Page last updated: 2024-10-25

cimetidine and Burns

cimetidine has been researched along with Burns in 42 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.

Research Excerpts

ExcerptRelevanceReference
"The relationship of silver sulfadiazine therapy to leukopenia has been controversial."9.05Leukopenia and silver sulfadiazine. ( Bingham, HG; Caffee, HH, 1982)
"The efficacy of prophylactic therapy with cimetidine or antacids combined with early enteral feeding to prevent gastrointestinal bleeding in patients with severe burns was evaluated."7.67Prevention of gastrointestinal bleeding in burns: the effects of cimetidine or antacids combined with early enteral feeding. ( Hirshowitz, B; Jacobs, R; Kaufman, T; Moscona, R, 1985)
"This paper presents clinical observations on the preventive effect of cimetidine for stress ulcer bleeding in severe burns."7.66Prevention of stress ulcer bleeding with cimetidine in severe burns. ( Liu, YL; Yuan, KJ, 1983)
"Large doses of cimetidine significantly inhibit edema formation in thermally injured rat skeletal muscle."7.66Cimetidine inhibits burn edema formation. ( Ayvazian, VH; Deitz, F; Flynn, D; Monafo, WW; Yoshioka, T, 1978)
"We have compared the effectiveness of non-acid neutralizing stress ulcer prophylaxis (SUC) with sucralfate (n = 48) with that of acid neutralizing prophylaxis (AN) utilizing antacids and cimetidine (n = 48) in the prevention of stress ulcer bleeding and nosocomial pneumonia (PN) in thermally injured patients."5.07Comparison of acid neutralizing and non-acid neutralizing stress ulcer prophylaxis in thermally injured patients. ( Cioffi, WG; Mason, AD; McManus, AT; McManus, WF; Pruitt, BA; Rue, LW, 1994)
"The relationship of silver sulfadiazine therapy to leukopenia has been controversial."5.05Leukopenia and silver sulfadiazine. ( Bingham, HG; Caffee, HH, 1982)
"Peritoneal bactericidal activity is suppressed in mice after 20% third degree burns and this effect may be partly reversed by cimetidine and famotidine."3.68Restoration of bactericidal activity of peritoneal fluid by cimetidine but not ranitidine or famotidine in burned mice. ( Akalin, E; Altaca, G; Gür, D; Onat, D; Sayek, I, 1993)
"The pathogenesis of burn edema in the skin of rats appears to be related to a role for histamine, xanthine oxidase and oxygen radicals."3.67Roles of histamine, complement and xanthine oxidase in thermal injury of skin. ( Friedl, HP; Till, GO; Trentz, O; Ward, PA, 1989)
" Two H2 receptor antagonists, cimetidine and ranitidine, reversed the nonspecific immunosuppression of CS induced by burns."3.67The effect of histamine receptor antagonists on specific and nonspecific suppression of experimental contact sensitivity. ( Bender, EM; Claman, HN; Hansbrough, JF; Mekori, YA; Zapata-Sirvent, R, 1985)
"The efficacy of prophylactic therapy with cimetidine or antacids combined with early enteral feeding to prevent gastrointestinal bleeding in patients with severe burns was evaluated."3.67Prevention of gastrointestinal bleeding in burns: the effects of cimetidine or antacids combined with early enteral feeding. ( Hirshowitz, B; Jacobs, R; Kaufman, T; Moscona, R, 1985)
"This paper presents clinical observations on the preventive effect of cimetidine for stress ulcer bleeding in severe burns."3.66Prevention of stress ulcer bleeding with cimetidine in severe burns. ( Liu, YL; Yuan, KJ, 1983)
"2 N sodium hydroxide, 25% sodium chloride, or boiling water produced extensive necrosis of the gastric mucosa."3.66Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. ( Hanchar, AJ; Lancaster, C; Nezamis, JE; Robert, A, 1979)
"Large doses of cimetidine significantly inhibit edema formation in thermally injured rat skeletal muscle."3.66Cimetidine inhibits burn edema formation. ( Ayvazian, VH; Deitz, F; Flynn, D; Monafo, WW; Yoshioka, T, 1978)
