cimetidine has been researched along with Celiac Sprue in 26 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Enteric-coated microspheres of pancreatin were compared with non-enteric-coated pancreatin combined with cimetidine taken 40 min before meals in the treatment of patients with cystic fibrosis." | 9.06 | Treatment of steatorrhoea in cystic fibrosis: a comparison of enteric-coated microspheres of pancreatin versus non-enteric-coated pancreatin and adjuvant cimetidine. ( Hodson, ME; Skypala, I; Stead, RJ, 1988) |
| "Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination." | 9.05 | Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980) |
| "The effects of two doses orally administered Cimetidine on gastric and acid production and on intestinal absorption in 13 patients with cystic fibrosis who were treated with pancreatin supplementation were studied." | 7.66 | Cimetidine as an adjunct to oral enzymes in the treatment of malabsorption due to cystic fibrosis. ( de Biéville, F; Fernandes, J; Kerrebijn, KF; Neijens, HJ; van Caillie, M, 1981) |
| "The effectiveness and safety of the use of cimetidine as an adjunct to pancreatic enzymes was evaluated in eight patients with cystic fibrosis having pancreatic insufficiency." | 7.66 | Effectiveness of cimetidine as an adjunct to supplemental pancreatic enzymes in patients with cystic fibrosis. ( Dunn, GD; Hubbard, VS; Lester, LA, 1980) |
| "Ten patients (6 to 27 years of age) who had severe pancreatic exocrine insufficiency due to cystic fibrosis were studied to determine whether cimetidine would improve dietary fat and nitrogen absorption." | 7.66 | The effect of cimetidine on maldigestion in cystic fibrosis. ( Cox, KL; Dooley, RR; Isenberg, JN; Osher, AB, 1979) |
| "Enteric-coated microspheres of pancreatin were compared with non-enteric-coated pancreatin combined with cimetidine taken 40 min before meals in the treatment of patients with cystic fibrosis." | 5.06 | Treatment of steatorrhoea in cystic fibrosis: a comparison of enteric-coated microspheres of pancreatin versus non-enteric-coated pancreatin and adjuvant cimetidine. ( Hodson, ME; Skypala, I; Stead, RJ, 1988) |
| " In this controlled randomized study, 8 hospitalized patients with severe exocrine pancreatic insufficiency and considerable steatorrhoea (greater than 15 g faecal fat/day) were treated with a conventional pancreatic enzyme preparation (Pankreon 700; 3 X 3 dragees daily), with (300 mg) and without cimetidine before meals, and with a new pH-sensitive enzyme preparation (Kreon; 3 X 6 capsules daily) comprising acid-protected granules." | 5.06 | Therapy of pancreatogenic steatorrhoea: does acid protection of pancreatic enzymes offer any advantage? ( Creutzfeldt, W; Göke, B; Lankisch, PG; Lembcke, B, 1986) |
| "Fifteen patients with cystic fibrosis and pancreatic insufficiency were studied during four randomised seven day treatment periods in which they received only pancreatic supplement (Pancrelipase, 27 capsules per day) or supplement plus cimetidine (20 mg/kg body weight/24 h) or sodium bicarbonate (15 g/m2/24 h) alone or in combination." | 5.05 | Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. ( Bell, L; Corey, ML; Durie, PR; Forstner, GG; Linton, W, 1980) |
| "The effect of the addition of sodium bicarbonate, aluminum hydroxide, magnesium hydroxide, calcium carbonate, or cimetidine to supplemental pancreatic enzyme therapy was investigated in patients with severe exocrine pancreatic insufficiency." | 3.66 | Pancreatic enzyme replacement: the effect of antacids or cimetidine. ( Graham, DY, 1982) |
| "The effects of two doses orally administered Cimetidine on gastric and acid production and on intestinal absorption in 13 patients with cystic fibrosis who were treated with pancreatin supplementation were studied." | 3.66 | Cimetidine as an adjunct to oral enzymes in the treatment of malabsorption due to cystic fibrosis. ( de Biéville, F; Fernandes, J; Kerrebijn, KF; Neijens, HJ; van Caillie, M, 1981) |
| "The effectiveness and safety of the use of cimetidine as an adjunct to pancreatic enzymes was evaluated in eight patients with cystic fibrosis having pancreatic insufficiency." | 3.66 | Effectiveness of cimetidine as an adjunct to supplemental pancreatic enzymes in patients with cystic fibrosis. ( Dunn, GD; Hubbard, VS; Lester, LA, 1980) |
