cimetidine has been researched along with Cancer of Kidney in 27 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cimetidine is an H2-receptor antagonist used in the management of peptic ulcer disease and other hypersecretory gastrointestinal disorders." | 2.69 | A phase II study of high-dose cimetidine and the combination 5-fluorouracil, interferon alpha-2A, and leucovorin in advanced renal cell adenocarcinoma. ( Burch, PA; Creagan, ET; Dalton, RJ; Hatfield, AK; Maples, WJ; Pfeifle, DM; Poon, MA; Schaefer, PL; Suman, VJ; Veeder, MH, 1998) |
| "The prognosis of advanced renal cell carcinoma, especially with metastatic lesions was very poor." | 2.67 | [Management of advanced renal cell carcinoma: surgical treatment of metastasis]. ( Kinouchi, T; Kotake, T, 1994) |
| "Toxicity was minimal." | 2.67 | High-dose cimetidine for the treatment of metastatic renal cell carcinoma. A Hoosier Oncology Group study. ( Inhorn, L; Nattam, S; Stephens, D; Williams, SD, 1992) |
| "We reviewed the outcomes of metastatic renal cell carcinoma patients with the primary tumor in situ who initially underwent interferon-α-based immunotherapy to evaluate the effect of this therapy on metastatic sites as well as primary kidney tumor and survival." | 1.38 | Interferon-α-based immunotherapy in metastatic renal cell carcinoma patients with the primary tumor in situ. ( Abe, T; Maruyama, S; Nonomura, K; Sato, S; Sazawa, A; Shindo, J; Shinohara, N; Suzuki, S, 2012) |
| "We report three cases of metastatic renal cell carcinoma (RCC) in which combination treatment of cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin system inhibitor (angiotensin converting enzyme inhibitor or angiotensin II type 1 receptor antagonist) (CCA therapy) was effective." | 1.35 | Favorable response to combination treatment of cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin system inhibitor in metastatic renal cell carcinoma: Report of three cases. ( Fujii, Y; Fukui, I; Fukui, N; Kawakami, S; Kihara, K; Koga, F; Komai, Y; Morimoto, S; Saito, K; Tatokoro, M, 2008) |
| "Cimetidine has been demonstrated to block histamine mediated activation of suppressor T cells in man and in animal models, resulting in an anti-tumor immune response." | 1.29 | [Successful treatment of metastatic renal cell carcinoma with cimetidine--report of two cases]. ( Kurita, T; Matsuda, H; Nagano, T; Park, YC, 1996) |
| "Forty-five patients with metastatic renal cell carcinoma were treated with coumarin (1,2-benzopyrone) and cimetidine." | 1.27 | Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: a pilot study. ( Butler, K; Cantrell, J; Macdonald, JS; Marshall, ME; Mendelsohn, L; Riley, L; Taylor, R; Wiseman, C, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (22.22) | 18.7374 |
| 1990's | 14 (51.85) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kinouchi, T | 5 |
| Meguro, N | 1 |
| Maeda, O | 1 |
| Saiki, S | 2 |
| Kuroda, M | 2 |
| Usami, M | 2 |
| Kotake, T | 5 |
| Kandela, I | 1 |
| Zervantonakis, I | 1 |
| Tatokoro, M | 2 |
| Fujii, Y | 2 |
| Kawakami, S | 2 |
| Fukui, N | 1 |
| Komai, Y | 1 |
| Saito, K | 2 |
| Koga, F | 2 |
| Morimoto, S | 1 |
| Fukui, I | 1 |
| Kihara, K | 2 |
| Matsuoka, Y | 1 |
| Iimura, Y | 1 |
| Masuda, H | 1 |
| Shinohara, N | 1 |
| Abe, T | 1 |
| Sazawa, A | 1 |
| Maruyama, S | 1 |
