cimetidine has been researched along with Cirrhosis, Liver in 35 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Toxic hepatitis developed but in one out of 127 peptic ulcer patients treated with cimetidine." | 7.68 | [The effect of cimetidine and gastrozepin on liver function and the pharmacotherapy of "hepatogenous" gastroduodenal ulcers and erosions]. ( Bessonova, GA; Geller, LI; Griaznova, MV, 1991) |
| "The effect of cimetidine treatment, 1 g daily over 6 days, on the disposition of theophylline was studied in nine patients with liver cirrhosis and in nine patients without liver disease." | 7.67 | The inhibition of drug metabolism by cimetidine in patients with liver cirrhosis. ( Gugler, R; Hansen, HH; Jensen, JC; Wolf, M, 1984) |
| "Portal pressure and systemic hemodynamics were evaluated for 30 minutes after intravenous injection of 400 mg of cimetidine in patients with and without liver cirrhosis when they were operated upon for varying surgical diseases." | 7.67 | Effect of cimetidine on portal pressure and systemic hemodynamics in patients with and without liver cirrhosis. ( Higashi, T; Nagasue, N; Ogawa, Y; Okita, M; Yamamoto, M; Yukaya, H, 1985) |
| "Blood concentrations and pharmacokinetic parameters of cimetidine were studied in 16 patients with liver cirrhosis and in 8 apparently healthy subjects." | 7.66 | Blood levels of cimetidine in patients with liver cirrhosis. ( Bianchi Porro, G; Lazzaroni, M; Lodola, E, 1983) |
| " cimetidine was studied in 12 patients with compensated liver cirrhosis in a crossover study." | 7.66 | Oral and intravenous pharmacokinetics of cimetidine in liver cirrhosis. ( Benvenuti, C; Lirussi, F; Nassuato, G; Okolicsanyi, L; Orlando, R; Venuti, M, 1982) |
| "Cimetidine kinetics were followed in 16 cirrhotic patients after a single IV 300-mg dose." | 5.27 | Hepatic encephalopathy and altered cimetidine kinetics. ( Bernhard, H; Schentag, JJ; Ziemniak, JA, 1983) |
| "In an exploratory study the 24-h urinary excretion pattern of caffeine and 14 of its major metabolites was studied in 32 volunteers (adults, adolescents and children), 14 patients either with end stage renal disease or liver cirrhosis, 7 heavy smokers and 27 patients on therapy with cimetidine, allopurinol, theophylline or phenytoin." | 3.68 | Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations. ( Bircher, J; Brandes, A; Compagnone, D; Hille, H; Münch, B; Ullrich, D, 1992) |
| "Toxic hepatitis developed but in one out of 127 peptic ulcer patients treated with cimetidine." | 3.68 | [The effect of cimetidine and gastrozepin on liver function and the pharmacotherapy of "hepatogenous" gastroduodenal ulcers and erosions]. ( Bessonova, GA; Geller, LI; Griaznova, MV, 1991) |
| "The bioavailability of oral and intravenous cimetidine and ranitidine was studied in patients with compensated liver cirrhosis." | 3.67 | The pharmacokinetics of H2 receptor blocking agents in compensated liver cirrhosis. ( Iemmolo, RM; Lirussi, F; Nassuato, G; Okolicsányi, L; Orlando, R; Strazzabosco, M; Venuti, M, 1984) |
| "The effect of cimetidine on hepatic and systemic haemodynamic parameters was studied in seven patients with portal hypertension due to alcohol-induced cirrhosis of the liver and in one patient with peliosis hepatis following oral contraceptive steroids." | 3.67 | Effect of cimetidine on the hepatic extraction of indocyanine green, the portal pressure and the systemic circulation in patients with cirrhosis of the liver. ( Bonzel, T; Gerok, W; Herz, R; Keller, E; Rössle, M, 1984) |