| "Ten patients (6 to 27 years of age) who had severe pancreatic exocrine insufficiency due to cystic fibrosis were studied to determine whether cimetidine would improve dietary fat and nitrogen absorption." | 3.66 | The effect of cimetidine on maldigestion in cystic fibrosis. ( Cox, KL; Dooley, RR; Isenberg, JN; Osher, AB, 1979) |
| " With Pancrease, the number of daily dosage units is decreased even when fat intake is increased." | 2.66 | Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages. ( Ansaldi-Balocco, N; Santini, B; Sarchi, C, 1988) |
| "A symptomatic recurrence was controlled with the addition of propantheline." | 1.26 | The effect of cimetidine and propantheline on the symptoms of a patient with systemic mastocytosis. ( Achord, JL; Langford, H, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (92.31) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gow, R | 1 |
| Bradbear, R | 1 |
| Francis, P | 1 |
| Shepherd, R | 1 |
| Graham, DY | 2 |
| Lankisch, PG | 2 |
| Lembcke, B | 2 |
| Achord, JL | 1 |
| Langford, H | 1 |
| de Biéville, F | 1 |
| Neijens, HJ | 1 |
| Fernandes, J | 1 |
| van Caillie, M | 1 |
| Kerrebijn, KF | 1 |
| DiMagno, EP | 2 |
| Staub, JL | 1 |
| Sarles, H | 1 |
| Soule, JC | 1 |
| Galmiche, JP | 1 |
| Capron, JP | 1 |
| Ansaldi, N | 1 |
| Auricchio, S | 1 |
| Rominger, JM | 1 |
| Chey, WY | 1 |
| Chang, TM | 1 |
| Mitchell, EA | 1 |
| Wesley, AW | 1 |
| Elliott, RB | 1 |
| Boyle, BJ | 1 |
| Long, WB | 1 |
| Balistreri, WF | 1 |
| Widzer, SJ | 1 |
| Huang, N | 1 |
| Durie, PR | 1 |
| Bell, L | 1 |
| Linton, W | 1 |
| Corey, ML | 1 |
| Forstner, GG | 1 |
| Hubbard, VS | 1 |
| Dunn, GD | 1 |
| Lester, LA | 1 |
| Bredfeldt, JE | 1 |
| O'Laughlin, JC | 1 |
| Durham, JB | 1 |
| Blessing, LD | 1 |
| Bruno, MJ | 1 |
| Rauws, EA | 1 |
| Hoek, FJ | 1 |
| Tytgat, GN | 1 |
| Marzano, AV | 1 |
| Capsoni, F | 1 |
| Berti, E | 1 |
| Gasparini, G | 1 |
| Bottelli, S | 1 |
| Caputo, R | 1 |
| Regan, PT | 1 |
| Malagelada, JR | 1 |
| Glanzman, SL | 1 |
| Go, VL | 1 |
| Bianchi Porro, G | 1 |
| Dolcini, R | 1 |
| Grossi, E | 1 |
| Petrillo, M | 1 |
| Prada, A | 1 |
| Cox, KL | 1 |
| Isenberg, JN | 1 |
| Osher, AB | 1 |
| Dooley, RR | 1 |
| Stead, RJ | 1 |
| Skypala, I | 1 |
| Hodson, ME | 1 |
| Ansaldi-Balocco, N | 1 |
| Santini, B | 1 |
| Sarchi, C | 1 |
| Göke, B | 1 |
| Creutzfeldt, W | 1 |
| Zentler-Munro, PL | 1 |
| Fine, DR | 1 |
| Batten, JC | 1 |
| Northfield, TC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Proton Pump Inhibitors (PPI) and Fat Absorption in Subjects With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (EPI)[NCT03551691] | Phase 2 | 19 participants (Actual) | Interventional | 2018-08-07 | Completed | ||
| Pancreatic Enzyme Replacement Therapy (PERT) for Treatment of Exocrine Pancreatic Insufficiency in Patients With Unresectable Pancreatic Cancer[NCT02985801] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2016-12-31 | Terminated (stopped due to Study was terminated due to difficulty in recruiting subjects.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for cimetidine and Celiac Sprue
| Article | Year |
|---|---|
[Nutrition problems in cystic fibrosis].
Topics: Caseins; Celiac Disease; Cimetidine; Cystic Fibrosis; Humans; Linoleic Acids; Malabsorption Syndrome | 1981 |
[Therapy of digestive insufficiency in cystic fibrosis].
Topics: Antacids; Bile Acids and Salts; Celiac Disease; Cimetidine; Cystic Fibrosis; Exocrine Pancreatic Ins | 1981 |
Drug-nutrient interactions: use of Cimetidine in malabsorption syndromes.
Topics: Celiac Disease; Cimetidine; Drug Synergism; Gastric Juice; Guanidines; Humans; Malabsorption Syndrom | 1978 |
10 trials available for cimetidine and Celiac Sprue
| Article | Year |
|---|---|
Comparative study of varying regimens to improve steatorrhoea and creatorrhoea in cystic fibrosis: Effectiveness of an enteric-coated preparation with and without antacids and cimetidine.
Topics: Adolescent; Antacids; Celiac Disease; Child; Cimetidine; Clinical Trials as Topic; Cystic Fibrosis; | 1981 |
No effect of cimetidine on the therapeutic response to oral enzymes in severe pancreatic insufficiency.
Topics: Adult; Aged; Celiac Disease; Cimetidine; Clinical Trials as Topic; Guanidines; Humans; Middle Aged; | 1981 |
Effect of cimetidine and pancreatic enzymes on serum and fecal bile acids and fat absorption in cystic fibrosis.
