cimetidine has been researched along with Bone Loss, Osteoclastic in 7 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of cimetidine on rat adjuvant arthritis (AA) and rat osteoclast differentiation were studied." | 3.72 | The histamine H2-receptor antagonist, cimetidine, inhibits the articular osteopenia in rats with adjuvant-induced arthritis by suppressing the osteoclast differentiation induced by histamine. ( Nakamura, T; Ueno, K; Yamaura, K; Yano, S; Yonekawa, T, 2003) |
| "In this study cytokine-induced bone resorption was blocked with cimetidine and clotrimazole, which are selective inhibitors of the cytochrome P-450 IIIA family and 7-ethoxyresorufin, a nonspecific cytochrome P-450 inhibitor." | 1.30 | Cytokine-mediated bone resorption is cytochrome P-450 dependent. Student Research Award 1998. ( Chole, R; Young, N, 1999) |
| "Omeprazole is an inhibitor of gastric H+,K(+)-ATPase." | 1.29 | Effect of omeprazole, an inhibitor of H+,K(+)-ATPase, on bone resorption in humans. ( Abe, K; Furukawa, Y; Katano, K; Mizunashi, K, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jafarzadeh, A | 1 |
| Nemati, M | 1 |
| Khorramdelazad, H | 1 |
| Hassan, ZM | 1 |
| Yamaura, K | 1 |
| Yonekawa, T | 1 |
| Nakamura, T | 1 |
| Yano, S | 1 |
| Ueno, K | 1 |
| Lesclous, P | 2 |
| Guez, D | 2 |
| Baroukh, B | 1 |
| Vignery, A | 1 |
| Saffar, JL | 3 |
| Mizunashi, K | 1 |
| Furukawa, Y | 1 |
| Katano, K | 1 |
| Abe, K | 1 |
| Dobigny, C | 1 |
| Young, N | 1 |
| Chole, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Correlation Between Peri-implantitis and Assumptions of Medications: a Retrospective Study[NCT04783974] | 270 participants (Actual) | Observational | 2021-02-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for cimetidine and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Immunomodulatory properties of cimetidine: Its therapeutic potentials for treatment of immune-related diseases.
Topics: Animals; Bone Resorption; Burns; Cimetidine; Dendritic Cells; Histamine; Humans; Hypersensitivity; I | 2019 |
6 other studies available for cimetidine and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
The histamine H2-receptor antagonist, cimetidine, inhibits the articular osteopenia in rats with adjuvant-induced arthritis by suppressing the osteoclast differentiation induced by histamine.
Topics: Animals; Arthritis, Experimental; Bone Density; Bone Resorption; Cartilage, Articular; Cell Differen | 2003 |
Histamine participates in the early phase of trabecular bone loss in ovariectomized rats.
Topics: Animals; Body Weight; Bone Resorption; Cimetidine; Famotidine; Female; Femur; Histamine; Immunohisto | 2004 |
Effect of omeprazole, an inhibitor of H+,K(+)-ATPase, on bone resorption in humans.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Biomarkers; Body Weight; Bone Resorption; Calcium; Ch | 1993 |
H1 and H2 histamine receptors modulate osteoclastic resorption by different pathways: evidence obtained by using receptor antagonists in a rat synchronized resorption model.
Topics: Animals; Bone Resorption; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Degranulation; Cimetid | 1997 |
Cytokine-mediated bone resorption is cytochrome P-450 dependent. Student Research Award 1998.
Topics: Animals; Bone Resorption; Cimetidine; Clotrimazole; Cytochrome P-450 Enzyme System; Dose-Response Re | 1999 |
Short-term prevention of osteoclastic resorption and osteopenia in ovariectomized rats treated with the H(2) receptor antagonist cimetidine.
Topics: Animals; Bone Diseases, Metabolic; Bone Resorption; Cell Differentiation; Cell Size; Cimetidine; Fem | 2002 |