cimetidine and Burns
cimetidine has been researched along with Burns in 42 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The relationship of silver sulfadiazine therapy to leukopenia has been controversial." | 9.05 | Leukopenia and silver sulfadiazine. ( Bingham, HG; Caffee, HH, 1982) |
| "The efficacy of prophylactic therapy with cimetidine or antacids combined with early enteral feeding to prevent gastrointestinal bleeding in patients with severe burns was evaluated." | 7.67 | Prevention of gastrointestinal bleeding in burns: the effects of cimetidine or antacids combined with early enteral feeding. ( Hirshowitz, B; Jacobs, R; Kaufman, T; Moscona, R, 1985) |
| "This paper presents clinical observations on the preventive effect of cimetidine for stress ulcer bleeding in severe burns." | 7.66 | Prevention of stress ulcer bleeding with cimetidine in severe burns. ( Liu, YL; Yuan, KJ, 1983) |
| "Large doses of cimetidine significantly inhibit edema formation in thermally injured rat skeletal muscle." | 7.66 | Cimetidine inhibits burn edema formation. ( Ayvazian, VH; Deitz, F; Flynn, D; Monafo, WW; Yoshioka, T, 1978) |
| "We have compared the effectiveness of non-acid neutralizing stress ulcer prophylaxis (SUC) with sucralfate (n = 48) with that of acid neutralizing prophylaxis (AN) utilizing antacids and cimetidine (n = 48) in the prevention of stress ulcer bleeding and nosocomial pneumonia (PN) in thermally injured patients." | 5.07 | Comparison of acid neutralizing and non-acid neutralizing stress ulcer prophylaxis in thermally injured patients. ( Cioffi, WG; Mason, AD; McManus, AT; McManus, WF; Pruitt, BA; Rue, LW, 1994) |
| "The relationship of silver sulfadiazine therapy to leukopenia has been controversial." | 5.05 | Leukopenia and silver sulfadiazine. ( Bingham, HG; Caffee, HH, 1982) |
| "Peritoneal bactericidal activity is suppressed in mice after 20% third degree burns and this effect may be partly reversed by cimetidine and famotidine." | 3.68 | Restoration of bactericidal activity of peritoneal fluid by cimetidine but not ranitidine or famotidine in burned mice. ( Akalin, E; Altaca, G; Gür, D; Onat, D; Sayek, I, 1993) |
| "The pathogenesis of burn edema in the skin of rats appears to be related to a role for histamine, xanthine oxidase and oxygen radicals." | 3.67 | Roles of histamine, complement and xanthine oxidase in thermal injury of skin. ( Friedl, HP; Till, GO; Trentz, O; Ward, PA, 1989) |
| " Two H2 receptor antagonists, cimetidine and ranitidine, reversed the nonspecific immunosuppression of CS induced by burns." | 3.67 | The effect of histamine receptor antagonists on specific and nonspecific suppression of experimental contact sensitivity. ( Bender, EM; Claman, HN; Hansbrough, JF; Mekori, YA; Zapata-Sirvent, R, 1985) |
| "The efficacy of prophylactic therapy with cimetidine or antacids combined with early enteral feeding to prevent gastrointestinal bleeding in patients with severe burns was evaluated." | 3.67 | Prevention of gastrointestinal bleeding in burns: the effects of cimetidine or antacids combined with early enteral feeding. ( Hirshowitz, B; Jacobs, R; Kaufman, T; Moscona, R, 1985) |
