cimetidine has been researched along with Cardiac Hypertrophy in 2 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dose-response (D-R) curves for histamine (H) in the HT group shifted leftward and upward as compared with the sham-operated (S) group." | 1.28 | Effect of histamine on isolated working guinea pig heart with left ventricular hypertrophy produced by pressure overload. ( Guo, ZG; Luo, WS, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Luo, WS | 1 |
| Guo, ZG | 1 |
| Cameron, JS | 1 |
| Katz, D | 1 |
| Swigart, CR | 1 |
| Bassett, AL | 1 |
2 other studies available for cimetidine and Cardiac Hypertrophy
| Article | Year |
|---|---|
Effect of histamine on isolated working guinea pig heart with left ventricular hypertrophy produced by pressure overload.
Topics: Animals; Cardiomegaly; Cimetidine; Dose-Response Relationship, Drug; Guinea Pigs; Heart Function Tes | 1989 |
Histamine attenuates the arrhythmogenic effects of norepinephrine in hearts of spontaneously hypertensive rats.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cardiomegaly; Cimetidine; Electrocardiography; Hea | 1989 |