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cimetidine and Colorectal Cancer

cimetidine has been researched along with Colorectal Cancer in 22 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Research Excerpts

ExcerptRelevanceReference
"Cimetidine has been shown to have beneficial effects in colorectal cancer patients."9.10Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells. ( Imaeda, Y; Kobayashi, K; Matsumoto, S; Okamoto, T; Suzuki, H; Umemoto, S, 2002)
"Thirty-eight colorectal cancer patients were randomly assigned to treatment group, which took cimetidine in the perioperative period, and control group to which no drug was given."9.09Perioperative cimetidine application modulates natural killer cells in patients with colorectal cancer: a randomized clinical study. ( Bai, D; Li, Y; Shao, H; Wang, K; Yang, G; Yuan, H, 1999)
"Previous studies have suggested that cimetidine, a histamine-2 receptor antagonist with immunostimulatory effects, may improve survival in patients with colorectal carcinoma."9.09Randomized trial of preoperative cimetidine in patients with colorectal carcinoma with quantitative assessment of tumor-associated lymphocytes. ( Adams, WJ; Cherian, M; Dwerryhouse, SJ; Finlay, IG; Kelly, MD; King, DW; King, J; Lubowski, DZ; Morris, DL, 1999)
"Administration of cimetidine after curative surgery can improve prognosis of patients with colorectal cancer."7.73[Can the survival of patients with recurrent disease after curative resection of colorectal cancer be prolonged by the administration of cimetidine?]. ( Fujimoto, T; Ishibashi, K; Matsumoto, A; Ogawa, K; Osawa, G; Otani, T; Umehara, A; Watanabe, K; Yokomizo, H; Yoshida, K; Yoshimatsu, K, 2006)
"We herein report the result of a prospective study to investigate the efficacy of cimetidine administration in conjunction with chemotherapy for stage IV colorectal cancer."7.72[Effect of cimetidine with chemotherapy on stage IV colorectal cancer]. ( Fujimoto, T; Hashimoto, M; Ishibashi, K; Iwasaki, K; Ogawa, K; Umehara, A; Yokomizo, H; Yoshida, K; Yoshimatsu, K, 2003)
"Cimetidine has demonstrated a survival benefit in a randomized trial as adjuvant therapy for gastric cancer."6.68A randomized trial of cimetidine with 5-fluorouracil and folinic acid in metastatic colorectal cancer. ( Adams, WJ; Clingan, PR; Legge, J; Links, M; Morris, DL; O'Baugh, J; Phadke, K; Ross, WB, 1995)
" We divided gastric cancer and the colorectal cancer patients, who performed chemotherapy, into two groups of cimetidine administrated group and a non-administration group, and reviewed whether cimetidine inhibited an expression of E-selectin on vascular endothelial cells by measuring E-selectin in plasma."5.11[An interesting change of E-selectin in cimetidine administration during anticancer drug use]. ( Imaeda, Y; Kawase, J; Kobayashi, K; Matsumoto, S; Umemoto, S, 2005)
"Cimetidine has been shown to have beneficial effects in colorectal cancer patients."5.10Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells. ( Imaeda, Y; Kobayashi, K; Matsumoto, S; Okamoto, T; Suzuki, H; Umemoto, S, 2002)
"Thirty-eight colorectal cancer patients were randomly assigned to treatment group, which took cimetidine in the perioperative period, and control group to which no drug was given."5.09Perioperative cimetidine application modulates natural killer cells in patients with colorectal cancer: a randomized clinical study. ( Bai, D; Li, Y; Shao, H; Wang, K; Yang, G; Yuan, H, 1999)
"Previous studies have suggested that cimetidine, a histamine-2 receptor antagonist with immunostimulatory effects, may improve survival in patients with colorectal carcinoma."5.09Randomized trial of preoperative cimetidine in patients with colorectal carcinoma with quantitative assessment of tumor-associated lymphocytes. ( Adams, WJ; Cherian, M; Dwerryhouse, SJ; Finlay, IG; Kelly, MD; King, DW; King, J; Lubowski, DZ; Morris, DL, 1999)
"Fifty consecutive patients undergoing resection of colorectal cancer were randomized to either receive cimetidine at a dose of 400 mg bd for a minimum of 5 pre-operative days, then intravenously for 2 postoperative days, or to act as controls."5.07Cimetidine preserves non-specific immune function after colonic resection for cancer. ( Adams, WJ; King, DW; Lubowski, DZ; Morris, DL; Peters, L; Ross, WB, 1994)
