cimetidine has been researched along with Carcinoma, Renal Cell in 27 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Carcinoma, Renal Cell: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We found that cimetidine treatment in a xenograft model using A549 lung adenocarcinoma cells resulted in decreased tumor volume compared to vehicle control; however, while the effect was in the same direction as the original study (Figure 4C; Sirota et al." | 3.85 | Replication Study: Discovery and preclinical validation of drug indications using compendia of public gene expression data. ( Aird, F; Kandela, I, 2017) |
| "Cimetidine is an H2-receptor antagonist used in the management of peptic ulcer disease and other hypersecretory gastrointestinal disorders." | 2.69 | A phase II study of high-dose cimetidine and the combination 5-fluorouracil, interferon alpha-2A, and leucovorin in advanced renal cell adenocarcinoma. ( Burch, PA; Creagan, ET; Dalton, RJ; Hatfield, AK; Maples, WJ; Pfeifle, DM; Poon, MA; Schaefer, PL; Suman, VJ; Veeder, MH, 1998) |
| "The prognosis of advanced renal cell carcinoma, especially with metastatic lesions was very poor." | 2.67 | [Management of advanced renal cell carcinoma: surgical treatment of metastasis]. ( Kinouchi, T; Kotake, T, 1994) |
| "Toxicity was minimal." | 2.67 | High-dose cimetidine for the treatment of metastatic renal cell carcinoma. A Hoosier Oncology Group study. ( Inhorn, L; Nattam, S; Stephens, D; Williams, SD, 1992) |
| "We reviewed the outcomes of metastatic renal cell carcinoma patients with the primary tumor in situ who initially underwent interferon-α-based immunotherapy to evaluate the effect of this therapy on metastatic sites as well as primary kidney tumor and survival." | 1.38 | Interferon-α-based immunotherapy in metastatic renal cell carcinoma patients with the primary tumor in situ. ( Abe, T; Maruyama, S; Nonomura, K; Sato, S; Sazawa, A; Shindo, J; Shinohara, N; Suzuki, S, 2012) |
| "We report three cases of metastatic renal cell carcinoma (RCC) in which combination treatment of cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin system inhibitor (angiotensin converting enzyme inhibitor or angiotensin II type 1 receptor antagonist) (CCA therapy) was effective." | 1.35 | Favorable response to combination treatment of cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin system inhibitor in metastatic renal cell carcinoma: Report of three cases. ( Fujii, Y; Fukui, I; Fukui, N; Kawakami, S; Kihara, K; Koga, F; Komai, Y; Morimoto, S; Saito, K; Tatokoro, M, 2008) |
| "Cimetidine has been demonstrated to block histamine mediated activation of suppressor T cells in man and in animal models, resulting in an anti-tumor immune response." | 1.29 | [Successful treatment of metastatic renal cell carcinoma with cimetidine--report of two cases]. ( Kurita, T; Matsuda, H; Nagano, T; Park, YC, 1996) |
| "Forty-five patients with metastatic renal cell carcinoma were treated with coumarin (1,2-benzopyrone) and cimetidine." | 1.27 | Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: a pilot study. ( Butler, K; Cantrell, J; Macdonald, JS; Marshall, ME; Mendelsohn, L; Riley, L; Taylor, R; Wiseman, C, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.81) | 18.7374 |
| 1990's | 16 (59.26) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 4 (14.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kinouchi, T | 6 |