| "This paper presents clinical observations on the preventive effect of cimetidine for stress ulcer bleeding in severe burns." | 3.66 | Prevention of stress ulcer bleeding with cimetidine in severe burns. ( Liu, YL; Yuan, KJ, 1983) |
| "2 N sodium hydroxide, 25% sodium chloride, or boiling water produced extensive necrosis of the gastric mucosa." | 3.66 | Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. ( Hanchar, AJ; Lancaster, C; Nezamis, JE; Robert, A, 1979) |
| "Large doses of cimetidine significantly inhibit edema formation in thermally injured rat skeletal muscle." | 3.66 | Cimetidine inhibits burn edema formation. ( Ayvazian, VH; Deitz, F; Flynn, D; Monafo, WW; Yoshioka, T, 1978) |
| "The effects of the H2-antagonists, metiamide and cimetidine, on the oedema following limb ischaemia or scald have been investigated in two strains of rat." | 3.66 | H2-receptors and traumatic oedema. ( Little, RA; Savic, J; Stoner, HB, 1978) |
| "Cimetidine 50 mg/kg was injected intravenously into 12 patients immediately prior to IPHP." | 2.67 | Metabolic changes in cimetidine treatment for scald injury on the peritoneo-serosal surface in far-advanced gastric cancer patients treated by intraperitoneal hyperthermic perfusion. ( Fujimoto, S; Kiuchi, S; Kobayashi, K; Kokubun, M; Konno, C; Shrestha, RD; Takahashi, M, 1993) |
| "Treatment with Cimetidine increased the frequency of CD8+ T cells in the patient's peripheral blood." | 1.40 | Cimetidine effects on the immunosuppression induced by burn injury. ( Barough, MS; Hassan, ZM; Kokhaei, P, 2014) |
| "We have studied the mechanisms of the increased dosage requirements of the H2-receptor antagonist cimetidine in paediatric burned patients in a pharmacokinetic and pharmacodynamic study." | 1.28 | Alteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in children. ( Greenblatt, DJ; Hagen, J; Hoaglin, DC; Martyn, JA, 1989) |
| " Animals were then treated with the four agents in carefully defined dosage regimens, and survival was again determined on the tenth postburn day." | 1.27 | Postburn immunosuppression in an animal model. IV. Improved resistance to septic challenge with immunomodulating drugs. ( Bartle, EJ; Bender, EM; Carter, WH; Hansbrough, JF; Mansour, MA; Zapata-Sirvent, RL, 1986) |
| " Dosage and schedules for antacid prophylaxis in pediatric burn patients require further study." | 1.27 | Cimetidine and/or antacid for the control of gastric acidity in pediatric burn patients. ( Martyn, JA, 1985) |
| " The elimination half-life of cimetidine in burned patients was significantly reduced (2." | 1.27 | Increased cimetidine clearance in burn patients. ( Abernethy, DR; Greenblatt, DJ; Martyn, JA, 1985) |
Research
Studies (42)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (80.95) | 18.7374 |
| 1990's | 5 (11.90) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Jafarzadeh, A | 1 |
| Nemati, M | 1 |
| Khorramdelazad, H | 1 |
| Hassan, ZM | 2 |
| Kokhaei, P | 1 |
| Barough, MS | 1 |
| A, J | 1 |
| Zm, H | 1 |
| M, E | 1 |
| S, MH | 1 |
| T, T | 1 |
| Holtermüller, KH | 1 |
| Ebener, B | 1 |
| Kühl, HJ | 1 |
| Rolfs, A | 1 |
| Boykin, JV | 4 |
| Eriksson, E | 1 |
| Sholley, MM | 1 |
| Pittman, RN | 1 |
| Hansbrough, J | 1 |
| Peterson, V | 3 |
| Zapata-Sirvent, R | 5 |
| Claman, HN | 3 |
| Ziemniak, JA | 1 |
| Watson, WA | 1 |
| Saffle, JR | 1 |
| Smith, IL | 1 |
| Russo, J | 1 |
| Warden, GD | 1 |
