cimetidine has been researched along with Colorectal Cancer in 22 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cimetidine has been shown to have beneficial effects in colorectal cancer patients." | 9.10 | Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells. ( Imaeda, Y; Kobayashi, K; Matsumoto, S; Okamoto, T; Suzuki, H; Umemoto, S, 2002) |
| "Thirty-eight colorectal cancer patients were randomly assigned to treatment group, which took cimetidine in the perioperative period, and control group to which no drug was given." | 9.09 | Perioperative cimetidine application modulates natural killer cells in patients with colorectal cancer: a randomized clinical study. ( Bai, D; Li, Y; Shao, H; Wang, K; Yang, G; Yuan, H, 1999) |
| "Previous studies have suggested that cimetidine, a histamine-2 receptor antagonist with immunostimulatory effects, may improve survival in patients with colorectal carcinoma." | 9.09 | Randomized trial of preoperative cimetidine in patients with colorectal carcinoma with quantitative assessment of tumor-associated lymphocytes. ( Adams, WJ; Cherian, M; Dwerryhouse, SJ; Finlay, IG; Kelly, MD; King, DW; King, J; Lubowski, DZ; Morris, DL, 1999) |
| "Administration of cimetidine after curative surgery can improve prognosis of patients with colorectal cancer." | 7.73 | [Can the survival of patients with recurrent disease after curative resection of colorectal cancer be prolonged by the administration of cimetidine?]. ( Fujimoto, T; Ishibashi, K; Matsumoto, A; Ogawa, K; Osawa, G; Otani, T; Umehara, A; Watanabe, K; Yokomizo, H; Yoshida, K; Yoshimatsu, K, 2006) |
| "We herein report the result of a prospective study to investigate the efficacy of cimetidine administration in conjunction with chemotherapy for stage IV colorectal cancer." | 7.72 | [Effect of cimetidine with chemotherapy on stage IV colorectal cancer]. ( Fujimoto, T; Hashimoto, M; Ishibashi, K; Iwasaki, K; Ogawa, K; Umehara, A; Yokomizo, H; Yoshida, K; Yoshimatsu, K, 2003) |
| "Cimetidine has demonstrated a survival benefit in a randomized trial as adjuvant therapy for gastric cancer." | 6.68 | A randomized trial of cimetidine with 5-fluorouracil and folinic acid in metastatic colorectal cancer. ( Adams, WJ; Clingan, PR; Legge, J; Links, M; Morris, DL; O'Baugh, J; Phadke, K; Ross, WB, 1995) |
| " We divided gastric cancer and the colorectal cancer patients, who performed chemotherapy, into two groups of cimetidine administrated group and a non-administration group, and reviewed whether cimetidine inhibited an expression of E-selectin on vascular endothelial cells by measuring E-selectin in plasma." | 5.11 | [An interesting change of E-selectin in cimetidine administration during anticancer drug use]. ( Imaeda, Y; Kawase, J; Kobayashi, K; Matsumoto, S; Umemoto, S, 2005) |
| "Cimetidine has been shown to have beneficial effects in colorectal cancer patients." | 5.10 | Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells. ( Imaeda, Y; Kobayashi, K; Matsumoto, S; Okamoto, T; Suzuki, H; Umemoto, S, 2002) |
| "Thirty-eight colorectal cancer patients were randomly assigned to treatment group, which took cimetidine in the perioperative period, and control group to which no drug was given." | 5.09 | Perioperative cimetidine application modulates natural killer cells in patients with colorectal cancer: a randomized clinical study. ( Bai, D; Li, Y; Shao, H; Wang, K; Yang, G; Yuan, H, 1999) |