"Of the H(2)RAs evaluated cimetidine appears to confer a survival benefit when given as an adjunct to curative surgical resection of colorectal cancers."4.88Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer. ( Deva, S; Jameson, M, 2012)
"Administration of cimetidine after curative surgery can improve prognosis of patients with colorectal cancer."3.73[Can the survival of patients with recurrent disease after curative resection of colorectal cancer be prolonged by the administration of cimetidine?]. ( Fujimoto, T; Ishibashi, K; Matsumoto, A; Ogawa, K; Osawa, G; Otani, T; Umehara, A; Watanabe, K; Yokomizo, H; Yoshida, K; Yoshimatsu, K, 2006)
"We herein report the result of a prospective study to investigate the efficacy of cimetidine administration in conjunction with chemotherapy for stage IV colorectal cancer."3.72[Effect of cimetidine with chemotherapy on stage IV colorectal cancer]. ( Fujimoto, T; Hashimoto, M; Ishibashi, K; Iwasaki, K; Ogawa, K; Umehara, A; Yokomizo, H; Yoshida, K; Yoshimatsu, K, 2003)
"These data demonstrate that ASON in combination with cimetidine in vitro can significantly reduce the adhesion between endothelial cells and hepatic or colorectal cancer cells, which is stronger than ASON or cimetidine alone."3.72Cooperative inhibitory effects of antisense oligonucleotide of cell adhesion molecules and cimetidine on cancer cell adhesion. ( Chen, YL; Li, XJ; Tang, NH; Wang, XQ; Wang, XZ; Yin, FZ, 2004)
" We aimed to examine the effects of histamine, cimetidine, and ranitidine on in vitro proliferation and apoptosis in two human colorectal cancer cell lines, Caco-2 and LoVo."3.72The effect of H2 antagonists on proliferation and apoptosis in human colorectal cancer cell lines. ( Kumar, P; Mulcahy, H; Patchett, S; Rajendra, S, 2004)
"Although the beneficial effect of cimetidine on survival in cancer has been clinically demonstrated in colorectal cancer patients, the mode of action of cimetidine has not been elucidated."3.70Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression. ( Kawabe, T; Kobayashi, K; Matsumoto, S; Morishima, T; Okamoto, T, 2000)
"Cimetidine has demonstrated a survival benefit in a randomized trial as adjuvant therapy for gastric cancer."2.68A randomized trial of cimetidine with 5-fluorouracil and folinic acid in metastatic colorectal cancer. ( Adams, WJ; Clingan, PR; Legge, J; Links, M; Morris, DL; O'Baugh, J; Phadke, K; Ross, WB, 1995)
" The underlying mechanism for TL-118-treatment success was associated with hepatic perfusion attenuation resulting from reduced nitric-oxide (NO) serum levels as elucidated by using hemodynamic response imaging (HRI, a functional MRI combined with hypercapnia and hyperoxia)."1.38Improved efficacy of a novel anti-angiogenic drug combination (TL-118) against colorectal-cancer liver metastases; MRI monitoring in mice. ( Abramovitch, R; Corchia, N; Edrei, Y; Gross, E, 2012)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (45.45)18.2507
2000's10 (45.45)29.6817
2010's2 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Edrei, Y1
Gross, E1
Corchia, N1
Abramovitch, R1
Deva, S1
Jameson, M1
Bai, D1
Yang, G1
Yuan, H1
Li, Y2
Wang, K2
Shao, H1
Yoshimatsu, K2
Ishibashi, K2
Hashimoto, M1
Umehara, A2
Yokomizo, H2
Yoshida, K2
Fujimoto, T2
Iwasaki, K1
Ogawa, K2
Tang, NH1
Chen, YL1
Wang, XQ1
Li, XJ1
Yin, FZ1
Wang, XZ1
Lin, CY1
Bai, DJ1
Yuan, HY1
Yang, GL1
Hu, MB1
Wu, ZQ1
Rajendra, S1
Mulcahy, H1
Patchett, S1
Kumar, P1
Kawase, J1
Kobayashi, K3
Imaeda, Y2
Umemoto, S2
Matsumoto, S3
Watanabe, K1
Otani, T1
Matsumoto, A1
Osawa, G1
Morris, DL5
Adams, WJ5
Links, M1
Clingan, PR1
Phadke, K1
O'Baugh, J1
Legge, J1
Ross, WB2
Lubowski, DZ2
King, DW2
Peters, L1
Watson, SA1
Wilkinson, LJ1
Robertson, JF1
Hardcastle, JD1
Hellstrand, K1
Brune, M1
Mellqvist, UH1
Naredi, P1
Adams, W1
Morris, D1
Tavani, A1
Fioretti, F1
Franceschi, S1
La Vecchia, C1
Kelly, MD1
King, J1
Cherian, M1
Dwerryhouse, SJ1
Finlay, IG1
Morishima, T1
Kawabe, T1
Okamoto, T2
Eaton, D1
Hawkins, RE1
Suzuki, H1
Kubota, T1
Fujiwara, H1
Ueda, Y1
Itoh, T1
Yamashita, T1
Yoshimura, T1
Okugawa, K1
Yamamoto, Y1
Yano, Y1
Yamagishi, H1