| "The effect of cimetidine treatment, 1 g daily over 6 days, on the disposition of theophylline was studied in nine patients with liver cirrhosis and in nine patients without liver disease." | 3.67 | The inhibition of drug metabolism by cimetidine in patients with liver cirrhosis. ( Gugler, R; Hansen, HH; Jensen, JC; Wolf, M, 1984) |
| "The effect of ranitidine 300 mg po given at 1800 h (famotidine 40 mg/cimetidine 800 mg) on the night time gastric pH was tested using longterm intragastric pH monitoring in 27 patients with and 32 patients without liver cirrhosis." | 3.67 | Frequent non-response to histamine H2-receptor antagonists in cirrhotics. ( Bode, JC; Klotz, U; Krishna, DR; Walker, S, 1989) |
| "Portal pressure and systemic hemodynamics were evaluated for 30 minutes after intravenous injection of 400 mg of cimetidine in patients with and without liver cirrhosis when they were operated upon for varying surgical diseases." | 3.67 | Effect of cimetidine on portal pressure and systemic hemodynamics in patients with and without liver cirrhosis. ( Higashi, T; Nagasue, N; Ogawa, Y; Okita, M; Yamamoto, M; Yukaya, H, 1985) |
| "Blood concentrations and pharmacokinetic parameters of cimetidine were studied in 16 patients with liver cirrhosis and in 8 apparently healthy subjects." | 3.66 | Blood levels of cimetidine in patients with liver cirrhosis. ( Bianchi Porro, G; Lazzaroni, M; Lodola, E, 1983) |
| "1 The pharmacokinetics and bioavailability of cimetidine were studied after 200 mg oral and intravenous doses in 14 patients with liver cirrhosis, and results were compared to a control group of 12 ulcer patients." | 3.66 | Altered disposition and availability of cimetidine in liver cirrhotic patients. ( Gugler, R; Müller-Liebenau, B; Somogyi, A, 1982) |
| " cimetidine was studied in 12 patients with compensated liver cirrhosis in a crossover study." | 3.66 | Oral and intravenous pharmacokinetics of cimetidine in liver cirrhosis. ( Benvenuti, C; Lirussi, F; Nassuato, G; Okolicsanyi, L; Orlando, R; Venuti, M, 1982) |
| "Nine patients with compensated alcoholic and nonalcoholic cirrhosis of the liver and 11 patients with peptic ulcer received 200 mg of cimetidine orally and intravenously." | 3.66 | Cimetidine clearance and bioavailability in hepatic cirrhosis. ( Andreasen, PB; Døssing, M; Larsen, NE; Poulsen, HE; Sonne, J, 1981) |
| "Urapidil at a dosage of 25 mg intravenously reduced WHVP from 33." | 2.69 | [Effects of urapidil and cimetidine on wedged hepatic venous pressure and systemic hemodynamics in cirrhotic patients with portal hypertension]. ( Du, R; Feng, H; Leng, X; Li, S; Zhong, C; Zhu, J, 2000) |
| "Amlodipine, a dihydropyridine calcium antagonist, was synthesized in an attempt to develop a compound with a pharmacokinetic profile characteristic of this class, which would also have an increased oral bioavailability and extended clearance time." | 2.38 | The pharmacokinetic profile of amlodipine. ( Abernethy, DR, 1989) |
| "Furosemide kinetics were not affected in patients with hepatic cirrhosis but the effect was lower than in the controls: urinary excretion of sodium (0." | 1.29 | Lack of effect of cimetidine on furosemide kinetics and dynamics in patients with hepatic cirrhosis. ( du Souich, P; Lambert, C; Sanchis Closa, A, 1993) |
| "Cimetidine was given intravenously to 8 cirrhotic patients, an average lowering of 0." | 1.28 | [Effect of cimetidine on wedged hepatic venous pressure in cirrhotic patients]. ( Leng, XS, 1991) |
| "Cimetidine was given intravenously to 8 cirrhotic patients, in whom an average lowering of 0." | 1.28 | Effect of cimetidine on wedged hepatic venous pressure in cirrhotic patients. ( Du, RY; Huang, CT; Leng, XS; Wang, XG; Wang, XH, 1991) |
