cimetidine has been researched along with Breast Neoplasms in 19 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " While cimetidine, an H2 antagonist, has been shown to influence the presence of tumour infiltrating lymphocytes (TIL) in colorectal cancer (Adams and Morris, 1994, 1997) that was not found to be the case in breast cancer (Ng et al, 1995)." | 9.09 | Histamine, mast cells and tumour cell proliferation in breast cancer: does preoperative cimetidine administration have an effect? ( Bolton, E; Bowrey, PF; King, J; Magarey, C; Marr, P; Morris, DL; Schwartz, P, 2000) |
| "Cimetidine is known to have immunomodulatory effects and this study aimed to examine the effect of pre-operative cimetidine treatment on lymphocytic infiltration in n = 72 women with breast cancer randomised to 400 mg bd or placebo for five days presurgery." | 9.09 | Cimetidine does not influence TIL in breast cancer. ( Dwerryhouse, SJ; King, J; Magarey, C; Morris, DL; Schwartz, P; Soon Lee, C, 1999) |
| "The main focus of our study is to assess the anti-cancer activity of cimetidine and vitamin C via combating the tumor supportive role of mast cell mediators (histamine, VEGF, and TNF-α) within the tumor microenvironment and their effect on the protein kinase A(PKA)/insulin receptor substrate-1(IRS-1)/phosphatidylinositol-3-kinase (PI3K)/serine/threonine kinase-1 (AKT)/mammalian target of rapamycin (mTOR) cue in Ehrlich induced breast cancer in mice." | 8.12 | Anti-neoplastic action of Cimetidine/Vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer. ( Achy, SE; El-Aal, SAA; Ibrahim, SSA; Reda, AM; Shahine, Y, 2022) |
| "The odds ratio for breast cancer among regular users of cimetidine was 0." | 7.73 | Cimetidine and other histamine2-receptor antagonist use in relation to risk of breast cancer. ( Coogan, PF; Palmer, JR; Rosenberg, L; Strom, BL; Zhang, Y, 2005) |
| "It is established that histamine in the concentration of 10(-4)-10(-5) M possesses an inhibitory effect in the lymphocyte adherence inhibition test in patients with breast cancer." | 7.67 | [Histamine-receptor sensitivity of lymphocytes in patients with early and advanced stage breast cancer]. ( Kharkevich, DD; Polevaia, EB, 1988) |
| " Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model." | 5.62 | Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model. ( Hassan, ZM; Jafarzadeh, A; Khorramdelazad, H; Masoumi, J; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2021) |
| "Cimetidine has been hypothesized to exert a cancer preventive effect on the prostate due to its ability to inhibit the binding of dihydrotestosterone to androgen receptors." | 5.31 | Cimetidine use and risk of prostate and breast cancer. ( Cushing-Haugen, KL; Rossing, MA; Scholes, D; Voigt, LF, 2000) |
| " While cimetidine, an H2 antagonist, has been shown to influence the presence of tumour infiltrating lymphocytes (TIL) in colorectal cancer (Adams and Morris, 1994, 1997) that was not found to be the case in breast cancer (Ng et al, 1995)." | 5.09 | Histamine, mast cells and tumour cell proliferation in breast cancer: does preoperative cimetidine administration have an effect? ( Bolton, E; Bowrey, PF; King, J; Magarey, C; Marr, P; Morris, DL; Schwartz, P, 2000) |
| "Cimetidine is known to have immunomodulatory effects and this study aimed to examine the effect of pre-operative cimetidine treatment on lymphocytic infiltration in n = 72 women with breast cancer randomised to 400 mg bd or placebo for five days presurgery." | 5.09 | Cimetidine does not influence TIL in breast cancer. ( Dwerryhouse, SJ; King, J; Magarey, C; Morris, DL; Schwartz, P; Soon Lee, C, 1999) |
| "The main focus of our study is to assess the anti-cancer activity of cimetidine and vitamin C via combating the tumor supportive role of mast cell mediators (histamine, VEGF, and TNF-α) within the tumor microenvironment and their effect on the protein kinase A(PKA)/insulin receptor substrate-1(IRS-1)/phosphatidylinositol-3-kinase (PI3K)/serine/threonine kinase-1 (AKT)/mammalian target of rapamycin (mTOR) cue in Ehrlich induced breast cancer in mice." | 4.12 | Anti-neoplastic action of Cimetidine/Vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer. ( Achy, SE; El-Aal, SAA; Ibrahim, SSA; Reda, AM; Shahine, Y, 2022) |
| "Current use of H(2) blockers overall, cimetidine, and famotidine was not associated with an increased risk of either invasive ductal or invasive lobular breast cancer." | 3.74 | Relationship between histamine2-receptor antagonist medications and risk of invasive breast cancer. ( Daling, JR; Li, CI; Malone, KE; Mathes, RW; Porter, PL, 2008) |