"The effects of the H2-antagonists, metiamide and cimetidine, on the oedema following limb ischaemia or scald have been investigated in two strains of rat."3.66H2-receptors and traumatic oedema. ( Little, RA; Savic, J; Stoner, HB, 1978)
"Cimetidine 50 mg/kg was injected intravenously into 12 patients immediately prior to IPHP."2.67Metabolic changes in cimetidine treatment for scald injury on the peritoneo-serosal surface in far-advanced gastric cancer patients treated by intraperitoneal hyperthermic perfusion. ( Fujimoto, S; Kiuchi, S; Kobayashi, K; Kokubun, M; Konno, C; Shrestha, RD; Takahashi, M, 1993)
"Treatment with Cimetidine increased the frequency of CD8+ T cells in the patient's peripheral blood."1.40Cimetidine effects on the immunosuppression induced by burn injury. ( Barough, MS; Hassan, ZM; Kokhaei, P, 2014)
"We have studied the mechanisms of the increased dosage requirements of the H2-receptor antagonist cimetidine in paediatric burned patients in a pharmacokinetic and pharmacodynamic study."1.28Alteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in children. ( Greenblatt, DJ; Hagen, J; Hoaglin, DC; Martyn, JA, 1989)
" Animals were then treated with the four agents in carefully defined dosage regimens, and survival was again determined on the tenth postburn day."1.27Postburn immunosuppression in an animal model. IV. Improved resistance to septic challenge with immunomodulating drugs. ( Bartle, EJ; Bender, EM; Carter, WH; Hansbrough, JF; Mansour, MA; Zapata-Sirvent, RL, 1986)
" Dosage and schedules for antacid prophylaxis in pediatric burn patients require further study."1.27Cimetidine and/or antacid for the control of gastric acidity in pediatric burn patients. ( Martyn, JA, 1985)
" The elimination half-life of cimetidine in burned patients was significantly reduced (2."1.27Increased cimetidine clearance in burn patients. ( Abernethy, DR; Greenblatt, DJ; Martyn, JA, 1985)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199034 (80.95)18.7374
1990's5 (11.90)18.2507
2000's0 (0.00)29.6817
2010's3 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jafarzadeh, A1
Nemati, M1
Khorramdelazad, H1
Hassan, ZM2
Kokhaei, P1
Barough, MS1
A, J1
Zm, H1
M, E1
S, MH1
T, T1
Holtermüller, KH1
Ebener, B1
Kühl, HJ1
Rolfs, A1
Boykin, JV4
Eriksson, E1
Sholley, MM1
Pittman, RN1
Hansbrough, J1
Peterson, V3
Zapata-Sirvent, R5
Claman, HN3
Ziemniak, JA1
Watson, WA1
Saffle, JR1
Smith, IL1
Russo, J1
Warden, GD1
Schentag, JJ1
Ellis, D1
Gartner, JC1
Galvis, AG1
Björk, J1
Arturson, G1
Liu, YL1
Yuan, KJ1
Fusamoto, H1
Saito, M1
Nakagawa, A1
Kawano, S1
Sato, N1
Kamada, T1
Abe, H1
Caffee, HH1
Bingham, HG1
Searcy, RM1
Cone, JB1
Bowser, BH1
Caldwell, FT1
Menguy, R1
Cioffi, WG1
McManus, AT1
Rue, LW1
Mason, AD1
McManus, WF1
Pruitt, BA1
Altaca, G1
Sayek, I1
Onat, D1
Gür, D1
Akalin, E1
Fujimoto, S2
Takahashi, M2
Kobayashi, K2
Kokubun, M2
Shrestha, RD2
Kiuchi, S2
Konno, C2
Raff, T1
Germann, G1
Hartmann, B1
Watson, WC1
Kutty, PK1
Colcleugh, RG1
Ahmad, S1
Yoshioka, T2
Monafo, WW2
Ayvazian, VH2
Dietz, F1
Flynn, D2
Robert, A1
Nezamis, JE1
Lancaster, C1
Hanchar, AJ1
McElwee, HP1
Sirinek, KR1
Levine, BA1
Nasilowski, W1
Deitz, F1
Little, RA1
Savic, J1
Stoner, HB1
Ohta, M1
Friedl, HP1
Till, GO1
Trentz, O1
Ward, PA1
Martyn, JA3
Greenblatt, DJ2
Hagen, J1
Hoaglin, DC1
Hansbrough, JF5
Wang, XW1
Claman, H1
Zapata-Sirvent, RL1
Bender, EM4
Bartle, EJ1
Mansour, MA1
Carter, WH1
Sullivan, J1
Mekori, YA1
Manson, NH2
Zehavi-Willner, T1
Markenson, J1
Pinto, M1
Moscona, R1
Kaufman, T1
Jacobs, R1
Hirshowitz, B1
Abernethy, DR1
Crute, SL1
Haynes, BW1
Myerson, RM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Enteral Nutrition on Stress Ulcer Hemorrage. Multicenter Randomized Controlled[NCT03098537]500 participants (Anticipated)Interventional2016-08-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for cimetidine and Burns

