cimetidine has been researched along with Carcinoma, Hepatocellular in 6 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cimetidine is known to have an anti-tumor effect on certain types of malignancies, though on hepatocellular carcinomas (HCCs), its effect remains unclear." | 7.74 | Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats. ( Adachi, K; Amano, Y; Furuta, K; Ishihara, S; Ishine, J; Kinoshita, Y; Miyake, T; Okamoto, E; Sato, S, 2008) |
| " In the current study, we clarified that cimetidine inhibits both epidermal growth factor (EGF)-induced cell proliferation and migration in hepatocellular carcinoma (HCC) cell lines." | 3.74 | Cimetidine inhibits epidermal growth factor-induced cell signaling. ( Fujikawa, T; Nakanishi, Y; Shiraha, H; Shiratori, Y; Suzuki, M; Takaoka, N; Ueda, N, 2007) |
| "Cimetidine is known to have an anti-tumor effect on certain types of malignancies, though on hepatocellular carcinomas (HCCs), its effect remains unclear." | 3.74 | Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats. ( Adachi, K; Amano, Y; Furuta, K; Ishihara, S; Ishine, J; Kinoshita, Y; Miyake, T; Okamoto, E; Sato, S, 2008) |
| " These results were consistent with the cell-level pharmacodynamic (PD) modeling analysis which leveraged the time-course effects of drugs as single agents and drug combinations." | 1.72 | Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin. ( Ait-Oudhia, S; Lesko, LJ; Mody, H; Vaidya, TR, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mody, H | 1 |
| Vaidya, TR | 1 |
| Lesko, LJ | 1 |
| Ait-Oudhia, S | 1 |
| Borentain, P | 1 |
| Carmona, S | 1 |
| Mathieu, S | 1 |
| Jouve, E | 1 |
| El-Battari, A | 1 |
| Gérolami, R | 1 |
| Fujikawa, T | 1 |
| Shiraha, H | 1 |
| Nakanishi, Y | 1 |
| Takaoka, N | 1 |
| Ueda, N | 1 |
| Suzuki, M | 1 |
| Shiratori, Y | 1 |
| Furuta, K | 1 |
| Sato, S | 1 |
| Miyake, T | 1 |
| Okamoto, E | 1 |
| Ishine, J | 1 |
| Ishihara, S | 1 |
| Amano, Y | 1 |
| Adachi, K | 1 |
| Kinoshita, Y | 1 |
| Cheng, JS | 1 |
| Lee, KC | 1 |
| Wang, JL | 1 |
| Tseng, LL | 1 |
| Chou, KJ | 1 |
| Tang, KY | 1 |
| Jan, CR | 1 |
| Ling, HY | 1 |
| Wang, NZ | 1 |
| Zhu, HZ | 1 |
6 other studies available for cimetidine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin.
Topics: Carcinoma, Hepatocellular; Cimetidine; Cisplatin; Drug-Related Side Effects and Adverse Reactions; H | 2022 |
Inhibition of E-selectin expression on the surface of endothelial cells inhibits hepatocellular carcinoma growth by preventing tumor angiogenesis.
Topics: Amiloride; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cimetidine; E-Selectin; Endotheli | 2016 |
Cimetidine inhibits epidermal growth factor-induced cell signaling.
Topics: Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cimetidine; Epidermal Growth Factor; H | 2007 |
Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cimeti | 2008 |
Histamine-Induced increases in intracellular free Ca2+ levels in hepatoma cells.
Topics: Biological Transport; Calcium; Carcinoma, Hepatocellular; Cimetidine; Cytosol; Extracellular Space; | 2000 |
[Preliminary study of traditional Chinese medicine-Western medicine treatment of patients with primary liver carcinoma].
Topics: Adjuvants, Immunologic; Adult; Camptothecin; Carcinoma, Hepatocellular; Cimetidine; Drugs, Chinese H | 1989 |