| Schentag, JJ | 1 |
| Ellis, D | 1 |
| Gartner, JC | 1 |
| Galvis, AG | 1 |
| Björk, J | 1 |
| Arturson, G | 1 |
| Liu, YL | 1 |
| Yuan, KJ | 1 |
| Fusamoto, H | 1 |
| Saito, M | 1 |
| Nakagawa, A | 1 |
| Kawano, S | 1 |
| Sato, N | 1 |
| Kamada, T | 1 |
| Abe, H | 1 |
| Caffee, HH | 1 |
| Bingham, HG | 1 |
| Searcy, RM | 1 |
| Cone, JB | 1 |
| Bowser, BH | 1 |
| Caldwell, FT | 1 |
| Menguy, R | 1 |
| Cioffi, WG | 1 |
| McManus, AT | 1 |
| Rue, LW | 1 |
| Mason, AD | 1 |
| McManus, WF | 1 |
| Pruitt, BA | 1 |
| Altaca, G | 1 |
| Sayek, I | 1 |
| Onat, D | 1 |
| Gür, D | 1 |
| Akalin, E | 1 |
| Fujimoto, S | 2 |
| Takahashi, M | 2 |
| Kobayashi, K | 2 |
| Kokubun, M | 2 |
| Shrestha, RD | 2 |
| Kiuchi, S | 2 |
| Konno, C | 2 |
| Raff, T | 1 |
| Germann, G | 1 |
| Hartmann, B | 1 |
| Watson, WC | 1 |
| Kutty, PK | 1 |
| Colcleugh, RG | 1 |
| Ahmad, S | 1 |
| Yoshioka, T | 2 |
| Monafo, WW | 2 |
| Ayvazian, VH | 2 |
| Dietz, F | 1 |
| Flynn, D | 2 |
| Robert, A | 1 |
| Nezamis, JE | 1 |
| Lancaster, C | 1 |
| Hanchar, AJ | 1 |
| McElwee, HP | 1 |
| Sirinek, KR | 1 |
| Levine, BA | 1 |
| Nasilowski, W | 1 |
| Deitz, F | 1 |
| Little, RA | 1 |
| Savic, J | 1 |
| Stoner, HB | 1 |
| Ohta, M | 1 |
| Friedl, HP | 1 |
| Till, GO | 1 |
| Trentz, O | 1 |
| Ward, PA | 1 |
| Martyn, JA | 3 |
| Greenblatt, DJ | 2 |
| Hagen, J | 1 |
| Hoaglin, DC | 1 |
| Hansbrough, JF | 5 |
| Wang, XW | 1 |
| Claman, H | 1 |
| Zapata-Sirvent, RL | 1 |
| Bender, EM | 4 |
| Bartle, EJ | 1 |
| Mansour, MA | 1 |
| Carter, WH | 1 |
| Sullivan, J | 1 |
| Mekori, YA | 1 |
| Manson, NH | 2 |
| Zehavi-Willner, T | 1 |
| Markenson, J | 1 |
| Pinto, M | 1 |
| Moscona, R | 1 |
| Kaufman, T | 1 |
| Jacobs, R | 1 |
| Hirshowitz, B | 1 |
| Abernethy, DR | 1 |
| Crute, SL | 1 |
| Haynes, BW | 1 |
| Myerson, RM | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Enteral Nutrition on Stress Ulcer Hemorrage. Multicenter Randomized Controlled[NCT03098537] | 500 participants (Anticipated) | Interventional | 2016-08-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
3 reviews available for cimetidine and Burns
| Article | Year |
|---|---|
Immunomodulatory properties of cimetidine: Its therapeutic potentials for treatment of immune-related diseases.
Topics: Animals; Bone Resorption; Burns; Cimetidine; Dendritic Cells; Histamine; Humans; Hypersensitivity; I | 2019 |
Side effects of cimetidine.
Topics: Acute Disease; Aged; Agranulocytosis; Burns; Central Nervous System; Cimetidine; Female; Glucose; Gu | 1979 |
Mechanisms of cimetidine protection following thermal injury.
Topics: Animals; Body Fluids; Burns; Cimetidine; Shock, Traumatic | 1987 |
Trials
4 trials available for cimetidine and Burns
| Article | Year |
|---|---|
Leukopenia and silver sulfadiazine.
Topics: Adult; Burns; Cimetidine; Drug Interactions; Guanidines; Humans; Leukopenia; Peptic Ulcer; Prospecti | 1982 |
Comparison of acid neutralizing and non-acid neutralizing stress ulcer prophylaxis in thermally injured patients.
Topics: Adult; Antacids; Burns; Cimetidine; Drug Therapy, Combination; Humans; Peptic Ulcer; Pneumonia; Stre | 1994 |
Metabolic changes in cimetidine treatment for scald injury on the peritoneo-serosal surface in far-advanced gastric cancer patients treated by intraperitoneal hyperthermic perfusion.
