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cimetidine and Brain Edema

cimetidine has been researched along with Brain Edema in 5 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)

Research Excerpts

ExcerptRelevanceReference
"The possibility that histamine plays a role in the formation of traumatic brain edema was investigated in the rat."7.67Role of histamine in traumatic brain edema. An experimental study in the rat. ( Chansouria, JP; Dey, PK; Mohanty, S; Olsson, Y; Sharma, HS; Singh, S, 1989)
"The possibility that histamine plays a role in the formation of traumatic brain edema was investigated in the rat."3.67Role of histamine in traumatic brain edema. An experimental study in the rat. ( Chansouria, JP; Dey, PK; Mohanty, S; Olsson, Y; Sharma, HS; Singh, S, 1989)
"In cimetidine-pretreated animals, the cerebral blood flow was significantly elevated and the plasma and brain 5-hydroxytryptamine (serotonin) levels were slightly but significantly reduced as compared with the untreated stressed group."1.28Histamine modulates heat stress-induced changes in blood-brain barrier permeability, cerebral blood flow, brain oedema and serotonin levels: an experimental study in conscious young rats. ( Cervos-Navarro, J; Dey, PK; Nyberg, F; Sharma, HS, 1992)
"Pretreatment with histamine H2 receptor antagonist cimetidine significantly reduced the extravasation of both the tracers and thwarted the increase of brain water content as compared to the untreated group."1.28Role of histamine in pathophysiology of heat stress in rats. ( Cervós-Navarro, J; Sharma, HS, 1991)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Csanda, E1
Patnaik, R1
Mohanty, S2
Sharma, HS4
Nyberg, F1
Cervos-Navarro, J2
Dey, PK2
Singh, S1
Chansouria, JP1
Olsson, Y1

Other Studies

5 other studies available for cimetidine and Brain Edema

ArticleYear
Radiation brain edema.
    Advances in neurology, 1980, Volume: 28

    Topics: Animals; Brain; Brain Edema; Cats; Cimetidine; Dogs; Electrons; Evans Blue; Metiamide; Rabbits; Rats

1980
Blockade of histamine H2 receptors attenuate blood-brain barrier permeability, cerebral blood flow disturbances, edema formation and cell reactions following hyperthermic brain injury in the rat.
    Acta neurochirurgica. Supplement, 2000, Volume: 76

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Capillary Permeability; Cimetidine

2000
Histamine modulates heat stress-induced changes in blood-brain barrier permeability, cerebral blood flow, brain oedema and serotonin levels: an experimental study in conscious young rats.
    Neuroscience, 1992, Volume: 50, Issue:2

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Cimetidine; Histamine; Hot Temperature; Male; Orga

1992
Role of histamine in pathophysiology of heat stress in rats.
    Agents and actions. Supplements, 1991, Volume: 33

    Topics: Animals; Blood-Brain Barrier; Body Water; Brain; Brain Edema; Cimetidine; Histamine; Hot Temperature

1991
Role of histamine in traumatic brain edema. An experimental study in the rat.
    Journal of the neurological sciences, 1989, Volume: 90, Issue:1

    Topics: Animals; Brain Edema; Brain Injuries; Cimetidine; Histamine; Male; Pyrilamine; Rats; Rats, Inbred St

1989