Topics: Adolescent; Adult; Bile Acids and Salts; Celiac Disease; Cimetidine; Cystic Fibrosis; Diet; Drug Com | 1980 |
Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis.
Topics: Adolescent; Bicarbonates; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; Dietary Fats; Drug The | 1980 |
Comparative effects of adjuvant cimetidine and omeprazole during pancreatic enzyme replacement therapy.
Topics: Adult; Aged; Celiac Disease; Cimetidine; Double-Blind Method; Exocrine Pancreatic Insufficiency; Fem | 1994 |
Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency.
Topics: Administration, Oral; Antacids; Celiac Disease; Chronic Disease; Cimetidine; Clinical Trials as Topi | 1977 |
Treatment of steatorrhoea in cystic fibrosis: a comparison of enteric-coated microspheres of pancreatin versus non-enteric-coated pancreatin and adjuvant cimetidine.
Topics: Adult; Celiac Disease; Cimetidine; Cystic Fibrosis; Drug Therapy, Combination; Female; Humans; Male; | 1988 |
Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages.
Topics: Adolescent; Age Factors; Celiac Disease; Child; Child, Preschool; Cimetidine; Clinical Trials as Top | 1988 |
Therapy of pancreatogenic steatorrhoea: does acid protection of pancreatic enzymes offer any advantage?
Topics: Celiac Disease; Chronic Disease; Cimetidine; Clinical Trials as Topic; Drug Therapy, Combination; Ex | 1986 |
Effect of cimetidine on enzyme inactivation, bile acid precipitation, and lipid solubilisation in pancreatic steatorrhoea due to cystic fibrosis.
Topics: Adolescent; Adult; Bile Acids and Salts; Celiac Disease; Chemical Precipitation; Cimetidine; Cystic | 1985 |
13 other studies available for cimetidine and Celiac Sprue
| Article | Year |
|---|---|
Pancreatic enzyme replacement: the effect of antacids or cimetidine.
Topics: Adult; Aluminum Hydroxide; Antacids; Bicarbonates; Calcium Carbonate; Celiac Disease; Cimetidine; Ex | 1982 |
[Therapy of exocrine pancreatic insufficiency].
Topics: Antacids; Biological Availability; Celiac Disease; Cimetidine; Exocrine Pancreatic Insufficiency; Hu | 1984 |
The effect of cimetidine and propantheline on the symptoms of a patient with systemic mastocytosis.
Topics: Adult; Celiac Disease; Cimetidine; Diarrhea; Female; Gastric Juice; Guanidines; Humans; Pepsin A; Pr | 1980 |
Cimetidine as an adjunct to oral enzymes in the treatment of malabsorption due to cystic fibrosis.
Topics: Administration, Oral; Adolescent; Body Weight; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; D | 1981 |
Controversies in the treatment of exocrine pancreatic insufficiency.
Topics: Adult; Antacids; Celiac Disease; Child, Preschool; Cimetidine; Exocrine Pancreatic Insufficiency; Ga | 1982 |
Plasma secretin concentrations and gastric pH in healthy subjects and patients with digestive diseases.
Topics: Achlorhydria; Adolescent; Adult; Aged; Antacids; Celiac Disease; Cimetidine; Digestion; Duodenal Ulc | 1981 |
The treatment of malabsorption in cystic fibrosis with pancreatic extracts and inhibition of gastric acidity by antacids and cimetidine.
Topics: Adolescent; Aluminum Hydroxide; Celiac Disease; Child; Child, Preschool; Cimetidine; Cystic Fibrosis | 1981 |
Effectiveness of cimetidine as an adjunct to supplemental pancreatic enzymes in patients with cystic fibrosis.
Topics: Adolescent; Adult; Body Weight; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; Drug Therapy, Co | 1980 |
Malabsorption and gastric hyperacidity in systemic mastocytosis. Results of cimetidine therapy.
Topics: Celiac Disease; Cimetidine; Gastric Acidity Determination; Gastric Juice; Guanidines; Humans; Jejuna | 1980 |
Amicrobial pustular dermatosis of cutaneous folds associated with autoimmune disorders: a new entity?
Topics: Adult; Ascorbic Acid; Autoantibodies; Autoimmune Diseases; Celiac Disease; Chemotaxis, Leukocyte; Ci | 1996 |
Cimetidine in treatment of pancreatic insufficiency.
Topics: Adjuvants, Pharmaceutic; Adult; Celiac Disease; Cimetidine; Drug Therapy, Combination; Guanidines; H | 1977 |
The effect of cimetidine on maldigestion in cystic fibrosis.
Topics: Adolescent; Adult; Celiac Disease; Child; Cimetidine; Cystic Fibrosis; Drug Therapy, Combination; Fe | 1979 |
Treatment of steatorrhea in chronic pancreatitis.
Topics: Antacids; Celiac Disease; Cimetidine; Exocrine Pancreatic Insufficiency; Humans; Pancreatic Extracts | 1986 |