Topics: Blood Pressure; Burns; Chemotherapy, Cancer, Regional Perfusion; Cimetidine; Combined Modality Thera | 1993 |
Cimetidine affords protection equal to antacids in prevention of stress ulceration following thermal injury.
Topics: Adolescent; Adult; Aged; Antacids; Burns; Cimetidine; Double-Blind Method; Duodenal Ulcer; Endoscopy | 1979 |
Other Studies
35 other studies available for cimetidine and Burns
| Article | Year |
|---|---|
Cimetidine effects on the immunosuppression induced by burn injury.
Topics: Antigens, CD; Burns; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Cimetidine; Hi | 2014 |
Time-dependent changes of immunologic responses after burn injury and immunomodulation by cimetidine and pyrimethamine in an animal model.
Topics: Animals; Anti-Infective Agents; Antibody Formation; Burns; Cimetidine; Histamine H2 Antagonists; Hyp | 2010 |
[Stress ulcerations: pathogenesis and prevention].
Topics: Animals; Antacids; Brain Injuries; Burns; Cimetidine; Histamine H2 Antagonists; Humans; Peptic Ulcer | 1983 |
Histamine-mediated delayed permeability response after scald burn inhibited by cimetidine or cold-water treatment.
Topics: Animals; Burns; Cell Membrane Permeability; Cimetidine; Cold Temperature; Edema; Guanidines; Histami | 1980 |
Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs.
Topics: Animals; Burns; Chlorides; Cimetidine; Cyclophosphamide; Dinitrofluorobenzene; Drug Hypersensitivity | 1984 |
Cimetidine kinetics during resuscitation from burn shock.
Topics: Adult; Burns; Cimetidine; Creatinine; Female; Humans; Kidney; Kinetics; Male; Metabolic Clearance Ra | 1984 |
Acute renal failure in infants and children: diagnosis, complications, and treatment.
Topics: Acidosis; Acute Kidney Injury; Age Factors; Amino Acids, Essential; Anti-Bacterial Agents; Burns; Ch | 1981 |
Effect of cimetidine, hydrocortisone superoxide dismutase and catalase on the development of oedema after thermal injury.
Topics: Animals; Blood Pressure; Burns; Capillary Permeability; Catalase; Cimetidine; Edema; Guanidines; Hyd | 1983 |
Prevention of stress ulcer bleeding with cimetidine in severe burns.
Topics: Adolescent; Adult; Aged; Burns; Cimetidine; Gastric Acidity Determination; Guanidines; Humans; Middl | 1983 |
[The preventive effect of cimetidine on acute gastroduodenal lesions following head and thermal injury].
Topics: Adolescent; Adult; Aged; Animals; Burns; Child; Child, Preschool; Cimetidine; Craniocerebral Trauma; | 1982 |
The deleterious effects of high dose cimetidine in acute thermal injury.
Topics: Animals; Body Water; Burns; Cimetidine; Guanidines; Male; Potassium; Rats; Rats, Inbred Strains; Sod | 1982 |
The prophylaxis of stress ulceration.
Topics: Animals; Antacids; Burns; Cimetidine; Gastric Mucosa; Guanidines; Humans; Intestinal Mucosa; Ischemi | 1980 |
Restoration of bactericidal activity of peritoneal fluid by cimetidine but not ranitidine or famotidine in burned mice.
Topics: Animals; Ascitic Fluid; Bacteria; Burns; Cimetidine; Famotidine; Female; Immune Tolerance; Mice; Per | 1993 |
The value of early enteral nutrition in the prophylaxis of stress ulceration in the severely burned patient.
Topics: Administration, Oral; Adult; Antacids; Anti-Ulcer Agents; Burns; Cimetidine; Endoscopy, Digestive Sy | 1997 |
Does cimetidine cause ileus in the burned patient?
Topics: Adult; Burns; Cimetidine; Female; Gastric Juice; Gastrointestinal Motility; Guanidines; Humans; Inte | 1977 |
Effect of cimetidine on acute mortality and plasma water loss in mice with burn shock.