| Shindo, J | 1 |
| Sato, S | 1 |
| Suzuki, S | 1 |
| Nonomura, K | 1 |
| Tozawa, K | 1 |
| Okamoto, T | 1 |
| Kawai, N | 1 |
| Hashimoto, Y | 1 |
| Hayashi, Y | 1 |
| Kohri, K | 1 |
| Walker, PR | 1 |
| Khuder, SA | 1 |
| Quan, WD | 1 |
| Sakamoto, J | 1 |
| Tsukamoto, T | 1 |
| Akaza, H | 1 |
| Kubota, Y | 1 |
| Ozono, S | 1 |
| Kanetake, H | 1 |
| Taguchi, T | 1 |
| Bilynskiĭ, BT | 1 |
| Shparik, IaV | 1 |
| Marshall, ME | 2 |
| Mohler, JL | 1 |
| Edmonds, K | 1 |
| Williams, B | 1 |
| Butler, K | 2 |
| Ryles, M | 1 |
| Weiss, L | 1 |
| Urban, D | 1 |
| Bueschen, A | 1 |
| Markiewicz, M | 1 |
| Graham, S | 2 |
| Babayan, RK | 2 |
| Lamm, DL | 2 |
| Sawczuk, I | 2 |
| Ross, SD | 1 |
| Lavin, PT | 3 |
| Osband, ME | 3 |
| Krane, RJ | 2 |
| Sagaster, P | 1 |
| Micksche, M | 1 |
| Flamm, J | 1 |
| Ludwig, H | 1 |
| Nagano, T | 1 |
| Matsuda, H | 1 |
| Park, YC | 1 |
| Kurita, T | 1 |
| Creagan, ET | 1 |
| Veeder, MH | 1 |
| Suman, VJ | 1 |
| Burch, PA | 1 |
| Maples, WJ | 1 |
| Schaefer, PL | 1 |
| Pfeifle, DM | 1 |
| Dalton, RJ | 1 |
| Hatfield, AK | 1 |
| Poon, MA | 1 |
| Wu, XX | 1 |
| Mizutani, Y | 1 |
| Kakehi, Y | 1 |
| Nakamura, E | 1 |
| Mitsumori, K | 1 |
| Takahashi, T | 1 |
| Terachi, T | 1 |
| Okada, Y | 1 |
| Yoshida, O | 1 |
| Maar, R | 1 |
| Franklin, M | 1 |
| Ross, S | 2 |
| Martin, J | 1 |
| Inhorn, L | 1 |
| Williams, SD | 1 |
| Nattam, S | 1 |
| Stephens, D | 1 |
| Parker, B | 1 |
| Kokron, O | 1 |
| Maca, S | 1 |
| Gasser, G | 1 |
| Schmidt, PR | 1 |
| Miki, T | 1 |
| Kiyohara, H | 1 |
| Dexeus, FH | 1 |
| Logothetis, CJ | 1 |
| Sella, A | 1 |
| Fitz, K | 1 |
| Amato, R | 1 |
| Reuben, JM | 1 |
| Dozier, N | 1 |
| Venook, AP | 1 |
| Davenport, Y | 1 |
| Tseng, A | 1 |
| Norton, JA | 1 |
| Sugarbaker, PH | 1 |
| Doppman, JL | 1 |
| Wesley, RA | 1 |
| Maton, PN | 1 |
| Gardner, JD | 1 |
| Jensen, RT | 1 |
| Kirkwood, JM | 1 |
| Ernstoff, MS | 1 |
| Mendelsohn, L | 1 |
| Riley, L | 1 |
| Cantrell, J | 1 |
| Wiseman, C | 1 |
| Taylor, R | 1 |
| Macdonald, JS | 1 |
3 reviews available for cimetidine and Cancer of Kidney
| Article | Year |
|---|---|
Continuous infusion interleukin-2 and antihistamines in metastatic kidney cancer.
Topics: Adjuvants, Immunologic; Antineoplastic Agents; Cimetidine; Famotidine; Histamine; Histamine H1 Antag | 2005 |
[Carcinogenicity of various drugs].
Topics: Adult; Animals; Anti-Bacterial Agents; Arsenicals; Barbiturates; Brain Neoplasms; Carcinogens; Child | 1984 |
An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin.
Topics: Adult; Aged; Carcinoma, Renal Cell; Chemotherapy, Adjuvant; Cimetidine; Coumarins; Drug Therapy, Com | 1994 |
10 trials available for cimetidine and Cancer of Kidney
| Article | Year |
|---|---|
Phase-II trial of combination treatment of interferon-α, cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin-system inhibitor (I-CCA therapy) for advanced renal cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Biph | 2011 |
Prospective randomized trial of natural interferon-alpha versus natural interferon-alpha plus cimetidine in advanced renal cell carcinoma with pulmonary metastasis.
Topics: Adult; Aged; Carcinoma, Renal Cell; Cimetidine; Disease Progression; Drug Therapy, Combination; Fema | 2006 |
[Management of advanced renal cell carcinoma: surgical treatment of metastasis].