| "Previous studies have suggested that cimetidine, a histamine-2 receptor antagonist with immunostimulatory effects, may improve survival in patients with colorectal carcinoma." | 5.09 | Randomized trial of preoperative cimetidine in patients with colorectal carcinoma with quantitative assessment of tumor-associated lymphocytes. ( Adams, WJ; Cherian, M; Dwerryhouse, SJ; Finlay, IG; Kelly, MD; King, DW; King, J; Lubowski, DZ; Morris, DL, 1999) |
| "Fifty consecutive patients undergoing resection of colorectal cancer were randomized to either receive cimetidine at a dose of 400 mg bd for a minimum of 5 pre-operative days, then intravenously for 2 postoperative days, or to act as controls." | 5.07 | Cimetidine preserves non-specific immune function after colonic resection for cancer. ( Adams, WJ; King, DW; Lubowski, DZ; Morris, DL; Peters, L; Ross, WB, 1994) |
| "Of the H(2)RAs evaluated cimetidine appears to confer a survival benefit when given as an adjunct to curative surgical resection of colorectal cancers." | 4.88 | Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer. ( Deva, S; Jameson, M, 2012) |
| "Administration of cimetidine after curative surgery can improve prognosis of patients with colorectal cancer." | 3.73 | [Can the survival of patients with recurrent disease after curative resection of colorectal cancer be prolonged by the administration of cimetidine?]. ( Fujimoto, T; Ishibashi, K; Matsumoto, A; Ogawa, K; Osawa, G; Otani, T; Umehara, A; Watanabe, K; Yokomizo, H; Yoshida, K; Yoshimatsu, K, 2006) |
| "We herein report the result of a prospective study to investigate the efficacy of cimetidine administration in conjunction with chemotherapy for stage IV colorectal cancer." | 3.72 | [Effect of cimetidine with chemotherapy on stage IV colorectal cancer]. ( Fujimoto, T; Hashimoto, M; Ishibashi, K; Iwasaki, K; Ogawa, K; Umehara, A; Yokomizo, H; Yoshida, K; Yoshimatsu, K, 2003) |
| "These data demonstrate that ASON in combination with cimetidine in vitro can significantly reduce the adhesion between endothelial cells and hepatic or colorectal cancer cells, which is stronger than ASON or cimetidine alone." | 3.72 | Cooperative inhibitory effects of antisense oligonucleotide of cell adhesion molecules and cimetidine on cancer cell adhesion. ( Chen, YL; Li, XJ; Tang, NH; Wang, XQ; Wang, XZ; Yin, FZ, 2004) |
| " We aimed to examine the effects of histamine, cimetidine, and ranitidine on in vitro proliferation and apoptosis in two human colorectal cancer cell lines, Caco-2 and LoVo." | 3.72 | The effect of H2 antagonists on proliferation and apoptosis in human colorectal cancer cell lines. ( Kumar, P; Mulcahy, H; Patchett, S; Rajendra, S, 2004) |
| "Although the beneficial effect of cimetidine on survival in cancer has been clinically demonstrated in colorectal cancer patients, the mode of action of cimetidine has not been elucidated." | 3.70 | Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression. ( Kawabe, T; Kobayashi, K; Matsumoto, S; Morishima, T; Okamoto, T, 2000) |
| "Cimetidine has demonstrated a survival benefit in a randomized trial as adjuvant therapy for gastric cancer." | 2.68 | A randomized trial of cimetidine with 5-fluorouracil and folinic acid in metastatic colorectal cancer. ( Adams, WJ; Clingan, PR; Legge, J; Links, M; Morris, DL; O'Baugh, J; Phadke, K; Ross, WB, 1995) |