| " No significant change in half-life was found." | 1.27 | Pharmacokinetics of cimetidine in advanced cirrhosis. ( Grahnén, A; Jameson, S; Lindström, B; Lööf, L; Tyllström, J, 1984) |
| "Cimetidine kinetics were followed in 16 cirrhotic patients after a single IV 300-mg dose." | 1.27 | Hepatic encephalopathy and altered cimetidine kinetics. ( Bernhard, H; Schentag, JJ; Ziemniak, JA, 1983) |
| "43 l/kg) and mean half-life (2." | 1.27 | Pharmacokinetics of cimetidine in patients with liver disease. ( Arancibia, A; Chesta, J; Fajuri, M; González-Martin, G; Novoa, X, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (71.43) | 18.7374 |
| 1990's | 7 (20.00) | 18.2507 |
| 2000's | 2 (5.71) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujimori, N | 1 |
| Komatsu, M | 1 |
| Tanaka, N | 1 |
| Iwaya, M | 1 |
| Nakano, H | 1 |
| Sugiura, A | 1 |
| Yamazaki, T | 1 |
| Shibata, S | 1 |
| Iwaya, Y | 1 |
| Muraki, T | 1 |
| Ichikawa, Y | 1 |
| Kimura, T | 1 |
| Joshita, S | 1 |
| Umemura, T | 1 |
| Matsumoto, A | 1 |
| Tanaka, E | 1 |
| Li, S | 3 |
| Feng, H | 1 |
| Zhu, J | 1 |
| Zhong, C | 1 |
| Leng, X | 2 |
| Du, R | 1 |
| Okolicsányi, L | 2 |
| Venuti, M | 2 |
| Strazzabosco, M | 1 |
| Iemmolo, RM | 1 |
| Nassuato, G | 2 |
| Orlando, R | 2 |
| Lirussi, F | 2 |
| Masciariello, S | 1 |
| Santini, M | 1 |
| Casucci, R | 1 |
| Sodo, M | 1 |
| Aprea, G | 1 |
| Bogaert, MG | 1 |
| Rosseel, MT | 1 |
| Herz, R | 1 |
| Rössle, M | 1 |
| Bonzel, T | 1 |
| Keller, E | 1 |
| Gerok, W | 1 |
| Gugler, R | 2 |
| Wolf, M | 1 |
| Hansen, HH | 1 |
| Jensen, JC | 1 |
| Vorobioff, J | 1 |
| Carnovale, C | 1 |
| Topol, R | 1 |
| Picabea, E | 1 |
| Villavicencio, R | 1 |
| Tanno, H | 1 |
| Audano, M | 1 |
| Audano, G | 1 |
| Nagasue, N | 2 |
| Yukaya, H | 2 |
| Ogawa, Y | 2 |
| Sasaki, Y | 1 |
| Hirose, S | 1 |
| Grahnén, A | 2 |
| Jameson, S | 2 |
| Lööf, L | 2 |
| Tyllström, J | 2 |
| Lindström, B | 1 |
| Burroughs, AK | 1 |
| Walt, R | 1 |
| Dunk, A | 1 |
| Jenkins, W | 1 |
| Sherlock, S | 1 |
| Mackie, S | 1 |
| Dick, R | 1 |
| Ziemniak, JA | 1 |
| Bernhard, H | 1 |
| Schentag, JJ | 1 |
| Bianchi Porro, G | 1 |
| Lazzaroni, M | 1 |
| Lodola, E | 1 |
| Dupont, T | 1 |
| Beaugrand, M | 1 |
| Brunet, JM | 1 |
| Azouz-Abdallah, M | 1 |
| Baylocq, D | 1 |
| Champault, G | 1 |
| Ferrier, JP | 1 |
| Eisenburg, J | 1 |
| Tyllström, B | 1 |
| Müller-Liebenau, B | 1 |
| Somogyi, A | 1 |
| Benvenuti, C | 1 |
| Dölle, W | 1 |
| Sewing, KF | 1 |
| Elashoff, JD | 1 |
| Sonne, J | 1 |
| Poulsen, HE | 1 |
| Døssing, M | 1 |
| Larsen, NE | 1 |
| Andreasen, PB | 1 |
| Sanchis Closa, A | 1 |
| Lambert, C | 1 |
| du Souich, P | 1 |
| Hou, H | 1 |
| Sansoè, G | 1 |
| Ferrari, A | 1 |
| Castellana, CN | 1 |
| Bonardi, L | 1 |
| Villa, E | 1 |
| Manenti, F | 1 |
| Levine, ML | 1 |
| Chotkowski, L | 1 |
| Ullrich, D | 1 |
| Compagnone, D | 1 |
| Münch, B | 1 |
| Brandes, A | 1 |
| Hille, H | 1 |
| Bircher, J | 1 |
| Geller, LI | 1 |
| Bessonova, GA | 1 |
| Griaznova, MV | 1 |
| Leng, XS | 2 |
| Huang, CT | 1 |
| Wang, XG | 1 |
| Wang, XH | 1 |
| Du, RY | 1 |
| Abernethy, DR | 1 |
| Walker, S | 1 |
| Krishna, DR | 1 |
| Klotz, U | 1 |
| Bode, JC | 1 |
| Okita, M | 1 |
| Yamamoto, M | 1 |
| Higashi, T | 1 |
| González-Martin, G | 1 |
| Arancibia, A | 1 |
| Fajuri, M | 1 |
| Chesta, J | 1 |
| Novoa, X | 1 |
2 reviews available for cimetidine and Cirrhosis, Liver
| Article | Year |
|---|---|
[Typical risks in the treatment of acute and chronic liver diseases].
