cimetidine has been researched along with Cocarcinogenesis in 2 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Cocarcinogenesis: The combination of two or more different factors in the production of cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "N-Nitrosocimetidine (NCM) is a derivative of the drug cimetidine, a methylguanidine derivative used in the treatment of peptic ulcer, and is known to be inactive as a complete mouse skin carcinogen, even when given in repeated high doses for a long period." | 1.28 | N-nitrosocimetidine as an initiator of murine skin tumors with associated H-ras oncogene activation. ( Anderson, LM; Enomoto, T; Giner-Sorolla, A; Kovatch, RM; Perantoni, AO; Reed, CD; Rice, JM; Riggs, CW, 1989) |
| "N-Nitrosocimetidine (NCM) is a nitrosation product of cimetidine, a commonly-prescribed pharmaceutical agent." | 1.27 | N-nitrosocimetidine as a modifier of chemically-initiated tumors in mice. ( Anderson, LM; Giner-Sorolla, A; Hagiwara, A; Kovatch, RM; Rehm, S; Rice, JM; Riggs, CW, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, LM | 2 |
| Enomoto, T | 1 |
| Perantoni, AO | 1 |
| Riggs, CW | 2 |
| Kovatch, RM | 2 |
| Reed, CD | 1 |
| Giner-Sorolla, A | 2 |
| Rice, JM | 2 |
| Hagiwara, A | 1 |
| Rehm, S | 1 |
2 other studies available for cimetidine and Cocarcinogenesis
| Article | Year |
|---|---|
N-nitrosocimetidine as an initiator of murine skin tumors with associated H-ras oncogene activation.
Topics: Animals; Carcinogens; Cimetidine; Cocarcinogenesis; Dose-Response Relationship, Drug; Gene Expressio | 1989 |
N-nitrosocimetidine as a modifier of chemically-initiated tumors in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cimetidine; Cocarcinogenesis; Lung Neoplasms; Mice; Neopl | 1988 |