| " The underlying mechanism for TL-118-treatment success was associated with hepatic perfusion attenuation resulting from reduced nitric-oxide (NO) serum levels as elucidated by using hemodynamic response imaging (HRI, a functional MRI combined with hypercapnia and hyperoxia)." | 1.38 | Improved efficacy of a novel anti-angiogenic drug combination (TL-118) against colorectal-cancer liver metastases; MRI monitoring in mice. ( Abramovitch, R; Corchia, N; Edrei, Y; Gross, E, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Edrei, Y | 1 |
| Gross, E | 1 |
| Corchia, N | 1 |
| Abramovitch, R | 1 |
| Deva, S | 1 |
| Jameson, M | 1 |
| Bai, D | 1 |
| Yang, G | 1 |
| Yuan, H | 1 |
| Li, Y | 2 |
| Wang, K | 2 |
| Shao, H | 1 |
| Yoshimatsu, K | 2 |
| Ishibashi, K | 2 |
| Hashimoto, M | 1 |
| Umehara, A | 2 |
| Yokomizo, H | 2 |
| Yoshida, K | 2 |
| Fujimoto, T | 2 |
| Iwasaki, K | 1 |
| Ogawa, K | 2 |
| Tang, NH | 1 |
| Chen, YL | 1 |
| Wang, XQ | 1 |
| Li, XJ | 1 |
| Yin, FZ | 1 |
| Wang, XZ | 1 |
| Lin, CY | 1 |
| Bai, DJ | 1 |
| Yuan, HY | 1 |
| Yang, GL | 1 |
| Hu, MB | 1 |
| Wu, ZQ | 1 |
| Rajendra, S | 1 |
| Mulcahy, H | 1 |
| Patchett, S | 1 |
| Kumar, P | 1 |
| Kawase, J | 1 |
| Kobayashi, K | 3 |
| Imaeda, Y | 2 |
| Umemoto, S | 2 |
| Matsumoto, S | 3 |
| Watanabe, K | 1 |
| Otani, T | 1 |
| Matsumoto, A | 1 |
| Osawa, G | 1 |
| Morris, DL | 5 |
| Adams, WJ | 5 |
| Links, M | 1 |
| Clingan, PR | 1 |
| Phadke, K | 1 |
| O'Baugh, J | 1 |
| Legge, J | 1 |
| Ross, WB | 2 |
| Lubowski, DZ | 2 |
| King, DW | 2 |
| Peters, L | 1 |
| Watson, SA | 1 |
| Wilkinson, LJ | 1 |
| Robertson, JF | 1 |
| Hardcastle, JD | 1 |
| Hellstrand, K | 1 |
| Brune, M | 1 |
| Mellqvist, UH | 1 |
| Naredi, P | 1 |
| Adams, W | 1 |
| Morris, D | 1 |
| Tavani, A | 1 |
| Fioretti, F | 1 |
| Franceschi, S | 1 |
| La Vecchia, C | 1 |
| Kelly, MD | 1 |
| King, J | 1 |
| Cherian, M | 1 |
| Dwerryhouse, SJ | 1 |
| Finlay, IG | 1 |
| Morishima, T | 1 |
| Kawabe, T | 1 |
| Okamoto, T | 2 |
| Eaton, D | 1 |
| Hawkins, RE | 1 |
| Suzuki, H | 1 |
| Kubota, T | 1 |
| Fujiwara, H | 1 |
| Ueda, Y | 1 |
| Itoh, T | 1 |
| Yamashita, T | 1 |
| Yoshimura, T | 1 |
| Okugawa, K | 1 |
| Yamamoto, Y | 1 |
| Yano, Y | 1 |
| Yamagishi, H | 1 |
1 review available for cimetidine and Colorectal Cancer
| Article | Year |
|---|---|
Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer.
Topics: Antineoplastic Agents; Chemotherapy, Adjuvant; Cimetidine; Colorectal Neoplasms; Histamine H2 Antago | 2012 |
9 trials available for cimetidine and Colorectal Cancer
| Article | Year |
|---|---|
Perioperative cimetidine application modulates natural killer cells in patients with colorectal cancer: a randomized clinical study.
Topics: Cimetidine; Colorectal Neoplasms; Humans; Killer Cells, Natural; Perioperative Period | 1999 |
Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial.
Topics: Adjuvants, Immunologic; Adult; Aged; B-Lymphocytes; Cimetidine; Colorectal Neoplasms; Female; Humans | 2004 |
[An interesting change of E-selectin in cimetidine administration during anticancer drug use].
Topics: Cimetidine; Colorectal Neoplasms; E-Selectin; Endothelial Cells; Humans; Neoplastic Cells, Circulati | 2005 |
A randomized trial of cimetidine with 5-fluorouracil and folinic acid in metastatic colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Ant | 1995 |
Cimetidine preserves non-specific immune function after colonic resection for cancer.
