cimetidine has been researched along with Cancer of Liver in 20 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cimetidine is known to have an anti-tumor effect on certain types of malignancies, though on hepatocellular carcinomas (HCCs), its effect remains unclear." | 7.74 | Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats. ( Adachi, K; Amano, Y; Furuta, K; Ishihara, S; Ishine, J; Kinoshita, Y; Miyake, T; Okamoto, E; Sato, S, 2008) |
| " In the current study, we clarified that cimetidine inhibits both epidermal growth factor (EGF)-induced cell proliferation and migration in hepatocellular carcinoma (HCC) cell lines." | 3.74 | Cimetidine inhibits epidermal growth factor-induced cell signaling. ( Fujikawa, T; Nakanishi, Y; Shiraha, H; Shiratori, Y; Suzuki, M; Takaoka, N; Ueda, N, 2007) |
| "Cimetidine is known to have an anti-tumor effect on certain types of malignancies, though on hepatocellular carcinomas (HCCs), its effect remains unclear." | 3.74 | Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats. ( Adachi, K; Amano, Y; Furuta, K; Ishihara, S; Ishine, J; Kinoshita, Y; Miyake, T; Okamoto, E; Sato, S, 2008) |
| "These data demonstrate that ASON in combination with cimetidine in vitro can significantly reduce the adhesion between endothelial cells and hepatic or colorectal cancer cells, which is stronger than ASON or cimetidine alone." | 3.72 | Cooperative inhibitory effects of antisense oligonucleotide of cell adhesion molecules and cimetidine on cancer cell adhesion. ( Chen, YL; Li, XJ; Tang, NH; Wang, XQ; Wang, XZ; Yin, FZ, 2004) |
| "Although the beneficial effect of cimetidine on survival in cancer has been clinically demonstrated in colorectal cancer patients, the mode of action of cimetidine has not been elucidated." | 3.70 | Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression. ( Kawabe, T; Kobayashi, K; Matsumoto, S; Morishima, T; Okamoto, T, 2000) |
| " These results were consistent with the cell-level pharmacodynamic (PD) modeling analysis which leveraged the time-course effects of drugs as single agents and drug combinations." | 1.72 | Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin. ( Ait-Oudhia, S; Lesko, LJ; Mody, H; Vaidya, TR, 2022) |
| " The underlying mechanism for TL-118-treatment success was associated with hepatic perfusion attenuation resulting from reduced nitric-oxide (NO) serum levels as elucidated by using hemodynamic response imaging (HRI, a functional MRI combined with hypercapnia and hyperoxia)." | 1.38 | Improved efficacy of a novel anti-angiogenic drug combination (TL-118) against colorectal-cancer liver metastases; MRI monitoring in mice. ( Abramovitch, R; Corchia, N; Edrei, Y; Gross, E, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (30.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 8 (40.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mody, H | 1 |
| Vaidya, TR | 1 |
| Lesko, LJ | 1 |
| Ait-Oudhia, S | 1 |
| Borentain, P | 1 |
| Carmona, S | 1 |
| Mathieu, S | 1 |
| Jouve, E | 1 |
| El-Battari, A | 1 |
| Gérolami, R | 1 |
| Edrei, Y | 1 |
| Gross, E | 1 |
| Corchia, N | 1 |
| Abramovitch, R | 1 |
| Tang, NH | 1 |
| Chen, YL | 1 |
| Wang, XQ | 1 |
| Li, XJ | 1 |
| Yin, FZ | 1 |
| Wang, XZ | 1 |
| Lefranc, F | 1 |
| Yeaton, P | 1 |
| Brotchi, J | 1 |
| Kiss, R | 1 |
| Fujikawa, T | 1 |
| Shiraha, H | 1 |
| Nakanishi, Y | 1 |
| Takaoka, N | 1 |
| Ueda, N | 1 |
| Suzuki, M | 1 |
| Shiratori, Y | 1 |
| Furuta, K | 1 |
| Sato, S | 1 |
| Miyake, T | 1 |
| Okamoto, E | 1 |
| Ishine, J | 1 |
| Ishihara, S | 1 |
| Amano, Y | 1 |
| Adachi, K | 1 |
| Kinoshita, Y | 1 |
| Kolts, BE | 1 |
| Langfitt, M | 1 |
| Rödl, W | 1 |
| Nebel, G | 1 |
| Harms, D | 1 |
| Gold, JE | 1 |
| Malamud, SC | 1 |
| LaRosa, F | 1 |
| Osband, ME | 1 |
| Walton, GD | 1 |
| Schreeder, MT | 1 |
| Rizzo, J | 1 |
| Jobe, DR | 1 |
| Kuhn, J | 1 |
| Schmidt, H | 1 |
| Geertsen, PF | 1 |
| Fode, K | 1 |
| Rytter, C | 1 |
| Bastholt, L | 1 |
| von der Maase, H | 1 |
| Kobayashi, K | 1 |
| Matsumoto, S | 1 |
| Morishima, T | 1 |
| Kawabe, T | 1 |
| Okamoto, T | 1 |
| Katsumoto, Y | 1 |
| Furukawa, J | 1 |
| Yoshioka, S | 1 |
| Shingai, T | 1 |
| Takekuni, K | 1 |
| Yukawa, M | 1 |
| Nakaguchi, K | 1 |
| Okajima, S | 1 |
| Sue, F | 1 |
| Hashimoto, T | 1 |
| Teshima, S | 1 |
| Cheng, JS | 1 |
| Lee, KC | 1 |
| Wang, JL | 1 |
| Tseng, LL | 1 |
| Chou, KJ | 1 |
| Tang, KY | 1 |
| Jan, CR | 1 |
| Johnston, SR | 1 |
| Wright, PL | 1 |
| Ling, HY | 1 |
| Wang, NZ | 1 |
| Zhu, HZ | 1 |
| Shike, M | 1 |
| Gillin, JS | 1 |
| Kemeny, N | 1 |
| Daly, JM | 1 |
| Kurtz, RC | 1 |
| Norton, JA | 1 |
| Sugarbaker, PH | 1 |
| Doppman, JL | 1 |
| Wesley, RA | 1 |
| Maton, PN | 1 |
| Gardner, JD | 1 |
| Jensen, RT | 1 |
| Fujishita, M | 1 |
| Uemura, Y | 1 |
| Kotani, S | 1 |
| Takehara, N | 1 |
| Matsuoka, T | 1 |
| Taguchi, H | 1 |
| Miyoshi, I | 1 |
| Okazaki, K | 1 |
1 review available for cimetidine and Cancer of Liver
| Article | Year |
|---|---|
Cimetidine, an unexpected anti-tumor agent, and its potential for the treatment of glioblastoma (review).