Topics: Androgens; Ascites; Cholestyramine Resin; Cimetidine; Disseminated Intravascular Coagulation; Diuret | 1982 |
The pharmacokinetic profile of amlodipine.
Topics: Administration, Oral; Aging; Amlodipine; Angina Pectoris; Animals; Biological Availability; Calcium | 1989 |
2 trials available for cimetidine and Cirrhosis, Liver
| Article | Year |
|---|---|
[Effects of urapidil and cimetidine on wedged hepatic venous pressure and systemic hemodynamics in cirrhotic patients with portal hypertension].
Topics: Adult; Aged; Blood Pressure; Cimetidine; Female; Heart Rate; Hemodynamics; Humans; Hypertension, Por | 2000 |
Prophylaxis of upper gastrointestinal bleeding with cimetidine in patients undergoing partial hepatectomy.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Female; Hepatectomy; Humans; Liver | 1984 |
31 other studies available for cimetidine and Cirrhosis, Liver
| Article | Year |
|---|---|
Cimetidine/lactulose therapy ameliorates erythropoietic protoporphyria-related liver injury.
Topics: 5-Aminolevulinate Synthetase; Cimetidine; Gastrointestinal Agents; Humans; Lactulose; Liver; Liver C | 2017 |
The pharmacokinetics of H2 receptor blocking agents in compensated liver cirrhosis.
Topics: Administration, Oral; Cimetidine; Dose-Response Relationship, Drug; Half-Life; Humans; Injections, I | 1984 |
[Recent developments in the medical treatment of emergency cirrhotic hemorrhage. Vasopressin and glipressin, prostaglandins, somatostatin, propranolol, cimetidine and ranitidine].
Topics: Cimetidine; Emergencies; Hemorrhage; Humans; Liver Cirrhosis; Lypressin; Propranolol; Prostaglandins | 1983 |
Fate of orally given isosorbide dinitrate in man: factors of variability.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Cimetidine; Drug Interactions; Humans; Isosorbide | 1983 |
Effect of cimetidine on the hepatic extraction of indocyanine green, the portal pressure and the systemic circulation in patients with cirrhosis of the liver.
Topics: Adult; Cimetidine; Female; Hemodynamics; Humans; Hypertension, Portal; Indocyanine Green; Liver; Liv | 1984 |
The inhibition of drug metabolism by cimetidine in patients with liver cirrhosis.
Topics: Adult; Aged; Cimetidine; Drug Antagonism; Female; Half-Life; Humans; Liver Cirrhosis; Male; Middle A | 1984 |
[Determination of hepatic blood flow in chronic liver diseases using the constant infusion technic].
Topics: Adult; Aged; Cimetidine; Female; Hemodynamics; Humans; Indocyanine Green; Liver Circulation; Liver C | 1984 |
Pharmacokinetics of cimetidine in advanced cirrhosis.
Topics: Administration, Oral; Adult; Aged; Biological Availability; Cimetidine; Creatinine; Female; Half-Lif | 1984 |
Effect of cimetidine on portal hypertension in cirrhotic patients.
Topics: Adult; Aged; Cimetidine; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Guanid | 1982 |
Hepatic encephalopathy and altered cimetidine kinetics.
Topics: Adult; Cimetidine; Female; Guanidines; Hepatic Encephalopathy; Humans; Kinetics; Liver Cirrhosis; Li | 1983 |
Blood levels of cimetidine in patients with liver cirrhosis.
Topics: Cimetidine; Guanidines; Humans; Kinetics; Liver Cirrhosis; Middle Aged | 1983 |
[Plasma concentrations of cimetidine in cirrhotic and non-cirrhotic patients with upper digestive tract hemorrhage (author's transl)].
Topics: Cimetidine; Gastrointestinal Hemorrhage; Guanidines; Humans; Liver Cirrhosis | 1981 |
Cimetidine accumulation and mental confusion in cirrhosis.