Topics: Adrenal Gland Neoplasms; Aged; Bone Neoplasms; Carcinoma, Renal Cell; Cimetidine; Combined Modality | 1994 |
The use of ex vivo-activated memory T cells (autolymphocyte therapy) in the treatment of metastatic renal cell carcinoma: final results from a randomized, controlled, multisite study.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell; Cimetidine; Combined Modality Therapy; Female | 1993 |
Randomised study using IFN-alpha versus IFN-alpha plus coumarin and cimetidine for treatment of advanced renal cell cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coum | 1995 |
A phase II study of high-dose cimetidine and the combination 5-fluorouracil, interferon alpha-2A, and leucovorin in advanced renal cell adenocarcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Fema | 1998 |
Autolymphocyte therapy for metastatic renal cell carcinoma: initial clinical results from 335 patients treated in a multisite clinical practice.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell; Cimetidine; Cohort Studies; Female; Follow-Up | 1992 |
High-dose cimetidine for the treatment of metastatic renal cell carcinoma. A Hoosier Oncology Group study.
Topics: Carcinoma, Renal Cell; Cimetidine; Drug Evaluation; Female; Humans; Kidney Neoplasms; Male; Middle A | 1992 |
Effect of autolymphocyte therapy on survival and quality of life in patients with metastatic renal-cell carcinoma.
Topics: Actuarial Analysis; Administration, Oral; Adult; Aged; Blood Transfusion, Autologous; Carcinoma, Ren | 1990 |
Cimetidine and coumarin therapy of renal cell carcinoma. A pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cel | 1991 |
14 other studies available for cimetidine and Cancer of Kidney
| Article | Year |
|---|---|
Treatment of advanced renal cell carcinoma with a combination of human lymphoblastoid interferon-alpha and cimetidine.
Topics: Adult; Aged; Carcinoma, Renal Cell; Cimetidine; Drug Therapy, Combination; Enzyme Inhibitors; Female | 1996 |
Registered report: Discovery and preclinical validation of drug indications using compendia of public gene expression data.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antibiotics, Antineoplastic; Carcinoma, Renal Cell; | 2015 |
Favorable response to combination treatment of cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin system inhibitor in metastatic renal cell carcinoma: Report of three cases.
Topics: Angiotensins; Carcinoma, Renal Cell; Cimetidine; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combinat | 2008 |
Interferon-α-based immunotherapy in metastatic renal cell carcinoma patients with the primary tumor in situ.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma in Situ; C | 2012 |
Positive correlation between sialyl Lewis X expression and pathologic findings in renal cell carcinoma.
Topics: Adjuvants, Immunologic; Carcinoma, Renal Cell; Cimetidine; Humans; Immunohistochemistry; Kidney Neop | 2005 |
[Successful treatment of metastatic renal cell carcinoma with cimetidine--report of two cases].
Topics: Administration, Oral; Carcinoma, Renal Cell; Cimetidine; Female; Histamine H2 Antagonists; Humans; K | 1996 |
[Expression of major histocompatibility complex antigens and adhesion molecules on renal cell carcinoma cells, and effect of interferon-alpha and/or cimetidine on the expression].
Topics: Adjuvants, Immunologic; Antineoplastic Agents; Carcinoma, Renal Cell; Cimetidine; Cytotoxicity, Immu | 1998 |
Treatment of metastatic renal cell carcinoma with a combination of human lymphoblastoid interferon-alpha and cimetidine.
Topics: Administration, Oral; Aged; Bone Neoplasms; Carcinoma, Renal Cell; Cimetidine; Female; Humans; Injec | 1991 |
Phase II study of coumarin and cimetidine in patients with metastatic renal cell carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coum | 1990 |
The treatment of advanced renal cell carcinoma with a combination of human lymphoblastoid interferon-alpha and cimetidine.
Topics: Aged; Carcinoma, Renal Cell; Cimetidine; Combined Modality Therapy; Female; Humans; Interferon Type | 1989 |
Activity of coumarin and cimetidine in metastatic renal cell carcinoma.
Topics: Carcinoma, Renal Cell; Cimetidine; Coumarins; Drug Evaluation; Drug Therapy, Combination; Humans; Ki | 1989 |
Aggressive resection of metastatic disease in selected patients with malignant gastrinoma.
Topics: Abdominal Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Combin | 1986 |
Coumarin plus cimetidine: yet another angle for therapy of renal cell carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coumarins; Humans | 1987 |
Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: a pilot study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cimetidine; Coum | 1987 |