Reviews

1 review available for cimetidine and Colorectal Cancer

ArticleYear
Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer.
    The Cochrane database of systematic reviews, 2012, Aug-15, Issue:8

    Topics: Antineoplastic Agents; Chemotherapy, Adjuvant; Cimetidine; Colorectal Neoplasms; Histamine H2 Antago

2012

Trials

9 trials available for cimetidine and Colorectal Cancer

ArticleYear
Perioperative cimetidine application modulates natural killer cells in patients with colorectal cancer: a randomized clinical study.
    Journal of Tongji Medical University = Tong ji yi ke da xue xue bao, 1999, Volume: 19, Issue:4

    Topics: Cimetidine; Colorectal Neoplasms; Humans; Killer Cells, Natural; Perioperative Period

1999
Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial.
    World journal of gastroenterology, 2004, Volume: 10, Issue:1

    Topics: Adjuvants, Immunologic; Adult; Aged; B-Lymphocytes; Cimetidine; Colorectal Neoplasms; Female; Humans

2004
[An interesting change of E-selectin in cimetidine administration during anticancer drug use].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:11

    Topics: Cimetidine; Colorectal Neoplasms; E-Selectin; Endothelial Cells; Humans; Neoplastic Cells, Circulati

2005
A randomized trial of cimetidine with 5-fluorouracil and folinic acid in metastatic colorectal cancer.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 1995, Volume: 21, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Ant

1995
Cimetidine preserves non-specific immune function after colonic resection for cancer.
    The Australian and New Zealand journal of surgery, 1994, Volume: 64, Issue:12

    Topics: Aged; Cimetidine; Colectomy; Colorectal Neoplasms; Female; Humans; Immunity, Cellular; Immunosuppres

1994
Pilot study--cimetidine enhances lymphocyte infiltration of human colorectal carcinoma: results of a small randomized control trial.
    Cancer, 1997, Jul-01, Volume: 80, Issue:1

    Topics: Aged; Cimetidine; Colorectal Neoplasms; Female; Histamine; Histamine H2 Antagonists; Humans; Immunit

1997
Pilot study--cimetidine enhances lymphocyte infiltration of human colorectal carcinoma: results of a small randomized control trial.
    Cancer, 1998, Jun-01, Volume: 82, Issue:11

    Topics: Adult; Aged; Cimetidine; Colorectal Neoplasms; Female; Histamine H2 Antagonists; Humans; Lymphocytes

