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cimetidine and Cardiac Hypertrophy

cimetidine has been researched along with Cardiac Hypertrophy in 2 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.

Research Excerpts

ExcerptRelevanceReference
" The dose-response (D-R) curves for histamine (H) in the HT group shifted leftward and upward as compared with the sham-operated (S) group."1.28Effect of histamine on isolated working guinea pig heart with left ventricular hypertrophy produced by pressure overload. ( Guo, ZG; Luo, WS, 1989)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Luo, WS1
Guo, ZG1
Cameron, JS1
Katz, D1
Swigart, CR1
Bassett, AL1

Other Studies

2 other studies available for cimetidine and Cardiac Hypertrophy

ArticleYear
Effect of histamine on isolated working guinea pig heart with left ventricular hypertrophy produced by pressure overload.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1989, Volume: 10, Issue:2

    Topics: Animals; Cardiomegaly; Cimetidine; Dose-Response Relationship, Drug; Guinea Pigs; Heart Function Tes

1989
Histamine attenuates the arrhythmogenic effects of norepinephrine in hearts of spontaneously hypertensive rats.
    European journal of pharmacology, 1989, Oct-04, Volume: 169, Issue:1

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cardiomegaly; Cimetidine; Electrocardiography; Hea

1989