| Meguro, N | 1 |
| Maeda, O | 2 |
| Saiki, S | 3 |
| Kuroda, M | 3 |
| Usami, M | 3 |
| Kotake, T | 6 |
| Kandela, I | 2 |
| Zervantonakis, I | 1 |
| Aird, F | 1 |
| Tatokoro, M | 2 |
| Fujii, Y | 2 |
| Kawakami, S | 2 |
| Fukui, N | 1 |
| Komai, Y | 1 |
| Saito, K | 2 |
| Koga, F | 2 |
| Morimoto, S | 1 |
| Fukui, I | 1 |
| Kihara, K | 2 |
| Matsuoka, Y | 1 |
| Iimura, Y | 1 |
| Masuda, H | 1 |
| Shinohara, N | 1 |
| Abe, T | 1 |
| Sazawa, A | 1 |
| Maruyama, S | 1 |
| Shindo, J | 1 |
| Sato, S | 1 |
| Suzuki, S | 1 |
| Nonomura, K | 1 |
| Tozawa, K | 1 |
| Okamoto, T | 1 |
| Kawai, N | 1 |
| Hashimoto, Y | 1 |
| Hayashi, Y | 1 |
| Kohri, K | 1 |
| Sakamoto, J | 1 |
| Tsukamoto, T | 1 |
| Akaza, H | 1 |
| Kubota, Y | 1 |
| Ozono, S | 1 |
| Kanetake, H | 1 |
| Taguchi, T | 1 |
| Marshall, ME | 2 |
| Mohler, JL | 1 |
| Edmonds, K | 1 |
| Williams, B | 1 |
| Butler, K | 2 |
| Ryles, M | 1 |
| Weiss, L | 1 |
| Urban, D | 1 |
| Bueschen, A | 1 |
| Markiewicz, M | 1 |
| Graham, S | 2 |
| Babayan, RK | 2 |
| Lamm, DL | 2 |
| Sawczuk, I | 2 |
| Ross, SD | 1 |
| Lavin, PT | 3 |
| Osband, ME | 3 |
| Krane, RJ | 2 |
| Sagaster, P | 1 |
| Micksche, M | 1 |
| Flamm, J | 1 |
| Ludwig, H | 1 |
| Nagano, T | 1 |
| Matsuda, H | 1 |
| Park, YC | 1 |
| Kurita, T | 1 |
| Creagan, ET | 1 |
| Veeder, MH | 1 |
| Suman, VJ | 1 |
| Burch, PA | 1 |
| Maples, WJ | 1 |
| Schaefer, PL | 1 |
| Pfeifle, DM | 1 |
| Dalton, RJ | 1 |
| Hatfield, AK | 1 |
| Poon, MA | 1 |
| Wu, XX | 1 |
| Mizutani, Y | 1 |
| Kakehi, Y | 1 |
| Nakamura, E | 1 |
| Mitsumori, K | 1 |
| Takahashi, T | 1 |
| Terachi, T | 1 |
| Okada, Y | 1 |
| Yoshida, O | 1 |
| Maar, R | 1 |
| Franklin, M | 1 |
| Ross, S | 2 |
| Martin, J | 1 |
| Inhorn, L | 1 |
| Williams, SD | 1 |
| Nattam, S | 1 |
| Stephens, D | 1 |
| Parker, B | 1 |
| Kokron, O | 1 |
| Maca, S | 1 |
| Gasser, G | 1 |
| Schmidt, PR | 1 |
| Miki, T | 1 |
| Kiyohara, H | 1 |
| Herrmann, R | 1 |
| Manegold, C | 1 |
| Maurer, B | 1 |
| Hennig, FW | 1 |
| Matthiessen, W | 1 |
| Dexeus, FH | 1 |
| Logothetis, CJ | 1 |
| Sella, A | 1 |
| Fitz, K | 1 |
| Amato, R | 1 |
| Reuben, JM | 1 |
| Dozier, N | 1 |
| Venook, AP | 1 |
| Davenport, Y | 1 |
| Tseng, A | 1 |
| Kirkwood, JM | 1 |
| Ernstoff, MS | 1 |
| Mendelsohn, L | 1 |
| Riley, L | 1 |
| Cantrell, J | 1 |
| Wiseman, C | 1 |
| Taylor, R | 1 |
| Macdonald, JS | 1 |
1 review available for cimetidine and Carcinoma, Renal Cell
| Article | Year |
|---|---|
An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin.
Topics: Adult; Aged; Carcinoma, Renal Cell; Chemotherapy, Adjuvant; Cimetidine; Coumarins; Drug Therapy, Com | 1994 |
12 trials available for cimetidine and Carcinoma, Renal Cell
| Article | Year |
|---|---|
Phase-II trial of combination treatment of interferon-α, cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin-system inhibitor (I-CCA therapy) for advanced renal cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Biph | 2011 |
Prospective randomized trial of natural interferon-alpha versus natural interferon-alpha plus cimetidine in advanced renal cell carcinoma with pulmonary metastasis.
Topics: Adult; Aged; Carcinoma, Renal Cell; Cimetidine; Disease Progression; Drug Therapy, Combination; Fema | 2006 |
[Management of advanced renal cell carcinoma: surgical treatment of metastasis].