ArticleYear
Immunomodulatory properties of cimetidine: Its therapeutic potentials for treatment of immune-related diseases.
    International immunopharmacology, 2019, Volume: 70

    Topics: Animals; Bone Resorption; Burns; Cimetidine; Dendritic Cells; Histamine; Humans; Hypersensitivity; I

2019
Side effects of cimetidine.
    Southern medical journal, 1979, Volume: 72, Issue:5

    Topics: Acute Disease; Aged; Agranulocytosis; Burns; Central Nervous System; Cimetidine; Female; Glucose; Gu

1979
Mechanisms of cimetidine protection following thermal injury.
    The American journal of medicine, 1987, Dec-18, Volume: 83, Issue:6A

    Topics: Animals; Body Fluids; Burns; Cimetidine; Shock, Traumatic

1987

Trials

4 trials available for cimetidine and Burns

ArticleYear
Leukopenia and silver sulfadiazine.
    The Journal of trauma, 1982, Volume: 22, Issue:7

    Topics: Adult; Burns; Cimetidine; Drug Interactions; Guanidines; Humans; Leukopenia; Peptic Ulcer; Prospecti

1982
Comparison of acid neutralizing and non-acid neutralizing stress ulcer prophylaxis in thermally injured patients.
    The Journal of trauma, 1994, Volume: 36, Issue:4

    Topics: Adult; Antacids; Burns; Cimetidine; Drug Therapy, Combination; Humans; Peptic Ulcer; Pneumonia; Stre

1994
Metabolic changes in cimetidine treatment for scald injury on the peritoneo-serosal surface in far-advanced gastric cancer patients treated by intraperitoneal hyperthermic perfusion.
    Surgery today, 1993, Volume: 23, Issue:5

    Topics: Blood Pressure; Burns; Chemotherapy, Cancer, Regional Perfusion; Cimetidine; Combined Modality Thera

1993
Cimetidine affords protection equal to antacids in prevention of stress ulceration following thermal injury.
    Surgery, 1979, Volume: 86, Issue:4

    Topics: Adolescent; Adult; Aged; Antacids; Burns; Cimetidine; Double-Blind Method; Duodenal Ulcer; Endoscopy

1979

Other Studies

35 other studies available for cimetidine and Burns

ArticleYear
Cimetidine effects on the immunosuppression induced by burn injury.
    International immunopharmacology, 2014, Volume: 22, Issue:1

    Topics: Antigens, CD; Burns; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Cimetidine; Hi

2014
Time-dependent changes of immunologic responses after burn injury and immunomodulation by cimetidine and pyrimethamine in an animal model.
    Pakistan journal of pharmaceutical sciences, 2010, Volume: 23, Issue:4

    Topics: Animals; Anti-Infective Agents; Antibody Formation; Burns; Cimetidine; Histamine H2 Antagonists; Hyp

2010
[Stress ulcerations: pathogenesis and prevention].
    Zeitschrift fur Gastroenterologie, 1983, Volume: 21 Suppl

    Topics: Animals; Antacids; Brain Injuries; Burns; Cimetidine; Histamine H2 Antagonists; Humans; Peptic Ulcer

1983
Histamine-mediated delayed permeability response after scald burn inhibited by cimetidine or cold-water treatment.
    Science (New York, N.Y.), 1980, Aug-15, Volume: 209, Issue:4458

    Topics: Animals; Burns; Cell Membrane Permeability; Cimetidine; Cold Temperature; Edema; Guanidines; Histami

1980
Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs.
    Surgery, 1984, Volume: 95, Issue:3