Topics: Aged; Cimetidine; Colectomy; Colorectal Neoplasms; Female; Humans; Immunity, Cellular; Immunosuppres | 1994 |
Pilot study--cimetidine enhances lymphocyte infiltration of human colorectal carcinoma: results of a small randomized control trial.
Topics: Aged; Cimetidine; Colorectal Neoplasms; Female; Histamine; Histamine H2 Antagonists; Humans; Immunit | 1997 |
Pilot study--cimetidine enhances lymphocyte infiltration of human colorectal carcinoma: results of a small randomized control trial.
Topics: Adult; Aged; Cimetidine; Colorectal Neoplasms; Female; Histamine H2 Antagonists; Humans; Lymphocytes | 1998 |
Randomized trial of preoperative cimetidine in patients with colorectal carcinoma with quantitative assessment of tumor-associated lymphocytes.
Topics: Adjuvants, Immunologic; Antineoplastic Agents; Carcinoma; Cimetidine; Colorectal Neoplasms; Dose-Res | 1999 |
Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Biomarkers, Tumor; CA-19-9 Antig | 2002 |
12 other studies available for cimetidine and Colorectal Cancer
| Article | Year |
|---|---|
Improved efficacy of a novel anti-angiogenic drug combination (TL-118) against colorectal-cancer liver metastases; MRI monitoring in mice.
Topics: Angiogenesis Inhibitors; Animals; Cimetidine; Colorectal Neoplasms; Cyclophosphamide; Diclofenac; Di | 2012 |
[Effect of cimetidine with chemotherapy on stage IV colorectal cancer].
Topics: Adjuvants, Immunologic; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Colorectal | 2003 |
Cooperative inhibitory effects of antisense oligonucleotide of cell adhesion molecules and cimetidine on cancer cell adhesion.
Topics: Cell Adhesion; Cell Line, Tumor; Cimetidine; Colorectal Neoplasms; E-Selectin; Electrophoresis, Agar | 2004 |
The effect of H2 antagonists on proliferation and apoptosis in human colorectal cancer cell lines.
Topics: Adenocarcinoma; Apoptosis; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Cimetidine; Colorecta | 2004 |
[Can the survival of patients with recurrent disease after curative resection of colorectal cancer be prolonged by the administration of cimetidine?].
Topics: Cimetidine; Colorectal Neoplasms; Humans; Neoplasm Metastasis; Neoplasm Recurrence, Local; Prognosis | 2006 |
Cimetidine and colorectal cancer--old drug, new use?
Topics: Antimetabolites, Antineoplastic; Cimetidine; Colorectal Neoplasms; Drug Synergism; Fluorouracil; For | 1995 |
Effect of histamine on the growth of human gastrointestinal tumours: reversal by cimetidine.
Topics: Animals; Cell Division; Cimetidine; Colorectal Neoplasms; Cyclic AMP; Dose-Response Relationship, Dr | 1993 |
Histamine, cimetidine and colorectal cancer.
Topics: Cimetidine; Colorectal Neoplasms; Histamine; Histamine H2 Antagonists; Humans; Randomized Controlled | 1996 |
Cimetidine and colorectal cancer.
Topics: Chemotherapy, Adjuvant; Cimetidine; Colorectal Neoplasms; Histamine H2 Antagonists; Humans; Survival | 1996 |
Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression.
Topics: Animals; Cell Adhesion; Cell Nucleus; Cimetidine; Colorectal Neoplasms; Dose-Response Relationship, | 2000 |
Cimetidine in colorectal cancer--are the effects immunological or adhesion-mediated?
Topics: Antimetabolites, Antineoplastic; Cell Adhesion; Chemotherapy, Adjuvant; Cimetidine; Colorectal Neopl | 2002 |
Cimetidine modulates the antigen presenting capacity of dendritic cells from colorectal cancer patients.
Topics: Adult; Aged; Antigen Presentation; Cell Differentiation; Cimetidine; Colorectal Neoplasms; Dendritic | 2002 |