Topics: Antineoplastic Agents; Brain Neoplasms; Cimetidine; Clinical Trials as Topic; Colonic Neoplasms; Gli | 2006 |
1 trial available for cimetidine and Cancer of Liver
| Article | Year |
|---|---|
Subcutaneous interleukin-2 and interferon-alpha plus cisplatin with and without prophylactic cimetidine in patients with metastatic malignant melanoma: a phase II study.
Topics: Adjuvants, Immunologic; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; | 2000 |
18 other studies available for cimetidine and Cancer of Liver
| Article | Year |
|---|---|
Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin.
Topics: Carcinoma, Hepatocellular; Cimetidine; Cisplatin; Drug-Related Side Effects and Adverse Reactions; H | 2022 |
Inhibition of E-selectin expression on the surface of endothelial cells inhibits hepatocellular carcinoma growth by preventing tumor angiogenesis.
Topics: Amiloride; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cimetidine; E-Selectin; Endotheli | 2016 |
Improved efficacy of a novel anti-angiogenic drug combination (TL-118) against colorectal-cancer liver metastases; MRI monitoring in mice.
Topics: Angiogenesis Inhibitors; Animals; Cimetidine; Colorectal Neoplasms; Cyclophosphamide; Diclofenac; Di | 2012 |
Cooperative inhibitory effects of antisense oligonucleotide of cell adhesion molecules and cimetidine on cancer cell adhesion.
Topics: Cell Adhesion; Cell Line, Tumor; Cimetidine; Colorectal Neoplasms; E-Selectin; Electrophoresis, Agar | 2004 |
Cimetidine inhibits epidermal growth factor-induced cell signaling.
Topics: Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cimetidine; Epidermal Growth Factor; H | 2007 |
Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cimeti | 2008 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
[Computer tomography in juvenile malignant gastrinoma].
Topics: Child; Cimetidine; Hepatectomy; Humans; Liver Neoplasms; Lymph Node Excision; Male; Tomography, X-Ra | 1983 |
Adoptive chemoimmunotherapy using ex vivo activated memory T-cells and cyclophosphamide: tumor lysis syndrome of a metastatic soft tissue sarcoma.
Topics: Aged; Cimetidine; Clinical Protocols; Cyclophosphamide; Humans; Immunologic Memory; Immunotherapy, A | 1993 |
Hepatic artery administration of paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carc | 1999 |
Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression.
Topics: Animals; Cell Adhesion; Cell Nucleus; Cimetidine; Colorectal Neoplasms; Dose-Response Relationship, | 2000 |
[A case of locally advanced rectal carcinoma with liver metastasis treated with a combination of CRT, HAI, and systemic chemotherapy].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Combined Modality | 2000 |
Histamine-Induced increases in intracellular free Ca2+ levels in hepatoma cells.
Topics: Biological Transport; Calcium; Carcinoma, Hepatocellular; Cimetidine; Cytosol; Extracellular Space; | 2000 |
Control of metastatic Zollinger-Ellison syndrome with high-dose H2-receptor antagonists.
Topics: Adult; Cimetidine; Gastrinoma; Humans; Liver Neoplasms; Male; Ranitidine; Zollinger-Ellison Syndrome | 1990 |
[Preliminary study of traditional Chinese medicine-Western medicine treatment of patients with primary liver carcinoma].
Topics: Adjuvants, Immunologic; Adult; Camptothecin; Carcinoma, Hepatocellular; Cimetidine; Drugs, Chinese H | 1989 |
Severe gastroduodenal ulcerations complicating hepatic artery infusion chemotherapy for metastatic colon cancer.
Topics: Acute Disease; Adult; Aged; Cimetidine; Colonic Neoplasms; Drug Therapy, Combination; Duodenal Ulcer | 1986 |
Aggressive resection of metastatic disease in selected patients with malignant gastrinoma.
Topics: Abdominal Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Combin | 1986 |
[Cimetidine-induced hypoplastic anemia complicated by hepatoma: report of a case].
Topics: Anemia, Aplastic; Cimetidine; Embolization, Therapeutic; Hematoma; Humans; Liver Neoplasms; Male; Mi | 1985 |