Page last updated: 2024-10-25

cimetidine and Carcinoma

cimetidine has been researched along with Carcinoma in 13 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.

Research Excerpts

ExcerptRelevanceReference
"Previous studies have suggested that cimetidine, a histamine-2 receptor antagonist with immunostimulatory effects, may improve survival in patients with colorectal carcinoma."9.09Randomized trial of preoperative cimetidine in patients with colorectal carcinoma with quantitative assessment of tumor-associated lymphocytes. ( Adams, WJ; Cherian, M; Dwerryhouse, SJ; Finlay, IG; Kelly, MD; King, DW; King, J; Lubowski, DZ; Morris, DL, 1999)
"The present study was designed to elucidate the effect of cimetidine and PSK on T-cell subsets, interleukin-2 (IL-2) production and its receptor in peripheral blood lymphocytes (PBL) from patients with advanced ovarian carcinoma during the course of chemotherapy."7.67[Effects of cimetidine and PSK on interleukin-2 production by PBL in patients with advanced ovarian carcinoma during the course of chemotherapy]. ( Iwano, I; Kato, K; Kikuchi, Y; Kita, T; Kizawa, I; Miyauchi, M; Oomori, K, 1987)
"The effect of cimetidine on basal and pentagastrin-stimulated serum immunoreactive calcitonin (S-iCT) concentrations was studied in six patients with medullary carcinoma of the thyroid (MCT)."7.66No effect of cimetidine on calcitonin secretion from medullary thyroid carcinoma. ( Emmertsen, K; Hansen, HH; Mosekilde, L; Nielsen, HE, 1980)
"Previous studies have suggested that cimetidine, a histamine-2 receptor antagonist with immunostimulatory effects, may improve survival in patients with colorectal carcinoma."5.09Randomized trial of preoperative cimetidine in patients with colorectal carcinoma with quantitative assessment of tumor-associated lymphocytes. ( Adams, WJ; Cherian, M; Dwerryhouse, SJ; Finlay, IG; Kelly, MD; King, DW; King, J; Lubowski, DZ; Morris, DL, 1999)
"The present study was designed to elucidate the effect of cimetidine and PSK on T-cell subsets, interleukin-2 (IL-2) production and its receptor in peripheral blood lymphocytes (PBL) from patients with advanced ovarian carcinoma during the course of chemotherapy."3.67[Effects of cimetidine and PSK on interleukin-2 production by PBL in patients with advanced ovarian carcinoma during the course of chemotherapy]. ( Iwano, I; Kato, K; Kikuchi, Y; Kita, T; Kizawa, I; Miyauchi, M; Oomori, K, 1987)
"The histamine-2 receptor antagonist cimetidine (10(-5)M) and the prostaglandin synthesis inhibitor indomethacin (10(-8)M) augmented natural killer cell activity in the majority of healthy controls and patients with advanced melanoma and in a lower frequency of patients with colorectal carcinoma."3.67Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon. ( Flodgren, P; Sjögren, HO, 1985)
"The effect of cimetidine on basal and pentagastrin-stimulated serum immunoreactive calcitonin (S-iCT) concentrations was studied in six patients with medullary carcinoma of the thyroid (MCT)."3.66No effect of cimetidine on calcitonin secretion from medullary thyroid carcinoma. ( Emmertsen, K; Hansen, HH; Mosekilde, L; Nielsen, HE, 1980)
" Weekly paclitaxel at a dose of 67 mg/m2/week was found to have a better safety profile and seemed to be as effective as the equivalently dosed schedule every 3 weeks."2.70Randomized trial of single agent paclitaxel given weekly versus every three weeks and with peroral versus intravenous steroid premedication to patients with ovarian cancer previously treated with platinum. ( Andersson, H; Boman, K; Parö, G; Puistola, U; Ridderheim, M; Rosenberg, P; Sorbe, B, 2002)
"Gastro-oesophageal reflux disease (GERD) is common in obese patients."2.41Gastro-oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations. ( Barak, N; Ehrenpreis, ED; Harrison, JR; Sitrin, MD, 2002)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19906 (46.15)18.7374
1990's4 (30.77)18.2507
2000's3 (23.08)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barak, N1
Ehrenpreis, ED1
Harrison, JR1
Sitrin, MD1
Rosenberg, P1
Andersson, H1
Boman, K1
Ridderheim, M1
Sorbe, B1
Puistola, U1
Parö, G1
Sulochana, G1
Kalavathy, R1
Padmanabhan, L1
Emmertsen, K1
Nielsen, HE1
Mosekilde, L1
Hansen, HH1
Wagner, S1
Beil, W1
Mai, UE1
Bokemeyer, C1
Meyer, HJ1
Manns, MP1
Teicher, BA1
Holden, SA1
Goff, DA1
Wright, JE1
Tretyakov, O1
Ayash, LJ1
Anesini, C1
Genaro, A1
Cremaschi, G1
Zubillaga, M1
Boccio, J1
Sterin-Borda, L1
Borda, E1
Kelly, MD1
King, J1
Cherian, M1
Dwerryhouse, SJ1
Finlay, IG1
Adams, WJ1
King, DW1
Lubowski, DZ1
Morris, DL1
Moon, C1
Verschraegen, CF1
Bevers, M1
Freedman, R1
Kudelka, AP1
Kavanagh, JJ1
Armitage, JO1
Sidner, RD1
Klimczak, J1
Kikuchi, Y1
Kizawa, I1
Oomori, K1
Iwano, I1
Kita, T1
Miyauchi, M1
Kato, K1
Flodgren, P1
Sjögren, HO1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Long Term Effects of Laparoscopic Roux-en-Y Gastric Bypass on Gastro-esophageal Reflux: Clinical Impact of Weakly Acidic Reflux[NCT02618044]86 participants (Actual)Observational2006-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for cimetidine and Carcinoma