| "The odds ratio for breast cancer among regular users of cimetidine was 0." | 3.73 | Cimetidine and other histamine2-receptor antagonist use in relation to risk of breast cancer. ( Coogan, PF; Palmer, JR; Rosenberg, L; Strom, BL; Zhang, Y, 2005) |
| "The cellular actions of genistein are believed to mediate the decreased risk of breast cancer associated with high soy consumption." | 3.73 | The intracellular genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway. ( Cadenas, E; Hernandez-Montes, E; Nguyen, DT; Rice-Evans, C; Schönthal, AH; Spencer, JP; Vauzour, D, 2006) |
| "It is established that histamine in the concentration of 10(-4)-10(-5) M possesses an inhibitory effect in the lymphocyte adherence inhibition test in patients with breast cancer." | 3.67 | [Histamine-receptor sensitivity of lymphocytes in patients with early and advanced stage breast cancer]. ( Kharkevich, DD; Polevaia, EB, 1988) |
| "Paclitaxel 135 mg/m2 was infused as a single dose over 1 hour or was divided into three doses infused over 1 hour on 3 consecutive days." | 2.68 | One-hour paclitaxel infusion schedules: a phase I/II comparative trial. ( Greco, FA; Hainsworth, JD, 1995) |
| "Docetaxel is active for metastatic breast cancer." | 2.68 | Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer. ( Balmaceda, C; Baselga, J; Bruno, R; Crown, JP; Currie, V; Freilich, R; Gilewski, TA; Gollub, M; Hakes, TB; Hudis, CA; Lebwohl, DE; Norton, L; Raptis, G; Robles, M; Seidman, AD, 1996) |
| " Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model." | 1.62 | Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model. ( Hassan, ZM; Jafarzadeh, A; Khorramdelazad, H; Masoumi, J; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2021) |
| "Three metastatic breast cancer cell lines (1590, KM22, ZE) were studied." | 1.37 | Breast cancer cell-derived cytokines, macrophages and cell adhesion: implications for metastasis. ( Bischofs, E; Brodt, P; Bruckner, T; Eichbaum, C; Eichbaum, MH; Meyer, AS; Sohn, C; Steinborn, A; Wang, N, 2011) |
| "Cimetidine-treated RBCs were optimally prepared at room temperature and needed to be tested on the day of preparation." | 1.36 | Immune hemolytic anemia due to cimetidine: the first example of a cimetidine antibody. ( Arndt, PA; Asuncion, DJ; Brasfield, FM; Garratty, G; Vemuri, SL, 2010) |
| "Cimetidine has been hypothesized to exert a cancer preventive effect on the prostate due to its ability to inhibit the binding of dihydrotestosterone to androgen receptors." | 1.31 | Cimetidine use and risk of prostate and breast cancer. ( Cushing-Haugen, KL; Rossing, MA; Scholes, D; Voigt, LF, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Taghipour, F | 1 |
| Oladpour, O | 1 |
| Rezayati, MT | 1 |
| Khorramdelazad, H | 1 |
| Nemati, M | 1 |
| Taghipour, Z | 1 |
| Masoumi, J | 1 |
| Hassan, ZM | 1 |
| Jafarzadeh, A | 1 |
| Ibrahim, SSA | 1 |
| El-Aal, SAA | 1 |
| Reda, AM | 1 |
| Achy, SE | 1 |
| Shahine, Y | 1 |
| Arndt, PA | 1 |
| Garratty, G | 1 |
| Brasfield, FM | 1 |
| Vemuri, SL | 1 |
| Asuncion, DJ | 1 |
| Eichbaum, C | 1 |
| Meyer, AS | 1 |
| Wang, N | 1 |
| Bischofs, E | 1 |
| Steinborn, A | 1 |
| Bruckner, T | 1 |
| Brodt, P | 1 |
| Sohn, C | 1 |
| Eichbaum, MH | 1 |
| Bobek, V | 1 |
| Boubelik, M | 1 |
| Kovarík, J | 1 |
| Taltynov, O | 1 |
| Coogan, PF | 1 |
| Zhang, Y | 1 |
| Palmer, JR | 1 |
| Strom, BL | 1 |
| Rosenberg, L | 1 |
| Nguyen, DT | 1 |
| Hernandez-Montes, E | 1 |
| Vauzour, D | 1 |
| Schönthal, AH | 1 |
| Rice-Evans, C | 1 |
| Cadenas, E | 1 |
| Spencer, JP | 1 |
| Mathes, RW | 1 |
| Malone, KE | 1 |
| Daling, JR | 1 |
| Porter, PL | 1 |
| Li, CI | 1 |
| de Levin, RW | 1 |
| Puig, OR | 1 |
| Levin, E | 1 |
| Greco, FA | 2 |
| Hainsworth, JD | 2 |
| Capron, MH | 1 |
| Lauga, J | 1 |
| Hudis, CA | 1 |
| Seidman, AD | 1 |
| Crown, JP | 1 |
| Balmaceda, C | 1 |
| Freilich, R | 1 |
| Gilewski, TA | 1 |
| Hakes, TB | 1 |
| Currie, V | 1 |
| Lebwohl, DE | 1 |
| Baselga, J | 1 |
| Raptis, G | 1 |
| Gollub, M | 1 |
| Robles, M | 1 |
| Bruno, R | 1 |
| Norton, L | 1 |
| Boehm, DK | 1 |
| Maksymiuk, AW | 1 |
| Murray, LS | 1 |
| Jodrell, DI | 1 |
| Morrison, JG | 1 |
| Cook, A | 1 |
| Kerr, DJ | 1 |
| Whiting, B | 1 |
| Kaye, SB | 1 |
| Cassidy, J | 1 |
| Bowrey, PF | 1 |
| King, J | 2 |
| Magarey, C | 2 |
| Schwartz, P | 2 |
| Marr, P | 1 |
| Bolton, E | 1 |
| Morris, DL | 2 |
| Rossing, MA | 1 |
| Scholes, D | 1 |
| Cushing-Haugen, KL | 1 |
| Voigt, LF | 1 |
| Dwerryhouse, SJ | 1 |
| Soon Lee, C | 1 |
| Kharkevich, DD | 1 |
| Polevaia, EB | 1 |
7 trials available for cimetidine and Breast Neoplasms
| Article | Year |
|---|---|
One-hour paclitaxel infusion schedules: a phase I/II comparative trial.
