cimetidine has been researched along with Brain Neoplasms in 9 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cimetidine added to temozolomide compared with temozolomide alone induced survival benefits in nude mice with U373 human glioblastoma multiforme (GBM) cells orthotopically xenografted in the brain." | 7.73 | Combined cimetidine and temozolomide, compared with temozolomide alone: significant increases in survival in nude mice bearing U373 human glioblastoma multiforme orthotopic xenografts. ( Brotchi, J; Camby, I; Darro, F; Gabius, J; Gaussin, JF; James, S; Kiss, R; Lefranc, F, 2005) |
| "Cimetidine added to temozolomide compared with temozolomide alone induced survival benefits in nude mice with U373 human glioblastoma multiforme (GBM) cells orthotopically xenografted in the brain." | 3.73 | Combined cimetidine and temozolomide, compared with temozolomide alone: significant increases in survival in nude mice bearing U373 human glioblastoma multiforme orthotopic xenografts. ( Brotchi, J; Camby, I; Darro, F; Gabius, J; Gaussin, JF; James, S; Kiss, R; Lefranc, F, 2005) |
| "The authors studied the effect of intracarotid administration of histamine on the regional cerebral blood flow (rCBF) in transplanted rat C6 glioma by the hydrogen clearance method." | 3.68 | Altered response to histamine in brain tumor vessels: the selective increase of regional cerebral blood flow in transplanted rat brain tumor. ( Fukui, M; Ikezaki, K; Natori, Y; Nomura, T, 1993) |
| "Cimetidine is an H2 blocker and has been shown to inhibit tumour cell growth." | 1.29 | Effect of histamine and the H2 antagonist cimetidine on the growth and migration of human neoplastic glia. ( Finn, PE; Pilkington, GJ; Purnell, P, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lefranc, F | 2 |
| James, S | 1 |
| Camby, I | 1 |
| Gaussin, JF | 1 |
| Darro, F | 1 |
| Brotchi, J | 2 |
| Gabius, J | 1 |
| Kiss, R | 2 |
| Yeaton, P | 1 |
| Bilynskiĭ, BT | 1 |
| Shparik, IaV | 1 |
| Volkin, RL | 1 |
| Shadduck, RK | 1 |
| Winkelstein, A | 1 |
| Zeigler, ZR | 1 |
| Selker, RG | 1 |
| Van der Ven, LT | 1 |
| Prinsen, IM | 1 |
| Jansen, GH | 1 |
| Roholl, PJ | 1 |
| Defferrari, R | 1 |
| Slater, R | 1 |
| Den Otter, W | 1 |
| Nomura, T | 1 |
| Ikezaki, K | 1 |
| Natori, Y | 1 |
| Fukui, M | 1 |
| Finn, PE | 1 |
| Purnell, P | 1 |
| Pilkington, GJ | 1 |
| Armitage, JO | 1 |
| Sidner, RD | 1 |
| Ross, AJ | 1 |
| Siegel, KR | 1 |
| Bell, W | 1 |
| Templeton, JM | 1 |
| Schnaufer, L | 1 |
| Bishop, HC | 1 |
2 reviews available for cimetidine and Brain Neoplasms
| Article | Year |
|---|---|
Cimetidine, an unexpected anti-tumor agent, and its potential for the treatment of glioblastoma (review).
Topics: Antineoplastic Agents; Brain Neoplasms; Cimetidine; Clinical Trials as Topic; Colonic Neoplasms; Gli | 2006 |
[Carcinogenicity of various drugs].
Topics: Adult; Animals; Anti-Bacterial Agents; Arsenicals; Barbiturates; Brain Neoplasms; Carcinogens; Child | 1984 |
7 other studies available for cimetidine and Brain Neoplasms
| Article | Year |
|---|---|
Combined cimetidine and temozolomide, compared with temozolomide alone: significant increases in survival in nude mice bearing U373 human glioblastoma multiforme orthotopic xenografts.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cimetidine; Dac | 2005 |
Potentiation of carmustine-cranial irradiation-induced myelosuppression by cimetidine.
Topics: Adult; Aged; Brain Neoplasms; Carmustine; Cimetidine; Drug Synergism; Female; Glioma; Guanidines; He | 1982 |
Growth of cultured human glioma tumour cells can be regulated with histamine and histamine antagonists.
Topics: Adult; Aged; Brain Neoplasms; Cell Division; Cell Survival; Cimetidine; DNA, Neoplasm; Female; Gliom | 1993 |
Altered response to histamine in brain tumor vessels: the selective increase of regional cerebral blood flow in transplanted rat brain tumor.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Cerebral Arte | 1993 |
Effect of histamine and the H2 antagonist cimetidine on the growth and migration of human neoplastic glia.
Topics: Brain Neoplasms; Cell Cycle; Cell Movement; Cimetidine; Depression, Chemical; Glioma; Histamine; His | 1996 |
Antitumour effect of cimetidine.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Cimetidine; Female | 1979 |
Massive gastrointestinal hemorrhage in children with posterior fossa tumors.
Topics: Antacids; Brain Neoplasms; Cerebellar Neoplasms; Cerebral Ventricle Neoplasms; Child, Preschool; Cim | 1987 |