ArticleYear
Gastro-oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations.
    Obesity reviews : an official journal of the International Association for the Study of Obesity, 2002, Volume: 3, Issue:1

    Topics: Body Composition; Carcinoma; Cimetidine; Esophageal Neoplasms; Gastroesophageal Reflux; Hernia, Hiat

2002

Trials

2 trials available for cimetidine and Carcinoma

ArticleYear
Randomized trial of single agent paclitaxel given weekly versus every three weeks and with peroral versus intravenous steroid premedication to patients with ovarian cancer previously treated with platinum.
    Acta oncologica (Stockholm, Sweden), 2002, Volume: 41, Issue:5

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemot

2002
Randomized trial of preoperative cimetidine in patients with colorectal carcinoma with quantitative assessment of tumor-associated lymphocytes.
    Cancer, 1999, Apr-15, Volume: 85, Issue:8

    Topics: Adjuvants, Immunologic; Antineoplastic Agents; Carcinoma; Cimetidine; Colorectal Neoplasms; Dose-Res

1999

Other Studies

10 other studies available for cimetidine and Carcinoma

ArticleYear
Protein & aminoacid concentrations in the gastric aspirate in the diagnosis of gastric carcinoma.
    The Indian journal of medical research, 1983, Volume: 78 Suppl

    Topics: Amino Acids; Carcinoma; Cimetidine; Gastric Juice; Humans; Proteins; Stomach Neoplasms

1983
No effect of cimetidine on calcitonin secretion from medullary thyroid carcinoma.
    Acta medica Scandinavica, 1980, Volume: 207, Issue:5

    Topics: Adult; Aged; Calcitonin; Carcinoma; Cimetidine; Female; Guanidines; Humans; Male; Middle Aged; Penta

1980
Interaction between Helicobacter pylori and human gastric epithelial cells in culture: effect of antiulcer drugs.
    Pharmacology, 1994, Volume: 49, Issue:4

    Topics: Anti-Ulcer Agents; Bacterial Adhesion; Carcinoma; Cells, Cultured; Cimetidine; Duodenal Ulcer; Epith

1994
Antitumor efficacy and pharmacokinetic analysis of 4-hydroperoxycyclophosphamide in comparison with cyclophosphamide +/- hepatic enzyme effectors.
    Cancer chemotherapy and pharmacology, 1996, Volume: 38, Issue:6

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Pro

1996
"In vivo" and "in vitro" antitumoral action of Larrea divaricata Cav.
    Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia, 1996, Volume: 46, Issue:1

    Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Carcinoma; Cell Division; Cimetidi

1996
Use of docetaxel (Taxotere) in patients with paclitaxel (Taxol) hypersensitivity.
    Anti-cancer drugs, 2000, Volume: 11, Issue:7

    Topics: Adult; Antineoplastic Agents, Phytogenic; Carcinoma; Cimetidine; Cystadenocarcinoma; Dexamethasone;

2000
Antitumour effect of cimetidine.
    Lancet (London, England), 1979, Apr-21, Volume: 1, Issue:8121

    Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Cimetidine; Female

1979
[Use of cimetidine with histamine in 4 patients with inoperable neoplasms of the upper part of the digestive tract].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1985, Oct-15, Volume: 38, Issue:20

    Topics: Adenocarcinoma; Aged; Carcinoma; Cimetidine; Drug Therapy, Combination; Esophageal Neoplasms; Histam

1985
[Effects of cimetidine and PSK on interleukin-2 production by PBL in patients with advanced ovarian carcinoma during the course of chemotherapy].
    Nihon Sanka Fujinka Gakkai zasshi, 1987, Volume: 39, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cimetidine; Cisplatin; Cyclophosphamide;

1987
Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon.
    Cancer immunology, immunotherapy : CII, 1985, Volume: 19, Issue:1

    Topics: Antibody-Dependent Cell Cytotoxicity; Carcinoma; Cimetidine; Colonic Neoplasms; Cytotoxicity, Immuno

1985