Illness

ArticleYear
Upper gastrointestinal bleeding in critically ill patients: proton-pump inhibitors, histamine-2 receptor antagonists or placebo? Many questions remain unanswered.
    Current medical research and opinion, 2018, Volume: 34, Issue:11

    Topics: Cimetidine; Critical Illness; Double-Blind Method; Esomeprazole; Gastrointestinal Hemorrhage; Histam

2018
Intermittent intravenous pantoprazole and continuous cimetidine infusion: effect on gastric pH control in critically ill patients at risk of developing stressed related mucosal disease.
    The Journal of trauma, 2008, Volume: 65, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Cimetidine; Critical Illness; Gastric Mu

2008
H2 blockers decrease gut mucus production and lead to barrier dysfunction in vitro.
    Surgery, 2011, Volume: 150, Issue:4

    Topics: Bacterial Adhesion; Cimetidine; Critical Illness; Escherichia coli; Histamine H2 Antagonists; HT29 C

2011