Topics: Blood Cell Count; Breast Neoplasms; Cimetidine; Dexamethasone; Diphenhydramine; Drug Administration | 1995 |
Paclitaxel administered by 1-hour infusion. Preliminary results of a phase I/II trial comparing two schedules.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cimetidine; Dexamethasone; Diphenhydr | 1994 |
Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cimetidine; Dexamethasone; Diphenh | 1996 |
Paclitaxel premedication regimens.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cimetidine; Dexamethasone; Drug Hypersensitivit | 1996 |
The effect of cimetidine on the pharmacokinetics of epirubicin in patients with advanced breast cancer: preliminary evidence of a potentially common drug interaction.
Topics: Administration, Oral; Antibiotics, Antineoplastic; Antineoplastic Agents, Hormonal; Area Under Curve | 1998 |
Histamine, mast cells and tumour cell proliferation in breast cancer: does preoperative cimetidine administration have an effect?
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Cell Count; Cell Division; Cime | 2000 |
Cimetidine does not influence TIL in breast cancer.
Topics: Breast Neoplasms; Cimetidine; Female; Histamine H2 Antagonists; Humans; Lymphocytes, Tumor-Infiltrat | 1999 |
12 other studies available for cimetidine and Breast Neoplasms
| Article | Year |
|---|---|
Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model.
Topics: Animals; Biomarkers; Breast Neoplasms; Cell Line, Tumor; Cimetidine; Disease Models, Animal; Female; | 2021 |
Anti-neoplastic action of Cimetidine/Vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer.
Topics: Animals; Apoptosis; Ascorbic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cimetidin | 2022 |
Immune hemolytic anemia due to cimetidine: the first example of a cimetidine antibody.
Topics: Anemia, Hemolytic; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Breast Neoplas | 2010 |
Breast cancer cell-derived cytokines, macrophages and cell adhesion: implications for metastasis.
Topics: Animals; Antibodies, Monoclonal; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cimetidine; Cyto | 2011 |
Inhibition of adhesion breast cancer cells by anticoagulant drugs and cimetidine.
Topics: Aged; Anticoagulants; Breast Neoplasms; Cell Adhesion; Cimetidine; Female; Humans; Killer Cells, Nat | 2003 |
Cimetidine and other histamine2-receptor antagonist use in relation to risk of breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Case-Control Studies; Cimetidine; Female; Histamine H2 Antagonists; H | 2005 |
The intracellular genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway.
Topics: Breast; Breast Neoplasms; CDC2 Protein Kinase; Cell Cycle; Cell Division; Cell Line; Cell Line, Tumo | 2006 |
Relationship between histamine2-receptor antagonist medications and risk of invasive breast cancer.
Topics: Aged; Anti-Ulcer Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Case-Contr | 2008 |
Increased risk for cancer of the breast due to previous medication.
Topics: 20-alpha-Dihydroprogesterone; Adult; Aged; Amitriptyline; Amphetamines; Breast Neoplasms; Cimetidine | 1984 |
[Breast cancer in the male].
Topics: Breast Neoplasms; Cimetidine; Digitalis Glycosides; Humans; Isoniazid; Male; Risk Factors; Sex Facto | 1993 |
Cimetidine use and risk of prostate and breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Case-Control Studies; Cimetidine; Female; Histamin | 2000 |
[Histamine-receptor sensitivity of lymphocytes in patients with early and advanced stage breast cancer].
Topics: Breast Neoplasms; Cimetidine; Diphenhydramine; Female; Histamine; Humans; In Vitro Techniques; Leuko | 1988 |