Topics: Adult; Aged; Cimetidine; Cognition Disorders; Confusion; Guanidines; Humans; Liver Cirrhosis; Middle | 1982 |
Altered disposition and availability of cimetidine in liver cirrhotic patients.
Topics: Adult; Aged; Biological Availability; Cimetidine; Creatinine; Female; Guanidines; Humans; Kinetics; | 1982 |
Oral and intravenous pharmacokinetics of cimetidine in liver cirrhosis.
Topics: Administration, Oral; Adult; Aged; Biological Availability; Cimetidine; Guanidines; Half-Life; Human | 1982 |
Agranulocytosis after cimetidine after agranulocytosis induced by carbimazole in a woman with cirrhosis of the liver, hypersplenism and hyperthyroidism.
Topics: Agranulocytosis; Blood Transfusion; Carbimazole; Cimetidine; Female; Granulocytes; Guanidines; Human | 1980 |
Risk factors in acute gastric mucosal bleeding.
Topics: Acute Disease; Antacids; Cimetidine; Guanidines; Humans; Liver Cirrhosis; Peptic Ulcer Hemorrhage; R | 1980 |
Cimetidine clearance and bioavailability in hepatic cirrhosis.
Topics: Administration, Oral; Aged; Biological Availability; Cimetidine; Female; Guanidines; Humans; Injecti | 1981 |
Lack of effect of cimetidine on furosemide kinetics and dynamics in patients with hepatic cirrhosis.
Topics: Adult; Aged; Cimetidine; Diuresis; Furosemide; Humans; Kidney; Liver Cirrhosis; Middle Aged; Sodium | 1993 |
[The effects of cimetidine on splanchnic hemodynamics in cirrhotic patients with portal hypertension].
Topics: Adult; Cimetidine; Female; Hemodynamics; Humans; Hypertension, Portal; Liver Cirrhosis; Male; Middle | 1993 |
[Computed sonography observation on the effects of cimetidine on the liver blood flow in cirrhotic patients with portal hypertension].
Topics: Adult; Cimetidine; Female; Hepatic Veins; Histamine H2 Antagonists; Humans; Hypertension, Portal; Li | 1995 |
Cimetidine administration and tubular creatinine secretion in patients with compensated cirrhosis.
Topics: Adult; Aged; Cimetidine; Colorimetry; Creatinine; Female; Glomerular Filtration Rate; Histamine H2 A | 2002 |
Cimetidine-induced coma in cirrhosis of the liver.
Topics: Cimetidine; Coma; Duodenal Ulcer; Guanidines; Humans; Liver Cirrhosis; Male; Middle Aged | 1978 |
Etiologic mechanism questioned.
Topics: Cimetidine; Guanidines; Hepatic Encephalopathy; Humans; Liver Cirrhosis | 1979 |
Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations.
Topics: Adolescent; Adult; Age Factors; Allopurinol; Caffeine; Child; Cimetidine; Drug Interactions; Female; | 1992 |
[The effect of cimetidine and gastrozepin on liver function and the pharmacotherapy of "hepatogenous" gastroduodenal ulcers and erosions].
Topics: Adult; Anti-Ulcer Agents; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Evaluation; Drug | 1991 |
[Effect of cimetidine on wedged hepatic venous pressure in cirrhotic patients].
Topics: Adolescent; Adult; Cimetidine; Esophageal and Gastric Varices; Female; Hepatic Veins; Humans; Hypert | 1991 |
Effect of cimetidine on wedged hepatic venous pressure in cirrhotic patients.
Topics: Adolescent; Adult; Cimetidine; Female; Hepatic Veins; Humans; Liver Cirrhosis; Male; Middle Aged; Po | 1991 |
Frequent non-response to histamine H2-receptor antagonists in cirrhotics.
Topics: Anti-Ulcer Agents; Cimetidine; Esophagitis, Peptic; Famotidine; Female; Gastric Acidity Determinatio | 1989 |
Effect of cimetidine on portal pressure and systemic hemodynamics in patients with and without liver cirrhosis.
Topics: Adult; Aged; Cimetidine; Female; Hemodynamics; Humans; Liver Cirrhosis; Male; Middle Aged; Portal Ve | 1985 |
Pharmacokinetics of cimetidine in patients with liver disease.
Topics: Adult; Aged; Cimetidine; Female; Half-Life; Humans; Kinetics; Liver Cirrhosis; Liver Diseases; Male; | 1985 |