Topics: Adrenal Gland Neoplasms; Aged; Bone Neoplasms; Carcinoma, Renal Cell; Cimetidine; Combined Modality | 1994 |
The use of ex vivo-activated memory T cells (autolymphocyte therapy) in the treatment of metastatic renal cell carcinoma: final results from a randomized, controlled, multisite study.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell; Cimetidine; Combined Modality Therapy; Female | 1993 |
Randomised study using IFN-alpha versus IFN-alpha plus coumarin and cimetidine for treatment of advanced renal cell cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coum | 1995 |
Treatment of advanced renal cell carcinoma with a combination of human lymphoblastoid interferon-alpha and cimetidine.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Renal Cell; Cimetidine; Female; Histamine H2 Antagoni | 1997 |
A phase II study of high-dose cimetidine and the combination 5-fluorouracil, interferon alpha-2A, and leucovorin in advanced renal cell adenocarcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Fema | 1998 |
Autolymphocyte therapy for metastatic renal cell carcinoma: initial clinical results from 335 patients treated in a multisite clinical practice.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell; Cimetidine; Cohort Studies; Female; Follow-Up | 1992 |
High-dose cimetidine for the treatment of metastatic renal cell carcinoma. A Hoosier Oncology Group study.
Topics: Carcinoma, Renal Cell; Cimetidine; Drug Evaluation; Female; Humans; Kidney Neoplasms; Male; Middle A | 1992 |
Effect of autolymphocyte therapy on survival and quality of life in patients with metastatic renal-cell carcinoma.
Topics: Actuarial Analysis; Administration, Oral; Adult; Aged; Blood Transfusion, Autologous; Carcinoma, Ren | 1990 |
Cimetidine and coumarin therapy of renal cell carcinoma. A pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cel | 1991 |
Phase II trial of coumarin and cimetidine in advanced renal cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cel | 1990 |
14 other studies available for cimetidine and Carcinoma, Renal Cell
| Article | Year |
|---|---|
Treatment of advanced renal cell carcinoma with a combination of human lymphoblastoid interferon-alpha and cimetidine.
Topics: Adult; Aged; Carcinoma, Renal Cell; Cimetidine; Drug Therapy, Combination; Enzyme Inhibitors; Female | 1996 |
Registered report: Discovery and preclinical validation of drug indications using compendia of public gene expression data.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antibiotics, Antineoplastic; Carcinoma, Renal Cell; | 2015 |
Replication Study: Discovery and preclinical validation of drug indications using compendia of public gene expression data.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Carcinoma, Renal Cell; Cimetidine; Data | 2017 |
Favorable response to combination treatment of cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin system inhibitor in metastatic renal cell carcinoma: Report of three cases.
Topics: Angiotensins; Carcinoma, Renal Cell; Cimetidine; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combinat | 2008 |
Interferon-α-based immunotherapy in metastatic renal cell carcinoma patients with the primary tumor in situ.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma in Situ; C | 2012 |
Positive correlation between sialyl Lewis X expression and pathologic findings in renal cell carcinoma.
Topics: Adjuvants, Immunologic; Carcinoma, Renal Cell; Cimetidine; Humans; Immunohistochemistry; Kidney Neop | 2005 |
[Successful treatment of metastatic renal cell carcinoma with cimetidine--report of two cases].
Topics: Administration, Oral; Carcinoma, Renal Cell; Cimetidine; Female; Histamine H2 Antagonists; Humans; K | 1996 |
[Expression of major histocompatibility complex antigens and adhesion molecules on renal cell carcinoma cells, and effect of interferon-alpha and/or cimetidine on the expression].
Topics: Adjuvants, Immunologic; Antineoplastic Agents; Carcinoma, Renal Cell; Cimetidine; Cytotoxicity, Immu | 1998 |
Treatment of metastatic renal cell carcinoma with a combination of human lymphoblastoid interferon-alpha and cimetidine.
Topics: Administration, Oral; Aged; Bone Neoplasms; Carcinoma, Renal Cell; Cimetidine; Female; Humans; Injec | 1991 |
Phase II study of coumarin and cimetidine in patients with metastatic renal cell carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coum | 1990 |
The treatment of advanced renal cell carcinoma with a combination of human lymphoblastoid interferon-alpha and cimetidine.
Topics: Aged; Carcinoma, Renal Cell; Cimetidine; Combined Modality Therapy; Female; Humans; Interferon Type | 1989 |
Activity of coumarin and cimetidine in metastatic renal cell carcinoma.
Topics: Carcinoma, Renal Cell; Cimetidine; Coumarins; Drug Evaluation; Drug Therapy, Combination; Humans; Ki | 1989 |
Coumarin plus cimetidine: yet another angle for therapy of renal cell carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coumarins; Humans | 1987 |
Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: a pilot study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coum | 1987 |