    Topics: Animals; Burns; Chlorides; Cimetidine; Cyclophosphamide; Dinitrofluorobenzene; Drug Hypersensitivity

1984
Cimetidine kinetics during resuscitation from burn shock.
    Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:2

    Topics: Adult; Burns; Cimetidine; Creatinine; Female; Humans; Kidney; Kinetics; Male; Metabolic Clearance Ra

1984
Acute renal failure in infants and children: diagnosis, complications, and treatment.
    Critical care medicine, 1981, Volume: 9, Issue:8

    Topics: Acidosis; Acute Kidney Injury; Age Factors; Amino Acids, Essential; Anti-Bacterial Agents; Burns; Ch

1981
Effect of cimetidine, hydrocortisone superoxide dismutase and catalase on the development of oedema after thermal injury.
    Burns, including thermal injury, 1983, Volume: 9, Issue:4

    Topics: Animals; Blood Pressure; Burns; Capillary Permeability; Catalase; Cimetidine; Edema; Guanidines; Hyd

1983
Prevention of stress ulcer bleeding with cimetidine in severe burns.
    Burns, including thermal injury, 1983, Volume: 9, Issue:5

    Topics: Adolescent; Adult; Aged; Burns; Cimetidine; Gastric Acidity Determination; Guanidines; Humans; Middl

1983
[The preventive effect of cimetidine on acute gastroduodenal lesions following head and thermal injury].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1982, Volume: 79, Issue:6

    Topics: Adolescent; Adult; Aged; Animals; Burns; Child; Child, Preschool; Cimetidine; Craniocerebral Trauma;

1982
The deleterious effects of high dose cimetidine in acute thermal injury.
    Burns, including thermal injury, 1982, Volume: 9, Issue:1

    Topics: Animals; Body Water; Burns; Cimetidine; Guanidines; Male; Potassium; Rats; Rats, Inbred Strains; Sod

1982
The prophylaxis of stress ulceration.
    The New England journal of medicine, 1980, Feb-21, Volume: 302, Issue:8

    Topics: Animals; Antacids; Burns; Cimetidine; Gastric Mucosa; Guanidines; Humans; Intestinal Mucosa; Ischemi

1980
Restoration of bactericidal activity of peritoneal fluid by cimetidine but not ranitidine or famotidine in burned mice.
    The European journal of surgery = Acta chirurgica, 1993, Volume: 159, Issue:10

    Topics: Animals; Ascitic Fluid; Bacteria; Burns; Cimetidine; Famotidine; Female; Immune Tolerance; Mice; Per

1993
The value of early enteral nutrition in the prophylaxis of stress ulceration in the severely burned patient.
    Burns : journal of the International Society for Burn Injuries, 1997, Volume: 23, Issue:4

    Topics: Administration, Oral; Adult; Antacids; Anti-Ulcer Agents; Burns; Cimetidine; Endoscopy, Digestive Sy

1997
Does cimetidine cause ileus in the burned patient?
    Lancet (London, England), 1977, Oct-01, Volume: 2, Issue:8040

    Topics: Adult; Burns; Cimetidine; Female; Gastric Juice; Gastrointestinal Motility; Guanidines; Humans; Inte

1977
Effect of cimetidine on acute mortality and plasma water loss in mice with burn shock.
    Surgical forum, 1978, Volume: 29

    Topics: Animals; Burns; Cimetidine; Hematocrit; Mice; Shock, Traumatic; Sodium; Water-Electrolyte Balance

1978
Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury.
    Gastroenterology, 1979, Volume: 77, Issue:3

    Topics: Animals; Antacids; Burns; Cimetidine; Ethanol; Female; Gastric Juice; Gastric Mucosa; Hydrochloric A

1979
[A new proposal for the cure and prevention of Curling's ulcer].
    Annales de chirurgie plastique, 1979, Volume: 24, Issue:3

    Topics: Burns; Cimetidine; Duodenal Ulcer; Guanidines; Humans

1979
Cimetidine inhibits burn edema formation.
    American journal of surgery, 1978, Volume: 136, Issue:6

    Topics: Animals; Burns; Cimetidine; Dose-Response Relationship, Drug; Edema; Guanidines; Potassium; Rats; So