Topics: Animals; Burns; Cimetidine; Hematocrit; Mice; Shock, Traumatic; Sodium; Water-Electrolyte Balance | 1978 |
Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury.
Topics: Animals; Antacids; Burns; Cimetidine; Ethanol; Female; Gastric Juice; Gastric Mucosa; Hydrochloric A | 1979 |
[A new proposal for the cure and prevention of Curling's ulcer].
Topics: Burns; Cimetidine; Duodenal Ulcer; Guanidines; Humans | 1979 |
Cimetidine inhibits burn edema formation.
Topics: Animals; Burns; Cimetidine; Dose-Response Relationship, Drug; Edema; Guanidines; Potassium; Rats; So | 1978 |
H2-receptors and traumatic oedema.
Topics: Animals; Body Temperature; Burns; Cimetidine; Depression, Chemical; Edema; Guanidines; Male; Metiami | 1978 |
[Prevention of scald injury due to intraperitoneal hyperthermic perfusion for far-advanced gastric cancer].
Topics: Body Temperature; Burns; Cimetidine; Female; Histamine; Humans; Hyperthermia, Induced; Infusions, Pa | 1991 |
Roles of histamine, complement and xanthine oxidase in thermal injury of skin.
Topics: Animals; Burns; Cimetidine; Complement Inactivator Proteins; Complement System Proteins; Cromolyn So | 1989 |
Alteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in children.
Topics: Adolescent; Adult; Aging; Burns; Child; Child, Preschool; Cimetidine; Creatinine; Female; Gastric Ac | 1989 |
Restoration of suppressed immunity in burned mice with cimetidine.
Topics: Animals; Burns; Cimetidine; Female; Histamine H2 Antagonists; Immunity, Cellular; Mice; T-Lymphocyte | 1985 |
Postburn immunosuppression in an animal model. IV. Improved resistance to septic challenge with immunomodulating drugs.
Topics: Animals; Anti-Infective Agents, Local; Burns; Cerium; Cimetidine; Cyclophosphamide; Dose-Response Re | 1986 |
Restoration of immunity in burned mice by cimetidine.
Topics: Animals; Burns; Cimetidine; Concanavalin A; Dinitrofluorobenzene; Female; Immunity, Cellular; Lympho | 1985 |
The effect of histamine receptor antagonists on specific and nonspecific suppression of experimental contact sensitivity.
Topics: Animals; Burns; Cimetidine; Dermatitis, Contact; Dinitrofluorobenzene; Female; Histamine Antagonists | 1985 |
Treatment of burn shock.
Topics: Burns; Cimetidine; Fluid Therapy; Humans; Shock, Traumatic | 1988 |
Protective effect of cimetidine against Pseudomonas aeruginosa: infection in an experimental burned mouse model.
Topics: Animals; Burns; Cimetidine; Mice; Pseudomonas Infections | 1986 |
Prevention of gastrointestinal bleeding in burns: the effects of cimetidine or antacids combined with early enteral feeding.
Topics: Adult; Aged; Antacids; Burns; Cimetidine; Duodenal Ulcer; Enteral Nutrition; Female; Humans; Male; M | 1985 |
Cimetidine and/or antacid for the control of gastric acidity in pediatric burn patients.
Topics: Antacids; Burns; Child; Cimetidine; Drug Combinations; Drug Evaluation; Gastric Acidity Determinatio | 1985 |
Increased cimetidine clearance in burn patients.
Topics: Adult; Burns; Chromatography, High Pressure Liquid; Cimetidine; Female; Gastric Acidity Determinatio | 1985 |
Prevention of suppressed cell-mediated immunity in burned mice with histamine-2 receptor antagonist drugs.
Topics: Animals; Burns; Cimetidine; Dinitrofluorobenzene; Diphenhydramine; Female; Immunity, Cellular; Mice; | 1985 |
Cimetidine therapy for burn shock: a quantitative assessment.
Topics: Animals; Blood Pressure; Blood Volume; Burns; Cardiac Output; Cimetidine; Combined Modality Therapy; | 1985 |
Cimetidine in burned patients.
Topics: Burns; Cimetidine; Humans; Peptic Ulcer; Stress, Physiological | 1985 |