1998
Randomized trial of preoperative cimetidine in patients with colorectal carcinoma with quantitative assessment of tumor-associated lymphocytes.
    Cancer, 1999, Apr-15, Volume: 85, Issue:8

    Topics: Adjuvants, Immunologic; Antineoplastic Agents; Carcinoma; Cimetidine; Colorectal Neoplasms; Dose-Res

1999
Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells.
    British journal of cancer, 2002, Jan-21, Volume: 86, Issue:2

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Biomarkers, Tumor; CA-19-9 Antig

2002

Other Studies

12 other studies available for cimetidine and Colorectal Cancer

ArticleYear
Improved efficacy of a novel anti-angiogenic drug combination (TL-118) against colorectal-cancer liver metastases; MRI monitoring in mice.
    British journal of cancer, 2012, Aug-07, Volume: 107, Issue:4

    Topics: Angiogenesis Inhibitors; Animals; Cimetidine; Colorectal Neoplasms; Cyclophosphamide; Diclofenac; Di

2012
[Effect of cimetidine with chemotherapy on stage IV colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:11

    Topics: Adjuvants, Immunologic; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Colorectal

2003
Cooperative inhibitory effects of antisense oligonucleotide of cell adhesion molecules and cimetidine on cancer cell adhesion.
    World journal of gastroenterology, 2004, Volume: 10, Issue:1

    Topics: Cell Adhesion; Cell Line, Tumor; Cimetidine; Colorectal Neoplasms; E-Selectin; Electrophoresis, Agar

2004
The effect of H2 antagonists on proliferation and apoptosis in human colorectal cancer cell lines.
    Digestive diseases and sciences, 2004, Volume: 49, Issue:10

    Topics: Adenocarcinoma; Apoptosis; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Cimetidine; Colorecta

2004
[Can the survival of patients with recurrent disease after curative resection of colorectal cancer be prolonged by the administration of cimetidine?].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:12

    Topics: Cimetidine; Colorectal Neoplasms; Humans; Neoplasm Metastasis; Neoplasm Recurrence, Local; Prognosis

2006
Cimetidine and colorectal cancer--old drug, new use?
    Nature medicine, 1995, Volume: 1, Issue:12

    Topics: Antimetabolites, Antineoplastic; Cimetidine; Colorectal Neoplasms; Drug Synergism; Fluorouracil; For

1995
Effect of histamine on the growth of human gastrointestinal tumours: reversal by cimetidine.
    Gut, 1993, Volume: 34, Issue:8

    Topics: Animals; Cell Division; Cimetidine; Colorectal Neoplasms; Cyclic AMP; Dose-Response Relationship, Dr

1993
Histamine, cimetidine and colorectal cancer.
    Nature medicine, 1996, Volume: 2, Issue:4

    Topics: Cimetidine; Colorectal Neoplasms; Histamine; Histamine H2 Antagonists; Humans; Randomized Controlled

1996
Cimetidine and colorectal cancer.
    Diseases of the colon and rectum, 1996, Volume: 39, Issue:1

    Topics: Chemotherapy, Adjuvant; Cimetidine; Colorectal Neoplasms; Histamine H2 Antagonists; Humans; Survival

1996
Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression.
    Cancer research, 2000, Jul-15, Volume: 60, Issue:14

    Topics: Animals; Cell Adhesion; Cell Nucleus; Cimetidine; Colorectal Neoplasms; Dose-Response Relationship,

2000
Cimetidine in colorectal cancer--are the effects immunological or adhesion-mediated?
    British journal of cancer, 2002, Jan-21, Volume: 86, Issue:2

    Topics: Antimetabolites, Antineoplastic; Cell Adhesion; Chemotherapy, Adjuvant; Cimetidine; Colorectal Neopl

2002
Cimetidine modulates the antigen presenting capacity of dendritic cells from colorectal cancer patients.
    British journal of cancer, 2002, Apr-22, Volume: 86, Issue:8

    Topics: Adult; Aged; Antigen Presentation; Cell Differentiation; Cimetidine; Colorectal Neoplasms; Dendritic

2002