1978
H2-receptors and traumatic oedema.
    The Journal of pathology, 1978, Volume: 125, Issue:4

    Topics: Animals; Body Temperature; Burns; Cimetidine; Depression, Chemical; Edema; Guanidines; Male; Metiami

1978
[Prevention of scald injury due to intraperitoneal hyperthermic perfusion for far-advanced gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:11

    Topics: Body Temperature; Burns; Cimetidine; Female; Histamine; Humans; Hyperthermia, Induced; Infusions, Pa

1991
Roles of histamine, complement and xanthine oxidase in thermal injury of skin.
    The American journal of pathology, 1989, Volume: 135, Issue:1

    Topics: Animals; Burns; Cimetidine; Complement Inactivator Proteins; Complement System Proteins; Cromolyn So

1989
Alteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in children.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Aging; Burns; Child; Child, Preschool; Cimetidine; Creatinine; Female; Gastric Ac

1989
Restoration of suppressed immunity in burned mice with cimetidine.
    Chinese medical journal, 1985, Volume: 98, Issue:5

    Topics: Animals; Burns; Cimetidine; Female; Histamine H2 Antagonists; Immunity, Cellular; Mice; T-Lymphocyte

1985
Postburn immunosuppression in an animal model. IV. Improved resistance to septic challenge with immunomodulating drugs.
    Surgery, 1986, Volume: 99, Issue:1

    Topics: Animals; Anti-Infective Agents, Local; Burns; Cerium; Cimetidine; Cyclophosphamide; Dose-Response Re

1986
Restoration of immunity in burned mice by cimetidine.
    The Journal of trauma, 1985, Volume: 25, Issue:2

    Topics: Animals; Burns; Cimetidine; Concanavalin A; Dinitrofluorobenzene; Female; Immunity, Cellular; Lympho

1985
The effect of histamine receptor antagonists on specific and nonspecific suppression of experimental contact sensitivity.
    The Journal of allergy and clinical immunology, 1985, Volume: 76, Issue:1

    Topics: Animals; Burns; Cimetidine; Dermatitis, Contact; Dinitrofluorobenzene; Female; Histamine Antagonists

1985
Treatment of burn shock.
    Virginia medical, 1988, Volume: 115, Issue:5

    Topics: Burns; Cimetidine; Fluid Therapy; Humans; Shock, Traumatic

1988
Protective effect of cimetidine against Pseudomonas aeruginosa: infection in an experimental burned mouse model.
    Israel journal of medical sciences, 1986, Volume: 22, Issue:6

    Topics: Animals; Burns; Cimetidine; Mice; Pseudomonas Infections

1986
Prevention of gastrointestinal bleeding in burns: the effects of cimetidine or antacids combined with early enteral feeding.
    Burns, including thermal injury, 1985, Volume: 12, Issue:1

    Topics: Adult; Aged; Antacids; Burns; Cimetidine; Duodenal Ulcer; Enteral Nutrition; Female; Humans; Male; M

1985
Cimetidine and/or antacid for the control of gastric acidity in pediatric burn patients.
    Critical care medicine, 1985, Volume: 13, Issue:1

    Topics: Antacids; Burns; Child; Cimetidine; Drug Combinations; Drug Evaluation; Gastric Acidity Determinatio

1985
Increased cimetidine clearance in burn patients.
    JAMA, 1985, Mar-01, Volume: 253, Issue:9

    Topics: Adult; Burns; Chromatography, High Pressure Liquid; Cimetidine; Female; Gastric Acidity Determinatio

1985
Prevention of suppressed cell-mediated immunity in burned mice with histamine-2 receptor antagonist drugs.
    The Journal of surgical research, 1985, Volume: 39, Issue:2

    Topics: Animals; Burns; Cimetidine; Dinitrofluorobenzene; Diphenhydramine; Female; Immunity, Cellular; Mice;

1985
Cimetidine therapy for burn shock: a quantitative assessment.
    The Journal of trauma, 1985, Volume: 25, Issue:9

    Topics: Animals; Blood Pressure; Blood Volume; Burns; Cardiac Output; Cimetidine; Combined Modality Therapy;

1985
Cimetidine in burned patients.
    JAMA, 1985, Nov-08, Volume: 254, Issue:18

    Topics: Burns; Cimetidine; Humans; Peptic Ulcer; Stress, Physiological

1985